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Does using melatonin raise heart failure risk? A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without a documented use of melatonin. There are some...

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Dr. Rhonda Patrick

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69,995 görüntüleme • 5 ay önce •via X (Twitter)

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A recent study associated melatonin with an 89% higher risk of heart failure, but this is likely an association, not causation. Poor sleep, which melatonin users often try to correct, is the real culprit. #Melatonin #HeartHealth
2:29

A recent study associated melatonin with an 89% higher risk of heart failure, but this is likely an association, not causation. Poor sleep, which melatonin users often try to correct, is the real culprit. #Melatonin #HeartHealth

Matt Walker

29,363 görüntüleme • 5 ay önce

A startling new study links melatonin and heart failure. Dr. Mike Varshavski breaks down what you need to know. “Melatonin is probably the most misused supplement in my patient population.”
0:40

A startling new study links melatonin and heart failure. Dr. Mike Varshavski breaks down what you need to know. “Melatonin is probably the most misused supplement in my patient population.”

FOX & Friends

14,982 görüntüleme • 7 ay önce

HEART FAILURE FROM MELATONIN? 👉 [click, FULL urgent news]
0:25

HEART FAILURE FROM MELATONIN? 👉 [click, FULL urgent news]

Chris MMHealth

66,091 görüntüleme • 7 ay önce

Sleep doctor says taking melatonin without understanding what it does can cause serious harm to your body “Melatonin is by prescription only almost everywhere outside the United States. Melatonin is a hormone. There’s a reason you can’t go to CVS and get testosterone and estrogen, right? Hormones affect the entire system. What you don’t want to do is have somebody just willy-nilly grabbing a hormone and starting to take it without understanding what’s going on with them” “More importantly, melatonin in particular interacts with SSRI medications. An SSRI is a serotonin-specific reuptake inhibitor, an antidepressant, things like Prozac, Zoloft, and Celexa. All of those are medications that can be affected by melatonin ingestion. In addition, melatonin can affect birth control, blood pressure medication, and diabetes medication” “Melatonin is a sleep regulator, not a sleep initiator. Melatonin doesn’t affect sleep drive, it affects sleep rhythm. It mainly affects your brain, telling it when it’s time to go to bed. It does not directly make you sleepy”
1:35

Sleep doctor says taking melatonin without understanding what it does can cause serious harm to your body “Melatonin is by prescription only almost everywhere outside the United States. Melatonin is a hormone. There’s a reason you can’t go to CVS and get testosterone and estrogen, right? Hormones affect the entire system. What you don’t want to do is have somebody just willy-nilly grabbing a hormone and starting to take it without understanding what’s going on with them” “More importantly, melatonin in particular interacts with SSRI medications. An SSRI is a serotonin-specific reuptake inhibitor, an antidepressant, things like Prozac, Zoloft, and Celexa. All of those are medications that can be affected by melatonin ingestion. In addition, melatonin can affect birth control, blood pressure medication, and diabetes medication” “Melatonin is a sleep regulator, not a sleep initiator. Melatonin doesn’t affect sleep drive, it affects sleep rhythm. It mainly affects your brain, telling it when it’s time to go to bed. It does not directly make you sleepy”

Mikli

80,337 görüntüleme • 1 ay önce

This! All of this! So many people do not realize that melatonin is a HORMONE! Do not create an imbalance to your developing child’s hormones! Magnesium > Melatonin
1:57

This! All of this! So many people do not realize that melatonin is a HORMONE! Do not create an imbalance to your developing child’s hormones! Magnesium > Melatonin

Sarah Fields

649,439 görüntüleme • 1 yıl önce

A short tutorial re your pineal gland, the several roles of melatonin including tissue repair and blood glucose regulation, and how you can regulate melatonin with light & temperature.
7:22

A short tutorial re your pineal gland, the several roles of melatonin including tissue repair and blood glucose regulation, and how you can regulate melatonin with light & temperature.

Andrew D. Huberman, Ph.D.

282,260 görüntüleme • 1 yıl önce

A study shows 88% of melatonin brands have inaccurate labels, with melatonin content ranging from 26% less to 347% more than claimed. Look for brands with 3rd-party tested batches. It's a chronobiotic, not a sleep aid. #SleepScience #Melatonin
2:03

A study shows 88% of melatonin brands have inaccurate labels, with melatonin content ranging from 26% less to 347% more than claimed. Look for brands with 3rd-party tested batches. It's a chronobiotic, not a sleep aid. #SleepScience #Melatonin

Matt Walker

20,682 görüntüleme • 8 ay önce

The only thing worse than Homeopathy? Scientists on the internet without any knowledge on clinical medical practice, selling supplements that they endorse, using misinformation masquerading as "solid peer reviewed science." Check this video out, when Huberman bullshits everyone in just half a minute on the Joe Rogan Experience Podcast. Before I go on, please remember this The Bullshit Asymmetry Principle, also known as Brandolini’s Law, states that the amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it. Which means, I have to put extra effort just to debunk the 36 seconds of that podcast. First, a little about sleep disorders Sleep disorders are of different types and due to different causes. The diagnosis is simply not "I can't sleep" and so here, take this sleep cocktail. Many patients come with sleep disorders that are associated with other conditions. For example, cirrhosis patients have sleep disorders that require management with ammonia lowering therapies and severe cases can only be reversed with a liver transplant. Patients with alcohol use disorders have sleep disorders that require management with de-addiction therapies along with sedatives. Sleep disorders in the ICU set up has different causes. People with mental health disorders have associated sleep disorders. Certain sleep disorders have no identifiable causes and are called "idiopathic." Which means, coming on a podcast and blindly giving out a "sleep cocktail" to millions of viewers, who may be suffering from a sleep disorder which has an as yet unidentified cause, is one of the most foolish things one can do. And Huberman, not being an actual clinical doctor, makes that exact mistake. Huberman claims (very generally and casually), melatonin helps you to go to sleep, but does not maintain sleep. But "solid peer reviewed" studies have much more to say about melatonin. Melatonin improved sleep onset latency and total sleep time in children/adolescents with neurodevelopmental disorders. Melatonin also improved and sleep onset latency and total sleep time in adults with delayed sleep phase disorder. Treatment with melatonin has positive effects on sleep quality in adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases. This meta-analysis demonstrated that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. Another large meta-analysis showed that melatonin dosing and timing matters: for circadian phase advancement, an earlier time and smaller dose, but for sleep quality/consolidation a larger and later dose seemed appropriate. See here: So melatonin does increase total sleep time, total sleep quality and reduces time to sleep and has beneficial effects in specific groups of patients. Now the "solid peer reviewed studies" on the cocktail - which Huberman claims on three supplements - magnesium threonate, apigenin and L-theanine. Unfortunately, such "solid peer-reviewed papers" DO NOT EXIST. Lets see. Magnesium supplements: First of all, there is no conclusive evidence that magnesium, dietary or supplemented has any actual effect on sleep. Randomized clinical trials showed an uncertain association between magnesium supplementation and sleep disorders. See here: Forget sleep, magnesium has absolutely no evidence for involvement even in mood disorders. See here: This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. See here: Apigenin (from Chamomille): The possible sleep inducing effects of apigenin is still speculative. There are absolutely no solid peer reviewed studies or evidence for benefits of apigenin in sleep as Huberman claims. See here: A randomized, double-blind, placebo-controlled pilot trial showed that chamomille DID NOT have conclusive effects on sleep. See here: Even better, a systematic review and meta-analysis of randomized trials and quasi-randomized trials showed that there was very little evidence to show effect of chamomille on insomnia. See here: L-theanine supplements: There is absolutely NO study or data to suggest that L-theanine is useful for sleep induction, improving sleep quality or increasing total sleep time. The only studies that are of "better quality" shows that L-theanine "maybe" useful in reducing anxiety/ stress levels due to caffeine at night. See here and here The only other "study" on L-theanine which was done on mice and not humans showed effects only on brain related biomarkers and were not applicable in the clinical sense to humans - And coming to SOLID EVIDENCE on the "Huberman cocktail" - there is absolutely nothing in published literature to confirm that it works and there is no convincing mode of action of this cocktail in humans. A large systematic review and meta-analysis showed that Cognitive-Behavior Therapy for Insomnia was the best and not some random supplements proclaimed on a podcast by half-baked scientists who are full time supplement sellers. See here: There are basic scientists, with no or half-baked clinical practice knowledge, trying to sell you a bunch of useless supplements that they endorse for a paid-commission, using "science-sounding" words without any practical, rational or logical meaning; and push untested and unregulated therapies that are NEVER recommended, approved or promoted by any active, medical, scientific clinical societies worldwide. They are worse than pseudoscience peddlers. Be aware of where you find your health information. There is pseudoscience, but then there is also another terrible type of misinformation: BAD SCIENCE.
0:37

The only thing worse than Homeopathy? Scientists on the internet without any knowledge on clinical medical practice, selling supplements that they endorse, using misinformation masquerading as "solid peer reviewed science." Check this video out, when Huberman bullshits everyone in just half a minute on the Joe Rogan Experience Podcast. Before I go on, please remember this The Bullshit Asymmetry Principle, also known as Brandolini’s Law, states that the amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it. Which means, I have to put extra effort just to debunk the 36 seconds of that podcast. First, a little about sleep disorders Sleep disorders are of different types and due to different causes. The diagnosis is simply not "I can't sleep" and so here, take this sleep cocktail. Many patients come with sleep disorders that are associated with other conditions. For example, cirrhosis patients have sleep disorders that require management with ammonia lowering therapies and severe cases can only be reversed with a liver transplant. Patients with alcohol use disorders have sleep disorders that require management with de-addiction therapies along with sedatives. Sleep disorders in the ICU set up has different causes. People with mental health disorders have associated sleep disorders. Certain sleep disorders have no identifiable causes and are called "idiopathic." Which means, coming on a podcast and blindly giving out a "sleep cocktail" to millions of viewers, who may be suffering from a sleep disorder which has an as yet unidentified cause, is one of the most foolish things one can do. And Huberman, not being an actual clinical doctor, makes that exact mistake. Huberman claims (very generally and casually), melatonin helps you to go to sleep, but does not maintain sleep. But "solid peer reviewed" studies have much more to say about melatonin. Melatonin improved sleep onset latency and total sleep time in children/adolescents with neurodevelopmental disorders. Melatonin also improved and sleep onset latency and total sleep time in adults with delayed sleep phase disorder. Treatment with melatonin has positive effects on sleep quality in adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases. This meta-analysis demonstrated that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. Another large meta-analysis showed that melatonin dosing and timing matters: for circadian phase advancement, an earlier time and smaller dose, but for sleep quality/consolidation a larger and later dose seemed appropriate. See here: So melatonin does increase total sleep time, total sleep quality and reduces time to sleep and has beneficial effects in specific groups of patients. Now the "solid peer reviewed studies" on the cocktail - which Huberman claims on three supplements - magnesium threonate, apigenin and L-theanine. Unfortunately, such "solid peer-reviewed papers" DO NOT EXIST. Lets see. Magnesium supplements: First of all, there is no conclusive evidence that magnesium, dietary or supplemented has any actual effect on sleep. Randomized clinical trials showed an uncertain association between magnesium supplementation and sleep disorders. See here: Forget sleep, magnesium has absolutely no evidence for involvement even in mood disorders. See here: This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. See here: Apigenin (from Chamomille): The possible sleep inducing effects of apigenin is still speculative. There are absolutely no solid peer reviewed studies or evidence for benefits of apigenin in sleep as Huberman claims. See here: A randomized, double-blind, placebo-controlled pilot trial showed that chamomille DID NOT have conclusive effects on sleep. See here: Even better, a systematic review and meta-analysis of randomized trials and quasi-randomized trials showed that there was very little evidence to show effect of chamomille on insomnia. See here: L-theanine supplements: There is absolutely NO study or data to suggest that L-theanine is useful for sleep induction, improving sleep quality or increasing total sleep time. The only studies that are of "better quality" shows that L-theanine "maybe" useful in reducing anxiety/ stress levels due to caffeine at night. See here and here The only other "study" on L-theanine which was done on mice and not humans showed effects only on brain related biomarkers and were not applicable in the clinical sense to humans - And coming to SOLID EVIDENCE on the "Huberman cocktail" - there is absolutely nothing in published literature to confirm that it works and there is no convincing mode of action of this cocktail in humans. A large systematic review and meta-analysis showed that Cognitive-Behavior Therapy for Insomnia was the best and not some random supplements proclaimed on a podcast by half-baked scientists who are full time supplement sellers. See here: There are basic scientists, with no or half-baked clinical practice knowledge, trying to sell you a bunch of useless supplements that they endorse for a paid-commission, using "science-sounding" words without any practical, rational or logical meaning; and push untested and unregulated therapies that are NEVER recommended, approved or promoted by any active, medical, scientific clinical societies worldwide. They are worse than pseudoscience peddlers. Be aware of where you find your health information. There is pseudoscience, but then there is also another terrible type of misinformation: BAD SCIENCE.

TheLiverDoc™

475,648 görüntüleme • 2 yıl önce

The NYPost reported that there is a growing trend of adults "swapping melatonin and meditation for an adult-sized binky"... Shawn Farash - "This is what happens when we over coddle society..." Watch Fine Point with Chanel Rion OAN Weeknights 10pm ET Watch Here:
1:18

The NYPost reported that there is a growing trend of adults "swapping melatonin and meditation for an adult-sized binky"... Shawn Farash - "This is what happens when we over coddle society..." Watch Fine Point with Chanel Rion OAN Weeknights 10pm ET Watch Here:

One America News

28,640 görüntüleme • 10 ay önce

A recent study indicates standard melatonin doses (2-3mg) taken shortly before bed have no impact on sleep. 4mg taken 3 hours prior shows benefits. Melatonin is ineffective for insomnia. #Melatonin #SleepScience
2:30

A recent study indicates standard melatonin doses (2-3mg) taken shortly before bed have no impact on sleep. 4mg taken 3 hours prior shows benefits. Melatonin is ineffective for insomnia. #Melatonin #SleepScience

Matt Walker

30,879 görüntüleme • 5 ay önce

EXTRAPINEAL MELATONIN, MADE IN THE MITOCHONDRIA OF ~EVERY CELL, ACCOUNTS FOR ~95% OF THE TOTAL MELATONIN PRODUCED IN YOUR BODY. This melatonin is produced in response to near-infrared light from the sun. Full 28 minute video is up on YouTube.
1:13

EXTRAPINEAL MELATONIN, MADE IN THE MITOCHONDRIA OF ~EVERY CELL, ACCOUNTS FOR ~95% OF THE TOTAL MELATONIN PRODUCED IN YOUR BODY. This melatonin is produced in response to near-infrared light from the sun. Full 28 minute video is up on YouTube.

Jonathan Jarecki

45,025 görüntüleme • 9 ay önce

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?
0:45

Stop downing melatonin like candy. Andrew Huberman is sounding the alarm: High-dose melatonin supplements (20mg, 50mg — yes, people actually take that much) can suppress the hypothalamic-gonadal axis and potentially delay puberty and adolescence, especially in young people. While melatonin is naturally produced in many cells and has antioxidant properties, flooding your system with large supplemental amounts is a bad idea. His practical take: maybe a tiny bit occasionally, but not the mega-doses you see everywhere. It’s a timely reality check for anyone relying on melatonin nightly to fall asleep. Have you ever taken high-dose melatonin? Did it help or cause any weird side effects?

Camus

22,989 görüntüleme • 2 ay önce

Melatonin is not what you think it is.
1:00

Melatonin is not what you think it is.

SkriptkeeperElect

136,344 görüntüleme • 1 yıl önce

Wow. Scientists are now warning that the latest COVID variant could trigger a “heart failure pandemic.” And get this: Pfizer, the same company that sold you the so-called vaccines, is making a big bet on that “heart failure pandemic.” The pharmaceutical giant recently acquired several companies. This includes a major $6.7 billion cash acquisition of Arena Pharmaceuticals, a firm specializing in developing treatments, particularly for heart inflammation conditions like myocarditis and pericarditis. So, the company that caused the heart damage is now looking to profit from heart damage. Is my analysis wrong here?
3:57

Wow. Scientists are now warning that the latest COVID variant could trigger a “heart failure pandemic.” And get this: Pfizer, the same company that sold you the so-called vaccines, is making a big bet on that “heart failure pandemic.” The pharmaceutical giant recently acquired several companies. This includes a major $6.7 billion cash acquisition of Arena Pharmaceuticals, a firm specializing in developing treatments, particularly for heart inflammation conditions like myocarditis and pericarditis. So, the company that caused the heart damage is now looking to profit from heart damage. Is my analysis wrong here?

The Vigilant Fox 🦊

1,911,998 görüntüleme • 2 yıl önce

CO2 is way more effective than melatonin
1:42

CO2 is way more effective than melatonin

gianmarco

368,200 görüntüleme • 9 ay önce

Professor Peter Gøtzsche estimates that “prescription drugs are the leading cause of death, ahead of heart disease and cancer.” “Psychiatric drugs … are the third-leading cause of death, after heart disease and cancer.” “It would be better if we took all [psychiatric drugs] off the market.” “The way people use psychiatric drugs definitely causes much more harm than benefit.” “Psychiatric drugs can be useful in acute situations … but doctors often use psychiatric drugs for many years to the same patients, and that’s definitely harmful.” “The mantra is that drugs are safe and effective.” “This is an impossibility.” “If a drug has benefits, it will always harm some people, so nothing can be both safe and effective.” “It’s only a question about how frequent are the harms and how serious are they compared to the benefits.” Dr. Josef Prof. Peter C Gøtzsche
3:08

Professor Peter Gøtzsche estimates that “prescription drugs are the leading cause of death, ahead of heart disease and cancer.” “Psychiatric drugs … are the third-leading cause of death, after heart disease and cancer.” “It would be better if we took all [psychiatric drugs] off the market.” “The way people use psychiatric drugs definitely causes much more harm than benefit.” “Psychiatric drugs can be useful in acute situations … but doctors often use psychiatric drugs for many years to the same patients, and that’s definitely harmful.” “The mantra is that drugs are safe and effective.” “This is an impossibility.” “If a drug has benefits, it will always harm some people, so nothing can be both safe and effective.” “It’s only a question about how frequent are the harms and how serious are they compared to the benefits.” Dr. Josef Prof. Peter C Gøtzsche

Holden Culotta

35,622 görüntüleme • 7 ay önce

My top five tips to battle jet lag. 1. Early morning bright light exposure - This must be outside light from the sun. Aim for 30 minutes minimum. Light is the strongest zeitgeber that synchronizes the brain and body with the time zone you are in and resets your biological clock. The bright light signals to the brain that it's morning and time to wake up, and also activates the cortisol awakening response and inhibits melatonin production. 2. Exercise - Another zeitgeber that helps realign your circadian rhythm (your internal clock). Plus, it's great for your health. 3. High-dose creatine - Creatine can help support brain health in the context of stress. Jet lag is a big stress in the brain. Creatine starts to accumulate in the brain at a dose of 10g per day, and studies have found that 20-25g of creatine can improve brain function in the context of sleep deprivation. May not work for everyone but it works for me. 4. Strategic melatonin timing - A small dose of melatonin a couple of hours before you want to sleep helps signal to the brain it’s time to get ready for bed. This really helps when your internal clock thinks it is still daytime. 5. Avoid blue light exposure during the evening - Blue light inhibits melatonin, which is the last thing you want to do in the evening. Melatonin is the hormone that helps make you feel ready to sleep. Dimming lights or blue light-blocking glasses do the trick.
2:55

My top five tips to battle jet lag. 1. Early morning bright light exposure - This must be outside light from the sun. Aim for 30 minutes minimum. Light is the strongest zeitgeber that synchronizes the brain and body with the time zone you are in and resets your biological clock. The bright light signals to the brain that it's morning and time to wake up, and also activates the cortisol awakening response and inhibits melatonin production. 2. Exercise - Another zeitgeber that helps realign your circadian rhythm (your internal clock). Plus, it's great for your health. 3. High-dose creatine - Creatine can help support brain health in the context of stress. Jet lag is a big stress in the brain. Creatine starts to accumulate in the brain at a dose of 10g per day, and studies have found that 20-25g of creatine can improve brain function in the context of sleep deprivation. May not work for everyone but it works for me. 4. Strategic melatonin timing - A small dose of melatonin a couple of hours before you want to sleep helps signal to the brain it’s time to get ready for bed. This really helps when your internal clock thinks it is still daytime. 5. Avoid blue light exposure during the evening - Blue light inhibits melatonin, which is the last thing you want to do in the evening. Melatonin is the hormone that helps make you feel ready to sleep. Dimming lights or blue light-blocking glasses do the trick.

Dr. Rhonda Patrick

86,509 görüntüleme • 8 ay önce

Beavis and buttbead but youre faded off that dollar general melatonin gummy
0:54

Beavis and buttbead but youre faded off that dollar general melatonin gummy

DOGRUSH (COMMS CLOSED)

55,971 görüntüleme • 3 ay önce

Insulin sensitivity and glucose handling are most effective in the morning. That’s one reason I’m a fan of early time-restricted eating and not a fan of eating large meals (especially carb-heavy ones) within about 3 hours of bed. You can eat the exact same meal, with the same calories and macros, and get a very different insulin response depending on when you eat it. One reason is melatonin. As melatonin rises in the last few hours before your natural bedtime, it’s signaling to organs, including the pancreas, that it’s time to shift into recovery mode. That means insulin secretion may be less efficient late at night. This is how I prefer to eat, and many people find it to be beneficial. From my discussion with Andrew D. Huberman, Ph.D. earlier this year.
0:59

Insulin sensitivity and glucose handling are most effective in the morning. That’s one reason I’m a fan of early time-restricted eating and not a fan of eating large meals (especially carb-heavy ones) within about 3 hours of bed. You can eat the exact same meal, with the same calories and macros, and get a very different insulin response depending on when you eat it. One reason is melatonin. As melatonin rises in the last few hours before your natural bedtime, it’s signaling to organs, including the pancreas, that it’s time to shift into recovery mode. That means insulin secretion may be less efficient late at night. This is how I prefer to eat, and many people find it to be beneficial. From my discussion with Andrew D. Huberman, Ph.D. earlier this year.

Dr. Rhonda Patrick

122,749 görüntüleme • 11 gün önce

Two of our peer-reviewed studies prove that mRNA “vaccines” integrate into the human genome and disrupt THOUSANDS of genes — triggering turbo cancers, mitochondrial failure, and immune system collapse. mRNA technology is NOT SAFE FOR HUMAN USE — for ANY indication.
1:41

Two of our peer-reviewed studies prove that mRNA “vaccines” integrate into the human genome and disrupt THOUSANDS of genes — triggering turbo cancers, mitochondrial failure, and immune system collapse. mRNA technology is NOT SAFE FOR HUMAN USE — for ANY indication.

Nicolas Hulscher, MPH

66,308 görüntüleme • 7 ay önce