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. David Sinclair is working towards a future in which we take a pill for 4 weeks and get younger...

Peter H. Diamandis, MD

409,642 subscribers

73,139 views • 1 year ago •via X (Twitter)

Health & Wellness Science & Technology

Anya Rossi• Live Now

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10 Comments

Peter H. Diamandis, MD1 year ago

full episode here:

Anwarino1 year ago

@davidasinclair Whenever someone now predicts something will happen 10 years into the future, my working assumption is that it will happen much much sooner

Jeff Lewis1 year ago

@davidasinclair Faster please

Most interesting man on X ☦️1 year ago

@davidasinclair Faster please. Some of us may not have 10 years

Endrina Pavlić1 year ago

@davidasinclair Perfect…future is great 👍

Joel Collinson1 year ago

@davidasinclair Great episode. The near-term future is bright.

Stephen Schifani1 year ago

@davidasinclair Fascinating. So many questions. I began typing some out, but there are too many.

Faith Cited1 year ago

@davidasinclair Yes, the day you’re dreaming for will come and then you’ll seek death and not find it.

İsmail Keskin1 year ago

@davidasinclair This and the robotic servants are the only tech I am excited about honestly. No space travel, FSD, quantum computing, nanomaterials.

Taylor-Valmere Theory of Awareness1 year ago

I LOVE every video you put out, Pete. (I can call you Pete, right? Feels like we’re on a first name basis after watching all your vids and summits). Dr. Sinclair is one of my very favorite people you put in front and center for us. So much appreciation for the level-headed optimism you are bringing to medical and AI advancement.

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Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

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David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

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New: Joe Rogan is visibly concerned when longevity scientist David Sinclair reveals that the first potential human age-reversal technology is already being tested in humans: ROGAN: “This sounds like the beginning of a horror movie.” SINCLAIR: “I admit it is science fiction, and I even have to pinch myself that it’s actually happening.” “The first potential human age-reversal technology is in people right now.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “ER-100 is the drug we put into people that makes them younger, and then they work like they were young again.” ROGAN: “Horror movie.” SINCLAIR: “This trial is FDA approved.” ROGAN: “Oh great they never f*ck anything up.” SINCLAIR: “I don’t see an old person anymore on the street. I just see a person that needs to be rebooted.”

New: Joe Rogan is visibly concerned when longevity scientist David Sinclair reveals that the first potential human age-reversal technology is already being tested in humans: ROGAN: “This sounds like the beginning of a horror movie.” SINCLAIR: “I admit it is science fiction, and I even have to pinch myself that it’s actually happening.” “The first potential human age-reversal technology is in people right now.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “ER-100 is the drug we put into people that makes them younger, and then they work like they were young again.” ROGAN: “Horror movie.” SINCLAIR: “This trial is FDA approved.” ROGAN: “Oh great they never f*ck anything up.” SINCLAIR: “I don’t see an old person anymore on the street. I just see a person that needs to be rebooted.”

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