🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR:... “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclairshow more

Yeah. Regular injections into the eyeball to buy a few more years. Hard pass.

ER-100 is specifically engineered as a gene therapy for retinal cells. I think the bigger idea is that the same epigenetic-reprogramming platform could eventually be adapted to other organs or potentially multiple tissues. So it wouldn't always be an injection into the eyeball

So this would only change cells in the retina? Is it adding telomeres or actually changing out protein-coding DNA? A systematic approach would require hundreds of different therapies, and many other tissues don’t currently have a therapy… the therapy also can’t undo already-sustained damage and scar tissue always stays scar tissue… @grok can you elaborate on the above and tell me what a potential future systematic approach could look like? Pin cushion people getting hundreds of injections? Nano robots running around administering hundreds of different therapies?

@KanekoaTheGreat @daniel_knauf The trial is a treatment for reversing blindness, not general age reversal.

@KanekoaTheGreat @daniel_knauf @grok reversing or halting progression of a specific type of blindness with a known genetic basis? I would be surprised if it were actually “reversing”

It's the Life Biosciences ER-100 trial (AAV2-OSK) for open-angle glaucoma and NAION. Mechanism is partial epigenetic reprogramming of retinal ganglion cells to reset age-related marks, not correction of a specific mutation. Most glaucoma is complex/polygenic, not monogenic. Preclinical animal data showed functional vision restoration after damage. Human Phase 1 is early (safety first); true reversal remains unproven.

@johnrobb @KanekoaTheGreat @daniel_knauf Wow, how would it “reset” DNA methylation, exactly?

OSK (Oct4/Sox2/Klf4) transcription factors open chromatin and upregulate TET1/TET2 demethylases. These enzymes actively strip age- and injury-linked methyl groups from specific CpG sites (via 5mC oxidation), restoring youthful methylation patterns and gene expression in RGCs. No DNA sequence change occurs; cell identity stays intact. Effects depend on the TETs.

"Shot in the eye, and you're to blame, darling you give gene therapy, a bad name."

Boomers will take their gold reverse their age and we will all live under their horrible rule forever. 😂

I'd pass.. I'll take God's word

No thanks. If you hadn’t noticed; this is not Heaven nor was it meant to be. Why would I delay for a nanosecond my chance to spend eternity with God?

If you don’t deal with dementia and Alzheimer’s too, looking young may only get you more attention at Memory Care.

That’s not creepy.

This dude Sinclair is 5’1 and looks like a child. he isn’t reverse aging, he’s the size of a fucking muppet. He is pulling supps (adenine) off the market originally this was vitamin B4 to reintroduce them as proprietary to cash in on it. He promote metformin for everyone…again he is a swindler has been a swindler for decades. he is proof anti aging is fake… cause hes in the space. A muppet🤏🏻

I don’t know if this man believes in God, but my guess is that he and others like him do not have a strong faith, if any at all. They seek to live forever because they fear there’s nothing more after this life. It’s sad really.

The state of modern medicine: "We can make you immortal in just few years, promise!" "Nice... what about fixing my hurting joint?" "Are you kidding?! That's impossible!" Don't get deceived by modern alchemists, folks.

Why isn't @bryan_johnson in these clinical trials?

@bryan_johnson I'm sure he's interested, but I don't think he should volunteer himself for the early stages of clinical trials Let the data come in first

Sinclair is a scam artist. Hes bee at this for decades and has produced nothing. All of the compunds hes found like nmn and Resveratrol do nothing on humans when studied independently.

Please just hold off until the Boomers are gone. Please.

lol

Bro… “In the current FDA clinical trial, the therapy is delivered by injection into the eye.” WTF?!

Does it leave the recipient with a black eye?

Injection in the eye, 🤔 no thanks I’ll just get old

Yeah I'm sure this will be available to the masses and not just a select group of families who then try and rule over the rest of us.

some folk on earth are already much older than you would think.

When I attended Harvard we were required to write a paper on the ethics on genetic manipulation based on the work of Michael Sandel, another famous Harvard professor, about the ethics of rich western nations doing thing like living forever while the downtrodden die normally

Humans will always search for the fountain of youth and never find it. Closest thing we have today is the same thing we had in the beginning. Treat your body like a temple and have real expectations from your genetic lineage.

Yeah…completely lost me when it said “inject it into the eye.” I’m out.

Maybe Trump would volunteer for these treatments? America needs 10 or 20 more terms just to reverse what Obama did.

Sounds awesome, but... in the *eye*?!?

NO THANKS!!!!!

Even if this compound proved to work with no side effects, the general public would never get access to it. Only the ultra wealthy like Rogan. The people with all the power behind the curtain already think the earths population is unsustainable. Do the math.

Make sure the Boomers are all dead before you push this out to the public.

Yup, it will be an mRNA treatment, just as I predicted years ago. The mRNA shots were a multi-billion person test to see the effects on the body before the tech was rolled out to keep the high rollers alive forever. That's why there were different batches with different lethalities - need to gauge the safe dosage.

Does it work in dogs. My Husky is almost 11. I would like an extension.

If we do end up living longer than the 96 years that’s common, dear Lord, social security would be gone in a decade.

The core question becomes, "Why are so many afraid of death?" We should enjoy life but the end must come for everyone. It is a common truth all over the world.

I wouldn't buy a cellphone from this guy, let alone "age-reversal" treatments.

The wealthy, powerful political assholes will be the first to live longer. The absolute worst people on the planet.

There's already a plan for eternal life, and it's not through extending this life. "Just as people are destined to die once, and after that to face judgment,..." Hebrews 9:27 "He has made everything beautiful in its time. He has also set eternity in the human heart; yet no one can fathom what God has done from beginning to end." Ecclesiastes 3:11 "For my Father’s will is that everyone who looks to the Son and believes in him shall have eternal life, and I will raise them up at the last day.”" John 6:40

Just because you CAN do something, doesn’t mean you SHOULD do that something.