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Does your patient really need that peripheral IV “just in case”? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), sums up a recent article challenging the routine practice of maintaining idle PIVCs in clinically stable patients. Full summary: Visit for This Week’s Must-Know Medicine, including: • HPV Vaccination —...

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29,925 просмотров • 7 месяцев назад •via X (Twitter)

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As we ring in the new year, NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), announces the Year in Review edition, available now at
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As we ring in the new year, NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), announces the Year in Review edition, available now at

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11,667 просмотров • 7 месяцев назад

Management of hospitalized patients with viral pneumonia: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains recent research into routine antibiotics for hospitalized patients with community-acquired pneumonia and a positive respiratory viral assay. Full context and comment by Dr. Aaron J. Calderon: Visit for the Insights You Need in the Time You Have, including: • Anemia in Chronic Kidney Disease: A New Guideline from KDIGO • People Are Misinformed about Alcohol’s Cancer Risk • Should We Replete Marginally Low Magnesium Levels? • The Public’s Knowledge about Hypertension
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Management of hospitalized patients with viral pneumonia: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains recent research into routine antibiotics for hospitalized patients with community-acquired pneumonia and a positive respiratory viral assay. Full context and comment by Dr. Aaron J. Calderon: Visit for the Insights You Need in the Time You Have, including: • Anemia in Chronic Kidney Disease: A New Guideline from KDIGO • People Are Misinformed about Alcohol’s Cancer Risk • Should We Replete Marginally Low Magnesium Levels? • The Public’s Knowledge about Hypertension

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18,584 просмотров • 6 месяцев назад

NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), talks about a new study on using cap-refill time to manage resuscitation in septic shock. Read the full summary and comment from Dr. Daniel Dressler: Also in this week's issue of NEJM Clinician: Unprovoked VTE: Should Patients Continue Oral Anticoagulants Beyond 90 Days? Partial vs. Total Knee Arthroplasty: Long-Term Results Variability in PSA Levels During Prostate Cancer Screening
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NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), talks about a new study on using cap-refill time to manage resuscitation in septic shock. Read the full summary and comment from Dr. Daniel Dressler: Also in this week's issue of NEJM Clinician: Unprovoked VTE: Should Patients Continue Oral Anticoagulants Beyond 90 Days? Partial vs. Total Knee Arthroplasty: Long-Term Results Variability in PSA Levels During Prostate Cancer Screening

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19,821 просмотров • 8 месяцев назад

Catheter-Directed PE Treatment: Does it Deliver? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a trial recently published in NEJM that compared catheter-directed thrombolysis to anticoagulation alone for acute, intermediate-risk pulmonary embolism. Read the key results and comment from Michael E. Billington, MD: Visit to see What Matters Most This Week, including: 🫀 New ACC/AHA Guideline on Lipid Management and ASCVD Prevention 💊 Chronic Beta-Blocker Use in Low-Risk Patients after MI: Time to Re-Evaluate 🧠 Reducing the Risk of Recurrent Stroke in Patients with Left Ventricular Dysfunction 🎯 What's the Ideal LDL Target for Patients with Cardiovascular Disease?
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Catheter-Directed PE Treatment: Does it Deliver? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a trial recently published in NEJM that compared catheter-directed thrombolysis to anticoagulation alone for acute, intermediate-risk pulmonary embolism. Read the key results and comment from Michael E. Billington, MD: Visit to see What Matters Most This Week, including: 🫀 New ACC/AHA Guideline on Lipid Management and ASCVD Prevention 💊 Chronic Beta-Blocker Use in Low-Risk Patients after MI: Time to Re-Evaluate 🧠 Reducing the Risk of Recurrent Stroke in Patients with Left Ventricular Dysfunction 🎯 What's the Ideal LDL Target for Patients with Cardiovascular Disease?

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12,682 просмотров • 4 месяцев назад

Protecting infants against RSV: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a head-to-head comparison of active immunization of pregnant women and monoclonal antibody administration to young infants. Full context and comment by Deborah Lehman, MD: Visit for the Insights You Need in the Time You Have, including: • Does Stepping Up to High-Dose Inhaled Steroids Decrease Asthma Exacerbations? • How Common Is Hypercortisolism in Type 2 Diabetes? • Do Short-Term Benefits of Total Knee Arthroplasty Hold in the Long-Term? • Intravenous Thrombolysis for Basilar Artery Occlusion
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Protecting infants against RSV: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a head-to-head comparison of active immunization of pregnant women and monoclonal antibody administration to young infants. Full context and comment by Deborah Lehman, MD: Visit for the Insights You Need in the Time You Have, including: • Does Stepping Up to High-Dose Inhaled Steroids Decrease Asthma Exacerbations? • How Common Is Hypercortisolism in Type 2 Diabetes? • Do Short-Term Benefits of Total Knee Arthroplasty Hold in the Long-Term? • Intravenous Thrombolysis for Basilar Artery Occlusion

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17,778 просмотров • 6 месяцев назад

Weight Regain after Stopping Obesity Medications: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a recent meta-analysis that showed projected return to baseline weight within 2 years. Full context and comment by Sarah E. Post, MD: Visit for more Insights You’ll Love This Week, including: 🩺 A Streamlined Approach to Blood Pressure Measurement 🎗️ Risk-Based Breast Cancer Screening vs. Annual Mammograms 🧬 Predicting Acute Chest Syndrome in Sickle Cell Disease 💉 Ketamine vs. Etomidate for Emergent Intubation #MedTwitter
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Weight Regain after Stopping Obesity Medications: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a recent meta-analysis that showed projected return to baseline weight within 2 years. Full context and comment by Sarah E. Post, MD: Visit for more Insights You’ll Love This Week, including: 🩺 A Streamlined Approach to Blood Pressure Measurement 🎗️ Risk-Based Breast Cancer Screening vs. Annual Mammograms 🧬 Predicting Acute Chest Syndrome in Sickle Cell Disease 💉 Ketamine vs. Etomidate for Emergent Intubation #MedTwitter

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20,573 просмотров • 6 месяцев назад

Are PPIs Linked to COPD Flares? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a retrospective study investigating if proton pump inhibitor (PPI) use is associated with exacerbations of chronic obstructive airway diseases. Read the full summary by Molly S. Brett, MD: Visit for more Insights to Break Your Routine, including: 💊 Early Transition to Oral Antibiotics after Hospitalization for Serious Infection 🩸 Breaking the Unfractionated Heparin Habit in Acute VTE 🫘 Ablation for Small Localized Renal Cell Carcinomas 📈 How Helpful Are Continuous Glucose Monitors for Type 2 Diabetes?
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Are PPIs Linked to COPD Flares? NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), explains a retrospective study investigating if proton pump inhibitor (PPI) use is associated with exacerbations of chronic obstructive airway diseases. Read the full summary by Molly S. Brett, MD: Visit for more Insights to Break Your Routine, including: 💊 Early Transition to Oral Antibiotics after Hospitalization for Serious Infection 🩸 Breaking the Unfractionated Heparin Habit in Acute VTE 🫘 Ablation for Small Localized Renal Cell Carcinomas 📈 How Helpful Are Continuous Glucose Monitors for Type 2 Diabetes?

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GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock
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GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock

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In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary:
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In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary:

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Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more in the Clinical Practice article “Peripheral Artery Disease in the Legs” by Mary M. McDermott, MD, from the Northwestern University Feinberg School of Medicine (Northwestern Feinberg School of Medicine):
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Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more in the Clinical Practice article “Peripheral Artery Disease in the Legs” by Mary M. McDermott, MD, from the Northwestern University Feinberg School of Medicine (Northwestern Feinberg School of Medicine):

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For patients with MRSA or VRE, would you continue the use of contact precautions in the hospital or discontinue them? Read the case vignette, options, and vote:
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For patients with MRSA or VRE, would you continue the use of contact precautions in the hospital or discontinue them? Read the case vignette, options, and vote:

NEJM

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In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results and Research Summary:
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In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results and Research Summary:

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12,257 просмотров • 5 месяцев назад

Patients with giant-cell arteritis need better treatments. This video, in partnership with Dr. Glaucomflecken, summarizes new research findings on the JAK-1 inhibitor upadacitinib in patients with giant-cell arteritis. Access the article for free:
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Patients with giant-cell arteritis need better treatments. This video, in partnership with Dr. Glaucomflecken, summarizes new research findings on the JAK-1 inhibitor upadacitinib in patients with giant-cell arteritis. Access the article for free:

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92,870 просмотров • 1 год назад

Today’s real-world case on Doctordle is from NEJM! A 47-year-old presents to the ED for dyspnea and sensation of tongue swelling. Watch one of NEJM Clinician editors, Clement Lee, MD, play today’s game! Can you guess the diagnosis in five tries or less? Test yourself at
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Today’s real-world case on Doctordle is from NEJM! A 47-year-old presents to the ED for dyspnea and sensation of tongue swelling. Watch one of NEJM Clinician editors, Clement Lee, MD, play today’s game! Can you guess the diagnosis in five tries or less? Test yourself at

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23,710 просмотров • 8 дней назад

In the latest video in our partnership with Dr. Glaucomflecken, the REGENCY trial investigating the efficacy and safety of obinutuzumab when added to standard therapy in patients with active proliferative lupus nephritis is explained. Access the article for free:
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In the latest video in our partnership with Dr. Glaucomflecken, the REGENCY trial investigating the efficacy and safety of obinutuzumab when added to standard therapy in patients with active proliferative lupus nephritis is explained. Access the article for free:

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144,797 просмотров • 1 год назад

What are the challenges of recommending bisphosphonates to patients who have normal bone density? Dr. Ann Garment, chief of general internal and hospital medicine at Bellevue Hospital in New York (NYC Health + Hospitals), discusses this in the latest episode of Beyond Journal Club, a collaboration between CORE IM and NEJM Group. Listen to the full episode: 📖 Further reading Original Article by M.J. Bolland et al.: Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age
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What are the challenges of recommending bisphosphonates to patients who have normal bone density? Dr. Ann Garment, chief of general internal and hospital medicine at Bellevue Hospital in New York (NYC Health + Hospitals), discusses this in the latest episode of Beyond Journal Club, a collaboration between CORE IM and NEJM Group. Listen to the full episode: 📖 Further reading Original Article by M.J. Bolland et al.: Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age

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19,925 просмотров • 9 месяцев назад

A pars plana vitrectomy was performed to remove the worm that had been found on funduscopy. Read the full case details in the Images in Clinical Medicine article “Ocular Gnathostomiasis”:
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A pars plana vitrectomy was performed to remove the worm that had been found on funduscopy. Read the full case details in the Images in Clinical Medicine article “Ocular Gnathostomiasis”:

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Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone. Full phase 3 REPLENISH trial results and Research Summary:
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Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone. Full phase 3 REPLENISH trial results and Research Summary:

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21,492 просмотров • 3 дней назад

NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:
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NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:

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16,994 просмотров • 21 дней назад

In the latest episode of the Not Otherwise Specified podcast, Dr. Kurt Stange, a family physician CWRU School of Medicine who practiced primary care for several decades, tells a story about how he helped to guide one of his patients to several specialists to treat two different types of cancer and an aneurysm. Hear more from Dr. Stange in the full episode hosted by NEJM National Correspondent Dr. Lisa Rosenbaum: Listen to past episodes and subscribe to the podcast:
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In the latest episode of the Not Otherwise Specified podcast, Dr. Kurt Stange, a family physician CWRU School of Medicine who practiced primary care for several decades, tells a story about how he helped to guide one of his patients to several specialists to treat two different types of cancer and an aneurysm. Hear more from Dr. Stange in the full episode hosted by NEJM National Correspondent Dr. Lisa Rosenbaum: Listen to past episodes and subscribe to the podcast:

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10,874 просмотров • 9 месяцев назад