A SINGLE 20g dose of creatine increases cognitive processing speed by 24.5% within 3.5 hours. A placebo-controlled trial found that creatine rapidly enhanced brain bioenergetics and improved cognitive performance during sleep deprivation, with effects lasting up to nine hours.

Creatine has long been regarded as just a muscle supplement — something for the gym that requires weeks of “loading” to saturate muscle stores. A recent randomized trial overturns that assumption.

So the pre-workout creatine loading guys were accidentally biohacking their brains this whole time.

This study is fascinating — and from a longevity perspective, it’s even bigger than just a quick cognitive boost. Creatine supports brain ATP (energy), which helps protect against cognitive decline as we age. A single 20g dose during sleep deprivation is impressive, but consistent low-dose (5g daily) can build long-term resilience for your brain, muscles, and overall healthspan.

20g in 1 shot will have you shittin water all day too lol, *experience*

I’m beginning to wonder if this “increase to cognitive processing” is really just a result of one’s inevitable awareness and need to use the bathroom more frequently…

@tyler_durdenn69 @Warszawski_R podbijamy dawki panowie!

This is great. I've been taking creatine for a couple of years now for my workouts. I wondered why I could think more clearly but never put it together.

So you can do math and compose a prosẽ while strapped to the toilet all day.

20g? That’s 4x what I’ve read to take.

You know how much creatine that is ha.. I’m parched on 4g of creatine and I drink water like a fish

There should be focus on creatine and gut issues as well. Pretty sure this thing cases people to take 3 times more shits and not the one that is in any form healthy

Creatine isn't just for bicep peaks; it’s an ATP buffer for your prefrontal cortex. If you're sleep-deprived, your brain is a misfiring engine; boosting brain bioenergetics by 24% isn't a "hack"—it's just finally taking the parking brake off your cognition.

Which creatine was this study using? Creatine mono hydrate or creatine hcl?

Will also have you sprinting to the bathroom 30 mins after taking it

My dad has Parkinson's. Does this work for people with Parkinson's? If so, where can I get it? Just any seller on Amazon?

20g single dose is wild but makes sense - creatine loads brain ATP fast. For cognitive benefits without the GI chaos, I do 5g daily + 200mg caffeine AM. Works better than any nootropic stack I've tried. The 24.5% boost during sleep deprivation is the real kicker.

@BrianRoemmele @grok what are the dangers to high doses of Creatine

You need more creatine, dude. You sound like you’re about to pass out.

@BrianRoemmele Has anyone invented a way to choke down 20g of creatine palatably?

Now, how to figure out how to take creatine without it giving you the shits. That's the part I struggle with.

I hear there are bad brands? Anyone recommend any good ones?

I'm only concerned about the hair fall due to creatine.

@BrianRoemmele Dont need the study. You will know it once youve experienced feeling like supercomputer and a terminator simultaneously.

I think I'm going to start giving it to my husband who has dementia. I might take it myself! B12, hold our beer.

Would shit my pants at 20g lol no way this doesn’t cause some serious gastric problems

Take your 20g dose of creatine before the big exam

How do you do this without icky GI upset? Like I’m suffering right now…

@larrybirdizzel2 stack with a pouchy 🔥

@NicHulscher I'm interested in the impact creatine would then have on a brain during the clean up phase, soon after falling asleep? More thorough particle removal or unrelated...any planned follow up study foci?

Others found zero effect. Meanwhile there are pollutants in the powders that can be dangerous.

It has nearly zero effect on non-sleep deprived people. As significant as this is it's far more important to achieve optimal sleep than it is to take creatine.

It’s honestly crazy how much sleep deprivation disrupts life. Messes the whole mind-body system up

Hmmm? That explains it. And, I was just doing it for my running.

Creatine is amazing! 💪 🧠