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A startling new study links melatonin and heart failure. Dr. Mike Varshavski breaks down what you need to know. “Melatonin is probably the most misused supplement in my patient population.”

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14,982 views • 9 months ago •via X (Twitter)

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A recent study associated melatonin with an 89% higher risk of heart failure, but this is likely an association, not causation. Poor sleep, which melatonin users often try to correct, is the real culprit. #Melatonin #HeartHealth
2:29

A recent study associated melatonin with an 89% higher risk of heart failure, but this is likely an association, not causation. Poor sleep, which melatonin users often try to correct, is the real culprit. #Melatonin #HeartHealth

Matt Walker

29,388 views • 7 months ago

Does using melatonin raise heart failure risk? A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without a documented use of melatonin. There are some major caveats: this is observational (an association, not causation), the database mixed countries where melatonin is over-the-counter vs prescription, and insomnia severity and other psychiatric conditions weren’t captured. Importantly, randomized trials in people with established heart failure show no harm from melatonin use and some signals of benefit including better quality of life and improved ejection fraction. This is an interesting real-world signal that merits peer review and careful follow-up, but it is not proof that melatonin causes heart failure.
7:57

Does using melatonin raise heart failure risk? A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without a documented use of melatonin. There are some major caveats: this is observational (an association, not causation), the database mixed countries where melatonin is over-the-counter vs prescription, and insomnia severity and other psychiatric conditions weren’t captured. Importantly, randomized trials in people with established heart failure show no harm from melatonin use and some signals of benefit including better quality of life and improved ejection fraction. This is an interesting real-world signal that merits peer review and careful follow-up, but it is not proof that melatonin causes heart failure.

Dr. Rhonda Patrick

69,995 views • 7 months ago

Sleep doctor says taking melatonin without understanding what it does can cause serious harm to your body “Melatonin is by prescription only almost everywhere outside the United States. Melatonin is a hormone. There’s a reason you can’t go to CVS and get testosterone and estrogen, right? Hormones affect the entire system. What you don’t want to do is have somebody just willy-nilly grabbing a hormone and starting to take it without understanding what’s going on with them” “More importantly, melatonin in particular interacts with SSRI medications. An SSRI is a serotonin-specific reuptake inhibitor, an antidepressant, things like Prozac, Zoloft, and Celexa. All of those are medications that can be affected by melatonin ingestion. In addition, melatonin can affect birth control, blood pressure medication, and diabetes medication” “Melatonin is a sleep regulator, not a sleep initiator. Melatonin doesn’t affect sleep drive, it affects sleep rhythm. It mainly affects your brain, telling it when it’s time to go to bed. It does not directly make you sleepy”
1:35

Sleep doctor says taking melatonin without understanding what it does can cause serious harm to your body “Melatonin is by prescription only almost everywhere outside the United States. Melatonin is a hormone. There’s a reason you can’t go to CVS and get testosterone and estrogen, right? Hormones affect the entire system. What you don’t want to do is have somebody just willy-nilly grabbing a hormone and starting to take it without understanding what’s going on with them” “More importantly, melatonin in particular interacts with SSRI medications. An SSRI is a serotonin-specific reuptake inhibitor, an antidepressant, things like Prozac, Zoloft, and Celexa. All of those are medications that can be affected by melatonin ingestion. In addition, melatonin can affect birth control, blood pressure medication, and diabetes medication” “Melatonin is a sleep regulator, not a sleep initiator. Melatonin doesn’t affect sleep drive, it affects sleep rhythm. It mainly affects your brain, telling it when it’s time to go to bed. It does not directly make you sleepy”

Mikli

80,499 views • 3 months ago

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CBC Edmonton

12,954 views • 3 years ago

All you need to know about the latest hot science in #HeartFailure is brought to you by Carolyn Lam and Marco Metra, and moderated by Levent Pay, FESC👇 DAPA ACT HF-TIMI 68: Dapagliflozin in Patients Hospitalised for Acute Heart Failure VICTOR: Vericiguat Global Study in Participants with Chronic Heart Failure VICTOR: Vericiguat Global Study in Participants with Chronic Heart Failure and VICTORIA: Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction ODYSSEY-HCM: Mavacamten in nHCM MAPLE-HCM: aficamten vs metoprolol in oHCM #ESCCongress #ESCsnacks
9:30

All you need to know about the latest hot science in #HeartFailure is brought to you by Carolyn Lam and Marco Metra, and moderated by Levent Pay, FESC👇 DAPA ACT HF-TIMI 68: Dapagliflozin in Patients Hospitalised for Acute Heart Failure VICTOR: Vericiguat Global Study in Participants with Chronic Heart Failure VICTOR: Vericiguat Global Study in Participants with Chronic Heart Failure and VICTORIA: Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction ODYSSEY-HCM: Mavacamten in nHCM MAPLE-HCM: aficamten vs metoprolol in oHCM #ESCCongress #ESCsnacks

European Society of Cardiology

13,834 views • 11 months ago

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?
0:45

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?

Camus

26,404 views • 4 months ago

Andrew Huberman had a pretty strong take on melatonin on JRE. He doesn’t recommend it for sleep. High melatonin levels suppress puberty in kids. In animal studies, giving it to male hamsters made their testes shrink from marble-sized to rice-grain-sized in just one week. Females’ ovaries basically shriveled. It might knock you out at first, but it often wears off after a few hours, leaving you staring at the ceiling. And there are real concerns about what it does to testosterone and estrogen balance. I always thought melatonin was harmless because it’s “natural,” but this made me pause. Sleep is everything, but if a popular supplement is messing with hormones without even delivering deep, quality rest, we should probably be smarter about it. What do you use to help you sleep?
1:16

Andrew Huberman had a pretty strong take on melatonin on JRE. He doesn’t recommend it for sleep. High melatonin levels suppress puberty in kids. In animal studies, giving it to male hamsters made their testes shrink from marble-sized to rice-grain-sized in just one week. Females’ ovaries basically shriveled. It might knock you out at first, but it often wears off after a few hours, leaving you staring at the ceiling. And there are real concerns about what it does to testosterone and estrogen balance. I always thought melatonin was harmless because it’s “natural,” but this made me pause. Sleep is everything, but if a popular supplement is messing with hormones without even delivering deep, quality rest, we should probably be smarter about it. What do you use to help you sleep?

Camus

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