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A ribozyme that cuts DNA - programmably!! It has a ways to go before it can be a precision genome editing tool - short target recognition sequence, doesn’t bind dsDNA well - but an exciting discovery nonetheless! Study from Jun-Jie Gogo Liu lab at Tsinghua University, published in Science Magazine

Julia Bauman

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41,530 次观看 • 2 年前 •via X (Twitter)

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The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine

Julia Bauman

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DNA origami can create comparably giant structures, but protein design offers atomic precision, enabling molecular recognition and catalytic functions. Potential there for combining these approaches in the future. Science Magazine

DNA origami can create comparably giant structures, but protein design offers atomic precision, enabling molecular recognition and catalytic functions. Potential there for combining these approaches in the future. Science Magazine

Hendrik Dietz

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Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Nancy Grace warns sending crucial DNA to a private lab could risk destroying limited evidence, questioning why it’s not being handled by the FBI: “There are cases where DNA is sent to a particular lab, a specialty lab, a lab that could have expertise in diluted, destroyed, old, or degraded DNA. But even if that’s why he’s hanging his hat on an excuse to send it to a private lab in Florida, they don’t have anything that the FBI doesn’t have, so that’s not going to wash. If there’s a small amount of DNA inside one of those gloves and it is sent to a lab for testing, that DNA could be used up in the testing. So what I’m saying is, if that lab in Florida uses up that touch DNA, it’s over. Does he not realize what he is risking? He needs to go back to his basketball game.”

Sean Hannity 🇺🇸

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"You can look at it from a lot of points of view. Obviously the gap is smaller now to Lando than it was before the disqualification but Max is also closer in the fight as well. It goes both ways but I think we've taken the lessons, analysed what happened in Vegas. Here is obviously very different to Vegas and a lot of other circuits we go to so hopefully it can be a good weekend! 😁☺️"

"You can look at it from a lot of points of view. Obviously the gap is smaller now to Lando than it was before the disqualification but Max is also closer in the fight as well. It goes both ways but I think we've taken the lessons, analysed what happened in Vegas. Here is obviously very different to Vegas and a lot of other circuits we go to so hopefully it can be a good weekend! 😁☺️"

a⁸¹ 🎐 | FAN ACCOUNT

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1/ Published in nature , a study led by Monash Biomedicine Discovery Institute's @Rhys__G Ashleigh Kropp & Chris Greening has discovered an enzyme – 'Huc' – that can covert air into energy & has the potential to become a new clean source of energy. Monash University Monash Medicine, Nursing and Health Sciences Read more

1/ Published in nature , a study led by Monash Biomedicine Discovery Institute's @Rhys__G Ashleigh Kropp & Chris Greening has discovered an enzyme – 'Huc' – that can covert air into energy & has the potential to become a new clean source of energy. Monash University Monash Medicine, Nursing and Health Sciences Read more

Monash Biomedicine Discovery Institute

33,646 次观看 • 3 年前

They lied. It can change your DNA...Sweden's study proves mRNA shots change the human genome in only 6 hours.

They lied. It can change your DNA...Sweden's study proves mRNA shots change the human genome in only 6 hours.

Valerie Anne Smith

22,766 次观看 • 5 个月前

Ha, clever idea! Grafting & mobile CRISPR for genome editing in plants. An unmodified shoot is grafted onto roots containing a mobile CRISPR/Cas9 moving from root to shoot. There it edits the plant DNA but leaves no trace of itself in the next gen! Voilà!

Ha, clever idea! Grafting & mobile CRISPR for genome editing in plants. An unmodified shoot is grafted onto roots containing a mobile CRISPR/Cas9 moving from root to shoot. There it edits the plant DNA but leaves no trace of itself in the next gen! Voilà!

Be the change you want to be

33,195 次观看 • 3 年前

It’s incredible that we can treat sickle cell disease with CRISPR, but it’d be extremely useful to have a pill that does the same thing. Work from Pamela Ting Jay Bradner, M.D. in Science Magazine show it may be possible with a molecular glue small molecule!

It’s incredible that we can treat sickle cell disease with CRISPR, but it’d be extremely useful to have a pill that does the same thing. Work from Pamela Ting Jay Bradner, M.D. in Science Magazine show it may be possible with a molecular glue small molecule!

Julia Bauman

34,308 次观看 • 1 年前

Demis Hassabis just described the moment medicine stops treating disease and starts deleting it from the source code. For all of human history, doctors have fought symptoms. The tumor. The organ failure. The collapse. Always downstream. Always after the damage has already started. The cause sits upstream. Written into the DNA. Ninety-eight percent of the human genome sits in non-coding regions. For decades, science understood the genes but couldn’t read the vast dark territory between them. That’s where most disease hides. Hassabis: “It takes the big, long genetic sequences and then it tries to predict, if you made a mutation to this particular single letter, single position in the genetic sequence, will that be a harmful mutation that might cause disease, or is it benign?” AlphaGenome reads your entire genetic sequence and identifies the exact letter that’s corrupted. Not a region. Not a probability range. A single position in a three-billion-letter sequence. That alone would be a generational breakthrough. But most diseases aren’t that clean. Hassabis: “What if they’re multigenic diseases where there’s cascades of mutations causing the problem? Those are even harder to detect, but actually perfect for sort of AI.” One mutation is hard enough to find. A cascade of mutations interacting across the genome is a problem no human researcher can hold in their head at once. Three billion data points. Compounding errors across all of them. The human brain cannot solve that. AI doesn’t solve it either. It maps it. All of it. At once. The most devastating diseases on Earth. The ones medicine has called untreatable for generations. They are not mysteries to the algorithm. They’re compute problems. But finding the error was only ever half the equation. You also need the ability to fix it. That tool already exists. CRISPR is a molecular scalpel. It cuts DNA at exact positions. The limitation was never the editing. It was knowing exactly where to cut. Hassabis: “A kind of combination of things like AlphaGenome and CRISPR could be incredibly powerful.” AI reads the code. CRISPR rewrites it. One finds the mutation. The other corrects it at the source. Not managing symptoms. Not slowing progression. Deleting the error from the genome. The implications go beyond treatment. A disease corrected at the genetic level doesn’t just disappear from one patient. It disappears from their bloodline. The read access is here. The write access exists. The merge is inevitable. The era of accepting a broken genetic hand is ending. We stopped being passengers in our own biology.

Demis Hassabis just described the moment medicine stops treating disease and starts deleting it from the source code. For all of human history, doctors have fought symptoms. The tumor. The organ failure. The collapse. Always downstream. Always after the damage has already started. The cause sits upstream. Written into the DNA. Ninety-eight percent of the human genome sits in non-coding regions. For decades, science understood the genes but couldn’t read the vast dark territory between them. That’s where most disease hides. Hassabis: “It takes the big, long genetic sequences and then it tries to predict, if you made a mutation to this particular single letter, single position in the genetic sequence, will that be a harmful mutation that might cause disease, or is it benign?” AlphaGenome reads your entire genetic sequence and identifies the exact letter that’s corrupted. Not a region. Not a probability range. A single position in a three-billion-letter sequence. That alone would be a generational breakthrough. But most diseases aren’t that clean. Hassabis: “What if they’re multigenic diseases where there’s cascades of mutations causing the problem? Those are even harder to detect, but actually perfect for sort of AI.” One mutation is hard enough to find. A cascade of mutations interacting across the genome is a problem no human researcher can hold in their head at once. Three billion data points. Compounding errors across all of them. The human brain cannot solve that. AI doesn’t solve it either. It maps it. All of it. At once. The most devastating diseases on Earth. The ones medicine has called untreatable for generations. They are not mysteries to the algorithm. They’re compute problems. But finding the error was only ever half the equation. You also need the ability to fix it. That tool already exists. CRISPR is a molecular scalpel. It cuts DNA at exact positions. The limitation was never the editing. It was knowing exactly where to cut. Hassabis: “A kind of combination of things like AlphaGenome and CRISPR could be incredibly powerful.” AI reads the code. CRISPR rewrites it. One finds the mutation. The other corrects it at the source. Not managing symptoms. Not slowing progression. Deleting the error from the genome. The implications go beyond treatment. A disease corrected at the genetic level doesn’t just disappear from one patient. It disappears from their bloodline. The read access is here. The write access exists. The merge is inevitable. The era of accepting a broken genetic hand is ending. We stopped being passengers in our own biology.

Dustin

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The BBC: "It could be on sale soon at a supermarket near you—food grown not on a farm but in a laboratory." "This Wagyu sirloin is claimed to be healthier because it can be designed with lower cholesterol and added nutrients." "The science of making lab-grown food is something that the UK is really good at. But the approvals process to have them sold in supermarkets takes far too long." "The government's science minister has a solution. It's to get the lab-grown food firms to work with the regulator to draw up an approvals process that is both faster and safer." "But critics are concerned there's a conflict of interest in having the lab-grown food companies involved in drawing up the new rules."

The BBC: "It could be on sale soon at a supermarket near you—food grown not on a farm but in a laboratory." "This Wagyu sirloin is claimed to be healthier because it can be designed with lower cholesterol and added nutrients." "The science of making lab-grown food is something that the UK is really good at. But the approvals process to have them sold in supermarkets takes far too long." "The government's science minister has a solution. It's to get the lab-grown food firms to work with the regulator to draw up an approvals process that is both faster and safer." "But critics are concerned there's a conflict of interest in having the lab-grown food companies involved in drawing up the new rules."

Wide Awake Media

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"It's a permanent fixture of their genome now" "Can the little pieces of DNA that are in the [Pfizer mRNA] vaccine ever get into the human genome?": “The Pfizer vaccine is contaminated with Plasmid DNA, it's not just mRNA...it's got bits of DNA in it [and I know] because I sequenced it in my own lab” Phillip Buckhaults, PhD Biochemistry and Molecular Biology. Scientist & Professor of Molecular Biology & Genetics

"It's a permanent fixture of their genome now" "Can the little pieces of DNA that are in the [Pfizer mRNA] vaccine ever get into the human genome?": “The Pfizer vaccine is contaminated with Plasmid DNA, it's not just mRNA...it's got bits of DNA in it [and I know] because I sequenced it in my own lab” Phillip Buckhaults, PhD Biochemistry and Molecular Biology. Scientist & Professor of Molecular Biology & Genetics

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It is very exciting to imagine a world where agricultural scale involves not vast reservoirs of chemicals, but high-tech, precision equipment Things like the weeder (shown below) that burns thousands of weeds a minute, dozens a second, saving farmers money and obviating RoundUp We shall see, but it is very exciting, and the sort of innovations that could come from an industrial sector that produces such equipment in America would be incredible This is what America has done so well in the past, with using the building of useful machinery to drive massive investment and innovation in an ever-growing sector. It would be really cool to see it happen again

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The American Tribune

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Duffy: This airport has a target of 37 controllers at Laguardia. We have 33 controllers employed and certified at Laguardia and we have six -- seven actually in training so as our airports go, Laguardia is a very well staffed airport. We are a couple controllers short in total but it is a well staffed airport.

Duffy: This airport has a target of 37 controllers at Laguardia. We have 33 controllers employed and certified at Laguardia and we have six -- seven actually in training so as our airports go, Laguardia is a very well staffed airport. We are a couple controllers short in total but it is a well staffed airport.

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disclaimer: i suck at editing but at least I gave it a try before hiring a video editor (hopefully he can make it much better)

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Whatever the next generation of IVAS looks like, it won't just be a tool for a solider on the battlefield. It can also be a tool for a worker in a shipyard. If we leverage new tech to fix old industrial problems, this will be an exciting time for the American industrial base.

Whatever the next generation of IVAS looks like, it won't just be a tool for a solider on the battlefield. It can also be a tool for a worker in a shipyard. If we leverage new tech to fix old industrial problems, this will be an exciting time for the American industrial base.

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“I’m a scientist and I study cancer. But sometimes I go for a wander”. richard white advocates going beyond the lab to search for a cancer cure in the unlikeliest of places. Join us on a journey of scientific discovery: Medical Sciences University of Oxford [1/2]

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The post summarizes a 2016 Temple University study published in Scientific Reports, where CRISPR/Cas9 excised HIV-1 DNA from infected human T-cells, rendering them resistant to re-infection without off-target effects. Also check out the work from leor weinberger at Gladstone Institutes on TIPs hijacking therapy! TED Talks

The post summarizes a 2016 Temple University study published in Scientific Reports, where CRISPR/Cas9 excised HIV-1 DNA from infected human T-cells, rendering them resistant to re-infection without off-target effects. Also check out the work from leor weinberger at Gladstone Institutes on TIPs hijacking therapy! TED Talks

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380,816 次观看 • 7 个月前

REMINDER: The genome for SARS-CoV-2 is a "consensus sequence." Anybody who says the gene sequence for SARS2 is confirmed is *confused or lying.* "[The reality is that] nobody has the code of the pathogen..." "What they set for the control [for the PCR 'test'] is a consensus sequence, which [means] they took AI, they averaged out a section of the genome that they want as that test, and they set it for that. So it doesn't even exist in nature anywhere." This is a clip from a recent discussion between former medical coder and whistleblower Zowe Smith (Zowe Smith) and retired pharma R&D executive Sasha Latypova (sashalatypova.substack.com "Due Diligence and Art"). Smith and Latypova discuss the many shortcomings of PCR "tests," as well as the fact that no genome for SARS-CoV-2 has ever been characterized—only a "consensus sequence," which Smith notes is developed when AI "average[s] out... a section of the genome that they want as a test." She adds, "it doesn't even exist in nature anywhere." Latypova confirms, "when they're saying, 'Oh, we have the COVID virus, the full genome...it's been sequenced. Look at all these papers.' [The reality is that] nobody has the code of the pathogen... Ralph Baric also wrote about it in his work all the time. So nobody has the pathogenic sequence." The pharma insider adds, "What they upload to GenBank is... averaged... And once it's averaged, it's no longer pathogenic anything. It's just a model. And then for PCR, [it] doesn't test the full genome. They do these, like, snippets, and then whatever snippet you wanna set it to, you will find it, and that's how they find... positive COVID. So all of this is total BS." Interestingly, Smith notes that when she worked with PCR in a lab at the Oregon Health and Science University "[she] realized that everything was controlled through EUA [Emergency Use Authorization] and the CDC, so there was no way to independently verify [the controls that were used]."

REMINDER: The genome for SARS-CoV-2 is a "consensus sequence." Anybody who says the gene sequence for SARS2 is confirmed is confused or lying. "[The reality is that] nobody has the code of the pathogen..." "What they set for the control [for the PCR 'test'] is a consensus sequence, which [means] they took AI, they averaged out a section of the genome that they want as that test, and they set it for that. So it doesn't even exist in nature anywhere." This is a clip from a recent discussion between former medical coder and whistleblower Zowe Smith (Zowe Smith) and retired pharma R&D executive Sasha Latypova (sashalatypova.substack.com "Due Diligence and Art"). Smith and Latypova discuss the many shortcomings of PCR "tests," as well as the fact that no genome for SARS-CoV-2 has ever been characterized—only a "consensus sequence," which Smith notes is developed when AI "average[s] out... a section of the genome that they want as a test." She adds, "it doesn't even exist in nature anywhere." Latypova confirms, "when they're saying, 'Oh, we have the COVID virus, the full genome...it's been sequenced. Look at all these papers.' [The reality is that] nobody has the code of the pathogen... Ralph Baric also wrote about it in his work all the time. So nobody has the pathogenic sequence." The pharma insider adds, "What they upload to GenBank is... averaged... And once it's averaged, it's no longer pathogenic anything. It's just a model. And then for PCR, [it] doesn't test the full genome. They do these, like, snippets, and then whatever snippet you wanna set it to, you will find it, and that's how they find... positive COVID. So all of this is total BS." Interestingly, Smith notes that when she worked with PCR in a lab at the Oregon Health and Science University "[she] realized that everything was controlled through EUA [Emergency Use Authorization] and the CDC, so there was no way to independently verify [the controls that were used]."

Sense Receptor

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