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Chris Camillo explains why Pokémon cards might keep going up for decades “I’ve always believed that Pokémon and an IP similar to Pokémon for a collector is where it’s at” “Unlike other collectibles, it’s not set in a period of time where you have a peak where the people...

97,928 просмотров • 4 месяцев назад •via X (Twitter)

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Marc Andreessen on the 3 things he looks for when investing in a startup The first thing Marc Andreesen looks for is a big market: “Is there a big existing market that you think you can go after and displace incumbents? Or do you believe there will be a new market that will be big?” The second thing he looks for is a 10x better product: “Is there a fundamental technology or economic change that justifies a new company? And the way I always think about that is: Is there a 10x change happening in the technology landscape? Is something 10x faster, 10x cheaper, or 10x better? If it’s not 10x, we as both VCs and entrepreneurs have to ask ourselves if it’s really worth doing because it’s really hard to start new companies . . . Existing companies are usually pretty good at what they do. So for a new company to exist, it has to bring a product to market that’s so much better than what exists that it punches through the status quo.” The third is the team: “Is the team outstanding? . . . You want to have a founding team of complementary skillsets. You want to have at least one super strong technologist — quite possibly more than one. Some of the best startups are actually more than one founding technologist. And then it often helps to have someone who is a marketing or salesperson who has a really good understanding of business.” Marc believes that you need all three of these, but if you’re going to compromise on one of those as an investor, it should be the product: “A great market is a lot easier to make up for with iterative product execution. The problem with a poor or small market is that even if you do a good job on the product, there just aren’t that many customers so it’s hard to ever get big and people get demoralized . . . And then we evaluate the team of a startup by its ability to get into a big market with a good product.”

Startup Archive

17,333 просмотров • 8 месяцев назад

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

Jack Prescott

31,665 просмотров • 2 месяцев назад

🚨Former Israeli Peace Negotiator Daniel Levy: ‘Israel is on a SUGAR HIGH of death and destruction, it’s not clear to me Zionism can RE-INVENT itself.’ ‘America may be feeling less pain, but America’s threshold for pain, certainly when it’s economic and it translates into political, is significantly less than it is for others. And this is where this question of how Netanyahu will respond is where it looks like many of us maybe used to watch cartoons, where the cartoon character goes off the edge of a cliff and then they stay in motion until they look down and then they’ve got nowhere to go, they can’t go back. And it feels like Israel may be going on that journey, that it has simply gone too far. The question for many is, well, why isn’t there an establishment inside Israel that’s stopping this? And that’s why I’ve tried to suggest that it’s not just Netanyahu, the country has gone off on this sugar high of death and destruction, that all that, all that was built up for decades has now come into play.’ Afshin Rattansi: ‘So would it unilaterally attack even after Trump saying no?’ Levy: ‘This is where you bump into the reality that America has tremendous leverage over Israel. And so I think if America wants this to stop, just as it has in Lebanon said enough. Although Israel is still physically inside Lebanese territory, it’s still ceasefire Israeli-style, which means you still kill the other side. But I think if America says stop, then Israel stops. But the question is, has Israel given itself an alternative path to pursue, or are we seeing that actual existing Zionism as practised by the State of Israel has nowhere to go now? And either you radically rethink what is the future for the Israeli Jewish community, not in a regime of an ethnostate, but as some kind of normal way of interacting with those in its midst. That is a very different future. And, it’s not clear to me that the project, the Zionist project, can reinvent itself.’ Watch the full interview in the quoted post below👇

Going Underground

70,023 просмотров • 5 месяцев назад

Why are so many young people single these days? Pooja Arora (Pooja Arora): So my last question: I wanted to talk about why people are single nowadays. I would have asked about human nature, but that’s for another day. I sent you an article—how do you think common knowledge fits into that area? Why do you think so many youngsters are single? Me: Yes, it’s a good question. I’m not sure that common knowledge is an important part of the answer, but some of it is that women no longer depend on the economic contributions of men for their livelihood, as was true, say, in my mother’s era, when women were not professionally trained. To pay the rent, they had to be married. Now, not only are women better educated, but the economy has shifted to favor the kinds of skills that women, as opposed to men, have. And just as women have been rising, men have been sinking because of the decline in blue-collar work. There have also been cultural trends that favor women’s temperaments. Men have been distracted by internet gaming, gambling, and pornography and are less desirable as marriage partners. Women with more economic power are more likely to raise their standards for what they want in a man. In my parents’ generation, it was not uncommon for a woman to marry a man with much less education and, sometimes, less intelligence. This was not unusual among my parents’ friends. The men often had a high school degree and then went immediately into a small business—sometimes a family business, sometimes one he started himself. The criterion was: does he make a living? No one cared about education. That has changed, with the result that there are fewer men who satisfy the criteria women now have. This was mentioned in the article you shared with me. Also, with more sexual freedom, people don’t have to get married simply to have sex, which was again true in my parents’ generation. There’s a process that has been in place since the baby boomers and has accelerated among millennials and Generation Z. For other reasons, I think a generation of men may also be incapable of socially skilled interaction, partly because they’ve grown up with screens instead of face-to-face contact. There is some fear that a sexual encounter could result in an accusation of rape or sexual harassment. There is so much pornography that, for an increasing number of men, it serves as an outlet for what in the past would have required actual human contact. There are many factors. The article from The Economist lists them, I think, quite skillfully. It’s not clear how to reverse the trend. Increasing the economic prospects of men and creating an educational system that is less feminized and more encouraging of male achievement might help. Another could be changing norms—and here common knowledge comes in. Among women, is it a sign of low status to be with a man who has less education than you? Men, from time immemorial, have been happy to marry women with less education than themselves. Women don't. That immediately reduces the marriage pool. Maybe that’s a norm that could change. Go back to the norm in my parents’ generation? Pooja Arora: No, let’s not do that. Me: Okay, let's not do that. Pooja Arora: We’re happy to marry men who are not as educated as us. It’s fine. They just have to be nice and kind at this point in time. Me: Well, yes—exactly. Nice and kind.

Steven Pinker

89,438 просмотров • 7 месяцев назад

jihoon answering teumes’ worries at dawn live 👤: I really wanted to receive a psychiatric (treatment) but I don’t have the courage to do it. Should I go? I think I’m going to have a hard time accepting that I am falling apart. 🐶: but I recommend going to the psychiatrist, whether if it’s receiving a psychological counselling or a psychiatric examination, it’s good to receive a treatment for it. Everyone, going to the psychiatrist doesn’t make you weird. If you caught a cold, you go to the internal medicine department, If your joints or bones hurts, you go to the orthopaedics. It’s just a cold that come to the mind. It’s not that going to the psychiatrist makes me a weird person, no it’s not that. It’s just that I’m exhausted for a while, it’s just a hospital. There’s more people going there more than you think, if you go to hospital, the queuing are the longest. Nowadays, it’s the same as the past too but there’s no one who doesn't have a hard time. In this hard world, although there are people who look at the hard times in a good way, & there are also people who don’t look at it in a good way… but since it’s a world where we lived together, there's nothing we can do about it, right? But those kind of, “ah I went to the psychiatrist & I collapsed” I don’t think you have think of that. It’s just, “I am having a hard time these days so I’m just going to get help for it” just think of it as if you caught a cold. I hope you don’t think of this deeply. Of course you can go. If your stomach hurt, you can go to the internal medicine, if your head hurts, you can go to the Otolaryngology. It’s just that your heart is having a hard time for a while. This is not something to be ashamed of, you don’t need to read the air with the people around you for this. Always cheer up, even if you collapse, let's practice the strength that can make you rise again slowly, treasure makers. You can do it, everyone, I know you can do it.

ain

376,990 просмотров • 2 лет назад