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Boosting exhausted T cells: Dr Daniel Utzschneider has identified how T cells can become exhausted from battling cancer, reducing the effectiveness of immunotherapy. He will use his CSL Centenary Fellowship to study these cells. Doherty Institute

CSL

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20,278 views • 2 years ago •via X (Twitter)

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Si Ming Man2 years ago

@TheDohertyInst ⭐️ ⭐️

Jennifer Juno2 years ago

@TheDohertyInst Congrats Daniel!! @UtzschneiderD

GRAS Lab2 years ago

@TheDohertyInst Congrats this is so great !!!!! 🎉🎉🎉🎉

Doherty Institute2 years ago

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not enough people know cancer cells can actually hide inside other cancer cells (stat3/ifny/egr1) just to hide from t cells and then they pop back out from the carcass of the cell they hid in once the t cell is gone

not enough people know cancer cells can actually hide inside other cancer cells (stat3/ifny/egr1) just to hide from t cells and then they pop back out from the carcass of the cell they hid in once the t cell is gone

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Jim Allison's conversation about treating the immune system and not the cancer and why he believed T cells should work for all tumor types. This was before he won the Nobel prize. Completely agree with him and met him for the first time at the Nixon / Milken Institute, Cancer 2035: A Roadmap for the Future. This conversation was a great prelude to my presentation on T and NK cells. From taking off the brakes of T cells to growing T cells and NK cells.

Jim Allison's conversation about treating the immune system and not the cancer and why he believed T cells should work for all tumor types. This was before he won the Nobel prize. Completely agree with him and met him for the first time at the Nixon / Milken Institute, Cancer 2035: A Roadmap for the Future. This conversation was a great prelude to my presentation on T and NK cells. From taking off the brakes of T cells to growing T cells and NK cells.

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Dr. Patrick Soon-Shiong points out a critical flaw in oncology, stating that 99.9% of oncologists fail to recognize the importance of natural killer cells and T-cells, which are vital for destroying cancer cells.

Dr. Patrick Soon-Shiong points out a critical flaw in oncology, stating that 99.9% of oncologists fail to recognize the importance of natural killer cells and T-cells, which are vital for destroying cancer cells.

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🚨ImmunityBio’s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your body’s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: • NK cells (natural killers) • CD8 T cells (main attackers) • CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. → It’s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (that’s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) — “Killing Cancer”

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Dr. Patrick Soon-Shiong reveals the "missing link" in cancer medicine that’s been hiding in plain sight for 450 million years of evolution: Natural Killer (NK) cells — your body’s built-in cancer assassins. Just like red blood cells prevent death from lack of oxygen, NK cells (and T cells) are designed to destroy cancer cells. Yet we’ve ignored them for most of medical history. In 2012, the National Cancer Institute reviewed 240 molecules and declared IL-15 the single most important one for curing cancer — because it supercharges NK cells and T cells. The problem? No one could deliver IL-15 safely and effectively… until Anktiva. 1:51 clip embedded — his passionate delivery makes the breakthrough feel like the missing piece we’ve overlooked for decades. Cancer isn’t just about killing tumors. It’s about waking up the immune system we were born with.

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When SARS-CoV-2 specific T cells are activated for too long, they lose their ability to fight, and become exhausted. Latent viruses can reactivate as the immune system becomes more dysregulated. David Putrino Putrino Lab

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Cancer is a shape shifting disease. We have figured a way to outsmart it through the power of IL-15 and natural killer cells. By 2026 we will grow trillions of natural killer cells from healthy donors and generate the 'world bank of natural killer cells' which can be administered to any patient without donor matching. That is how natural killer cells work. Special Report Bret Baier

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A revolutionary approach to defeating cancer: Dr. Patrick Soon-Shiong unveils a game-changing strategy In a riveting discussion, Dr. Patrick Soon-Shiong, a pioneering surgeon and biotech innovator, laid out a bold, chess-like strategy to outsmart cancer—an enemy he describes as diabolically clever, hiding from the body’s immune defenses with sinister precision. Forget checkers; this is a war requiring the sophistication of Go, where every move counts. Here’s how Dr. Soon-Shiong’s cutting-edge approach is rewriting the rules of cancer treatment: Step 1: Smoke Out the Enemy Cancer isn’t just a clump of cells—it’s a cunning adversary with genomic tricks that let it cloak itself from killer T-cells. Dr. Soon-Shiong’s protocol starts by exposing the cancer’s hidden receptors. Instead of blasting the tumor with high-dose chemotherapy, he uses a low metronomic dose—a tiny amount that stresses the cancer, forcing it to reveal itself. “It’s like smoking it out,” he explains. The cancer, sensing danger, exposes its surface molecules, making it a target for the immune system. Step 2: Unleash the Body’s Elite Forces With the tumor exposed, Dr. Soon-Shiong deploys the body’s natural killer (NK) cells and T-cells, supercharged by a breakthrough molecule called BioShield. This activates NK cells, stimulates killer T-cells, and—crucially—creates memory T-cells that remember the cancer’s signature. “For the first time, we’re seeing bladder cancer patients in complete remission for nine years, still alive, without losing their bladders,” he revealed. This isn’t just treatment; it’s a long-term defense system. Step 3: Orchestrate a Multi-Front Assault Cancer thrives by suppressing the immune system, but Dr. Soon-Shiong’s approach is a battlefield symphony. He educates T-cells with a tailored vaccine, activates killer macrophages, and suppresses the suppressors—all simultaneously. Radiation? Only in tiny, precise doses (SBRT) to expose, not destroy. “High-dose radiation kills your NK and T-cells,” he warns. This is precision warfare, not carpet bombing. A Future Without Suffering Unlike traditional cancer treatments that leave patients nauseous, bald, and broken, Dr. Soon-Shiong’s protocol is outpatient-based, minimizing suffering. “We’ve treated hundreds of patients this way,” he shared. Even more revolutionary? He envisions treating patients before surgery, using the tumor itself as a vaccine to train the immune system. Imagine a world where cancer is stopped in its tracks without invasive procedures. The American Red Cross of Cancer Dr. Soon-Shiong’s vision goes beyond individual patients. By extracting and cryopreserving NK and T-cells from a single pint of blood, his team can grow billions of these immune warriors, ready to be deployed for anyone. “We could become the American Red Cross of cancer,” he declared, hinting at a future where these innovations could even shape global health policy. Why This Matters Cancer isn’t just a disease; it’s a biological mastermind that demands respect and strategy. Dr. Soon-Shiong’s approach—expose, activate, educate, and suppress—offers hope to millions facing a life-threatening diagnosis. His work proves that with the right tools, we can turn the body into its own greatest weapon. The Call to Action The FDA must recognize this multi-pronged war requires battlefield awareness, not outdated single-drug approvals. Patients deserve access to these life-saving protocols now.

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Camus

94,391 views • 1 year ago

So here we are in 2026 and I was so excited to hear Jim's comment just before I gave my talk, "...the field has changed a bit and it was all about taking the brakes off T cells now its understanding how T cells are modulated by all all the other different components of the immune system so its a lot more complex..." That was exactly our focus and trials over the last decade to identify the killers and the suppressors in the tumor microenvironment and orchestrate our treatment based on the dynamics of "quantum" oncotherapeutics - how NK cells and T cells modulate each other.

So here we are in 2026 and I was so excited to hear Jim's comment just before I gave my talk, "...the field has changed a bit and it was all about taking the brakes off T cells now its understanding how T cells are modulated by all all the other different components of the immune system so its a lot more complex..." That was exactly our focus and trials over the last decade to identify the killers and the suppressors in the tumor microenvironment and orchestrate our treatment based on the dynamics of "quantum" oncotherapeutics - how NK cells and T cells modulate each other.

Dr. Pat Soon-Shiong

28,873 views • 5 months ago

Dr. Patrick Soon-Shiong, a pioneering surgeon and scientist, reveals a shocking truth about chemotherapy, immunity, and why we’ve been fighting cancer the wrong way for decades. Here’s what’s simple—and profound: When you undergo chemotherapy, the first casualty is your red blood cells, leading to anemia (treated with Epogen). Next, it wipes out neutrophils, leaving you vulnerable to infection (treated with Neupogen). But the most devastating effect? It destroys your NK and T cells—your body’s elite cancer-fighting forces. Think about that: The very treatment meant to kill cancer also annihilates the only cells that can actually protect you from it. For 35 years, medicine has ignored this paradox. We replace red blood cells and neutrophils—but not the lymphocytes that matter most. The result? A weakened immune system, vulnerable to relapse and secondary cancers. Now, consider long COVID. The virus is cunning—it targets the same NK and T cells, crippling immunity. The parallel is undeniable: Weakening these cells leaves the body defenseless, whether from chemo or chronic infection. Dr. Soon-Shiong’s message is clear: "We’ve been treating cancer wrong." The future lies in restoring immune function, not just attacking tumors. The fight isn’t just against cancer or viruses—it’s for the immune system itself. And after 20 years of challenging the status quo, Dr. Soon-Shiong is leading that revolution. It’s time to rethink everything.

Dr. Patrick Soon-Shiong, a pioneering surgeon and scientist, reveals a shocking truth about chemotherapy, immunity, and why we’ve been fighting cancer the wrong way for decades. Here’s what’s simple—and profound: When you undergo chemotherapy, the first casualty is your red blood cells, leading to anemia (treated with Epogen). Next, it wipes out neutrophils, leaving you vulnerable to infection (treated with Neupogen). But the most devastating effect? It destroys your NK and T cells—your body’s elite cancer-fighting forces. Think about that: The very treatment meant to kill cancer also annihilates the only cells that can actually protect you from it. For 35 years, medicine has ignored this paradox. We replace red blood cells and neutrophils—but not the lymphocytes that matter most. The result? A weakened immune system, vulnerable to relapse and secondary cancers. Now, consider long COVID. The virus is cunning—it targets the same NK and T cells, crippling immunity. The parallel is undeniable: Weakening these cells leaves the body defenseless, whether from chemo or chronic infection. Dr. Soon-Shiong’s message is clear: "We’ve been treating cancer wrong." The future lies in restoring immune function, not just attacking tumors. The fight isn’t just against cancer or viruses—it’s for the immune system itself. And after 20 years of challenging the status quo, Dr. Soon-Shiong is leading that revolution. It’s time to rethink everything.

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327,541 views • 1 year ago

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Kevin - WE THE PEOPLE🦁

836,350 views • 2 years ago

Dr Cole is concerned about our T cells Patrick Soon-Shiong also said that our NK and T cells are the cells that protect and surveil our body against cancer. And NK and T cells are made in the Bone Marrow and Thymus. Ryan Cole MD goes into some concerns about what it would mean if the mRNA lipid nano particles negatively impact the Thymus gland. Dr Cole - "What gland trains our T Cell? The Thymus". According to Pfizer's bio accumulation study released by FOI, 48 x hours after injection, the Lipid Nano Particles go to: 1. Liver - 24.29 2. Spleen - 23.35 3. Adrenal Glands - 18.21 4. Ovaries - 12.26 5. Bone Marrow - 3.77 6. Small Intestine - 1.472 7. Lymph Node (mesenteric) - 1.366 8. Large intestine - 1.34 9. Lung - 1.09 10. Thyroid - 1.00 11. Lymph node (mandibular) - 0.727 12. Pituitary gland - 0.694 13. Bone (femur) - 0.687 14. Pancreas - 0.599 15. Heart 0.55 16. Uterus - 0.456 17. Kidneys - 0.42 18. Bladder - 0.365 19. Thymus - 0.331 Dr Cole: "We've identified the production of this spike protein in these organs causing damage...it goes anywhere and everywhere...and then the immune system attacks where it lands [so] if I identify spike proteins and damage in that Thymus gland, now you can no longer [program] your T cells"

Dr Cole is concerned about our T cells Patrick Soon-Shiong also said that our NK and T cells are the cells that protect and surveil our body against cancer. And NK and T cells are made in the Bone Marrow and Thymus. Ryan Cole MD goes into some concerns about what it would mean if the mRNA lipid nano particles negatively impact the Thymus gland. Dr Cole - "What gland trains our T Cell? The Thymus". According to Pfizer's bio accumulation study released by FOI, 48 x hours after injection, the Lipid Nano Particles go to: 1. Liver - 24.29 2. Spleen - 23.35 3. Adrenal Glands - 18.21 4. Ovaries - 12.26 5. Bone Marrow - 3.77 6. Small Intestine - 1.472 7. Lymph Node (mesenteric) - 1.366 8. Large intestine - 1.34 9. Lung - 1.09 10. Thyroid - 1.00 11. Lymph node (mandibular) - 0.727 12. Pituitary gland - 0.694 13. Bone (femur) - 0.687 14. Pancreas - 0.599 15. Heart 0.55 16. Uterus - 0.456 17. Kidneys - 0.42 18. Bladder - 0.365 19. Thymus - 0.331 Dr Cole: "We've identified the production of this spike protein in these organs causing damage...it goes anywhere and everywhere...and then the immune system attacks where it lands [so] if I identify spike proteins and damage in that Thymus gland, now you can no longer [program] your T cells"

Humanspective

37,862 views • 10 months ago