正在加载视频...

视频加载失败

加载此视频时出现问题。这可能是由于临时网络问题，或视频可能不可用。

Blank Bio (Blank Bio) is building foundation models to power a computational toolkit for RNA therapeutics, starting with mRNA design and expanding to target ID, biomarker discovery, and more. Congrats on the launch, Jonny, Phil Fradkin & Ian Shi!

Y Combinator

1,614,397 subscribers

96,728 次观看 • 11 个月前 •via X (Twitter)

健康养生科学技术教育

Anya Rossi• Live Now

Private livecam show

0 条评论

暂无评论

原始帖子的评论将显示在这里

相关视频

Beacon Health is building AI agents for primary care - starting with value-based care. They are on a mission to bring joy back to the practice of medicine. Congrats on the launch, Mark and Obi!

Beacon Health is building AI agents for primary care - starting with value-based care. They are on a mission to bring joy back to the practice of medicine. Congrats on the launch, Mark and Obi!

Y Combinator

19,920 次观看 • 5 个月前

.Visibl Semiconductors is building the first coordination layer for chip design. As teams scale, workstreams drift out of sync, issues surface late and drive $XM+ delays and months of rework before tapeout. Visibl is building end-to-end AI to shrink chip design from years to weeks, starting where intent breaks first: coordination. Book a demo at Congrats on the launch Bryce N, and Jordon Kashanchi!

.Visibl Semiconductors is building the first coordination layer for chip design. As teams scale, workstreams drift out of sync, issues surface late and drive $XM+ delays and months of rework before tapeout. Visibl is building end-to-end AI to shrink chip design from years to weeks, starting where intent breaks first: coordination. Book a demo at Congrats on the launch Bryce N, and Jordon Kashanchi!

Y Combinator

22,189 次观看 • 4 个月前

🚀 We're thrilled to introduce Orthrus 🧬🐕—a groundbreaking mature RNA foundation model designed to push the boundaries of RNA property prediction! 🔬 What is Orthrus? Orthrus is a Mamba-based RNA foundation model, pre-trained using a novel self-supervised contrastive learning objective with biologically inspired augmentations. It optimizes the similarity between splicing isoforms and orthologous transcripts, capturing functional and evolutionary relationships to enhance mature RNA property prediction accuracy. 📑 Preprint: 💻 Code: 🌐 Project Page: 📦 Model Weights: 🧠 Why Orthrus? Decoding the RNA regulatory code is key to understanding biology, but traditional experimental approaches are slow and costly. Existing genomic foundation models rely on techniques like masked language modeling or next-token prediction, which aren't fully aligned with the complexities of genomic data—leading to suboptimal results. 🌟 Orthrus Highlights: - Biologically-Informed Contrastive Learning 🧪: A novel contrastive learning objective designed specifically for genomics, maximizing similarity between splicing isoforms and orthologous transcripts across species. - Extensive Pre-training 📊: Trained on splicing annotations from 10 species and orthologous alignments from 400+ mammalian species (Zoonomia Project), with a focus on sequences of high functional importance. - Superior Representations🏅: Orthrus outperforms existing genomic models on 5 mRNA property prediction tasks, often surpassing supervised methods with just a simple linear transformation. - Efficiency in Low-Data Settings📉: Orthrus excels in low-data regimes, achieving state-of-the-art results with as few as 45 labeled examples for fine-tuning on RNA half-life prediction. Shoutout to the amazing leading authors Phil (Phil Fradkin) and Ian (Ian Shi)! Also the work is impossible without an outstanding collaboration by Karina (Karin(a) Isaev), Brendan (Brendan Frey) , Quaid (Quaid Morris), Leo J. Lee! Vector Institute University Health Network U of T Department of Computer Science Temerty Centre for AI in Medicine (T-CAIREM) Department of Laboratory Medicine & Pathobiology

🚀 We're thrilled to introduce Orthrus 🧬🐕—a groundbreaking mature RNA foundation model designed to push the boundaries of RNA property prediction! 🔬 What is Orthrus? Orthrus is a Mamba-based RNA foundation model, pre-trained using a novel self-supervised contrastive learning objective with biologically inspired augmentations. It optimizes the similarity between splicing isoforms and orthologous transcripts, capturing functional and evolutionary relationships to enhance mature RNA property prediction accuracy. 📑 Preprint: 💻 Code: 🌐 Project Page: 📦 Model Weights: 🧠 Why Orthrus? Decoding the RNA regulatory code is key to understanding biology, but traditional experimental approaches are slow and costly. Existing genomic foundation models rely on techniques like masked language modeling or next-token prediction, which aren't fully aligned with the complexities of genomic data—leading to suboptimal results. 🌟 Orthrus Highlights: - Biologically-Informed Contrastive Learning 🧪: A novel contrastive learning objective designed specifically for genomics, maximizing similarity between splicing isoforms and orthologous transcripts across species. - Extensive Pre-training 📊: Trained on splicing annotations from 10 species and orthologous alignments from 400+ mammalian species (Zoonomia Project), with a focus on sequences of high functional importance. - Superior Representations🏅: Orthrus outperforms existing genomic models on 5 mRNA property prediction tasks, often surpassing supervised methods with just a simple linear transformation. - Efficiency in Low-Data Settings📉: Orthrus excels in low-data regimes, achieving state-of-the-art results with as few as 45 labeled examples for fine-tuning on RNA half-life prediction. Shoutout to the amazing leading authors Phil (Phil Fradkin) and Ian (Ian Shi)! Also the work is impossible without an outstanding collaboration by Karina (Karin(a) Isaev), Brendan (Brendan Frey) , Quaid (Quaid Morris), Leo J. Lee! Vector Institute University Health Network U of T Department of Computer Science Temerty Centre for AI in Medicine (T-CAIREM) Department of Laboratory Medicine & Pathobiology

Bo Wang

114,890 次观看 • 1 年前

Beluga Labs (@belugalabsai) is building Rippling for content creators, starting with automated taxes & bookkeeping. They're already saving creators thousands in deductions. Congrats on the launch, @ACKForeverYoung and Jack Swisher!

Beluga Labs (@belugalabsai) is building Rippling for content creators, starting with automated taxes & bookkeeping. They're already saving creators thousands in deductions. Congrats on the launch, @ACKForeverYoung and Jack Swisher!

Y Combinator

27,868 次观看 • 1 年前

AMBSE and the Arthur M. Blank Family Foundation are partnering with the USO Through a $1 million grant from the Arthur M. Blank Family Foundation, all USO Centers on U.S. Naval aircraft carriers will be outfitted and supported to benefit deployed service members at sea!

AMBSE and the Arthur M. Blank Family Foundation are partnering with the USO Through a $1 million grant from the Arthur M. Blank Family Foundation, all USO Centers on U.S. Naval aircraft carriers will be outfitted and supported to benefit deployed service members at sea!

Atlanta Falcons

39,811 次观看 • 1 年前

.CellType is building the agentic drug company. AI agents + foundation models that simulate human biology. They've already discovered and validated a novel cancer treatment signal and work with Top 10 pharma. Congrats on the launch David van Dijk and Ivan Vrkic!

.CellType is building the agentic drug company. AI agents + foundation models that simulate human biology. They've already discovered and validated a novel cancer treatment signal and work with Top 10 pharma. Congrats on the launch David van Dijk and Ivan Vrkic!

Y Combinator

46,752 次观看 • 4 个月前

.Cajal is massively scaling formal verification to accelerate scientific discovery. They deploy superhuman AI mathematicians to high-impact applied domains, starting with quantum computing and finance. Congrats on the launch, Luke & Pedro Nobre!

.Cajal is massively scaling formal verification to accelerate scientific discovery. They deploy superhuman AI mathematicians to high-impact applied domains, starting with quantum computing and finance. Congrats on the launch, Luke & Pedro Nobre!

Y Combinator

31,136 次观看 • 4 个月前

.Tensorfuse (YC W24) is a testing and evaluation platform for LLM apps. They make it easy for developers to experiment with various prompts, models, and retrieval methods to find the most effective one. Congrats on the launch agam & samagra14!

.Tensorfuse (YC W24) is a testing and evaluation platform for LLM apps. They make it easy for developers to experiment with various prompts, models, and retrieval methods to find the most effective one. Congrats on the launch agam & samagra14!

Y Combinator

14,195 次观看 • 2 年前

New Unsupervised Learning with Joshua Meier @ NeurIPS (Chai Discovery) on how AI x drug discovery is starting to inflect and: - The 3 waves of AI biotech - How AI models think differently than chemists - Building "Photoshop for molecules" - Deciding what to open source

New Unsupervised Learning with Joshua Meier @ NeurIPS (Chai Discovery) on how AI x drug discovery is starting to inflect and: - The 3 waves of AI biotech - How AI models think differently than chemists - Building "Photoshop for molecules" - Deciding what to open source

Jacob Effron

12,351 次观看 • 11 个月前

Refortifai is building Atrisa, agents for analog circuit design. It reasons hierarchically about your circuit, finds the right topologies for your specs, and does deep-dive debugging — all with awareness of parasitics, physical layout, reusability, and interference. Bring your existing PDKs, design docs, and toolkit and Atrisa will understand and adopt them. Congrats on the launch, Sayan Mitra, Rithik Jain, and Atman Kar!

Refortifai is building Atrisa, agents for analog circuit design. It reasons hierarchically about your circuit, finds the right topologies for your specs, and does deep-dive debugging — all with awareness of parasitics, physical layout, reusability, and interference. Bring your existing PDKs, design docs, and toolkit and Atrisa will understand and adopt them. Congrats on the launch, Sayan Mitra, Rithik Jain, and Atman Kar!

Y Combinator

12,728 次观看 • 1 个月前

Gravy is building Agents for your money. Gravy (YC P26) connects to your banks, investments, email and more to explain your money and automate your financial tasks. Congrats on the launch, Ali Tabba & Max Church!

Gravy is building Agents for your money. Gravy (YC P26) connects to your banks, investments, email and more to explain your money and automate your financial tasks. Congrats on the launch, Ali Tabba & Max Church!

Y Combinator

44,351 次观看 • 1 个月前

Rubric AI (Rubric AI (YC W26)) converts expert judgment into training signals for AI models and agents. The human + computational layer for AI reasoning and verification. Congrats on the launch, Pragya Saboo!

Rubric AI (Rubric AI (YC W26)) converts expert judgment into training signals for AI models and agents. The human + computational layer for AI reasoning and verification. Congrats on the launch, Pragya Saboo!

Y Combinator

16,199 次观看 • 4 个月前

Can bio foundation models solve the most critical therapeutics problem, predicting which patients will respond to a therapy? Today, we share more details in a white paper on our recently reported results using NOETIK TARIO-2 to predict responders in an actual clinical trial setting with Agenus.

Can bio foundation models solve the most critical therapeutics problem, predicting which patients will respond to a therapy? Today, we share more details in a white paper on our recently reported results using NOETIK TARIO-2 to predict responders in an actual clinical trial setting with Agenus.

Ron Alfa

17,153 次观看 • 28 天前

Excited to announce our new product: AI Protein Design Copilot Tamarind Bio has been the leading provider to use the top AI tools in computational protein engineering. Today we announce a completely new way to interface with computational molecular design. Available now!

Excited to announce our new product: AI Protein Design Copilot Tamarind Bio has been the leading provider to use the top AI tools in computational protein engineering. Today we announce a completely new way to interface with computational molecular design. Available now!

Deniz Kavi

33,395 次观看 • 1 年前

What if you could generate all your colors, typography styles, sizes, radii, and more as variables and tokens with just one click? No manual setup, in few minutes go from blank page to a solid design system foundation. With option to present everything nicely for dev doc and more. With this Figma plugin, it’s actually that simple. ✨

What if you could generate all your colors, typography styles, sizes, radii, and more as variables and tokens with just one click? No manual setup, in few minutes go from blank page to a solid design system foundation. With option to present everything nicely for dev doc and more. With this Figma plugin, it’s actually that simple. ✨

vijay verma

26,246 次观看 • 6 个月前

INTERNET OF μTHINGS, NANOTHINGS & BIO-NANOTHINGS - Dr. Ian F. Akyildiz 1. 2.(PDF) The internet of Bio-Nano things | Ian Akyildiz - 3.Ian F Akyildiz wants to teach everyone about his design for remotely

INTERNET OF μTHINGS, NANOTHINGS & BIO-NANOTHINGS - Dr. Ian F. Akyildiz 1. 2.(PDF) The internet of Bio-Nano things | Ian Akyildiz - 3.Ian F Akyildiz wants to teach everyone about his design for remotely

Ian Hurn

117,647 次观看 • 2 年前

The key to building a good base is starting with a small and reliable structure. Then expanding it, section by section.

The key to building a good base is starting with a small and reliable structure. Then expanding it, section by section.

Rust

104,335 次观看 • 2 年前

.Sureform (YC X25) connects real-world workplaces with robotics labs to collect task-specific training data for robot foundation models. Congrats on the launch, Ananth Kashyap!

.Sureform (YC X25) connects real-world workplaces with robotics labs to collect task-specific training data for robot foundation models. Congrats on the launch, Ananth Kashyap!

Y Combinator

35,876 次观看 • 4 个月前

YC W24’s Paradigm is building AI agents to complete your repetitive tasks. They're starting with sales, automating everything from lead generation to personalized outreach. Congrats on the launch Anna Monaco and Claire Oxner!

YC W24’s Paradigm is building AI agents to complete your repetitive tasks. They're starting with sales, automating everything from lead generation to personalized outreach. Congrats on the launch Anna Monaco and Claire Oxner!

Y Combinator

42,017 次观看 • 2 年前

Chert (Chert) is building the infrastructure for teams to send, receive, and automate conversations over iMessage using APIs. They’re already working with B2C startups, customer experience teams, and sales teams to reach end users through trusted and conversational messaging. Congrats on the launch, Gary Gao & Ian Fong!

Chert (Chert) is building the infrastructure for teams to send, receive, and automate conversations over iMessage using APIs. They’re already working with B2C startups, customer experience teams, and sales teams to reach end users through trusted and conversational messaging. Congrats on the launch, Gary Gao & Ian Fong!

Y Combinator

36,853 次观看 • 2 个月前