Bret Weinstein: “Most Disturbing Findings” Professor Robert Clancy: “We’re now creating [a] population of people who are on the cusp of getting more severe and more continuous COVID infections” How boosters are turning off our immune systems to “tolerate” infections

This rising health concern is alarming

Increased IgG4 production is a consequence of immune refocusing. This phenomenon leads to enhanced recognition of more conserved spike(S)-associated antigenic domains, some of which exhibit amino acid homology with self-epitopes. The immune system, in its sophistication, attenuates the functional activity of antibodies (Abs), and subsequently also of T cells, generated through immune refocusing to minimize the risk of autoimmune responses. Of course, with repeated vaccine breakthrough infections (VBTIs), the risk of autoimmunity increases, as more conserved, self-like Bc and Tc epitopes are increasingly targeted over time. This nuanced immunological adaptation is too often erroneously interpreted as evidence of tolerogenic responses induced by COVID-19 (C-19) vaccination. However, these responses are unrelated to central or peripheral tolerance. Rather, they involve the production of an immunoglobulin isotype (IgG4) or Tc clones that have reduced affinity for conserved S-associated antigenic domains and, consequently, diminished functional capacity to neutralize the infectious virus or eliminate virus-infected cells, respectively. The emergence of IgG4 Abs, for example, occurs indirectly due to high titers of previously induced Abs—primarily IgG1—which, for lack of functional binding to immunodominant spike domains, mask these domains. This insufficient binding leads to reduced neutralizing capacity of these Abs and may arise either from epitope alterations in newly circulating variants or from the inherently low affinity of vaccine-induced Abs, particularly following repeated mRNA-based vaccination. The masking of immunodominant domains impairs their recognition and contributes to immune refocusing, thereby first promoting the generation of IgG4 Abs with diminished antiviral functionality. Such low-affinity IgG4 Abs may also be induced to certain allergens to dampen the immune response towards these allergens upon natural exposure, as R. Clancy explains. In my book (“The Inescapable Immune Escape Pandemic”), I explain that immune refocusing—and, therefore, the associated induction of suboptimal IgG4 Abs—can be triggered directly by repeated administration of mRNA-based C-19 vaccines, or indirectly by non-mRNA C-19 vaccines, once high titers of neutralizing Abs have been generated. The latter may no longer strongly bind to mutated immunodominant regions of the S protein in newly circulating SARS-CoV-2 variants when these variants cause VBTIs, thereby causing immune refocusing. The bottom line is that vaccine efficacy declined with an increasing number of injections, not due to allegedly tolerogenic IgG4 Abs, but as an overall consequence of ongoing immune refocusing—induced through repeated VBTIs with immune escape variants and/or repeated injections of mRNA-based C-19 vaccines. I recognize that this immunological explanation is more comprehensive than the one advanced in this conversation. When one truly understands the immunological dynamics triggered by mRNA-based vaccines and/or VBTIs, it becomes clear that the generation of IgG4 Abs is merely a single ‘symptom’ in the cascade of immune dysregulatory events resulting from the dangerous immune refocusing induced by mRNA-based vaccines and/or VBTIs — both of which are tightly associated with the C-19 mass vaccination program.

Don’t put it out there then pretend like it was some oopsie. They knew exactly what they were doing!!

Well, we do know about the “bait and switch” brought to you by Pfizer

Repeated COVID-19 mRNA vaccination 💉💉💉 results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults | Immunity & Ageing Background Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked increase of SARS-CoV-2 spike-specific serum antibodies of the IgG4 subclass, indicating far-reaching immunoglobulin class switching after booster immunization. Considering that repeated vaccination has been recommended especially for older adults, the aim of this study was to investigate IgG subclass responses in the ageing population and assess their relation with Fc-mediated antibody effector functionality. Results Spike S1-specific IgG subclass concentrations (expressed in arbitrary units per mL), antibody-dependent NK cell activation, complement deposition and monocyte phagocytosis were quantified in serum from older adults (n = 38–50, 65–83 years) at one month post-second, -third and -fifth vaccination. Subclass distribution in serum was compared to that in younger adults (n = 64, 18–47 years) at one month post-second and -third vaccination. Compared to younger individuals, older adults showed increased levels of IgG2 and IgG4 at one month post-third vaccination (possibly related to factors other than age) and a further increase following a fifth dose. The capacity of specific serum antibodies to mediate NK cell activation and complement deposition relative to S1-specific total IgG concentrations decreased upon repeated vaccination. This decrease associated with an increased IgG4/IgG1 ratio. Conclusions In conclusion, these findings show that, like younger individuals, older adults produce antibodies with reduced functional capacity upon repeated COVID-19 mRNA vaccination.

So this lines up with the “T cell exhaustion” paper!

Or it was deliberate!

Wouldn’t surprise me

They knew. It was intentional. It was murder. Mass murder.

Very disturbing ~ as all discoveries about the mRNA shots are. PULL THEM NOW