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An article by Rose Anne Kenny, MD, DSc, summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients. Read “Syncope”:

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In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary:
1:48

In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary:

NEJM

10,641 görüntüleme • 1 yıl önce

Catheter-Directed PE Treatment: Does it Deliver? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a trial recently published in NEJM that compared catheter-directed thrombolysis to anticoagulation alone for acute, intermediate-risk pulmonary embolism. Read the key results and comment from Michael E. Billington, MD: Visit to see What Matters Most This Week, including: 🫀 New ACC/AHA Guideline on Lipid Management and ASCVD Prevention 💊 Chronic Beta-Blocker Use in Low-Risk Patients after MI: Time to Re-Evaluate 🧠 Reducing the Risk of Recurrent Stroke in Patients with Left Ventricular Dysfunction 🎯 What's the Ideal LDL Target for Patients with Cardiovascular Disease?
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Catheter-Directed PE Treatment: Does it Deliver? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a trial recently published in NEJM that compared catheter-directed thrombolysis to anticoagulation alone for acute, intermediate-risk pulmonary embolism. Read the key results and comment from Michael E. Billington, MD: Visit to see What Matters Most This Week, including: 🫀 New ACC/AHA Guideline on Lipid Management and ASCVD Prevention 💊 Chronic Beta-Blocker Use in Low-Risk Patients after MI: Time to Re-Evaluate 🧠 Reducing the Risk of Recurrent Stroke in Patients with Left Ventricular Dysfunction 🎯 What's the Ideal LDL Target for Patients with Cardiovascular Disease?

NEJM

12,682 görüntüleme • 5 ay önce

Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more in the Clinical Practice article “Peripheral Artery Disease in the Legs” by Mary M. McDermott, MD, from the Northwestern University Feinberg School of Medicine (Northwestern Feinberg School of Medicine):
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Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more in the Clinical Practice article “Peripheral Artery Disease in the Legs” by Mary M. McDermott, MD, from the Northwestern University Feinberg School of Medicine (Northwestern Feinberg School of Medicine):

NEJM

13,053 görüntüleme • 7 ay önce

A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes. Read the Review Article “Physiologic Pacing in Heart Failure” by Mihail G. Chelu, MD, PhD, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (Kenneth Ellenbogen), from the Baylor College of Medicine (BCMHouston), University of Washington (University of Washington), and Virginia Commonwealth University School of Medicine:
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A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes. Read the Review Article “Physiologic Pacing in Heart Failure” by Mihail G. Chelu, MD, PhD, MD, PhD, Jeanne E. Poole, MD, and Kenneth A. Ellenbogen, MD (Kenneth Ellenbogen), from the Baylor College of Medicine (BCMHouston), University of Washington (University of Washington), and Virginia Commonwealth University School of Medicine:

NEJM

13,765 görüntüleme • 7 ay önce

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

NEJM

89,842 görüntüleme • 7 ay önce

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage, but is it really better than standard care with blood components? NEJM Editorial Fellow Katerina Lin, MD, recaps the results of the SWiFT trial. Read the full trial results:
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Whole-blood transfusion has recently gained favor in the management of severe hemorrhage, but is it really better than standard care with blood components? NEJM Editorial Fellow Katerina Lin, MD, recaps the results of the SWiFT trial. Read the full trial results:

NEJM

19,223 görüntüleme • 27 gün önce

How is cumulative medical imaging in childhood associated with cancer risk? NEJM Editorial Fellow Katerina Lin, MD, summarizes a recent retrospective cohort study involving 3 million children. Read the full study:
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How is cumulative medical imaging in childhood associated with cancer risk? NEJM Editorial Fellow Katerina Lin, MD, summarizes a recent retrospective cohort study involving 3 million children. Read the full study:

NEJM

22,571 görüntüleme • 5 ay önce

In low-risk patients with MI and early complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy was noninferior to dual antiplatelet therapy for ischemic outcomes and led to reduced bleeding at 1 year. Read the full TARGET-FIRST trial results in the Original Article “Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction”:
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In low-risk patients with MI and early complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy was noninferior to dual antiplatelet therapy for ischemic outcomes and led to reduced bleeding at 1 year. Read the full TARGET-FIRST trial results in the Original Article “Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction”:

NEJM

32,419 görüntüleme • 9 ay önce

Cardiogenic shock is defined as a cardiac disorder that results in both clinical and biochemical evidence of sustained tissue hypoperfusion. Learn more about the management and diagnosis of this disorder in the Review Article “Cardiogenic Shock” by Holger Thiele, MD (Holger Thiele), and Christian Hassager, MD, from Heart Center Leipzig at Leipzig University, Leipzig Heart Science, Rigshospitalet, and the University of Copenhagen (Københavns Uni):
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Cardiogenic shock is defined as a cardiac disorder that results in both clinical and biochemical evidence of sustained tissue hypoperfusion. Learn more about the management and diagnosis of this disorder in the Review Article “Cardiogenic Shock” by Holger Thiele, MD (Holger Thiele), and Christian Hassager, MD, from Heart Center Leipzig at Leipzig University, Leipzig Heart Science, Rigshospitalet, and the University of Copenhagen (Københavns Uni):

NEJM

13,525 görüntüleme • 8 ay önce

NEJM Editorial Fellow Katerina Lin, MD, summarizes the diagnosis and treatment of complex regional pain syndrome (CRPS), a rare limb-pain disorder. Learn more about this disorder in a December 10, 2025, Clinical Practice article:
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NEJM Editorial Fellow Katerina Lin, MD, summarizes the diagnosis and treatment of complex regional pain syndrome (CRPS), a rare limb-pain disorder. Learn more about this disorder in a December 10, 2025, Clinical Practice article:

NEJM

17,459 görüntüleme • 2 ay önce

NEJM Editorial Fellow Minali Nigam, MD, describes the case of a 22-year-old man who presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms. Read the case details and diagnosis:
0:42

NEJM Editorial Fellow Minali Nigam, MD, describes the case of a 22-year-old man who presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms. Read the case details and diagnosis:

NEJM

36,141 görüntüleme • 1 ay önce

Patients with giant-cell arteritis need better treatments. This video, in partnership with Dr. Glaucomflecken, summarizes new research findings on the JAK-1 inhibitor upadacitinib in patients with giant-cell arteritis. Access the article for free:
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Patients with giant-cell arteritis need better treatments. This video, in partnership with Dr. Glaucomflecken, summarizes new research findings on the JAK-1 inhibitor upadacitinib in patients with giant-cell arteritis. Access the article for free:

NEJM

92,899 görüntüleme • 1 yıl önce

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:
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Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

NEJM

62,545 görüntüleme • 5 ay önce

An 82-year-old man presented after being “found down.” One week earlier, he had returned from a 1-month visit to Chad, his country of birth, and had started having weakness. His body temperature was 37.4°C, and his blood pressure was 88/47 mm Hg. The physical examination was notable for confusion. Laboratory studies showed a hemoglobin level of 12 g per deciliter (reference range, 13.5 to 17), an elevated lactate dehydrogenase level, thrombocytopenia, metabolic acidosis, and acute kidney injury. A peripheral-blood smear is shown. Which of the following is the most appropriate next step in management? Submit your answer and see how others responded:
0:42

An 82-year-old man presented after being “found down.” One week earlier, he had returned from a 1-month visit to Chad, his country of birth, and had started having weakness. His body temperature was 37.4°C, and his blood pressure was 88/47 mm Hg. The physical examination was notable for confusion. Laboratory studies showed a hemoglobin level of 12 g per deciliter (reference range, 13.5 to 17), an elevated lactate dehydrogenase level, thrombocytopenia, metabolic acidosis, and acute kidney injury. A peripheral-blood smear is shown. Which of the following is the most appropriate next step in management? Submit your answer and see how others responded:

NEJM

25,765 görüntüleme • 1 ay önce

Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial that evaluated whether management of shock without early arterial catheterization is noninferior to the practice of early catheter insertion with regard to death from any cause at day 28. Read the full results for free:
1:18

Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial that evaluated whether management of shock without early arterial catheterization is noninferior to the practice of early catheter insertion with regard to death from any cause at day 28. Read the full results for free:

NEJM

47,843 görüntüleme • 8 ay önce

Pharmacologic treatment options for cancer cachexia are limited. NEJM Editorial Fellow Harleen Marwah, MD, summarizes research on the safety and efficacy of the monoclonal antibody ponsegromab for treating cancer cachexia. Read the full trial results:
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Pharmacologic treatment options for cancer cachexia are limited. NEJM Editorial Fellow Harleen Marwah, MD, summarizes research on the safety and efficacy of the monoclonal antibody ponsegromab for treating cancer cachexia. Read the full trial results:

NEJM

16,522 görüntüleme • 1 yıl önce

Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial investigating the effectiveness of shunt surgery for idiopathic normal-pressure hydrocephalus. Read the full results for free: #neurology
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial investigating the effectiveness of shunt surgery for idiopathic normal-pressure hydrocephalus. Read the full results for free: #neurology

NEJM

56,868 görüntüleme • 7 ay önce