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Exercise IS THE LONGEVITY & LIFE BIOHACK So many people only think about exercise as a way to burn calories & look leaner, but exercise is SO much more than that Exercise lowers the risk of cardiovascular disease (CVD) & cancer independent of weight loss (PMIDs: 21673488, 31758975, &... 32741068) Exercise improves symptoms of depression with a MASSIVE effect size of 1.7 (for reference SSRIs have an ES of about 0.5) (PMID: 37429171) Exercise improves your brain’s sensitivity to satiety signals helping with appetite control (PMIDs: 36998025 & 30131457) Exercise improves insulin sensitivity independent of weight loss (PMID: 24454364) And the dosage required to get benefits is not big at all, in fact it’s ridiculously small. Just ~4 minutes of vigorous physical activity per day decreases the risk of getting cancer by ~20% (PMID: 37498576) & 50 minutes of resistance training per week was all that was needed to decrease the risk of depression in the previously cited study It doesn’t take hours per day. You may not have hours but you’ve got 4 MINUTES! Now is the time to drastically improve your life, physical, & mental health. Get after it 👊 From my convo with Dr. John Delony on his podcastshow more

Layne Norton, PhD

230,122 subscribers

30,966 views • 1 year ago •via X (Twitter)

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11 Comments

Nicholas Fabiano, MD1 year ago

Exercise is not more effective than antidepressants. I’ve written an entire paper on this.

Arnold1 year ago

I've done nearly 20,000 workouts in my life, and I've seen what works for all levels. I created a free workout guide to show you what works, whether you're a beginner or advanced.

Josh Greentree | Strength For Life1 year ago

Movement is medicine and you’ll never be able to convince me otherwise.

Keto Grill & Bakery1 year ago

a few people on here including @drmatthewnagra and @davidasinclair have suggested the effect on lifespan from exercise is actually pretty tiny

bobbyscaps.eth👺1 year ago

The key is having the ability to access movement through life.

A&Z MD1 year ago

It contributes to virtually everything that is beneficial for our health.

Josh Courage1 year ago

How do we collectively help people understand this? You and many others with decent influence are shouting it from the mountain tops, but shirtless fear mongering influencers are louder. And comforts are stronger to most than understanding the importance of strength training (and proper nutrition, hydration and sleep)

Algolete1 year ago

Benefits are nothing short of revolutionary when more understand the “minimal daily dose” pattern.

Andy1 year ago

Good stuff. Is there good data on the rate of diminishing returns? At what point would one with limited time be better off for longevity through training their mind through intellectual pursuits like complex reading or puzzles or even meditation?

Gary Redmond1 year ago

Wow 4 minutes that's crazy!!

Samurai1 year ago

Exercise also leads to much better sleep, right? At least for me, I tend to sleep much better after rigorous exercise.

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The amount of exercise you need to get massive benefits is surprisingly small Just 4 minutes of cumulative vigorous activity throughout the day was found to reduce cancer risk by ~20% How about 10 minutes? ~30% reduction Remember that next time you think to yourself "I don't have time to exercise" The benefits of short bursts of exercise are just too powerful to ignore

The amount of exercise you need to get massive benefits is surprisingly small Just 4 minutes of cumulative vigorous activity throughout the day was found to reduce cancer risk by ~20% How about 10 minutes? ~30% reduction Remember that next time you think to yourself "I don't have time to exercise" The benefits of short bursts of exercise are just too powerful to ignore

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478,086 views • 1 year ago

Vigorous exercise is far more potent than current guidelines suggest In one large wearable-data study, 1 minute of vigorous activity appeared roughly comparable to: • 4 minutes of moderate exercise for all-cause mortality • 8 minutes of moderate exercise for cardiovascular mortality • 10 minutes of moderate exercise for type 2 diabetes risk Light activity required dramatically more time, often 100–200+ minutes depending on the outcome If you want the highest return on your exercise time, add intensity

Vigorous exercise is far more potent than current guidelines suggest In one large wearable-data study, 1 minute of vigorous activity appeared roughly comparable to: • 4 minutes of moderate exercise for all-cause mortality • 8 minutes of moderate exercise for cardiovascular mortality • 10 minutes of moderate exercise for type 2 diabetes risk Light activity required dramatically more time, often 100–200+ minutes depending on the outcome If you want the highest return on your exercise time, add intensity

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Exercise can offset the mortality risk of short sleep People sleeping fewer than 7 hours a night have significantly higher all-cause mortality... but not if they exercise Longitudinal studies show that short sleepers who meet physical activity guidelines (75 min vigorous or 150 min moderate per week) have mortality rates comparable to people getting 7–9 hours of sleep If your sleep is off, exercise is one of the best levers you can still pull

Exercise can offset the mortality risk of short sleep People sleeping fewer than 7 hours a night have significantly higher all-cause mortality... but not if they exercise Longitudinal studies show that short sleepers who meet physical activity guidelines (75 min vigorous or 150 min moderate per week) have mortality rates comparable to people getting 7–9 hours of sleep If your sleep is off, exercise is one of the best levers you can still pull

FoundMyFitness Clips

63,501 views • 3 months ago

Physical activity doesn't have to be structured to be beneficial. Engaging in 4–9 minutes of vigorous movement per day is associated with a ~50% reduction in all-cause, CVD, and cancer mortality. These brief but high-intensity periods of movement are termed vigorous intermittent lifestyle physical activity or VILPA. Studies show the benefits can be equal to doing regular structured exercise. For example, women engaging in just 3 minutes per day of VILPA had a 45% lower risk of major cardiovascular events. The takeaway from these studies and others is clear - you can account for these brief bouts of movements in your total physical activity levels for the week. Every minute spent moving (if intense enough) counts toward your health.

Physical activity doesn't have to be structured to be beneficial. Engaging in 4–9 minutes of vigorous movement per day is associated with a ~50% reduction in all-cause, CVD, and cancer mortality. These brief but high-intensity periods of movement are termed vigorous intermittent lifestyle physical activity or VILPA. Studies show the benefits can be equal to doing regular structured exercise. For example, women engaging in just 3 minutes per day of VILPA had a 45% lower risk of major cardiovascular events. The takeaway from these studies and others is clear - you can account for these brief bouts of movements in your total physical activity levels for the week. Every minute spent moving (if intense enough) counts toward your health.

Dr. Rhonda Patrick

114,804 views • 7 months ago

Aim for 10 minutes of vigorous exercise a day instead of 10,000 steps For most people, "vigorous" means exercising at around 80% or more of your maximum heart rate While both are certainly worthwhile, vigorous exercise likely gets you more bang for your buck And the data backs it up As one example: A new study found that performing 10 bodyweight squats every 45 minutes during an 8.5-hour period of sitting improves blood sugar regulation better than a single 30-minute walk These brief, intense bursts of activity, often called 'exercise snacks,' offer a potent strategy to mitigate the health risks associated with our sedentary lifestyles Just 10 minutes of vigorous exercise a day It doesn't take much

Aim for 10 minutes of vigorous exercise a day instead of 10,000 steps For most people, "vigorous" means exercising at around 80% or more of your maximum heart rate While both are certainly worthwhile, vigorous exercise likely gets you more bang for your buck And the data backs it up As one example: A new study found that performing 10 bodyweight squats every 45 minutes during an 8.5-hour period of sitting improves blood sugar regulation better than a single 30-minute walk These brief, intense bursts of activity, often called 'exercise snacks,' offer a potent strategy to mitigate the health risks associated with our sedentary lifestyles Just 10 minutes of vigorous exercise a day It doesn't take much

FoundMyFitness Clips

73,256 views • 1 year ago

Patrick Bet-David gets blown away when doctor reveals which type of exercise truly cuts your risk of premature death. DR. RHONDA PATRICK: “New data shows that if you’re doing vigorous-intensity exercise… for every one minute you do of that, if you’re wanting to lower all-cause mortality, you have to do four minutes of moderate intensity or an hour and a half of light.” PBD looked confused and stopped her to clarify what he had just heard. DR. PATRICK REITERATED: “So for every one minute of vigorous intensity is four minutes of moderate intensity. You have to do four minutes [of moderate exercise] to get [the same] all-cause mortality [benefits]. Light is an hour and a half.” PBD: “Stop it.” DR. RHONDA PATRICK: “That’s for all-cause mortality. Dying from all non-accidental causes. It gets better.” PBD: “Oh my god.” DR. RHONDA PATRICK: “If you’re wanting to prevent cardiovascular-related mortality, for every one minute of vigorous [exercise], okay, this is cycling, this is jogging, swimming, you have to do eight minutes of moderate intensity [to reap the same benefits]… So eight minutes of that. Or… the one- to two-hour range of light exercise. So that would be just walking around the house basically.”

Patrick Bet-David gets blown away when doctor reveals which type of exercise truly cuts your risk of premature death. DR. RHONDA PATRICK: “New data shows that if you’re doing vigorous-intensity exercise… for every one minute you do of that, if you’re wanting to lower all-cause mortality, you have to do four minutes of moderate intensity or an hour and a half of light.” PBD looked confused and stopped her to clarify what he had just heard. DR. PATRICK REITERATED: “So for every one minute of vigorous intensity is four minutes of moderate intensity. You have to do four minutes [of moderate exercise] to get [the same] all-cause mortality [benefits]. Light is an hour and a half.” PBD: “Stop it.” DR. RHONDA PATRICK: “That’s for all-cause mortality. Dying from all non-accidental causes. It gets better.” PBD: “Oh my god.” DR. RHONDA PATRICK: “If you’re wanting to prevent cardiovascular-related mortality, for every one minute of vigorous [exercise], okay, this is cycling, this is jogging, swimming, you have to do eight minutes of moderate intensity [to reap the same benefits]… So eight minutes of that. Or… the one- to two-hour range of light exercise. So that would be just walking around the house basically.”

The Vigilant Fox 🦊

990,283 views • 4 months ago

Your 30-minute walk isn’t covering your health bases Here’s what the data actually shows: 1) 30 minutes of vigorous exercise delivers similar mortality benefits to hours of leisurely walking 2) Moderate activity is good, but it’s far less efficient per minute 3) Vigorous exercise doesn’t mean the gym 4) Climbing stairs fast enough to feel slightly breathless counts 5) These short bursts are called Vigorous Intermittent Lifestyle Physical Activity (VILPA) 6) Even brief bursts improve glucose control and reduce inflammation 7) In women, vigorous movement can partially offset estrogen-related metabolic decline If you can move with intent for short moments, vigorous exercise is already in your day. You don’t need more time. You need more intensity.

Your 30-minute walk isn’t covering your health bases Here’s what the data actually shows: 1) 30 minutes of vigorous exercise delivers similar mortality benefits to hours of leisurely walking 2) Moderate activity is good, but it’s far less efficient per minute 3) Vigorous exercise doesn’t mean the gym 4) Climbing stairs fast enough to feel slightly breathless counts 5) These short bursts are called Vigorous Intermittent Lifestyle Physical Activity (VILPA) 6) Even brief bursts improve glucose control and reduce inflammation 7) In women, vigorous movement can partially offset estrogen-related metabolic decline If you can move with intent for short moments, vigorous exercise is already in your day. You don’t need more time. You need more intensity.

Louisa Nicola

125,255 views • 6 months ago

What if simply sitting in a sauna could supercharge the benefits of exercise? Dr. Jari Laukkanen’s research shows that people who exercise and use the sauna have lower a all-cause mortality than those who only exercise Even more compelling? Studies reveal that adding sauna sessions to aerobic exercise boosts cardiorespiratory fitness beyond exercise alone The optimal dose: At least two sessions per week for benefits, with four or more linked to a staggering 40–50% drop in cardiovascular and all-cause mortality And the best part? You don’t need extreme heat—just 175°F for 20 minutes is enough to unlock powerful benefits

What if simply sitting in a sauna could supercharge the benefits of exercise? Dr. Jari Laukkanen’s research shows that people who exercise and use the sauna have lower a all-cause mortality than those who only exercise Even more compelling? Studies reveal that adding sauna sessions to aerobic exercise boosts cardiorespiratory fitness beyond exercise alone The optimal dose: At least two sessions per week for benefits, with four or more linked to a staggering 40–50% drop in cardiovascular and all-cause mortality And the best part? You don’t need extreme heat—just 175°F for 20 minutes is enough to unlock powerful benefits

FoundMyFitness Clips

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Research suggests that up to 40% of cancer cases could be prevented through lifestyle changes. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. Today’s interview features Dr. Kerry Courneya. With over 600 peer-reviewed studies, he is one of the most influential figures in exercise oncology. Even if you aren't someone who has personally experienced cancer in one form or another, you need to watch this episode. Episode 99 is Available now on X, YouTube, Spotify, and Apple Podcasts. Chapters: 0:00 - Introduction 1:47 - Why exercise should be effortful 2:33 - How to meaningfully reduce risk of cancer 6:22 - What type of exercise is best? 7:59 - How exercise reduces risk—even for smokers and the obese 10:48 - Weekend-only exercise 13:49 - 150 vs. 300 minutes per week (more is better—up to a point) 16:03 - Why pre-diagnosis exercise matters 19:09 - Why resilience to cancer treatment starts with exercise 21:01 - Why low muscle mass drives cancer death 23:58 - Why BMI fails to measure true obesity 27:51 - Why daily activity isn't enough (structured exercise matters) 29:34 - Breaking up sedentary time—do ‘exercise snacks’ help? 31:50 - Supplements vs. exercise 32:32 - Where exercise fits with chemo and immunotherapy 35:30 - Why rest is not the best medicine 41:20 - Aerobic vs. resistance 42:13 - How weight training improves 'chemo completion' 44:41 - Why exercise creates vulnerability in cancer cells (limitations do apply) 47:09 - Why exercise might be crucial for tumor elimination 53:03 - Why cardio may be better at clearing tumor cells 56:18 - When cancer spreads quickly—and when it doesn't 57:43 - Why liquid biopsies may prevent over-treatment 1:02:56 - Exercise-sensitive vs. exercise-resistant cancers 1:06:06 - Prostate cancer therapy—why strength training matters 1:08:10 - When exercise is the only therapy—does it work? 1:09:26 - Why HIIT reduces PSA in prostate cancer 1:11:40 - Avoiding overtreatment—can exercise buy you time? 1:12:00 - Why high-intensity exercise boosts anti-cancer biology 1:13:11 - Turning a diagnosis into a wake-up call 1:16:11 - Why oncologists are rethinking exercise 1:18:50 - Why exercise eases anxiety about cancer—proven psychological benefits 1:25:00 - Before, during, and after treatment 1:27:02 - Why exercise is unique among cancer therapies 1:28:16 - Why cancer patients stop exercising—the risky mistake almost everyone makes 1:30:41 - How to get sedentary cancer patients exercising (realistically) 1:33:15 - The $1 million case for including exercise 1:34:56 - Why recurrence trials haven't convinced doctors—yet 1:37:36 - The bottom-line message 1:37:55 - The myth of a cancer panacea (exercise included) 1:44:07 - What's the best $50 investment for staying active? 1:44:40 - Only 15 minutes per day—what’s the best anti-cancer exercise?

Research suggests that up to 40% of cancer cases could be prevented through lifestyle changes. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. Today’s interview features Dr. Kerry Courneya. With over 600 peer-reviewed studies, he is one of the most influential figures in exercise oncology. Even if you aren't someone who has personally experienced cancer in one form or another, you need to watch this episode. Episode 99 is Available now on X, YouTube, Spotify, and Apple Podcasts. Chapters: 0:00 - Introduction 1:47 - Why exercise should be effortful 2:33 - How to meaningfully reduce risk of cancer 6:22 - What type of exercise is best? 7:59 - How exercise reduces risk—even for smokers and the obese 10:48 - Weekend-only exercise 13:49 - 150 vs. 300 minutes per week (more is better—up to a point) 16:03 - Why pre-diagnosis exercise matters 19:09 - Why resilience to cancer treatment starts with exercise 21:01 - Why low muscle mass drives cancer death 23:58 - Why BMI fails to measure true obesity 27:51 - Why daily activity isn't enough (structured exercise matters) 29:34 - Breaking up sedentary time—do ‘exercise snacks’ help? 31:50 - Supplements vs. exercise 32:32 - Where exercise fits with chemo and immunotherapy 35:30 - Why rest is not the best medicine 41:20 - Aerobic vs. resistance 42:13 - How weight training improves 'chemo completion' 44:41 - Why exercise creates vulnerability in cancer cells (limitations do apply) 47:09 - Why exercise might be crucial for tumor elimination 53:03 - Why cardio may be better at clearing tumor cells 56:18 - When cancer spreads quickly—and when it doesn't 57:43 - Why liquid biopsies may prevent over-treatment 1:02:56 - Exercise-sensitive vs. exercise-resistant cancers 1:06:06 - Prostate cancer therapy—why strength training matters 1:08:10 - When exercise is the only therapy—does it work? 1:09:26 - Why HIIT reduces PSA in prostate cancer 1:11:40 - Avoiding overtreatment—can exercise buy you time? 1:12:00 - Why high-intensity exercise boosts anti-cancer biology 1:13:11 - Turning a diagnosis into a wake-up call 1:16:11 - Why oncologists are rethinking exercise 1:18:50 - Why exercise eases anxiety about cancer—proven psychological benefits 1:25:00 - Before, during, and after treatment 1:27:02 - Why exercise is unique among cancer therapies 1:28:16 - Why cancer patients stop exercising—the risky mistake almost everyone makes 1:30:41 - How to get sedentary cancer patients exercising (realistically) 1:33:15 - The $1 million case for including exercise 1:34:56 - Why recurrence trials haven't convinced doctors—yet 1:37:36 - The bottom-line message 1:37:55 - The myth of a cancer panacea (exercise included) 1:44:07 - What's the best $50 investment for staying active? 1:44:40 - Only 15 minutes per day—what’s the best anti-cancer exercise?

Dr. Rhonda Patrick

219,784 views • 1 year ago

Your Kids Don’t Eat too Many Calories… IT’S THE CARBS! This video is from Jason Whittrock where he is demonstrating that continuous glucose monitor shows a glucose increase in response to eating chicken nuggets In the least shocking news of 2025 thus far… they chicken nuggets increase blood glucose Big deal He claims kids aren’t eating too many calories, implying that it is the carbs that are the problem. He claims that kids aren’t eating too many calories because obesity affects poor families more, trying to imply that poor kids must eat less calories because they have less money… BUT WHAT DOES THE DATA ACTUALLY SAY????? Oh well look at that, poor families actually eat MORE calories compared to middle class & upper class families (PMIDs: 26809142, 27994148, & 31082447) OOPSIE! Guess he either didn’t bother to look up the actual research data or knew about it & didn’t care As for carbs causing obesity, this has been debunked many times over. In a large meta-analysis of controlled feeding studies that equated calories & protein but varied carbohydrate & fat intake, researchers found that people in high carb/low fat diets actually lost slightly MORE body fat than people following low carb high fat diets (about 16g more body fat loss per day… not a huge difference) PMID: 28193517. These results have even been demonstrated with huge differences in carb intake (over 300g per day vs. ketogenic diet) & insulin release (PMID: 27385608) While I agree with Jason that chicken nuggets probably aren’t the best nutritional choice, it’s not because they have breading, it’s because they tend to be high in calories overall. Sorry Jason, calories mattercise Makes You Smarter It seems like every day, new data is emerging demonstrating that the benefits of exercise extend far beyond the physical & go well into the mental space of the brain. Research has shown exercise can improve symptoms of depression, schizophrenia, bi-polar, & anxiety but more research is also demonstrating that exercise can enhance cognitive performance in healthy people This is highlighted by a new meta-analysis demonstrating that exercise of various forms improved academic performance in college students (PMID: 39310016). While the mechanisms behind the way this works still need to be further elucidated, we are starting to discover more & more that what happens in the body affects the mind & what happens in the mind affects the body. In the reverse direction, we see psychological stress associated with greater pain sensitivity, autoimmune disorders, cardiovascular disease, cancer, and all cause mortality (PMIDs: 31568044, 32983091, 18371552, 34830968, & 27407085) E]]] want to take care of your body, take care of your mind.]

Your Kids Don’t Eat too Many Calories… IT’S THE CARBS! This video is from Jason Whittrock where he is demonstrating that continuous glucose monitor shows a glucose increase in response to eating chicken nuggets In the least shocking news of 2025 thus far… they chicken nuggets increase blood glucose Big deal He claims kids aren’t eating too many calories, implying that it is the carbs that are the problem. He claims that kids aren’t eating too many calories because obesity affects poor families more, trying to imply that poor kids must eat less calories because they have less money… BUT WHAT DOES THE DATA ACTUALLY SAY????? Oh well look at that, poor families actually eat MORE calories compared to middle class & upper class families (PMIDs: 26809142, 27994148, & 31082447) OOPSIE! Guess he either didn’t bother to look up the actual research data or knew about it & didn’t care As for carbs causing obesity, this has been debunked many times over. In a large meta-analysis of controlled feeding studies that equated calories & protein but varied carbohydrate & fat intake, researchers found that people in high carb/low fat diets actually lost slightly MORE body fat than people following low carb high fat diets (about 16g more body fat loss per day… not a huge difference) PMID: 28193517. These results have even been demonstrated with huge differences in carb intake (over 300g per day vs. ketogenic diet) & insulin release (PMID: 27385608) While I agree with Jason that chicken nuggets probably aren’t the best nutritional choice, it’s not because they have breading, it’s because they tend to be high in calories overall. Sorry Jason, calories mattercise Makes You Smarter It seems like every day, new data is emerging demonstrating that the benefits of exercise extend far beyond the physical & go well into the mental space of the brain. Research has shown exercise can improve symptoms of depression, schizophrenia, bi-polar, & anxiety but more research is also demonstrating that exercise can enhance cognitive performance in healthy people This is highlighted by a new meta-analysis demonstrating that exercise of various forms improved academic performance in college students (PMID: 39310016). While the mechanisms behind the way this works still need to be further elucidated, we are starting to discover more & more that what happens in the body affects the mind & what happens in the mind affects the body. In the reverse direction, we see psychological stress associated with greater pain sensitivity, autoimmune disorders, cardiovascular disease, cancer, and all cause mortality (PMIDs: 31568044, 32983091, 18371552, 34830968, & 27407085) E]]] want to take care of your body, take care of your mind.]

Layne Norton, PhD

26,140 views • 1 year ago

My grandfather Dr. GS Kulkarni is 93 years old, he still works, studies and researches and most importantly he exercises for 45 mins to 1 hour everyday. It is extremely important for our parents and grandparents to be active and perform strength training. Exercise is important for older adults because it can improve their physical and mental health. Active people have lower mortality rates compared to inactive people. People who met the minimum exercise recommendations (150-300 min/week moderate or 75-150 min/week vigorous) saw a significant reduction in mortality rates. Adults who engage in aerobic and muscle strengthening activities show greatly reduced risk of all cause and cause specific mortality Exercise is extremely important for cognitive health with numerous studies showing that exercise improves cognition and potentially prevents or delay cognitive decline. Physical exercise can reduce global cognitive decline and lessen behavioural problems in people with MCI or dementia. Physical activity was associated with a decreased incidence of cognitive impairment or decline Exercise can also improve skin health, this one study found that exercise significantly improved skin elasticity upper dermal structure, and dermal thickness Older adults should exercise under the guidance of a professional. Disclaimer: This video is only for educational purposes and is not a replacement of health advice from a medical professional.

My grandfather Dr. GS Kulkarni is 93 years old, he still works, studies and researches and most importantly he exercises for 45 mins to 1 hour everyday. It is extremely important for our parents and grandparents to be active and perform strength training. Exercise is important for older adults because it can improve their physical and mental health. Active people have lower mortality rates compared to inactive people. People who met the minimum exercise recommendations (150-300 min/week moderate or 75-150 min/week vigorous) saw a significant reduction in mortality rates. Adults who engage in aerobic and muscle strengthening activities show greatly reduced risk of all cause and cause specific mortality Exercise is extremely important for cognitive health with numerous studies showing that exercise improves cognition and potentially prevents or delay cognitive decline. Physical exercise can reduce global cognitive decline and lessen behavioural problems in people with MCI or dementia. Physical activity was associated with a decreased incidence of cognitive impairment or decline Exercise can also improve skin health, this one study found that exercise significantly improved skin elasticity upper dermal structure, and dermal thickness Older adults should exercise under the guidance of a professional. Disclaimer: This video is only for educational purposes and is not a replacement of health advice from a medical professional.

Tejas Kulkarni

76,101 views • 1 year ago

Short “exercise snacks” might be one of the highest-ROI habits for longevity Observational data show that just 1–2 minutes of vigorous activity, done ~3 times per day (getting your heart rate ~≥80% max), is linked to ~40% lower cancer mortality, ~40% lower all-cause mortality, and ~50% lower cardiovascular mortality This is even in people who say they “don’t exercise” These bursts can be as simple as sprinting up stairs or a quick set of all-out bodyweight squats, burpees, or high knees

Short “exercise snacks” might be one of the highest-ROI habits for longevity Observational data show that just 1–2 minutes of vigorous activity, done ~3 times per day (getting your heart rate ~≥80% max), is linked to ~40% lower cancer mortality, ~40% lower all-cause mortality, and ~50% lower cardiovascular mortality This is even in people who say they “don’t exercise” These bursts can be as simple as sprinting up stairs or a quick set of all-out bodyweight squats, burpees, or high knees

FoundMyFitness Clips

154,303 views • 5 months ago

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time

Dr. Rhonda Patrick

105,960 views • 2 years ago

Vigorous exercise improves cognition and delays brain aging. Exercise causes muscles to produce lactate, which travels to the brain, triggering the production of neurotransmitters like norepinephrine and neurotrophic factors like BDNF. New episode on why we should incorporate more vigorous exercise into our routine. TIMESTAMPS: (01:51) What differentiates "vigorous" from "zone 2" (09:12) Why zone 2 training may not improve VO2 max (11:34) Balancing zone 2 & vigorous-intensity workouts (13:32) Norwegian 4x4 protocol improves VO2 max (16:52) Methods to estimate VO2 max outside a lab (19:49) What it takes to reverse 20 years of heart aging (25:40) How HIIT reduces type 2 diabetes risk (26:54) HIIT vs. Zone 2 for mitochondria (29:25) Should committed exercisers practice 80/20 rule? (32:35) Vigorous exercise enhances mitophagy (35:20) Why lactate from HIIT benefits the brain (37:45) How lactate allows "glucose sparing" in brain (40:43) The unique BDNF benefits of HIIT (41:59) Lactate signals the growth of new blood vessels (44:15) Exercise intensity increases myokine release (47:04) Exercise lowers mortality risk in cancer survivors (48:13) Vigorous exercise kills circulating tumor cells (49:53) Why exercise reduces depression and neurotoxicity (kynurenine mechanism) (51:58) How "exercise snacks" reduce mortality Get the 9-page companion guide "The Cognitive Enhancement Blueprint" at

Vigorous exercise improves cognition and delays brain aging. Exercise causes muscles to produce lactate, which travels to the brain, triggering the production of neurotransmitters like norepinephrine and neurotrophic factors like BDNF. New episode on why we should incorporate more vigorous exercise into our routine. TIMESTAMPS: (01:51) What differentiates "vigorous" from "zone 2" (09:12) Why zone 2 training may not improve VO2 max (11:34) Balancing zone 2 & vigorous-intensity workouts (13:32) Norwegian 4x4 protocol improves VO2 max (16:52) Methods to estimate VO2 max outside a lab (19:49) What it takes to reverse 20 years of heart aging (25:40) How HIIT reduces type 2 diabetes risk (26:54) HIIT vs. Zone 2 for mitochondria (29:25) Should committed exercisers practice 80/20 rule? (32:35) Vigorous exercise enhances mitophagy (35:20) Why lactate from HIIT benefits the brain (37:45) How lactate allows "glucose sparing" in brain (40:43) The unique BDNF benefits of HIIT (41:59) Lactate signals the growth of new blood vessels (44:15) Exercise intensity increases myokine release (47:04) Exercise lowers mortality risk in cancer survivors (48:13) Vigorous exercise kills circulating tumor cells (49:53) Why exercise reduces depression and neurotoxicity (kynurenine mechanism) (51:58) How "exercise snacks" reduce mortality Get the 9-page companion guide "The Cognitive Enhancement Blueprint" at

Dr. Rhonda Patrick

530,847 views • 2 years ago

Exercise is good for our bodies, but the reasons behind why and how are still being studied. “Basically, you will extend your life if you exercise,” Dr. Euan Ashley, a professor of genomics and cardiovascular medicine at Stanford University and chair of its Department of Medicine, told Horizons host William Brangham. Ashley is a part of a massive, decade-long multi-site investigation into how and why exercise changes our bodies at the molecular level. “It turns out that just a few minutes improvement in sleep, a few minutes of exercise a day and a little improvement in your diet can add a whole year of life to your life,” he said. Horizons from PBS News, dives into the science, health, technology and environmental issues making headlines each week. Visit the PBS News website to watch this week's episode.

Exercise is good for our bodies, but the reasons behind why and how are still being studied. “Basically, you will extend your life if you exercise,” Dr. Euan Ashley, a professor of genomics and cardiovascular medicine at Stanford University and chair of its Department of Medicine, told Horizons host William Brangham. Ashley is a part of a massive, decade-long multi-site investigation into how and why exercise changes our bodies at the molecular level. “It turns out that just a few minutes improvement in sleep, a few minutes of exercise a day and a little improvement in your diet can add a whole year of life to your life,” he said. Horizons from PBS News, dives into the science, health, technology and environmental issues making headlines each week. Visit the PBS News website to watch this week's episode.

PBS News

13,941 views • 4 months ago

A person asks Sadhguru, “How much weight training exercise do you recommend?” And Sadhguru answers, “Weight training is not useful, but do 25-50 Surya-Namaskars, it is complete exercise.” First of all, I am not sure why anyone would ask someone like Sadhguru, who is most of the time, in another dimension, a question on exercise and weight training. And secondly, Sadhguru is just plain wrong. Weight (or strength) training is one of the most important aspects of exercise regimen you can include in your daily or 3-4 times a week physical activity because there is great science behind its benefits. I advise my obese or sarcopenic (very poor muscle mass in advanced liver disease) patients to include weight training to improve clinical outcomes. The highest level of scientific evidence showed that standard muscle-strengthening activities were associated with lower risk of death in patients with non-communicable diseases – including cardiovascular disease, diabetes and lung cancer. Another metanalysis showed strong evidence for a considerable risk reduction of strength training for 60 minutes a week, on all-cause death (−15%), cardiovascular disease death (−19%), and cancer death (−14%). See here: here Sadhguru says the older we get, the better we do not weight train. He is again absolutely wrong. The findings of another systematic review/metanalysis support power (strength) training as an effective therapeutic intervention for improving physical function in adults diagnosed with frailty (poor physical function in old age) and patients with chronic medical conditions. See here: In fact, another study on strength training, this one again a metanalysis, concluded that strength training interventions can be used as a non-drug treatment for hypertension (!), as they promote significant decreases in blood pressure. See here: Strength training also reduces significantly, chronic inflammation as shown in another high quality systematic review and meta-analysis. See here: Resistance/Strength training improved muscle mass and muscle strength, thereby improving performance status. Improved performance status is a wonderful benchmark for an active and healthy life. See here: Even in fatty liver disease, independent of weight loss, exercise training was associated with 3 and a half times more meaningful treatment response towards lowering liver fat. Strength training is a powerful tool to maintain liver health. See here: and here Now Surya Namaskar. Surya Namaskar or Sun Salutation is a sequence of around twelve yoga poses connected by jumping or stretching movements, varying somewhat between various Yoga schools – which means, it has no regulation or standardization unlike weight training. In Iyengar Yoga there is a way, in Ashtanga Vinayasa Yoga there is Type A and B and there are other types followed by other schools or Yoga teachers. Along with the stretching and jumping, which is done is a slow and steady manner, the practice includes chanting a “mantra” calling out twelve names of the Sun God. In its classical form, Surya Namaskar is not an exercise, and is not aerobic. The energy cost of exercise is measured in units of metabolic equivalent of task (MET). Less than 3 METs counts as light exercise; 3 to 6 METs is moderate; 6 or over is vigorous. American College of Sports Medicine and American Heart Association guidelines count periods of at least 10 minutes of moderate MET level activity towards their recommended daily amounts of exercise. For healthy adults aged 18 to 65, the guidelines recommend moderate exercise for 30 minutes five days a week, or vigorous aerobic exercise for 20 minutes three days a week. Surya Namaskar in its classical form has a measly 2.9 METs and in its rigorous form (some people perform mutated highly active forms of Surya Namaskar to make it feel like an exercise) can go up to 7.4 METs – which requires a lot of jumping and little stretching and no time to chant the Sun God names - does not even come close to strength training by any margin. Those who are part of the Surya Namaskar and Yoga cult would provide anecdotal experiences on its benefits (please see comment section) through non-classical forms and would call it an “exhilarating experience.” Experiences are not scientific, evidence are. Many Yoga journals and some dubious and third rate Ayurveda journals have also have published on such experiences in small group of patients, which are not validated or published in better journals [like this junk here: There are no metanalysis level data to prove effectiveness of Surya Namaskar as beneficial as aerobic exercise or better than strength training as Sadhguru claims. Do Surya namaskar if you are doing nothing. But upgrade to strength training if you want something. And stop listening to pseudoscience peddlers who speak religion and culture for your healthcare needs. Sadhguru suffers seriously from Dunning Kruger fallacy: a type of cognitive bias, where people with little expertise or ability assume they have superior expertise or ability. This overestimation occurs because of the fact that they don’t have enough knowledge to know they don’t have enough knowledge.

A person asks Sadhguru, “How much weight training exercise do you recommend?” And Sadhguru answers, “Weight training is not useful, but do 25-50 Surya-Namaskars, it is complete exercise.” First of all, I am not sure why anyone would ask someone like Sadhguru, who is most of the time, in another dimension, a question on exercise and weight training. And secondly, Sadhguru is just plain wrong. Weight (or strength) training is one of the most important aspects of exercise regimen you can include in your daily or 3-4 times a week physical activity because there is great science behind its benefits. I advise my obese or sarcopenic (very poor muscle mass in advanced liver disease) patients to include weight training to improve clinical outcomes. The highest level of scientific evidence showed that standard muscle-strengthening activities were associated with lower risk of death in patients with non-communicable diseases – including cardiovascular disease, diabetes and lung cancer. Another metanalysis showed strong evidence for a considerable risk reduction of strength training for 60 minutes a week, on all-cause death (−15%), cardiovascular disease death (−19%), and cancer death (−14%). See here: here Sadhguru says the older we get, the better we do not weight train. He is again absolutely wrong. The findings of another systematic review/metanalysis support power (strength) training as an effective therapeutic intervention for improving physical function in adults diagnosed with frailty (poor physical function in old age) and patients with chronic medical conditions. See here: In fact, another study on strength training, this one again a metanalysis, concluded that strength training interventions can be used as a non-drug treatment for hypertension (!), as they promote significant decreases in blood pressure. See here: Strength training also reduces significantly, chronic inflammation as shown in another high quality systematic review and meta-analysis. See here: Resistance/Strength training improved muscle mass and muscle strength, thereby improving performance status. Improved performance status is a wonderful benchmark for an active and healthy life. See here: Even in fatty liver disease, independent of weight loss, exercise training was associated with 3 and a half times more meaningful treatment response towards lowering liver fat. Strength training is a powerful tool to maintain liver health. See here: and here Now Surya Namaskar. Surya Namaskar or Sun Salutation is a sequence of around twelve yoga poses connected by jumping or stretching movements, varying somewhat between various Yoga schools – which means, it has no regulation or standardization unlike weight training. In Iyengar Yoga there is a way, in Ashtanga Vinayasa Yoga there is Type A and B and there are other types followed by other schools or Yoga teachers. Along with the stretching and jumping, which is done is a slow and steady manner, the practice includes chanting a “mantra” calling out twelve names of the Sun God. In its classical form, Surya Namaskar is not an exercise, and is not aerobic. The energy cost of exercise is measured in units of metabolic equivalent of task (MET). Less than 3 METs counts as light exercise; 3 to 6 METs is moderate; 6 or over is vigorous. American College of Sports Medicine and American Heart Association guidelines count periods of at least 10 minutes of moderate MET level activity towards their recommended daily amounts of exercise. For healthy adults aged 18 to 65, the guidelines recommend moderate exercise for 30 minutes five days a week, or vigorous aerobic exercise for 20 minutes three days a week. Surya Namaskar in its classical form has a measly 2.9 METs and in its rigorous form (some people perform mutated highly active forms of Surya Namaskar to make it feel like an exercise) can go up to 7.4 METs – which requires a lot of jumping and little stretching and no time to chant the Sun God names - does not even come close to strength training by any margin. Those who are part of the Surya Namaskar and Yoga cult would provide anecdotal experiences on its benefits (please see comment section) through non-classical forms and would call it an “exhilarating experience.” Experiences are not scientific, evidence are. Many Yoga journals and some dubious and third rate Ayurveda journals have also have published on such experiences in small group of patients, which are not validated or published in better journals [like this junk here: There are no metanalysis level data to prove effectiveness of Surya Namaskar as beneficial as aerobic exercise or better than strength training as Sadhguru claims. Do Surya namaskar if you are doing nothing. But upgrade to strength training if you want something. And stop listening to pseudoscience peddlers who speak religion and culture for your healthcare needs. Sadhguru suffers seriously from Dunning Kruger fallacy: a type of cognitive bias, where people with little expertise or ability assume they have superior expertise or ability. This overestimation occurs because of the fact that they don’t have enough knowledge to know they don’t have enough knowledge.

TheLiverDoc™

505,792 views • 2 years ago

Bryan Johnson explains how lack of sleep can increase the risk of cancer ''When you get 4 hours of sleep per night or less for a few days, your NK cells, which are the cells that survey your body for cancer, go down in activity by roughly 70%. So a way to increase the risk of cancer is low sleep'' ''You can increase the risk of cancer when your body is in poor health. When you are older and when your immune system is not as strong, you have a higher chance of getting cancer''

Bryan Johnson explains how lack of sleep can increase the risk of cancer ''When you get 4 hours of sleep per night or less for a few days, your NK cells, which are the cells that survey your body for cancer, go down in activity by roughly 70%. So a way to increase the risk of cancer is low sleep'' ''You can increase the risk of cancer when your body is in poor health. When you are older and when your immune system is not as strong, you have a higher chance of getting cancer''

Mikli

53,527 views • 4 months ago

Fiber is Overrated! So Dr Shawn Baker 🌱 says fiber is overrated. What exactly about fiber is overrated? Is it the fact that it significantly increases longevity, reduces the risk of cancer, and cardiovascular disease in studies involving MILLIONS of total participants (PMIDs: 38011755, 35918724, & 37854351)? Is it the fact that it significantly reduces the risk of colon cancer (PMID: 34854791) Maybe it’s overrated because it helps you poop (PMID: 23326148) Shawn says that it’s just a waste that you flush down the toilet, but only insoluble fiber is not absorbed. And that can be a good thing because it helps with gut transit time, & eliminating stool in a timely fashion may actually help prevent GI inflammation & help eliminate potentially carcinogenic compounds produced as byproducts of digestion But soluble fiber doesn’t just have digestive benefits, it has metabolic benefits. Soluble fiber can be fermented by the gut microbiota to form short chain fatty acids like butyrate & propionate which can be absorbed into circulation & appear to have a myriad of benefits including improved insulin sensitivity & metabolic health (PMIDs: 35807739 & 3115666) I guess I”m confused about why any of this is overrated? Can you imagine if red meat had this kind of data? People like Shawn would absolutely lose their mind at the idea of anyone questioning the benefits, but since it doesn’t fit his bias he will never acknowledge the data fairly. And to be clear, I am not anti-meat at all. I’ve had my share of debates with vegans but I’m just not willing to buy into crazy nonsense like fiber being overrated Tired of feeling so confused by all the conflicting messages out there? Comment ‘FRAMEWORK’ below & I’ll send you a copy of my FREE simplified guide on how to build muscle & lose fat

Fiber is Overrated! So Dr Shawn Baker 🌱 says fiber is overrated. What exactly about fiber is overrated? Is it the fact that it significantly increases longevity, reduces the risk of cancer, and cardiovascular disease in studies involving MILLIONS of total participants (PMIDs: 38011755, 35918724, & 37854351)? Is it the fact that it significantly reduces the risk of colon cancer (PMID: 34854791) Maybe it’s overrated because it helps you poop (PMID: 23326148) Shawn says that it’s just a waste that you flush down the toilet, but only insoluble fiber is not absorbed. And that can be a good thing because it helps with gut transit time, & eliminating stool in a timely fashion may actually help prevent GI inflammation & help eliminate potentially carcinogenic compounds produced as byproducts of digestion But soluble fiber doesn’t just have digestive benefits, it has metabolic benefits. Soluble fiber can be fermented by the gut microbiota to form short chain fatty acids like butyrate & propionate which can be absorbed into circulation & appear to have a myriad of benefits including improved insulin sensitivity & metabolic health (PMIDs: 35807739 & 3115666) I guess I”m confused about why any of this is overrated? Can you imagine if red meat had this kind of data? People like Shawn would absolutely lose their mind at the idea of anyone questioning the benefits, but since it doesn’t fit his bias he will never acknowledge the data fairly. And to be clear, I am not anti-meat at all. I’ve had my share of debates with vegans but I’m just not willing to buy into crazy nonsense like fiber being overrated Tired of feeling so confused by all the conflicting messages out there? Comment ‘FRAMEWORK’ below & I’ll send you a copy of my FREE simplified guide on how to build muscle & lose fat

Layne Norton, PhD

41,789 views • 1 year ago

Vigorous intensity physical activity is 4–10x more effective than moderate activity for reducing the risk of major chronic diseases. One minute of vigorous activity offers roughly the same reduction in all-cause mortality risk as 4 minutes of moderate activity. When looking closer at specific outcomes, the impact becomes even clearer. For cardiovascular mortality, you'd need about 8 minutes of moderate activity to equal just one minute at vigorous intensity; for type 2 diabetes, it's closer to 10 minutes. In terms of cancer-related mortality, again, vigorous activity proves four times more potent than moderate intensity. These findings are eye-opening, but perhaps not surprising when we consider the superior cardiovascular and metabolic adaptations in response to vigorous-intensity activity, including better cardiorespiratory fitness and insulin sensitivity.

Vigorous intensity physical activity is 4–10x more effective than moderate activity for reducing the risk of major chronic diseases. One minute of vigorous activity offers roughly the same reduction in all-cause mortality risk as 4 minutes of moderate activity. When looking closer at specific outcomes, the impact becomes even clearer. For cardiovascular mortality, you'd need about 8 minutes of moderate activity to equal just one minute at vigorous intensity; for type 2 diabetes, it's closer to 10 minutes. In terms of cancer-related mortality, again, vigorous activity proves four times more potent than moderate intensity. These findings are eye-opening, but perhaps not surprising when we consider the superior cardiovascular and metabolic adaptations in response to vigorous-intensity activity, including better cardiorespiratory fitness and insulin sensitivity.

Dr. Rhonda Patrick

330,820 views • 7 months ago