Browser/Computer Automation Jared Friedman AI agents can now browse the web and use desktop applications. It means that every website and every app now effectively has an API, and any workflow that people can do on a computer can be automated.

From the AI breakthroughs of the last few months, a wave of new startup opportunities have been unlocked. Here are some of the ideas we think will be especially interesting to build now:

A Secure AI App Store @garrytan There is a small window today for a startup to create an AI App Store that provides computer use APIs and local LLaMA versioning with secure privacy controls, discovery, and payments. We hope you might build it.

Datacenters @sdianahu and @daltonc There is a bottleneck in technological change: the world needs more datacenters and high-tech factories. We are looking for startups building software and infrastructure to help construct and autonomously operate these facilities.

Compliance and Audit @t_blom 4 million people in the US & Europe work in compliance & audit. LLMs will automate the testing that these folks currently do by hand: spotting anomalies in data, identifying incomplete records, or highlighting contradictory policies.

DocuSign 2.0 @mwseibel There is an opportunity with AI to finally make the process of filling out and signing documents delightful.

AI Personal Staff for Everyone @dflieb The world’s richest people employ large staffs of humans, like tax accountants, lawyers, money managers, personal trainers, and even private doctors. AI will soon be good enough to do all these jobs for everyone.

Devtools for AI Agents @dessaigne AI agents are the next wave: autonomous tools that reason, decide, and amplify human productivity. We’re funding startups building devtools for agents, whether you’re creating agent builders or building blocks to perform complex tasks.

The Future of Software Engineering @koomen AI will bring the cost of building software down to zero, but this means we’ll need MORE human developers, not fewer. We’d like to fund startups building tools for this future.

AI Commercial Open Source Software (AICOSS) @daltonc Just as RedHat and YC W15 company @Gitlab built public companies around open source projects, we are looking for companies built around open source AI models like DeepSeek and Llama.

AI Coding Agent for Hardware Optimized Code @sdianahu AI hardware is still constrained by software. However, with reasoning models like Deepseek R1 or OpenAI o1 and o3, AI could generate hardware-optimized code that rivals—or surpasses—human CUDA code.

B2A: Business-to-Agent @daltonc Not b2b, not b2c, but b2a: Business-to-agent. We are looking for startups that are building products where AI agents are the intended customer. Make something agents want.

Vertical AI Agents @snowmaker At a recent event, a founder asked Sam Altman "If you were 24 and starting a startup today, what would you build?" His answer: A vertical AI agent.

Startup Founders with Systems Programming Expertise @daltonc As evidenced by DeepSeek, being able to optimize the entire stack is a competitive advantage. This expertise can be an advantage in all sorts of startup ideas, ie, @bunjavascript from YC S19.

Inference AI Infra in the World of Test-Time Compute @sdianahu There’s room to rebuild the AI infrastructure stack: better software at inference-layer tooling, cheaper ways to handle GPU workloads, and optimizations that let AI apps scale without bleeding money.

Want to learn how practical AI skills and automations for your business and work? Check out our 50+ step-by-step video tutorials 100% FREE 20+ hours of Ai and Automation goodness absolutely free 🥳

@snowmaker We are on it! @jaeyun_ha