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Bryan Johnson reveals 5-MeO-DMT therapy outperformed every longevity protocol he’s tried "If I compare my experience with 5-MeO to having a better diet, exercising every day, sleeping well, doing sauna, and hyperbaric oxygen therapy, this was more efficacious than all of them in terms of a reset of me... show more

Mikli

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905,141 views • 6 months ago •via X (Twitter)

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33 Comments

goodalexander6 months ago

"hard drugs seem much more powerful than going to the sauna"

Rex6 months ago

Yeah drugs make you feel awesome, what a fucking insight. Until they don't.

Geoff6 months ago

Lmao the low IQ ignorant masses in the comments calling him a druggie for using psychedelics in spite of all of the actual evidence for their efficacy in promoting neuroplasticity and genuine improvement in psychological wellbeing

jay6 months ago

5-MoE-DMT-4b-Qwen3.5-ClaudeOpus-Ablated has outperformed every model Bryan Johnson has tried. "If I compare my harness.."

Vamz6 months ago

He got banished by mechanical elves and now he’s trying to play it cool.

MRT 💹🧲6 months ago

"reset of me as a human" very scientific and not vague

Flea King6 months ago

All the people going "omg hard drugs" are so clueless and have no idea what they're talking about

eeL6 months ago

Regular 90-minute floatation therapy sessions for those who don’t want to be a junkie.

Romps6 months ago

Retards in here probably drinking alcohol while calling molecules like 5-MeO-DMT & N, N-DMT hard drugs. Fun fact you all have this hard “drug” DMT running through your bodies right now. You fucking druggos

Rish6 months ago

Me tomorrow night

Vesper6 months ago

I don't get why he can't just say "I enjoyed the experience" without larping that "it's an amazing longevity hack because I said so". Actually I do, because he has to loop everything back to longevity now even if it has very little to do with it.

sam6 months ago

love that it takes tech bros milions of investments and an exit just to discover drugs

Deep Thrill6 months ago

Did his longevity biomarkers improve after his drug experience? Or just vibes?

Ben6 months ago

All glory to the hypno toad 😵‍💫

robertus6 months ago

the problem with n=1 self-reported biohacking comparisons is you can't control for the "i just had a profoundly weird dissociative experience" confound, which is doing a lot of work in that sentence

Simone Ferretti6 months ago

outperformed? all bro has done is live 1 day longer

Mikli6 months ago

Feat. @bryan_johnson @theallinpod

🐐6 months ago

This dude is a massive psy op

Todd Williams6 months ago

Based on how he feels? Or are they measuring something that is related to longevity?

Philippe Tremblay6 months ago

@bryan_johnson most likely a permanent change occured. this happened for me with Ketamine. I was living with constant overwhelming existential angst (on top of my other chronic health issues), and that just went away. it's been over 3 years now.

Pulse Digital6 months ago

same but with crack better than a sauna at resetting you as a human

Viridis Genii6 months ago

Maybe if he takes another hit, he might actually start to talk like a regular human.

Rob6 months ago

He hasn't done the HG7 protocol. Detoxing copper and replenishing zinc removes your fear of mortality and the negative spiritual consequences therefrom.

Aditya Singh6 months ago

The missing layer here is durability. A single 5-MeO experience can radically change perceived meaning and stress, but unless that converts into new routines (bedtime, food, training, relationships), the long-term longevity curve still comes from boring, trackable behaviors.

kevin white6 months ago

@grok what the heck is 5-MeO?

UGA6 months ago

I simply don’t understand how so many safely obtain and use this substance. Am I missing something? What about the rest of us?

Ricardo6 months ago

Becoming a druggie now Bryan hahahaha nice

Breatharian Diet6 months ago

It's very interesting

PNW Life6 months ago

Psychedelics are amazing at letting you feel new, goals are achievable, walls and blockage is dissolved. Bad habits are washed away, becoming you again is a beautiful thing!

yhousegone6 months ago

What a rookie

C A Z R O6 months ago

5-MeO-DMT resetting the body better than diet and exercise? That’s huge

Tyler Baker6 months ago

Total pysop weirdo

SOvXI iF6 months ago

This is dangerous for young, impressionable minds (people in their 20s that feel like they already failed) to see.

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Bryan Johnson: 5-MeO-DMT therapy outperformed every longevity protocol so far “ If I just subjectively compare my experience with 5-MeO-DMT to having a better diet, and exercising every day, and sleeping well, and doing the sauna, and doing hyperbaric oxygen therapy, this was more efficacious than all of them in terms of the reset of me as a human. It just is incomparable. And I guess I'm really left pondering, for this molecule to have such a gigantic impact. Now, how long will it last? What's the decay curve like? You know, will I become the former Brian within 30 days, 60 days, so I have to repeat this again? I don't know. When you sleep well, you feel great. When you exercise, great. But nothing like what 5-MeO-DMT did in terms of like, the reset of me as a human.” Bryan Johnson ------------------------------------------ Thanks to our partner for making this happen! The Pod by Eight Sleep cools your bed to 55°F and uses Autopilot to optimize your sleep, all night. Use code ALLIN at for up to $350 off.

Bryan Johnson: 5-MeO-DMT therapy outperformed every longevity protocol so far “ If I just subjectively compare my experience with 5-MeO-DMT to having a better diet, and exercising every day, and sleeping well, and doing the sauna, and doing hyperbaric oxygen therapy, this was more efficacious than all of them in terms of the reset of me as a human. It just is incomparable. And I guess I'm really left pondering, for this molecule to have such a gigantic impact. Now, how long will it last? What's the decay curve like? You know, will I become the former Brian within 30 days, 60 days, so I have to repeat this again? I don't know. When you sleep well, you feel great. When you exercise, great. But nothing like what 5-MeO-DMT did in terms of like, the reset of me as a human.” Bryan Johnson ------------------------------------------ Thanks to our partner for making this happen! The Pod by Eight Sleep cools your bed to 55°F and uses Autopilot to optimize your sleep, all night. Use code ALLIN at for up to $350 off.

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Hello Crazymamifn You are 43 years of age i’m a minor speaking to me in this sort of manner as well as banning me from your tournament is acc horrible as fuck When all i did was play the efuse tournament like a normal person and killed you normally i did not deserve this at all

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Hello Crazymamifn You are 43 years of age i’m a minor speaking to me in this sort of manner as well as banning me from your tournament is acc horrible as fuck When all i did was play the efuse tournament like a normal person and killed you normally i did not deserve this at all

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