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Boosting exhausted T cells: Dr Daniel Utzschneider has identified how T cells can become exhausted from battling cancer, reducing the effectiveness of immunotherapy. He will use his CSL Centenary Fellowship to study these cells. Doherty Institute

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20,282 görüntüleme • 3 yıl önce •via X (Twitter)

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@TheDohertyInst Congrats Daniel!! @UtzschneiderD

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@TheDohertyInst Congrats this is so great !!!!! 🎉🎉🎉🎉

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Carl June the father of CAR-T cells discussing how to activate cold tumors (meaning cancer cells that are not recognized by T cells). These cold tumors which has lost their MHC expression are exactly the targets of NK cells.

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not enough people know cancer cells can actually hide inside other cancer cells (stat3/ifny/egr1) just to hide from t cells and then they pop back out from the carcass of the cell they hid in once the t cell is gone
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not enough people know cancer cells can actually hide inside other cancer cells (stat3/ifny/egr1) just to hide from t cells and then they pop back out from the carcass of the cell they hid in once the t cell is gone

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Jim Allison's conversation about treating the immune system and not the cancer and why he believed T cells should work for all tumor types. This was before he won the Nobel prize. Completely agree with him and met him for the first time at the Nixon / Milken Institute, Cancer 2035: A Roadmap for the Future. This conversation was a great prelude to my presentation on T and NK cells. From taking off the brakes of T cells to growing T cells and NK cells.
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Jim Allison's conversation about treating the immune system and not the cancer and why he believed T cells should work for all tumor types. This was before he won the Nobel prize. Completely agree with him and met him for the first time at the Nixon / Milken Institute, Cancer 2035: A Roadmap for the Future. This conversation was a great prelude to my presentation on T and NK cells. From taking off the brakes of T cells to growing T cells and NK cells.

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Dr. Patrick Soon-Shiong points out a critical flaw in oncology, stating that 99.9% of oncologists fail to recognize the importance of natural killer cells and T-cells, which are vital for destroying cancer cells.
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Dr. Patrick Soon-Shiong points out a critical flaw in oncology, stating that 99.9% of oncologists fail to recognize the importance of natural killer cells and T-cells, which are vital for destroying cancer cells.

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🚨ImmunityBio’s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your body’s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: • NK cells (natural killers) • CD8 T cells (main attackers) • CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. → It’s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (that’s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) — “Killing Cancer”
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Dr. Patrick Soon-Shiong reveals the "missing link" in cancer medicine that’s been hiding in plain sight for 450 million years of evolution: Natural Killer (NK) cells — your body’s built-in cancer assassins. Just like red blood cells prevent death from lack of oxygen, NK cells (and T cells) are designed to destroy cancer cells. Yet we’ve ignored them for most of medical history. In 2012, the National Cancer Institute reviewed 240 molecules and declared IL-15 the single most important one for curing cancer — because it supercharges NK cells and T cells. The problem? No one could deliver IL-15 safely and effectively… until Anktiva. 1:51 clip embedded — his passionate delivery makes the breakthrough feel like the missing piece we’ve overlooked for decades. Cancer isn’t just about killing tumors. It’s about waking up the immune system we were born with.
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Dr. Patrick Soon-Shiong just revealed that 52 million Americans reportedly have low T cell counts. And he warns having low T cells can double your risk of early death. “52 million Americans have low T cells.” “If you have low T cells, they showed statistically that it's below 1500.” “If it’s below 1000, the risk of dying earlier is two times.” “This is profound.” “If your T cells are low … you have a risk of dying earlier.” “Whether you’re without disease or whether you have cancer.” Dr. Pat Soon-Shiong
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Dr. Patrick Soon-Shiong just revealed that 52 million Americans reportedly have low T cell counts. And he warns having low T cells can double your risk of early death. “52 million Americans have low T cells.” “If you have low T cells, they showed statistically that it's below 1500.” “If it’s below 1000, the risk of dying earlier is two times.” “This is profound.” “If your T cells are low … you have a risk of dying earlier.” “Whether you’re without disease or whether you have cancer.” Dr. Pat Soon-Shiong

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Dr. Patrick Soon-Shiong unearths a 20 year old report in front of NIH Director Dr. Jay Bhattacharya Scientific leaders identified the most important molecule to stimulate the production of T Cells and NK Cells, which are “the most important cell in your body to kill cancer”. SOON-SHIONG - “Thought leaders of the country have known for close to 20 years”.

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Dr. Patrick Soon-Shiong calls out a massive blind spot in oncology "99.9% of oncologists ignore the only cells that actually kill cancer: natural killer cells and T-cells (lymphocytes in your CBC). They focus on anemia (red blood cells), low platelets, low neutrophils — but those don’t cure cancer. The real fighters? Completely overlooked in standard care." Eye-opening critique of how cancer treatment misses the immune system. 1:20 clip inside — must-watch for anyone following cancer science.
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Dr. Patrick Soon-Shiong calls out a massive blind spot in oncology "99.9% of oncologists ignore the only cells that actually kill cancer: natural killer cells and T-cells (lymphocytes in your CBC). They focus on anemia (red blood cells), low platelets, low neutrophils — but those don’t cure cancer. The real fighters? Completely overlooked in standard care." Eye-opening critique of how cancer treatment misses the immune system. 1:20 clip inside — must-watch for anyone following cancer science.

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Of all the casualties in the war on cancer, the most critical have been the most ignored: your NK and T cells. As Dr. Patrick Soon-Shiong explains, while oncology has long treated the anemia and neutropenia caused by chemotherapy, it has overlooked the destruction of the very immune cells that fight cancer. For 35 years, there was no treatment for this catastrophic side effect. That era is over. Dr. Soon-Shiong announces ANKTIVA, the first FDA-approved therapy proven to activate NK cells, T cells, and memory T cells. The result? Documented complete responses in bladder cancer patients, free of disease for over nine years. This breakthrough shatters a long-standing medical blind spot. Whether from chemo, radiation, or a severe viral infection, the body's primary defense is often wiped out. ANKTIVA represents a paradigm shift—from solely attacking disease to actively re-arming the patient's own immune system. The future of medicine is not just fighting the enemy, but empowering the army within.

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Dr. Patrick Soon-Shiong: We've ignored a key CBC metric for 75 years—Absolute Lymphocyte Count (ALC)—your body's count of cancer-fighting NK cells, T cells, memory T cells, B cells, dendritic cells (collectively lymphocytes). Low ALC ( 1,500–1,800 for immune "store." Chemo/radiation/COVID wipe it out—yet until now, nothing to fix it. His breakthrough: ANKTIVA (IL-15 superagonist, "BioShield") unlocks your body's factory to proliferate billions of these cells (FDA-approved for bladder cancer; expanded access/RMAT for lymphopenia reversal in trials). Lymphocytes are the forgotten guardians—ALC is like checking A1C or hemoglobin. Monitor it, boost via sleep/exercise/sunlight, and emerging therapies may restore what toxins deplete. Do you check your ALC on bloodwork? What's your level (or plan to ask next test)? Share experiences.
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Dr. Patrick Soon-Shiong: We've ignored a key CBC metric for 75 years—Absolute Lymphocyte Count (ALC)—your body's count of cancer-fighting NK cells, T cells, memory T cells, B cells, dendritic cells (collectively lymphocytes). Low ALC ( 1,500–1,800 for immune "store." Chemo/radiation/COVID wipe it out—yet until now, nothing to fix it. His breakthrough: ANKTIVA (IL-15 superagonist, "BioShield") unlocks your body's factory to proliferate billions of these cells (FDA-approved for bladder cancer; expanded access/RMAT for lymphopenia reversal in trials). Lymphocytes are the forgotten guardians—ALC is like checking A1C or hemoglobin. Monitor it, boost via sleep/exercise/sunlight, and emerging therapies may restore what toxins deplete. Do you check your ALC on bloodwork? What's your level (or plan to ask next test)? Share experiences.

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🚨 WHY ARE THERE OVER 400 PUBLISHED PAPERS ON IVERMECTIN AND CANCER? Because researchers discovered something unexpected. Ivermectin doesn't just target parasites. According to preclinical research, it appears to interact with cancer cells through multiple biological pathways. One of the most discussed? 📌 Cancer Stem Cells These are the cells believed to survive treatment, remain dormant for years, and potentially contribute to recurrence and spread. According to Dr. William Makis: 💊 Chemotherapy primarily targets rapidly dividing cancer cells. 💊 Ivermectin has been studied for its potential effects on cancer stem cells. That's why some researchers believe the combination deserves attention. But that's only part of the story. Researchers have also investigated ivermectin's potential ability to: ✅ Target cancer stem cells ✅ Influence tumor signaling pathways ✅ Alter cancer cell behavior ✅ Reverse chemotherapy resistance One of the most fascinating findings involves chemotherapy resistance. Over time, some cancer cells develop the ability to push chemotherapy drugs back out of the cell. Researchers have reported that ivermectin may interfere with these resistance mechanisms, potentially making cancer cells susceptible again. And then there's Fenbendazole and Mebendazole. While Ivermectin is being studied for one set of mechanisms, Fenbendazole and Mebendazole appear to work differently. Researchers have investigated their potential ability to: 📌 Block glucose transporters on cancer cells 📌 Reduce the cell's ability to use glucose as fuel 📌 Interfere with pathways associated with tumor growth Think about that. Different compounds. Different mechanisms. The same goal. That's why scientists continue publishing study after study. Not because these compounds are a fad. Because researchers keep uncovering new biological pathways worth investigating. And that's why the conversation around Ivermectin, Fenbendazole, and Mebendazole continues to grow. 💊 If you’re looking into these drugs, check out Ivermectin, Fenbendazole, and Mebendazole from RXMEDS.STORE. #Ivermectin #Fenbendazole #Mebendazole #CancerResearch #CancerStemCells #RepurposedDrugs #CancerBiology #RxMeds

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A revolutionary approach to defeating cancer: Dr. Patrick Soon-Shiong unveils a game-changing strategy In a riveting discussion, Dr. Patrick Soon-Shiong, a pioneering surgeon and biotech innovator, laid out a bold, chess-like strategy to outsmart cancer—an enemy he describes as diabolically clever, hiding from the body’s immune defenses with sinister precision. Forget checkers; this is a war requiring the sophistication of Go, where every move counts. Here’s how Dr. Soon-Shiong’s cutting-edge approach is rewriting the rules of cancer treatment: Step 1: Smoke Out the Enemy Cancer isn’t just a clump of cells—it’s a cunning adversary with genomic tricks that let it cloak itself from killer T-cells. Dr. Soon-Shiong’s protocol starts by exposing the cancer’s hidden receptors. Instead of blasting the tumor with high-dose chemotherapy, he uses a low metronomic dose—a tiny amount that stresses the cancer, forcing it to reveal itself. “It’s like smoking it out,” he explains. The cancer, sensing danger, exposes its surface molecules, making it a target for the immune system. Step 2: Unleash the Body’s Elite Forces With the tumor exposed, Dr. Soon-Shiong deploys the body’s natural killer (NK) cells and T-cells, supercharged by a breakthrough molecule called BioShield. This activates NK cells, stimulates killer T-cells, and—crucially—creates memory T-cells that remember the cancer’s signature. “For the first time, we’re seeing bladder cancer patients in complete remission for nine years, still alive, without losing their bladders,” he revealed. This isn’t just treatment; it’s a long-term defense system. Step 3: Orchestrate a Multi-Front Assault Cancer thrives by suppressing the immune system, but Dr. Soon-Shiong’s approach is a battlefield symphony. He educates T-cells with a tailored vaccine, activates killer macrophages, and suppresses the suppressors—all simultaneously. Radiation? Only in tiny, precise doses (SBRT) to expose, not destroy. “High-dose radiation kills your NK and T-cells,” he warns. This is precision warfare, not carpet bombing. A Future Without Suffering Unlike traditional cancer treatments that leave patients nauseous, bald, and broken, Dr. Soon-Shiong’s protocol is outpatient-based, minimizing suffering. “We’ve treated hundreds of patients this way,” he shared. Even more revolutionary? He envisions treating patients before surgery, using the tumor itself as a vaccine to train the immune system. Imagine a world where cancer is stopped in its tracks without invasive procedures. The American Red Cross of Cancer Dr. Soon-Shiong’s vision goes beyond individual patients. By extracting and cryopreserving NK and T-cells from a single pint of blood, his team can grow billions of these immune warriors, ready to be deployed for anyone. “We could become the American Red Cross of cancer,” he declared, hinting at a future where these innovations could even shape global health policy. Why This Matters Cancer isn’t just a disease; it’s a biological mastermind that demands respect and strategy. Dr. Soon-Shiong’s approach—expose, activate, educate, and suppress—offers hope to millions facing a life-threatening diagnosis. His work proves that with the right tools, we can turn the body into its own greatest weapon. The Call to Action The FDA must recognize this multi-pronged war requires battlefield awareness, not outdated single-drug approvals. Patients deserve access to these life-saving protocols now.
6:39

A revolutionary approach to defeating cancer: Dr. Patrick Soon-Shiong unveils a game-changing strategy In a riveting discussion, Dr. Patrick Soon-Shiong, a pioneering surgeon and biotech innovator, laid out a bold, chess-like strategy to outsmart cancer—an enemy he describes as diabolically clever, hiding from the body’s immune defenses with sinister precision. Forget checkers; this is a war requiring the sophistication of Go, where every move counts. Here’s how Dr. Soon-Shiong’s cutting-edge approach is rewriting the rules of cancer treatment: Step 1: Smoke Out the Enemy Cancer isn’t just a clump of cells—it’s a cunning adversary with genomic tricks that let it cloak itself from killer T-cells. Dr. Soon-Shiong’s protocol starts by exposing the cancer’s hidden receptors. Instead of blasting the tumor with high-dose chemotherapy, he uses a low metronomic dose—a tiny amount that stresses the cancer, forcing it to reveal itself. “It’s like smoking it out,” he explains. The cancer, sensing danger, exposes its surface molecules, making it a target for the immune system. Step 2: Unleash the Body’s Elite Forces With the tumor exposed, Dr. Soon-Shiong deploys the body’s natural killer (NK) cells and T-cells, supercharged by a breakthrough molecule called BioShield. This activates NK cells, stimulates killer T-cells, and—crucially—creates memory T-cells that remember the cancer’s signature. “For the first time, we’re seeing bladder cancer patients in complete remission for nine years, still alive, without losing their bladders,” he revealed. This isn’t just treatment; it’s a long-term defense system. Step 3: Orchestrate a Multi-Front Assault Cancer thrives by suppressing the immune system, but Dr. Soon-Shiong’s approach is a battlefield symphony. He educates T-cells with a tailored vaccine, activates killer macrophages, and suppresses the suppressors—all simultaneously. Radiation? Only in tiny, precise doses (SBRT) to expose, not destroy. “High-dose radiation kills your NK and T-cells,” he warns. This is precision warfare, not carpet bombing. A Future Without Suffering Unlike traditional cancer treatments that leave patients nauseous, bald, and broken, Dr. Soon-Shiong’s protocol is outpatient-based, minimizing suffering. “We’ve treated hundreds of patients this way,” he shared. Even more revolutionary? He envisions treating patients before surgery, using the tumor itself as a vaccine to train the immune system. Imagine a world where cancer is stopped in its tracks without invasive procedures. The American Red Cross of Cancer Dr. Soon-Shiong’s vision goes beyond individual patients. By extracting and cryopreserving NK and T-cells from a single pint of blood, his team can grow billions of these immune warriors, ready to be deployed for anyone. “We could become the American Red Cross of cancer,” he declared, hinting at a future where these innovations could even shape global health policy. Why This Matters Cancer isn’t just a disease; it’s a biological mastermind that demands respect and strategy. Dr. Soon-Shiong’s approach—expose, activate, educate, and suppress—offers hope to millions facing a life-threatening diagnosis. His work proves that with the right tools, we can turn the body into its own greatest weapon. The Call to Action The FDA must recognize this multi-pronged war requires battlefield awareness, not outdated single-drug approvals. Patients deserve access to these life-saving protocols now.

Camus

94,391 görüntüleme • 1 yıl önce

So here we are in 2026 and I was so excited to hear Jim's comment just before I gave my talk, "...the field has changed a bit and it was all about taking the brakes off T cells now its understanding how T cells are modulated by all all the other different components of the immune system so its a lot more complex..." That was exactly our focus and trials over the last decade to identify the killers and the suppressors in the tumor microenvironment and orchestrate our treatment based on the dynamics of "quantum" oncotherapeutics - how NK cells and T cells modulate each other.
0:27

So here we are in 2026 and I was so excited to hear Jim's comment just before I gave my talk, "...the field has changed a bit and it was all about taking the brakes off T cells now its understanding how T cells are modulated by all all the other different components of the immune system so its a lot more complex..." That was exactly our focus and trials over the last decade to identify the killers and the suppressors in the tumor microenvironment and orchestrate our treatment based on the dynamics of "quantum" oncotherapeutics - how NK cells and T cells modulate each other.

Dr. Pat Soon-Shiong

28,873 görüntüleme • 7 ay önce

Dr. Patrick Soon-Shiong, a pioneering surgeon and scientist, reveals a shocking truth about chemotherapy, immunity, and why we’ve been fighting cancer the wrong way for decades. Here’s what’s simple—and profound: When you undergo chemotherapy, the first casualty is your red blood cells, leading to anemia (treated with Epogen). Next, it wipes out neutrophils, leaving you vulnerable to infection (treated with Neupogen). But the most devastating effect? It destroys your NK and T cells—your body’s elite cancer-fighting forces. Think about that: The very treatment meant to kill cancer also annihilates the only cells that can actually protect you from it. For 35 years, medicine has ignored this paradox. We replace red blood cells and neutrophils—but not the lymphocytes that matter most. The result? A weakened immune system, vulnerable to relapse and secondary cancers. Now, consider long COVID. The virus is cunning—it targets the same NK and T cells, crippling immunity. The parallel is undeniable: Weakening these cells leaves the body defenseless, whether from chemo or chronic infection. Dr. Soon-Shiong’s message is clear: "We’ve been treating cancer wrong." The future lies in restoring immune function, not just attacking tumors. The fight isn’t just against cancer or viruses—it’s for the immune system itself. And after 20 years of challenging the status quo, Dr. Soon-Shiong is leading that revolution. It’s time to rethink everything.
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Dr. Patrick Soon-Shiong, a pioneering surgeon and scientist, reveals a shocking truth about chemotherapy, immunity, and why we’ve been fighting cancer the wrong way for decades. Here’s what’s simple—and profound: When you undergo chemotherapy, the first casualty is your red blood cells, leading to anemia (treated with Epogen). Next, it wipes out neutrophils, leaving you vulnerable to infection (treated with Neupogen). But the most devastating effect? It destroys your NK and T cells—your body’s elite cancer-fighting forces. Think about that: The very treatment meant to kill cancer also annihilates the only cells that can actually protect you from it. For 35 years, medicine has ignored this paradox. We replace red blood cells and neutrophils—but not the lymphocytes that matter most. The result? A weakened immune system, vulnerable to relapse and secondary cancers. Now, consider long COVID. The virus is cunning—it targets the same NK and T cells, crippling immunity. The parallel is undeniable: Weakening these cells leaves the body defenseless, whether from chemo or chronic infection. Dr. Soon-Shiong’s message is clear: "We’ve been treating cancer wrong." The future lies in restoring immune function, not just attacking tumors. The fight isn’t just against cancer or viruses—it’s for the immune system itself. And after 20 years of challenging the status quo, Dr. Soon-Shiong is leading that revolution. It’s time to rethink everything.

Camus

327,541 görüntüleme • 1 yıl önce

🚨🚨🚨🇮🇹 Dr. Tullio Simoncini is an Italian oncologist who has proposed a hypothesis regarding the cause and treatment of cancer : •According to his hypothesis, cancer is not a result of genetic mutations or uncontrolled cell growth, but rather a fungal infection caused primarily by the fungus Candida albicans. •Dr. Simoncini believes that cancer cells are actually fungal cells that have adapted to the body's internal environment. •His proposed treatment for cancer involves the use of sodium bicarbonate, also known as baking soda (Nahcolite), which he claims can effectively neutralize the acidic environment in which cancer cells thrive. •By raising the pH level of the tumor environment, Dr. Simoncini suggests that sodium bicarbonate can effectively kill the fungus and halt the progression of cancer. •Some studies have shown that sodium bicarbonate can have anti-cancer effects in certain in vitro and animal models. “Dr. Simoncini treat his patients with Sodium Bicarbonate” Can Cancer be treated with Baking Soda? What does that tell us about cancer? #Cancer #BakingSoda
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🚨🚨🚨🇮🇹 Dr. Tullio Simoncini is an Italian oncologist who has proposed a hypothesis regarding the cause and treatment of cancer : •According to his hypothesis, cancer is not a result of genetic mutations or uncontrolled cell growth, but rather a fungal infection caused primarily by the fungus Candida albicans. •Dr. Simoncini believes that cancer cells are actually fungal cells that have adapted to the body's internal environment. •His proposed treatment for cancer involves the use of sodium bicarbonate, also known as baking soda (Nahcolite), which he claims can effectively neutralize the acidic environment in which cancer cells thrive. •By raising the pH level of the tumor environment, Dr. Simoncini suggests that sodium bicarbonate can effectively kill the fungus and halt the progression of cancer. •Some studies have shown that sodium bicarbonate can have anti-cancer effects in certain in vitro and animal models. “Dr. Simoncini treat his patients with Sodium Bicarbonate” Can Cancer be treated with Baking Soda? What does that tell us about cancer? #Cancer #BakingSoda

Kevin - WE THE PEOPLE🦁

836,459 görüntüleme • 2 yıl önce