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Dr. Patrick Soon-Shiong: We've ignored a key CBC metric for 75 years—Absolute Lymphocyte Count (ALC)—your body's count of cancer-fighting NK cells, T cells, memory T cells, B cells, dendritic cells (collectively lymphocytes). Low ALC ( 1,500–1,800 for immune "store." Chemo/radiation/COVID wipe it out—yet until now, nothing to fix it....

68,193 views • 8 months ago •via X (Twitter)

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🚨ImmunityBio’s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your body’s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: • NK cells (natural killers) • CD8 T cells (main attackers) • CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. → It’s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (that’s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) — “Killing Cancer”

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Dr. Patrick Soon-Shiong challenges the core of cancer treatment: Are we fighting cancer incorrectly? In a compelling interview, he explains how lymphocytes—Natural Killer cells and T-cells—are the body’s critical defenders, essential for defeating cancer, infections, and sepsis. Yet, modern medicine has been undermining them. Lymphocytes are the body’s elite immune cells. Natural Killer cells and T-cells are uniquely equipped to destroy cancer cells and are vital for combating life-threatening infections and sepsis. Dr. Soon-Shiong describes them as the foundation for long life and survival. But there’s a problem. Conventional cancer treatments—chemotherapy, radiation, and steroids—destroy these lymphocytes, causing lymphopenia, a depletion akin to anemia but for the immune system. For decades, medicine has inadvertently targeted the very cells needed to win the war against cancer. A breakthrough molecule, IL-15, changes everything. This protein, produced naturally in the body, acts as a master switch to activate and proliferate lymphocytes, enabling them to eradicate cancer and infections. For the first time, medicine can harness this mechanism through BioShield. BioShield leverages IL-15 to empower lymphocytes, marking a revolutionary shift in treatment. Unlike chemotherapy, which Dr. Soon-Shiong likens to a nuclear bomb that devastates the body, IL-15 strengthens the immune system to fight smarter. Why have traditional treatments fallen short? Chemotherapy and radiation may shrink tumors, achieving what’s called a response, but at a steep cost. They deplete lymphocytes, weaken immunity, and allow resistant cancer cells to hide and later return as metastases. Dr. Soon-Shiong raises a provocative question: Have treatments induced incurability? The focus on response rates and progression-free survival, standard metrics for drug approval, misses the true goal: overall survival with high quality of life. Current therapies, often dosed at the maximum tolerated level, prioritize short-term wins over long-term health. Dr. Soon-Shiong critiques this approach, suggesting that medicine has been winning battles but losing wars. By destroying lymphocytes, treatments may shrink tumors temporarily but leave patients vulnerable to relapse. The regulatory system, he argues, has incentivized flawed endpoints. BioShield’s IL-15 therapy offers hope, activating the body’s natural defenses without obliterating them. This could redefine cancer care, prioritizing immune strength and long-term survival over transient tumor shrinkage. Dr. Soon-Shiong’s vision challenges 50 years of oncology dogma. Is it possible that medicine has misunderstood cancer treatment for decades? Dr. Soon-Shiong’s insights demand reflection. By protecting and activating lymphocytes, we might unlock the body’s true potential to heal.

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