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Brain imaging using a new technique called Hierarchical Phase-Contrast Tomography or ‘HiP-CT’: h/t BrainBridger News Credits: Walsh, C.L., Tafforeau, P., Wagner, W.L. et al. #neuroscience #MedTwitter

Hugo Chrost

42,614 subscribers

164,361 Aufrufe • vor 3 Jahren •via X (Twitter)

Wissenschaft & Technologie Gesundheit & Wellness #neuroscience #MedTwitter

Anya Rossi• Live Now

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10 Kommentare

Profilbild von L Brielmaier

L Brielmaiervor 3 Jahren

@BrainBridger A new X-ray technology allows for whole organs to be imaged down to a resolution of one micron.

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Hugo Chrostvor 3 Jahren

@BrainBridger Thanks for sharing! :)

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Sandeep Salujavor 3 Jahren

@BrainBridger Clinically when will you find it helpful?

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Neuropandavor 3 Jahren

@BrainBridger O.o

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Heather Raitz, LCSW.vor 3 Jahren

@HypnoJeanne @BrainBridger Beautiful

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Richymor25( Ricardo Yáñez Morales)vor 3 Jahren

@BrainBridger Beauty

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Orthospinologyvor 3 Jahren

@BrainBridger Memorizing beauty!

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Teelvor 3 Jahren

@BrainBridger Whooooooooo....sweet..

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Abel Ramirez Rvor 3 Jahren

@BrainBridger @DescargaBot

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Cuban Art Clubvor 3 Jahren

@BrainBridger The brain universe.

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HiP-CT is a revolutionary imaging technique that reveals the human body in extraordinary detail. Zoom from an entire organ down to cells and blood vessels. Here, exploring the human brain at micron-scale. [📹 Paul Tafforeau]

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HIP-CT JUST TURNED THE HUMAN BRAIN INTO A GOOGLE MAP This isn’t CGI. It’s not AI. It’s HiP-CT - Hierarchical Phase-Contrast Tomography - and it’s quietly breaking anatomy. One scan lets researchers zoom from a full human organ down to micron-scale detail. Blood vessels. Cellular architecture. Structural patterns you normally only see after cutting tissue apart. Except here, nothing is destroyed. The brain footage is the flex: intact hemispheres rendered so clean you can trace vascular networks like street grids. No stains. No dyes. Just synchrotron X-rays, and obscene resolution. Traditional histology gives detail but loses context. MRI keeps context but sacrifices precision. HiP-CT does both. Whole-organ truth, no trade-off. This is a new baseline for studying neurodegeneration, tumors, stroke damage, and developmental disorders. Pathology without guesswork. Anatomy without amputation. Within a decade, HiP-CT-style imaging becomes the gold standard for post-mortem research and drug validation - and forces medicine to rewrite parts of the anatomy textbooks we thought were “settled.” The body didn’t change. Our ability to see it just did. Source: Paul Tafforeau, Interesting World

HIP-CT JUST TURNED THE HUMAN BRAIN INTO A GOOGLE MAP This isn’t CGI. It’s not AI. It’s HiP-CT - Hierarchical Phase-Contrast Tomography - and it’s quietly breaking anatomy. One scan lets researchers zoom from a full human organ down to micron-scale detail. Blood vessels. Cellular architecture. Structural patterns you normally only see after cutting tissue apart. Except here, nothing is destroyed. The brain footage is the flex: intact hemispheres rendered so clean you can trace vascular networks like street grids. No stains. No dyes. Just synchrotron X-rays, and obscene resolution. Traditional histology gives detail but loses context. MRI keeps context but sacrifices precision. HiP-CT does both. Whole-organ truth, no trade-off. This is a new baseline for studying neurodegeneration, tumors, stroke damage, and developmental disorders. Pathology without guesswork. Anatomy without amputation. Within a decade, HiP-CT-style imaging becomes the gold standard for post-mortem research and drug validation - and forces medicine to rewrite parts of the anatomy textbooks we thought were “settled.” The body didn’t change. Our ability to see it just did. Source: Paul Tafforeau, Interesting World

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From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).

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