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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR:...

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KanekoaTheGreat

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Joe Rogan asks Harvard scientist David Sinclair if someone could "inject something in your coffee" to age you decades overnight. His answer: "We know how to do that." SINCLAIR: "We found that that happens largely due to DNA damage... We could use this to rapidly age a mouse, which we published in 2023." ROGAN: "Oh, so like some nefarious state actor, like some Russian spy, could inject something in your coffee, and you would turn 99 overnight." SINCLAIR: "We know how to do that." ROGAN: "Whoa!" SINCLAIR: "Yeah." ROGAN: "That's the dark side of this. You could. You could spike your husband's drink. 'F*ck that dude!' And turn him into an old man. 'What did you do?!'"
0:40

Joe Rogan asks Harvard scientist David Sinclair if someone could "inject something in your coffee" to age you decades overnight. His answer: "We know how to do that." SINCLAIR: "We found that that happens largely due to DNA damage... We could use this to rapidly age a mouse, which we published in 2023." ROGAN: "Oh, so like some nefarious state actor, like some Russian spy, could inject something in your coffee, and you would turn 99 overnight." SINCLAIR: "We know how to do that." ROGAN: "Whoa!" SINCLAIR: "Yeah." ROGAN: "That's the dark side of this. You could. You could spike your husband's drink. 'F*ck that dude!' And turn him into an old man. 'What did you do?!'"

The Vigilant Fox 🦊

267,215 Aufrufe • vor 1 Tag

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
2:55

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

John Cumbers

1,159,303 Aufrufe • vor 4 Monaten

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:02

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

21,184 Aufrufe • vor 4 Monaten

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

John Cumbers

416,363 Aufrufe • vor 4 Monaten

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

Goku

985,946 Aufrufe • vor 4 Monaten

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:04

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

84,263 Aufrufe • vor 3 Monaten

🇺🇸 HARVARD BEGINS TO REVERSE ALZHEIMER'S Professor of Genetics at Harvard, David Sinclair: "Curing blindness is a big deal. We didn't choose the eye because it was going to work; we chose it because it was difficult. If it's going to work in the eye, I think it's likely to work in other tissues. We can cure Alzheimer's in, or at least reverse large aspects of Alzheimer's, in a mouse now. Hopefully, reversing the age of the human brain will have the same effect, which means that memories will come back, and the ability to learn will come back. I'm saying that the eye is just the beginning." Source: Tsarathustra
1:22

🇺🇸 HARVARD BEGINS TO REVERSE ALZHEIMER'S Professor of Genetics at Harvard, David Sinclair: "Curing blindness is a big deal. We didn't choose the eye because it was going to work; we chose it because it was difficult. If it's going to work in the eye, I think it's likely to work in other tissues. We can cure Alzheimer's in, or at least reverse large aspects of Alzheimer's, in a mouse now. Hopefully, reversing the age of the human brain will have the same effect, which means that memories will come back, and the ability to learn will come back. I'm saying that the eye is just the beginning." Source: Tsarathustra

Mario Nawfal

411,616 Aufrufe • vor 2 Jahren

Caught up with David Sinclair on the pod, our best conversation to date. We covered: -- progress on a pill to reverse aging -- gene therapy breakthroughs and AI's role in reprogramming life -- when trials to reverse epigenetic aging in humans will begin -- controversial molecules: NMN, NAD+, rapamycin, and more -- Sinclair’s personal protocol: fasting, fitness, and what actually works -- women's health, economic implications, and ethical landmines -- the truth about age reversal and where we go next
0:45

Caught up with David Sinclair on the pod, our best conversation to date. We covered: -- progress on a pill to reverse aging -- gene therapy breakthroughs and AI's role in reprogramming life -- when trials to reverse epigenetic aging in humans will begin -- controversial molecules: NMN, NAD+, rapamycin, and more -- Sinclair’s personal protocol: fasting, fitness, and what actually works -- women's health, economic implications, and ethical landmines -- the truth about age reversal and where we go next

Peter H. Diamandis, MD

132,697 Aufrufe • vor 1 Jahr

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.
1:02

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.

John Cumbers

95,716 Aufrufe • vor 4 Monaten

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair
3:42

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

275,620 Aufrufe • vor 21 Stunden

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?
2:18

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?

Camus

22,258 Aufrufe • vor 5 Monaten

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.
1:24

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

John Cumbers

157,415 Aufrufe • vor 3 Monaten

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:
1:43

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:

John Cumbers

27,280 Aufrufe • vor 4 Monaten

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair
1:45

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

John Cumbers

203,147 Aufrufe • vor 4 Monaten

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.
0:27

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

John Cumbers

55,280 Aufrufe • vor 4 Monaten

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:
1:29

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

John Cumbers

56,080 Aufrufe • vor 3 Monaten

David Sinclair: "Sudden blindness has doubled because of GLP-1 drugs." ROGAN: “Holy shit!” SINCLAIR: “It’s like a stroke in your eye. And then your other eye can go. And there’s nothing you can do about it.” ROGAN: “Obviously, correlation does not equal causation, but...” SINCLAIR: “Yeah, there’s a scientist at Harvard, Joseph Rizzo. It looks like it’s repeatable across the planet.” ROGAN: “Wow, that’s terrible because there are so many people out there telling everyone they should get on GLP-1s.” Joe Rogan David Sinclair
2:39

David Sinclair: "Sudden blindness has doubled because of GLP-1 drugs." ROGAN: “Holy shit!” SINCLAIR: “It’s like a stroke in your eye. And then your other eye can go. And there’s nothing you can do about it.” ROGAN: “Obviously, correlation does not equal causation, but...” SINCLAIR: “Yeah, there’s a scientist at Harvard, Joseph Rizzo. It looks like it’s repeatable across the planet.” ROGAN: “Wow, that’s terrible because there are so many people out there telling everyone they should get on GLP-1s.” Joe Rogan David Sinclair

KanekoaTheGreat

1,288,855 Aufrufe • vor 1 Tag

If this holds up, it is absolutely mind blowing. 🤯 Reversing biological age by 50 to 75 percent in animals in weeks and now a first human trial cleared. We might be watching the first real crack in the concept of aging as inevitable.
2:18

If this holds up, it is absolutely mind blowing. 🤯 Reversing biological age by 50 to 75 percent in animals in weeks and now a first human trial cleared. We might be watching the first real crack in the concept of aging as inevitable.

VraserX e/acc

53,219 Aufrufe • vor 5 Monaten

David Sinclair's lab is using AI to build a pill that reverses aging for $100. Right now, their gene therapy costs roughly $10 million to manufacture. It requires a direct injection into the target organ. That's not going to work for 8 billion people. So Sinclair's team made a breakthrough. They found that the three age-reversal genes aren't the only path to resetting cells. They discovered CHEMICALS that do the same thing. In mice, they can now give an animal a liquid — not genes, not injections, a drink — and rejuvenate tissues in 4 weeks. Sinclair says it's now normal for his students to casually report: "We just rejuvenated the ear. We just rejuvenated the skin. We just cured ALS (motorneuron disease) in these animals." He calls his lab "Willy Wonka's chocolate factory" because the discoveries blow him away every week. But he wants one molecule that does everything. So they used AI to screen 8 BILLION candidates. They're now down to three molecules that work. And they're using AI to try to combine all three into one. The gene therapy could cost over $100,000 per treatment. Sinclair's goal: "What if it could be $100 instead? That's what I'm working for. I want to democratize this technology so anyone even in Kenya can take these medicines." They should know within a year or two if the molecules work in mice. The gene therapy is the proof of concept. The pill is the endgame. — David Sinclair
1:49

David Sinclair's lab is using AI to build a pill that reverses aging for $100. Right now, their gene therapy costs roughly $10 million to manufacture. It requires a direct injection into the target organ. That's not going to work for 8 billion people. So Sinclair's team made a breakthrough. They found that the three age-reversal genes aren't the only path to resetting cells. They discovered CHEMICALS that do the same thing. In mice, they can now give an animal a liquid — not genes, not injections, a drink — and rejuvenate tissues in 4 weeks. Sinclair says it's now normal for his students to casually report: "We just rejuvenated the ear. We just rejuvenated the skin. We just cured ALS (motorneuron disease) in these animals." He calls his lab "Willy Wonka's chocolate factory" because the discoveries blow him away every week. But he wants one molecule that does everything. So they used AI to screen 8 BILLION candidates. They're now down to three molecules that work. And they're using AI to try to combine all three into one. The gene therapy could cost over $100,000 per treatment. Sinclair's goal: "What if it could be $100 instead? That's what I'm working for. I want to democratize this technology so anyone even in Kenya can take these medicines." They should know within a year or two if the molecules work in mice. The gene therapy is the proof of concept. The pill is the endgame. — David Sinclair

Goku

674,370 Aufrufe • vor 4 Monaten

How much control do we actually have over how we age?? David Sinclair has spent decades studying the biology of ageing, and what actually drives it at a cellular level. David is a professor of genetics at Harvard Medical School and one of the leading researchers in the field of ageing. His work focuses on why our bodies decline over time and what influences that process. He’s not talking about extreme interventions or unrealistic outcomes, but he’s focused on what the science actually says, and what we can influence today. A lot of what we believe about ageing feels fixed. That it’s just time passing and that decline is inevitable. But David challenges that by explaining what’s happening underneath it all.
1:38

How much control do we actually have over how we age?? David Sinclair has spent decades studying the biology of ageing, and what actually drives it at a cellular level. David is a professor of genetics at Harvard Medical School and one of the leading researchers in the field of ageing. His work focuses on why our bodies decline over time and what influences that process. He’s not talking about extreme interventions or unrealistic outcomes, but he’s focused on what the science actually says, and what we can influence today. A lot of what we believe about ageing feels fixed. That it’s just time passing and that decline is inevitable. But David challenges that by explaining what’s happening underneath it all.

Steven Bartlett

67,272 Aufrufe • vor 4 Monaten