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Erectile dysfunction precedes cardiovascular disease in many men because both conditions share the same upstream mechanism: endothelial dysfunction and impaired nitric oxide signaling. Penile vasculature is smaller in diameter than coronary vasculature and reflects vascular compromise earlier. This means erectile function is one of the most accurate early indicators... show more

Dr. Gabrielle Lyon

34,428 subscribers

243,205 views • 4 months ago •via X (Twitter)

Health & Wellness Education Science & Technology

Anya Rossi• Live Now

Private livecam show

7 Comments

Toku4 months ago

This is why it's worth putting your chips into optimal heart health early. the dividends on all kinds of performance plays into later life.

George Touliatos MD4 months ago

Urologist say often, ED equals endothelial dysfunction; quite often coronary artery disease @DrMorgentaler

Precis Health4 months ago

52% of men over 40 face some degree of erectile dysfunction. this makes the condition a high-sensitivity marker for systemic vascular health.

Mark Wilson4 months ago

Good to know

Stalin Kay4 months ago

Damn!

skeletonwizard4 months ago

Wasn't Jack Kruse talking about this 16 years ago. I thought most dudes already knew this.

Ronin Art & Music4 months ago

@HotepJesus #griftbag

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Dr. Nathan Bryan drops a bold claim in this 1:34 clip: Nitric oxide deficiency is the hidden root behind many chronic diseases—and restoring it could be a game-changer. Key conditions he links directly to low nitric oxide: - Erectile dysfunction (the "canary in the coal mine" for early cardiovascular decline) - High blood pressure - Metabolic disease & diabetes - Alzheimer's (vascular + metabolic + inflammatory aspects) He argues Alzheimer's is fundamentally a vascular disease: Nitric oxide improves brain blood flow, glucose uptake, reduces inflammation, oxidative stress, immune dysfunction, and prevents protein misfolding/amyloid plaque buildup. His conclusion: "I'm absolutely convinced [nitric oxide] will eradicate and cure Alzheimer's... because it addresses every physiological root cause." Provocative take—science-backed or too optimistic? Watch & decide. What chronic condition do you think nitric oxide could impact most in your life? Thoughts below.

Dr. Nathan Bryan drops a bold claim in this 1:34 clip: Nitric oxide deficiency is the hidden root behind many chronic diseases—and restoring it could be a game-changer. Key conditions he links directly to low nitric oxide: - Erectile dysfunction (the "canary in the coal mine" for early cardiovascular decline) - High blood pressure - Metabolic disease & diabetes - Alzheimer's (vascular + metabolic + inflammatory aspects) He argues Alzheimer's is fundamentally a vascular disease: Nitric oxide improves brain blood flow, glucose uptake, reduces inflammation, oxidative stress, immune dysfunction, and prevents protein misfolding/amyloid plaque buildup. His conclusion: "I'm absolutely convinced [nitric oxide] will eradicate and cure Alzheimer's... because it addresses every physiological root cause." Provocative take—science-backed or too optimistic? Watch & decide. What chronic condition do you think nitric oxide could impact most in your life? Thoughts below.

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A daily erectile dysfunction pill quietly cut men's death rate by 44% in a study of 29,000 men. How? It boosts nitric oxide, the natural molecule that improves blood flow, lowering your risk of heart disease. Here are 8 ways to boost it and reduce your risk of heart disease:🧵

A daily erectile dysfunction pill quietly cut men's death rate by 44% in a study of 29,000 men. How? It boosts nitric oxide, the natural molecule that improves blood flow, lowering your risk of heart disease. Here are 8 ways to boost it and reduce your risk of heart disease:🧵

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🚨Many people prescribed SSRI antidepressants don’t realize that they can cause irreversible damage to sexual function, says leading sexual medicine clinician Dr. Irwin Goldstein San Diego Sexual Med. “SSRIs, selective serotonin reuptake inhibitors, are one of the most widely prescribed medications in the United States…The problem is they are recognized to raise serotonin—that's their mechanism—but serotonin is an inhibitor of sexual function. While using the medication, it's widely appreciated that individuals will suffer sexual health concerns. But…when they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function. And that's not what we're seeing in our sexual health clinic here. The name of the condition is post-SSRI sexual dysfunction, or PSSD, and it's an awful condition. It persists, causes frustration, embarrassment, humiliation. It causes erectile dysfunction in young men, libido problems, genital sensation changes, orgasmic dysfunction.”

🚨Many people prescribed SSRI antidepressants don’t realize that they can cause irreversible damage to sexual function, says leading sexual medicine clinician Dr. Irwin Goldstein San Diego Sexual Med. “SSRIs, selective serotonin reuptake inhibitors, are one of the most widely prescribed medications in the United States…The problem is they are recognized to raise serotonin—that's their mechanism—but serotonin is an inhibitor of sexual function. While using the medication, it's widely appreciated that individuals will suffer sexual health concerns. But…when they stop the medicine, the usual teaching is that everyone returns to their pre-medication sexual function. And that's not what we're seeing in our sexual health clinic here. The name of the condition is post-SSRI sexual dysfunction, or PSSD, and it's an awful condition. It persists, causes frustration, embarrassment, humiliation. It causes erectile dysfunction in young men, libido problems, genital sensation changes, orgasmic dysfunction.”

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43,672 views • 11 months ago

Vigorous physical activity is at least 8x more effective for cardiovascular disease prevention than lower intensities when compared minute-for-minute, according to recent data. Why? Higher activity intensities more potently stimulate shear stress, the friction of blood flow on the lining of vascular walls known as the endothelium. This is a stimulus for the endothelium to release nitric oxide and other vasodilating substances that improve endothelial function and arterial flexibility, important adaptations for reducing atherosclerosis risk. Lower exercise intensities don't replicate the pattern and magnitude of shear stress elevations of high-intensity activity. Hence why dozens of studies show that high-intensity exercise is superior for improving endothelial function, reducing artery stiffness, and ultimately lowering the risk of major adverse cardiovascular events.

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Dr. Nathan Bryan on nitric oxide deficiency & chronic disease — and the surprising diet fix Nitric oxide loss links to erectile dysfunction, cardiovascular disease, high blood pressure, metabolic disease, diabetes, and Alzheimer’s. Why? Because it’s crucial for blood flow, reducing inflammation, and preventing protein misfolding in the brain. He’s convinced nitric oxide could eradicate Alzheimer’s by addressing every root cause. But here’s the kicker: It’s not just about what to eat — it’s what NOT to eat. Avoid sugar and high-glycemic foods like the plague. They’re toxins that stick to everything, lower nitric oxide, and fuel diseases like heart attack, stroke, and neuropathy. Instead, focus on high-quality protein, good fats, and minimal carbs. Simple, but transformative. 3:52 clip inside — your health depends on it. Note: Always consult a healthcare professional before making significant dietary changes.

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38,658 views • 9 months ago

Dr. Benjamin Bikman drops a bombshell on high blood pressure, infertility, and erectile dysfunction that flips conventional medicine on its head: “High blood pressure is almost a guarantee of insulin resistance — the overwhelmingly most common cause.” He goes further: - Erectile dysfunction in men is often the earliest visible sign of insulin resistance — blood vessels can no longer dilate properly, making erections impossible. -PCOS (the leading cause of infertility in women) is at its core a metabolic disorder driven by insulin resistance — even in lean women who “look healthy” and don’t meet standard insulin resistance criteria. - Scratch beneath the surface, and insulin resistance is already present at the fat cell level — the true origin point. Science nugget: Insulin resistance begins in adipose (fat) tissue long before it shows up in blood tests. Chronically elevated insulin impairs nitric oxide production (needed for vasodilation), drives ovarian androgen excess in PCOS, and promotes vascular stiffness leading to hypertension and ED. Bottom line: Many “unexplained” conditions aren’t mysterious — they’re downstream effects of insulin resistance hiding in plain sight. What “healthy-looking” symptom or diagnosis in your life (or someone close) might actually be insulin resistance in disguise?

Dr. Benjamin Bikman drops a bombshell on high blood pressure, infertility, and erectile dysfunction that flips conventional medicine on its head: “High blood pressure is almost a guarantee of insulin resistance — the overwhelmingly most common cause.” He goes further: - Erectile dysfunction in men is often the earliest visible sign of insulin resistance — blood vessels can no longer dilate properly, making erections impossible. -PCOS (the leading cause of infertility in women) is at its core a metabolic disorder driven by insulin resistance — even in lean women who “look healthy” and don’t meet standard insulin resistance criteria. - Scratch beneath the surface, and insulin resistance is already present at the fat cell level — the true origin point. Science nugget: Insulin resistance begins in adipose (fat) tissue long before it shows up in blood tests. Chronically elevated insulin impairs nitric oxide production (needed for vasodilation), drives ovarian androgen excess in PCOS, and promotes vascular stiffness leading to hypertension and ED. Bottom line: Many “unexplained” conditions aren’t mysterious — they’re downstream effects of insulin resistance hiding in plain sight. What “healthy-looking” symptom or diagnosis in your life (or someone close) might actually be insulin resistance in disguise?

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Did you know 128hz is a penetrative frequency that goes through the tissues into the bones and helps release nitric oxide into your cells? Grok: Nitric oxide (NO) is a naturally produced signaling molecule in the body that plays a critical role in many physiological processes. It acts primarily as a vasodilator, relaxing and widening blood vessels to improve blood flow, deliver oxygen and nutrients more efficiently, and support overall cellular communication. Here are the key benefits of nitric oxide in the body, based on its established physiological functions: ### 1. Cardiovascular Health and Blood Pressure Regulation Nitric oxide helps relax the smooth muscles in blood vessel walls, leading to vasodilation. This increases blood flow, reduces vascular resistance, and helps maintain healthy blood pressure levels. It also protects the endothelium (the inner lining of blood vessels), reduces arterial stiffness, inhibits platelet aggregation (lowering clot risk), and may decrease inflammation and plaque buildup. Low NO levels are linked to endothelial dysfunction, hypertension, and higher cardiovascular disease risk. ### 2. Improved Exercise Performance and Muscle Function By enhancing blood flow to working muscles, nitric oxide improves oxygen and nutrient delivery while helping remove waste products like lactate. This can boost endurance, increase exercise tolerance (especially in less-trained individuals), reduce muscle soreness, and support better recovery. It may also influence muscle contraction speed and mitochondrial efficiency in cells. ### 3. Support for Erectile Function and Sexual Health Nitric oxide is a primary mediator of penile erection, as it promotes relaxation of smooth muscle in blood vessels, allowing increased blood flow. Supplements that boost NO (such as L-arginine or L-citrulline) have shown potential benefits for mild to moderate erectile dysfunction (ED) in some studies. It may also support sexual arousal more broadly. ### 4. Immune System Defense Nitric oxide acts as a key player in immune responses. It helps immune cells (like macrophages) kill bacteria, viruses, and even some cancer cells by producing higher levels during infection or inflammation. It also modulates inflammation—providing anti-inflammatory effects at normal physiological levels while aiding targeted defense at higher concentrations. ### 5. Brain and Nervous System Function As a neurotransmitter and neuromodulator, nitric oxide facilitates communication between brain cells. It supports cerebral blood flow, learning, memory, and other neurological processes. Adequate levels may help protect against cognitive decline by improving brain oxygenation and circulation. ### 6. Other Potential Benefits - Wound healing and tissue repair: Enhanced blood flow and signaling support recovery processes. - Respiratory support: In medical settings, inhaled NO helps relax lung blood vessels in certain conditions (like pulmonary hypertension in newborns). - Anti-aging and metabolic effects: By supporting circulation, reducing oxidative stress in balanced amounts, and aiding hormone regulation, it contributes to overall vitality. It may also play roles in reducing risks associated with diabetes complications or arthritis inflammation. Note that nitric oxide has a dual nature: beneficial at physiological (low-to-moderate) levels, but excessive production (often in chronic inflammation) can contribute to tissue damage or pro-inflammatory effects. The body produces NO via enzymes (nitric oxide synthase) from precursors like L-arginine, or through nitrate-nitrite pathways from diet. Natural ways to support nitric oxide levels include eating nitrate-rich foods (beets, leafy greens like spinach/arugula, garlic), consuming antioxidants (to preserve NO), regular exercise (which stimulates production), nose breathing, and maintaining good sleep and cardiovascular habits.

𝒦𝑒𝓁𝓁𝓎࿎☽

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If you have erectile dysfunction, there’s a 15% chance of a heart attack within 7 years. Dr. Rena Malik explained it on the Shawn Ryan Show. The blood vessels to the penis are half the size of those to the heart. So problems show up there first. She calls it the “canary in the coal mine” for your overall health. Multiple large studies confirm that ED is a strong independent predictor of future heart disease. Men with ED have roughly 2–3 times higher risk of heart attack or stroke, and symptoms often appear 3–5 years before a major cardiac event. ED is frequently an early warning sign of systemic vascular disease.

If you have erectile dysfunction, there’s a 15% chance of a heart attack within 7 years. Dr. Rena Malik explained it on the Shawn Ryan Show. The blood vessels to the penis are half the size of those to the heart. So problems show up there first. She calls it the “canary in the coal mine” for your overall health. Multiple large studies confirm that ED is a strong independent predictor of future heart disease. Men with ED have roughly 2–3 times higher risk of heart attack or stroke, and symptoms often appear 3–5 years before a major cardiac event. ED is frequently an early warning sign of systemic vascular disease.

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23,241 views • 4 months ago

"Every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil." - Andrew D. Huberman, Ph.D. Jordi: What do you think the best athletes in the world are doing this Olympics? Huberman: "People are taking vasodilators. You know, Viagra and tadalafil, which commonly goes by Cialis." "Tadalafil is a vasodilator. It lowers blood pressure, and people know of it as Cialis for erectile dysfunction. It was originally developed as a drug to improve prostate health." "The basic takeaway is that most every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil—not necessarily for erectile function, although it will augment that as well—but to lower blood pressure and to improve vasodilation for the brain and the prostate." "And I'm not saying this as a biohacker or a podcaster. Our head of male sexual health from Stanford, Mike Eisenberg, MD, PhD. He is best in class in terms of male sexual health endocrinology. That's his recommendation."

"Every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil." - Andrew D. Huberman, Ph.D. Jordi: What do you think the best athletes in the world are doing this Olympics? Huberman: "People are taking vasodilators. You know, Viagra and tadalafil, which commonly goes by Cialis." "Tadalafil is a vasodilator. It lowers blood pressure, and people know of it as Cialis for erectile dysfunction. It was originally developed as a drug to improve prostate health." "The basic takeaway is that most every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil—not necessarily for erectile function, although it will augment that as well—but to lower blood pressure and to improve vasodilation for the brain and the prostate." "And I'm not saying this as a biohacker or a podcaster. Our head of male sexual health from Stanford, Mike Eisenberg, MD, PhD. He is best in class in terms of male sexual health endocrinology. That's his recommendation."

TBPN

4,595,582 views • 8 months ago

"Every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil." - Andrew D. Huberman, Ph.D. Jordi: What do you think the best athletes in the world are doing this Olympics? Huberman: "People are taking vasodilators. You know, Viagra and tadalafil, which commonly goes by Cialis." "Tadalafil is a vasodilator. It lowers blood pressure, and people know of it as Cialis for erectile dysfunction. It was originally developed as a drug to improve prostate health." "The basic takeaway is that most every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil—not necessarily for erectile function, although it will augment that as well—but to lower blood pressure and to improve vasodilation for the brain and the prostate." "And I'm not saying this as a biohacker or a podcaster. Our head of male sexual health from Stanford, Mike Eisenberg, MD, PhD. He is best in class in terms of male sexual health endocrinology. That's his recommendation."

"Every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil." - Andrew D. Huberman, Ph.D. Jordi: What do you think the best athletes in the world are doing this Olympics? Huberman: "People are taking vasodilators. You know, Viagra and tadalafil, which commonly goes by Cialis." "Tadalafil is a vasodilator. It lowers blood pressure, and people know of it as Cialis for erectile dysfunction. It was originally developed as a drug to improve prostate health." "The basic takeaway is that most every male 40 and older should probably be taking somewhere between 2.5 and 5 milligrams of tadalafil—not necessarily for erectile function, although it will augment that as well—but to lower blood pressure and to improve vasodilation for the brain and the prostate." "And I'm not saying this as a biohacker or a podcaster. Our head of male sexual health from Stanford, Mike Eisenberg, MD, PhD. He is best in class in terms of male sexual health endocrinology. That's his recommendation."

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Most men are in the dark about their testosterone and what optimal levels are. That means they’re basically driving with the hand break on in terms of their goals, energy, and families. If you don’t want to be one of them, join me for this free webinar.

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107,453 views • 4 months ago

Justin Nault: This is the scandal they don’t want you to know about. Even after stopping antidepressants, your sex life may never recover. And one in eight Americans is about to learn this harsh truth. It’s called PSSD… Post-SSRI Sexual Dysfunction. We’re talking complete genital numbness, zero libido, and the inability to reproduce. And it could last decades after you stop taking the pills. Europe has had warning labels since 2019. Canada since 2021. Australia has documented cases lasting up to three and a half years. But in America? The FDA dismissed a lawsuit on a technicality, not science. A study of 1022 participants found that 73% of people on Celexa experience sexual dysfunction. That number is terrifying. Here’s what’s even scarier: Gen Z’s sexual collapse mirrors the rise in antidepressant prescriptions. • 28% of young men report no sex in the last year—triple the rate from 2008. • Teen prescriptions for SSRIs have skyrocketed—130% increase in girls. • Many of these young women are entering their twenties unable to feel pleasure. • Boys who started Zoloft in middle school are entering college with erectile dysfunction. • 63% of men under 30 are single. • Birth rates are at an all-time low—1.64, the lowest ever recorded. Millions of people are unknowingly being medicated in their prime years, losing their ability to love, connect, and reproduce. The system knew, and it still isn’t warning you. You can trust a system that ignores the facts, or you can share this and wake up before you lose more than depression.

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Camus

183,838 views • 1 year ago

Why are there two keys to Heaven, and why is one golden while the other silver? Why does Peter hold the keys to Heaven, and where is the Kingdom? For centuries, this symbolism has been hiding in plain sight. In my latest video, I explore one of the most overlooked esoteric interpretations of the Keys of Heaven and connect patterns that most people never notice. Once you see how these symbols fit together, you'll never look at them the same way again.

Why are there two keys to Heaven, and why is one golden while the other silver? Why does Peter hold the keys to Heaven, and where is the Kingdom? For centuries, this symbolism has been hiding in plain sight. In my latest video, I explore one of the most overlooked esoteric interpretations of the Keys of Heaven and connect patterns that most people never notice. Once you see how these symbols fit together, you'll never look at them the same way again.

Open Minded Approach

35,132 views • 3 months ago