Loading video...

Video Failed to Load

Go Home

Vigorous exercise improves cognition and delays brain aging. Exercise causes muscles to produce lactate, which travels to the brain, triggering the production of neurotransmitters like norepinephrine and neurotrophic factors like BDNF. New episode on why we should incorporate more vigorous exercise into our routine. TIMESTAMPS: (01:51) What differentiates "vigorous"...

foundmyfitness's profile picture

Dr. Rhonda Patrick

959,528 subscribers

530,847 views • 2 years ago •via X (Twitter)

Health & WellnessEducationScience & Technology
LIVE

Anya Rossi• Live Now

Private livecam show

9 Comments

Dr. Rhonda Patrick's profile picture
Dr. Rhonda Patrick2 years ago

This episode is also available on the FoundMyFitness Apple Podcasts, Spotify, and YouTube. Show notes and links here:

FoundMyFitness Clips's profile picture
FoundMyFitness Clips2 years ago

🔥 🔥 🔥

Tim Palmer's profile picture
Tim Palmer2 years ago

Agree 1000% Just finished my 10th IronMan at age 62. Came home from race to attend funerals of two classmates in one week. Your work has been transformative in my life! Much gratitude @foundmyfitness And yes, Broccoli Sprouts are my SUPERPOWER!!

revival.care's profile picture
revival.care2 years ago

A well balanced training program needs: - Low intensity cardio (zone 2/3) - VO2 max training (zone 4/5) - Strength training - Mobility work - Flexibility training

Gamera's profile picture
Gamera2 years ago

"Why zone 2 training may not improve VO2 max". Yes, but the more Z2 one does the more they can do of, and the quicker they can recover from, the type of training that really does improve VO2 MAX. Some of the greatest milers ever did nothing but Z2 for 6 months plus per year.

VALUE-HUNTER's profile picture
VALUE-HUNTER2 years ago

Goggins gonna be the first 1000 year old

wealthyprimate's profile picture
wealthyprimate2 years ago

If you’re reading this trying to figure out what the perfect exercise is I can sum this up for you: Find a physical activity that is hard, that you enjoy doing, and that you can do often. Don’t like HIIT (me)? Don’t do it because of a study. Run, rock climb, whatever you want

Talk_Data_To_Me's profile picture
Talk_Data_To_Me2 years ago

I'm really interested in how you measure the increase in longevity without actually waiting for the people to die?

Sean Michael Floyd's profile picture
Sean Michael Floyd2 years ago

Hey Rhonda, longtime fan. Really enjoyed this episode. Listened last night and did a 4x4 Norwegian session today (first time). Gonna add this in twice a week alongside my zone 2 work (been doing 180min). Keep putting out the great content!

Related Videos

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time
52:20

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time

Dr. Rhonda Patrick

106,049 views • 2 years ago

The current physical activity guidelines undervalue vigorous activity. Vigorous activity may be 4–9× more potent than moderate activity for reducing all-cause mortality, cardiovascular disease, diabetes, and cancer risk. The exercise guidelines assume a 2:1 ratio between moderate- and vigorous-intensity activity: two minutes of moderate activity equals one minute of vigorous. That's why the recommendations are 150–300 minutes of moderate or 75–150 minutes of vigorous activity each week. But new data suggest that ratio is wrong. In this brand-new journal-club episode, Brady Holmer (Brady Holmer) and I unpack a groundbreaking study that should change how we think about activity for disease prevention. The research identified that 1 minute of vigorous activity is roughly equivalent to 4–9 minutes of moderate activity, and 53–94 minutes of light activity, for disease risk reduction. It also shows a clear dose-response for vigorous activity that’s much weaker for moderate activity and barely detectable for light activity. We also do a deep dive into why vigorous activity is so powerful, the underlying mechanisms, and discuss practical takeaways, including how even very brief bouts of vigorous movement (think “exercise snacks”) can produce meaningful health benefits. Timestamps are below. You can find links to the episode on YouTube, Apple Podcasts, and Spotify in the next post. Enjoy! Timestamps: 0:00 - Introduction 2:14 - The 1:2 rule for exercise 6:28 - What counts as vigorous? 8:48 - Where exercise guidelines fail 9:32 - Inside the wearable-based study design 15:24 - Vigorous activity—easier than you think? 18:01 - Avoiding healthy user bias 19:12 - A better way to measure exercise 20:58 - Is vigorous 4–10x better? 25:08 - One vigorous min vs. one-hour walk 27:15 - Are light activity's benefits capped? 29:03 - Is vigorous 5x better for your heart? 30:12 - Does zone 2 count as vigorous? 31:24 - Dose-response comparison 32:35 - Vigorous exercise & younger arteries 38:29 - Why aging hearts need intensity 41:22 - Can intensity preserve VO₂ max? 42:40 - Moderate exercise & VO₂ max limits 44:34 - Is vigorous 10x better for diabetes? 51:01 - Why intensity boosts mitochondria 56:11 - Does intense exercise kill tumor cells? 1:02:28 - Hormonal benefits 1:03:19 - Preventing falls with intensity 1:07:49 - Fighting inflammation 1:09:42 - High-intensity training & brain aging 1:11:14 - The 2:1 ratio is out the door 1:13:03 - Could vigorous exercise become a pill? 1:14:21 - Short bursts for longer life 1:18:28 - Can short bouts match full workouts? 1:22:39 - Do wearables undervalue vigorous bursts? 1:25:19 - Can micro-workouts replace the gym? 1:30:23 - Updating exercise guidelines 1:41:48 - Is light activity useless? 1:44:17 - Is vigorous exercise safe for seniors? 1:48:41 - Is HIIT harmful to female hormones? 1:54:18 - Balancing intensity & recovery (80/20 rule) 1:56:43 - Brady’s exercise routine 2:00:30 - Vigorous activity & kids’ brainpower 2:03:27 - Are we undervaluing vigorous exercise? 2:05:16 - Why chasing steps doesn't work
2:10:24

The current physical activity guidelines undervalue vigorous activity. Vigorous activity may be 4–9× more potent than moderate activity for reducing all-cause mortality, cardiovascular disease, diabetes, and cancer risk. The exercise guidelines assume a 2:1 ratio between moderate- and vigorous-intensity activity: two minutes of moderate activity equals one minute of vigorous. That's why the recommendations are 150–300 minutes of moderate or 75–150 minutes of vigorous activity each week. But new data suggest that ratio is wrong. In this brand-new journal-club episode, Brady Holmer (Brady Holmer) and I unpack a groundbreaking study that should change how we think about activity for disease prevention. The research identified that 1 minute of vigorous activity is roughly equivalent to 4–9 minutes of moderate activity, and 53–94 minutes of light activity, for disease risk reduction. It also shows a clear dose-response for vigorous activity that’s much weaker for moderate activity and barely detectable for light activity. We also do a deep dive into why vigorous activity is so powerful, the underlying mechanisms, and discuss practical takeaways, including how even very brief bouts of vigorous movement (think “exercise snacks”) can produce meaningful health benefits. Timestamps are below. You can find links to the episode on YouTube, Apple Podcasts, and Spotify in the next post. Enjoy! Timestamps: 0:00 - Introduction 2:14 - The 1:2 rule for exercise 6:28 - What counts as vigorous? 8:48 - Where exercise guidelines fail 9:32 - Inside the wearable-based study design 15:24 - Vigorous activity—easier than you think? 18:01 - Avoiding healthy user bias 19:12 - A better way to measure exercise 20:58 - Is vigorous 4–10x better? 25:08 - One vigorous min vs. one-hour walk 27:15 - Are light activity's benefits capped? 29:03 - Is vigorous 5x better for your heart? 30:12 - Does zone 2 count as vigorous? 31:24 - Dose-response comparison 32:35 - Vigorous exercise & younger arteries 38:29 - Why aging hearts need intensity 41:22 - Can intensity preserve VO₂ max? 42:40 - Moderate exercise & VO₂ max limits 44:34 - Is vigorous 10x better for diabetes? 51:01 - Why intensity boosts mitochondria 56:11 - Does intense exercise kill tumor cells? 1:02:28 - Hormonal benefits 1:03:19 - Preventing falls with intensity 1:07:49 - Fighting inflammation 1:09:42 - High-intensity training & brain aging 1:11:14 - The 2:1 ratio is out the door 1:13:03 - Could vigorous exercise become a pill? 1:14:21 - Short bursts for longer life 1:18:28 - Can short bouts match full workouts? 1:22:39 - Do wearables undervalue vigorous bursts? 1:25:19 - Can micro-workouts replace the gym? 1:30:23 - Updating exercise guidelines 1:41:48 - Is light activity useless? 1:44:17 - Is vigorous exercise safe for seniors? 1:48:41 - Is HIIT harmful to female hormones? 1:54:18 - Balancing intensity & recovery (80/20 rule) 1:56:43 - Brady’s exercise routine 2:00:30 - Vigorous activity & kids’ brainpower 2:03:27 - Are we undervaluing vigorous exercise? 2:05:16 - Why chasing steps doesn't work

Dr. Rhonda Patrick

306,189 views • 7 months ago

New presentation! I discuss why high-intensity interval training is superior for glucose regulation, how avoiding late-night eating improves metabolic health, and the critical role of sleep in optimizing glucose control. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:31 - HIIT vs. zone 2 for metabolic health 3:52 - Lactate as a signaling molecule 6:39 - HIIT conditions for improving body composition 7:42 - Mitophagy from vigorous exercise 11:33 - HIIT vs. zone 2 for mitochondrial biogenesis 13:15 - Evidence-based HIIT protocols 14:52 - “Exercise snacks” pre- and post-meal 15:16 - 10 bodyweight squats vs. 45-minute walk 16:56 - Mortality benefits of short exercise bursts 20:14 - Why late-night eating is detrimental 24:43 - Brain atrophy from high-normal glucose 25:36 - Circadian misalignment 26:52 - Time-restricted eating 29:30 - Why early eating is best for metabolic health 31:54 - Mild sleep restriction’s metabolic effects 34:04 - Sleep restriction and type 2 diabetes 34:50 - Advanced glycation end products 36:45 - How sleep restriction affects insulin signaling 37:50 - Why short sleep facilitates obesity 39:09 - Sleep hygiene checklist 42:43 - Sleep extension 43:53 - Cognitive behavioral therapy for insomnia (CBT-I) 45:28 - Benefits of HIIT when sleep-restricted 48:01 - Can HIIT reduce mortality risk from poor sleep? To learn more about the A4M Metabolic Health conferences, make sure to give them a follow at American Academy of Anti-Aging Medicine (A4M).
49:57

New presentation! I discuss why high-intensity interval training is superior for glucose regulation, how avoiding late-night eating improves metabolic health, and the critical role of sleep in optimizing glucose control. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:31 - HIIT vs. zone 2 for metabolic health 3:52 - Lactate as a signaling molecule 6:39 - HIIT conditions for improving body composition 7:42 - Mitophagy from vigorous exercise 11:33 - HIIT vs. zone 2 for mitochondrial biogenesis 13:15 - Evidence-based HIIT protocols 14:52 - “Exercise snacks” pre- and post-meal 15:16 - 10 bodyweight squats vs. 45-minute walk 16:56 - Mortality benefits of short exercise bursts 20:14 - Why late-night eating is detrimental 24:43 - Brain atrophy from high-normal glucose 25:36 - Circadian misalignment 26:52 - Time-restricted eating 29:30 - Why early eating is best for metabolic health 31:54 - Mild sleep restriction’s metabolic effects 34:04 - Sleep restriction and type 2 diabetes 34:50 - Advanced glycation end products 36:45 - How sleep restriction affects insulin signaling 37:50 - Why short sleep facilitates obesity 39:09 - Sleep hygiene checklist 42:43 - Sleep extension 43:53 - Cognitive behavioral therapy for insomnia (CBT-I) 45:28 - Benefits of HIIT when sleep-restricted 48:01 - Can HIIT reduce mortality risk from poor sleep? To learn more about the A4M Metabolic Health conferences, make sure to give them a follow at American Academy of Anti-Aging Medicine (A4M).

Dr. Rhonda Patrick

130,077 views • 1 year ago

New episode on the optimal exercise intensity, duration, and frequency to prevent and reverse heart aging! In this podcast episode, Dr. Benjamin Levine discusses his groundbreaking research, which reveals how three weeks of bed rest can have a more detrimental impact on fitness than 30 years of aging. Dr. Levine details his research findings that show how a structured exercise regimen can reverse up to 20 years of heart aging by improving both shrinkage and compliance, as well as enhancing aspects of vascular age by 15 years. He also discusses how resistance training and aerobic training have profound differences on the heart, what risks are linked to high-intensity exercise, why recovery is key for the heart, how exercise duration and intensity affect coronary calcium levels, what exercise dose increases Afib risk, and so much more. This episode is a must! Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:31 - Bed rest vs. 30 years of aging 5:18 - Recovering from bed rest 6:49 - Does exercise protect against long COVID? 11:27 - Bed rest as a model for space flight 12:24 - How bed rest affects heart size 13:52 - Why a brand-new rubber band mimics a lifetime of endurance training 17:23 - The exercise dose that preserves youthful cardiovascular structure 19:32 - Reversing 20 years of heart aging 23:14 - Reversing vascular age by 15 years 28:38 - Why start an exercise regimen in your 70s? 34:26 - High-intensity exercise risks 37:51 - Balancing high- & moderate-intensity training 42:49 - Training for health vs. training for performance 43:57 - Why muscle mass & cardiorespiratory fitness are like retirement funds 45:12 - Make exercise part of your personal hygiene 46:16 - Why VO2 max correlates with longevity 53:43 - Cardiorespiratory fitness & mortality 59:21 - How does change in fitness over time affect mortality? 1:01:34 - Exercise non-responders 1:05:23 - Limiting factors for VO2 max improvements 1:08:20 - How marathon training affects heart size 1:12:34 - Heart adaptations in purely strength-trained vs. endurance athletes 1:18:23 - Why pure strength-trainers should incorporate endurance training 1:22:07 - How strength training affects blood pressure 1:26:41 - How exercise influences cardiac output 1:28:39 - Does CrossFit count as endurance training? 1:31:04 - Exercise for improving blood pressure 1:36:11 - Lifestyle strategies for treating hypertension 1:38:40 - Why recovery is key 1:42:36 - The best indicator of being overtrained 1:43:36 - Estimating training zones 2-5 1:50:00 - Why HRV is a poor recovery indicator 1:55:16 - Why men are faster runners than women 1:58:49 - Can women achieve similar aerobic exercise benefits doing 2x less? 2:00:21 - Possible cardiovascular benefits of HRT in women 2:02:12 - Defining “extreme exercise” 2:04:00 - How exercise volume affects coronary plaque calcification 2:10:50 - How exercise duration & intensity affect coronary calcium levels 2:14:03 - Why high exercise duration & intensity increases Afib risk 2:16:33 - What exercise dose increases Afib risk? 2:17:59 - Managing stroke risk in athletes prone to Afib 2:21:14 - Why you shouldn’t become an endurance athlete to “live longer”
2:24:58

New episode on the optimal exercise intensity, duration, and frequency to prevent and reverse heart aging! In this podcast episode, Dr. Benjamin Levine discusses his groundbreaking research, which reveals how three weeks of bed rest can have a more detrimental impact on fitness than 30 years of aging. Dr. Levine details his research findings that show how a structured exercise regimen can reverse up to 20 years of heart aging by improving both shrinkage and compliance, as well as enhancing aspects of vascular age by 15 years. He also discusses how resistance training and aerobic training have profound differences on the heart, what risks are linked to high-intensity exercise, why recovery is key for the heart, how exercise duration and intensity affect coronary calcium levels, what exercise dose increases Afib risk, and so much more. This episode is a must! Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:31 - Bed rest vs. 30 years of aging 5:18 - Recovering from bed rest 6:49 - Does exercise protect against long COVID? 11:27 - Bed rest as a model for space flight 12:24 - How bed rest affects heart size 13:52 - Why a brand-new rubber band mimics a lifetime of endurance training 17:23 - The exercise dose that preserves youthful cardiovascular structure 19:32 - Reversing 20 years of heart aging 23:14 - Reversing vascular age by 15 years 28:38 - Why start an exercise regimen in your 70s? 34:26 - High-intensity exercise risks 37:51 - Balancing high- & moderate-intensity training 42:49 - Training for health vs. training for performance 43:57 - Why muscle mass & cardiorespiratory fitness are like retirement funds 45:12 - Make exercise part of your personal hygiene 46:16 - Why VO2 max correlates with longevity 53:43 - Cardiorespiratory fitness & mortality 59:21 - How does change in fitness over time affect mortality? 1:01:34 - Exercise non-responders 1:05:23 - Limiting factors for VO2 max improvements 1:08:20 - How marathon training affects heart size 1:12:34 - Heart adaptations in purely strength-trained vs. endurance athletes 1:18:23 - Why pure strength-trainers should incorporate endurance training 1:22:07 - How strength training affects blood pressure 1:26:41 - How exercise influences cardiac output 1:28:39 - Does CrossFit count as endurance training? 1:31:04 - Exercise for improving blood pressure 1:36:11 - Lifestyle strategies for treating hypertension 1:38:40 - Why recovery is key 1:42:36 - The best indicator of being overtrained 1:43:36 - Estimating training zones 2-5 1:50:00 - Why HRV is a poor recovery indicator 1:55:16 - Why men are faster runners than women 1:58:49 - Can women achieve similar aerobic exercise benefits doing 2x less? 2:00:21 - Possible cardiovascular benefits of HRT in women 2:02:12 - Defining “extreme exercise” 2:04:00 - How exercise volume affects coronary plaque calcification 2:10:50 - How exercise duration & intensity affect coronary calcium levels 2:14:03 - Why high exercise duration & intensity increases Afib risk 2:16:33 - What exercise dose increases Afib risk? 2:17:59 - Managing stroke risk in athletes prone to Afib 2:21:14 - Why you shouldn’t become an endurance athlete to “live longer”

Dr. Rhonda Patrick

266,327 views • 2 years ago

Research suggests that up to 40% of cancer cases could be prevented through lifestyle changes. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. Today’s interview features Dr. Kerry Courneya. With over 600 peer-reviewed studies, he is one of the most influential figures in exercise oncology. Even if you aren't someone who has personally experienced cancer in one form or another, you need to watch this episode. Episode 99 is Available now on X, YouTube, Spotify, and Apple Podcasts. Chapters: 0:00 - Introduction 1:47 - Why exercise should be effortful 2:33 - How to meaningfully reduce risk of cancer 6:22 - What type of exercise is best? 7:59 - How exercise reduces risk—even for smokers and the obese 10:48 - Weekend-only exercise 13:49 - 150 vs. 300 minutes per week (more is better—up to a point) 16:03 - Why pre-diagnosis exercise matters 19:09 - Why resilience to cancer treatment starts with exercise 21:01 - Why low muscle mass drives cancer death 23:58 - Why BMI fails to measure true obesity 27:51 - Why daily activity isn't enough (structured exercise matters) 29:34 - Breaking up sedentary time—do ‘exercise snacks’ help? 31:50 - Supplements vs. exercise 32:32 - Where exercise fits with chemo and immunotherapy 35:30 - Why rest is not the best medicine 41:20 - Aerobic vs. resistance 42:13 - How weight training improves 'chemo completion' 44:41 - Why exercise creates vulnerability in cancer cells (limitations do apply) 47:09 - Why exercise might be crucial for tumor elimination 53:03 - Why cardio may be better at clearing tumor cells 56:18 - When cancer spreads quickly—and when it doesn't 57:43 - Why liquid biopsies may prevent over-treatment 1:02:56 - Exercise-sensitive vs. exercise-resistant cancers 1:06:06 - Prostate cancer therapy—why strength training matters 1:08:10 - When exercise is the only therapy—does it work? 1:09:26 - Why HIIT reduces PSA in prostate cancer 1:11:40 - Avoiding overtreatment—can exercise buy you time? 1:12:00 - Why high-intensity exercise boosts anti-cancer biology 1:13:11 - Turning a diagnosis into a wake-up call 1:16:11 - Why oncologists are rethinking exercise 1:18:50 - Why exercise eases anxiety about cancer—proven psychological benefits 1:25:00 - Before, during, and after treatment 1:27:02 - Why exercise is unique among cancer therapies 1:28:16 - Why cancer patients stop exercising—the risky mistake almost everyone makes 1:30:41 - How to get sedentary cancer patients exercising (realistically) 1:33:15 - The $1 million case for including exercise 1:34:56 - Why recurrence trials haven't convinced doctors—yet 1:37:36 - The bottom-line message 1:37:55 - The myth of a cancer panacea (exercise included) 1:44:07 - What's the best $50 investment for staying active? 1:44:40 - Only 15 minutes per day—what’s the best anti-cancer exercise?
1:48:23

Research suggests that up to 40% of cancer cases could be prevented through lifestyle changes. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. Today’s interview features Dr. Kerry Courneya. With over 600 peer-reviewed studies, he is one of the most influential figures in exercise oncology. Even if you aren't someone who has personally experienced cancer in one form or another, you need to watch this episode. Episode 99 is Available now on X, YouTube, Spotify, and Apple Podcasts. Chapters: 0:00 - Introduction 1:47 - Why exercise should be effortful 2:33 - How to meaningfully reduce risk of cancer 6:22 - What type of exercise is best? 7:59 - How exercise reduces risk—even for smokers and the obese 10:48 - Weekend-only exercise 13:49 - 150 vs. 300 minutes per week (more is better—up to a point) 16:03 - Why pre-diagnosis exercise matters 19:09 - Why resilience to cancer treatment starts with exercise 21:01 - Why low muscle mass drives cancer death 23:58 - Why BMI fails to measure true obesity 27:51 - Why daily activity isn't enough (structured exercise matters) 29:34 - Breaking up sedentary time—do ‘exercise snacks’ help? 31:50 - Supplements vs. exercise 32:32 - Where exercise fits with chemo and immunotherapy 35:30 - Why rest is not the best medicine 41:20 - Aerobic vs. resistance 42:13 - How weight training improves 'chemo completion' 44:41 - Why exercise creates vulnerability in cancer cells (limitations do apply) 47:09 - Why exercise might be crucial for tumor elimination 53:03 - Why cardio may be better at clearing tumor cells 56:18 - When cancer spreads quickly—and when it doesn't 57:43 - Why liquid biopsies may prevent over-treatment 1:02:56 - Exercise-sensitive vs. exercise-resistant cancers 1:06:06 - Prostate cancer therapy—why strength training matters 1:08:10 - When exercise is the only therapy—does it work? 1:09:26 - Why HIIT reduces PSA in prostate cancer 1:11:40 - Avoiding overtreatment—can exercise buy you time? 1:12:00 - Why high-intensity exercise boosts anti-cancer biology 1:13:11 - Turning a diagnosis into a wake-up call 1:16:11 - Why oncologists are rethinking exercise 1:18:50 - Why exercise eases anxiety about cancer—proven psychological benefits 1:25:00 - Before, during, and after treatment 1:27:02 - Why exercise is unique among cancer therapies 1:28:16 - Why cancer patients stop exercising—the risky mistake almost everyone makes 1:30:41 - How to get sedentary cancer patients exercising (realistically) 1:33:15 - The $1 million case for including exercise 1:34:56 - Why recurrence trials haven't convinced doctors—yet 1:37:36 - The bottom-line message 1:37:55 - The myth of a cancer panacea (exercise included) 1:44:07 - What's the best $50 investment for staying active? 1:44:40 - Only 15 minutes per day—what’s the best anti-cancer exercise?

Dr. Rhonda Patrick

219,900 views • 1 year ago

What micronutrients improve aging? There's no excuse for some of the widespread micronutrient deficiencies, especially in light of the fact that many may play a role in aging. Devoted to the ‘low hanging fruit’ of aging, I think many of you may enjoy this episode. TIMESTAMPS: (00:00) Introduction (01:10) Vitamin D deficiency (08:26) Magnesium's critical role in DNA repair (11:55) Dietary magnesium sources (13:11) Magnesium supplements (14:20) Exercise staves off age-related disease (14:58) Genetic SNPs & vitamin D deficiency (20:15) Low omega-3 intake from seafood (22:28) ALA's conversion into EPA & DHA (25:21) Omega-3 index (28:33) How omega-3s reduce inflammation (30:45) Omega-3s & muscle disuse atrophy (31:44) Don't avoid fish during pregnancy (34:08) Omega-3s are a low-hanging fruit (35:52) How to choose an omega-3 supplement (40:03) Why stressors benefit your genes (46:20) How to choose an exercise regimen (47:15) “Exercise snacks” (49:30) Brain benefits of lactate from vigorous exercise (52:29) Exercise & circulating tumor cells (54:36) Rhonda's workout regimen (55:44) Exercise for combating sleep deprivation (58:38) Exercise may be the best longevity "drug" Interview by Dr. Kalea Wattles (Dr. Kalea Wattles) originally for the ‘Pathways to Wellbeing’ podcast from The Institute for Functional Medicine (The Institute for Functional Medicine (IFM)).
1:00:02

What micronutrients improve aging? There's no excuse for some of the widespread micronutrient deficiencies, especially in light of the fact that many may play a role in aging. Devoted to the ‘low hanging fruit’ of aging, I think many of you may enjoy this episode. TIMESTAMPS: (00:00) Introduction (01:10) Vitamin D deficiency (08:26) Magnesium's critical role in DNA repair (11:55) Dietary magnesium sources (13:11) Magnesium supplements (14:20) Exercise staves off age-related disease (14:58) Genetic SNPs & vitamin D deficiency (20:15) Low omega-3 intake from seafood (22:28) ALA's conversion into EPA & DHA (25:21) Omega-3 index (28:33) How omega-3s reduce inflammation (30:45) Omega-3s & muscle disuse atrophy (31:44) Don't avoid fish during pregnancy (34:08) Omega-3s are a low-hanging fruit (35:52) How to choose an omega-3 supplement (40:03) Why stressors benefit your genes (46:20) How to choose an exercise regimen (47:15) “Exercise snacks” (49:30) Brain benefits of lactate from vigorous exercise (52:29) Exercise & circulating tumor cells (54:36) Rhonda's workout regimen (55:44) Exercise for combating sleep deprivation (58:38) Exercise may be the best longevity "drug" Interview by Dr. Kalea Wattles (Dr. Kalea Wattles) originally for the ‘Pathways to Wellbeing’ podcast from The Institute for Functional Medicine (The Institute for Functional Medicine (IFM)).

Dr. Rhonda Patrick

523,547 views • 2 years ago

By age 50, the average adult has lost at least 10% of their muscle mass and developed a stiffened left ventricle—yet the right exercise plan can reverse both. Over the years, I’ve interviewed some of the world’s top experts in exercise physiology, nutrition science, and human performance. In this brand-new podcast episode, I'm joined by guest Brady Holmer () to distill these insights to answer one key question: What does the science say about how to train? Get the new how to train according to the experts guide at TIMESTAMPS 0:00 - Introduction 3:35 - Training Goals 6:23 - Bed Rest vs. 30 Years of Aging 8:24 - Why Cardiorespiratory Fitness Matters 11:19 - VO2 Max and Longevity 18:47 - Zone 2 Limitations for VO2 Max 22:42 - Demystifying Training Zone Targets 28:29 - Smart Watches vs. Chest Straps 31:43 - Zone 2 vs. Interval Benefits 40:53 - Adjusting the 80/20 Rule 51:07 - Heart Stiffening Starts Early 54:09 - Optimal Four-Day Exercise Habit 1:02:16 - Reversing Twenty Years of Heart Age 1:14:51 - What Intensity Is Better for Mitochondria? 1:17:39 - Does Zone 2 Make You a Better “Fat Burner”? 1:27:04 - Intervals for Glucose Regulation 1:32:24 - Intensity Matters for Brain Health 1:36:20 - Exercise Snacks 1:42:27 - A Caffeine Alternative 1:43:32 - Timing Exercise Snacks 1:45:38 - Muscle Loss with Aging 1:48:19 - Powerpenia 1:50:04 - Resistance Training Principles 1:57:01 - Compound Exercises for Strength 2:00:05 - Rest Intervals Matter 2:02:02 - Lifting Heavy for Mental Resilience 2:05:26 - Should You Train to Failure? 2:08:57 - Strength Training Isn’t Cardio 2:12:16 - Hypertrophy Training 2:17:38 - Body Recomposition Strategies 2:22:52 - Time-Efficient Resistance Training 2:27:38 - The Interference Effect Myth 2:29:32 - Minimum Effective Dose for Resistance 2:31:16 - Sauna Use for Cardiorespiratory Fitness 2:36:17 - Heat vs. Cold for Training 2:39:06 - Anti-Atrophy Effects of Omega-3 2:41:21 - Protein Timing & Distribution 2:46:53 - Creatine Supplementation
2:52:47

By age 50, the average adult has lost at least 10% of their muscle mass and developed a stiffened left ventricle—yet the right exercise plan can reverse both. Over the years, I’ve interviewed some of the world’s top experts in exercise physiology, nutrition science, and human performance. In this brand-new podcast episode, I'm joined by guest Brady Holmer () to distill these insights to answer one key question: What does the science say about how to train? Get the new how to train according to the experts guide at TIMESTAMPS 0:00 - Introduction 3:35 - Training Goals 6:23 - Bed Rest vs. 30 Years of Aging 8:24 - Why Cardiorespiratory Fitness Matters 11:19 - VO2 Max and Longevity 18:47 - Zone 2 Limitations for VO2 Max 22:42 - Demystifying Training Zone Targets 28:29 - Smart Watches vs. Chest Straps 31:43 - Zone 2 vs. Interval Benefits 40:53 - Adjusting the 80/20 Rule 51:07 - Heart Stiffening Starts Early 54:09 - Optimal Four-Day Exercise Habit 1:02:16 - Reversing Twenty Years of Heart Age 1:14:51 - What Intensity Is Better for Mitochondria? 1:17:39 - Does Zone 2 Make You a Better “Fat Burner”? 1:27:04 - Intervals for Glucose Regulation 1:32:24 - Intensity Matters for Brain Health 1:36:20 - Exercise Snacks 1:42:27 - A Caffeine Alternative 1:43:32 - Timing Exercise Snacks 1:45:38 - Muscle Loss with Aging 1:48:19 - Powerpenia 1:50:04 - Resistance Training Principles 1:57:01 - Compound Exercises for Strength 2:00:05 - Rest Intervals Matter 2:02:02 - Lifting Heavy for Mental Resilience 2:05:26 - Should You Train to Failure? 2:08:57 - Strength Training Isn’t Cardio 2:12:16 - Hypertrophy Training 2:17:38 - Body Recomposition Strategies 2:22:52 - Time-Efficient Resistance Training 2:27:38 - The Interference Effect Myth 2:29:32 - Minimum Effective Dose for Resistance 2:31:16 - Sauna Use for Cardiorespiratory Fitness 2:36:17 - Heat vs. Cold for Training 2:39:06 - Anti-Atrophy Effects of Omega-3 2:41:21 - Protein Timing & Distribution 2:46:53 - Creatine Supplementation

Dr. Rhonda Patrick

378,320 views • 1 year ago

The new episode of Perform with Dr. Andy Galpin is out now: Dr. Tommy Wood: Enhancing Brain Performance & Preventing Dementia Tommy Wood MD, PhD This episode is available in full on X, YouTube, and all podcast platforms. (0:00) Tommy Wood (2:31) Cognitive Performance & Brain Health, Structure & Function (8:12) Brain Function & Stimulus, Brain Volume (12:13) Improve Cognitive Function, Skill Development (15:22) Sponsor: AG1 (17:03) Skills, Near- vs Far-Transfer (20:13) Assess Short-Term Cognitive Health, Tool: Blood Test; Nutritional Status (27:19) Long-Term Brain Health; Tool: Cognitively-Demanding Tasks, Dance, Novelty (35:00) Task-Switching, Kids vs Adults (41:20) Sponsor: LMNT (42:42) Brain Training?, Virtual Reality (47:22) Nutrition, Processed Foods; Supplementation, Creatine, Caffeine, Alpha-GPC (55:02) Supplements & Trade-Offs, Subjective Effects, Sleep (1:00:55) Brain Fog, Subjective Cognitive Decline (1:04:34) Three ‘S’ Model & Cognitive Health, Brain Fog (1:10:47) Recap: Improve Cognitive Function & Reduce Brain Fog; Hydration (1:13:33) Sponsor: Renaissance Periodization (1:14:38) Vision Assessment, Tool: Vision Training (1:21:54) Vitamin A, Antioxidants, Supplement Use (1:24:39) Creatine, Caffeine & Sleep Deficits; Methylation, Homocysteine, B Vitamins (1:35:30) Cognitive Function & Creatine Benefits; What is Methylation?, Epigenetics (1:39:50) Creatine & Short-Term Energy, Lactate (1:45:45) Sponsor: Momentous (1:47:12) What is a Concussion?, Egg Analogy (1:51:26) Traumatic Brain Injury (TBI), Lactate & Ketones (1:54:43) TBI, Inflammation, Metabolic Changes, Mitochondria (2:00:40) Acute Treatment & TBIs; Testing for TBI, Cognitive Tests, EEG Technology (2:08:58) Calcium Supplementation?, Vitamin D, Magnesium (2:13:18) Dementia & Late-Onset Alzheimer’s, Prevention? Reversal?, Tool: Modifiable Risk Factors (2:19:08) Education & Peak Cognitive Function, Dementia, Stimulating Job (2:25:59) Sensory Inputs & Dementia, Tool: Being in Nature (2:28:44) Exercise & Dementia, Tool: Resistance & High Intensity Training (2:35:50) Tool: Designing Exercise Protocol for Brain Health (2:39:15) Muscle Strength, Cognitive Function & Overall Brain Health, Mechanism (2:44:49) White Matter, Exercise, Energetic Processes (2:49:39) Alzheimer’s Disease, Tau, Amyloids, Markers of Brain Aging (2:55:40) Recap; Tommy’s Projects & Links (3:01:50) Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media, Perform Newsletter Includes paid partnerships.
3:03:32

The new episode of Perform with Dr. Andy Galpin is out now: Dr. Tommy Wood: Enhancing Brain Performance & Preventing Dementia Tommy Wood MD, PhD This episode is available in full on X, YouTube, and all podcast platforms. (0:00) Tommy Wood (2:31) Cognitive Performance & Brain Health, Structure & Function (8:12) Brain Function & Stimulus, Brain Volume (12:13) Improve Cognitive Function, Skill Development (15:22) Sponsor: AG1 (17:03) Skills, Near- vs Far-Transfer (20:13) Assess Short-Term Cognitive Health, Tool: Blood Test; Nutritional Status (27:19) Long-Term Brain Health; Tool: Cognitively-Demanding Tasks, Dance, Novelty (35:00) Task-Switching, Kids vs Adults (41:20) Sponsor: LMNT (42:42) Brain Training?, Virtual Reality (47:22) Nutrition, Processed Foods; Supplementation, Creatine, Caffeine, Alpha-GPC (55:02) Supplements & Trade-Offs, Subjective Effects, Sleep (1:00:55) Brain Fog, Subjective Cognitive Decline (1:04:34) Three ‘S’ Model & Cognitive Health, Brain Fog (1:10:47) Recap: Improve Cognitive Function & Reduce Brain Fog; Hydration (1:13:33) Sponsor: Renaissance Periodization (1:14:38) Vision Assessment, Tool: Vision Training (1:21:54) Vitamin A, Antioxidants, Supplement Use (1:24:39) Creatine, Caffeine & Sleep Deficits; Methylation, Homocysteine, B Vitamins (1:35:30) Cognitive Function & Creatine Benefits; What is Methylation?, Epigenetics (1:39:50) Creatine & Short-Term Energy, Lactate (1:45:45) Sponsor: Momentous (1:47:12) What is a Concussion?, Egg Analogy (1:51:26) Traumatic Brain Injury (TBI), Lactate & Ketones (1:54:43) TBI, Inflammation, Metabolic Changes, Mitochondria (2:00:40) Acute Treatment & TBIs; Testing for TBI, Cognitive Tests, EEG Technology (2:08:58) Calcium Supplementation?, Vitamin D, Magnesium (2:13:18) Dementia & Late-Onset Alzheimer’s, Prevention? Reversal?, Tool: Modifiable Risk Factors (2:19:08) Education & Peak Cognitive Function, Dementia, Stimulating Job (2:25:59) Sensory Inputs & Dementia, Tool: Being in Nature (2:28:44) Exercise & Dementia, Tool: Resistance & High Intensity Training (2:35:50) Tool: Designing Exercise Protocol for Brain Health (2:39:15) Muscle Strength, Cognitive Function & Overall Brain Health, Mechanism (2:44:49) White Matter, Exercise, Energetic Processes (2:49:39) Alzheimer’s Disease, Tau, Amyloids, Markers of Brain Aging (2:55:40) Recap; Tommy’s Projects & Links (3:01:50) Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media, Perform Newsletter Includes paid partnerships.

Andy Galpin, PhD

86,269 views • 1 year ago

The new Huberman Lab episode is out: Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood (Tommy Wood MD, PhD) 0:00 Tommy Wood 4:05 Neuroplasticity; Neurogenesis; Synaptic Pruning 11:11 Aging & Neuroplasticity; Familiar vs Novel Tasks 14:33 Protocols Book; Sponsor: David 16:49 Aging, Training & Processing Speed 21:56 Enhancing Neuroplasticity with Age, Tool: Motor & Cognitive Challenge 26:56 Learning New Skills, Dance, Sports, Arts; Psychological Benefits of Challenge 36:50 Flow, Clutch States; Virtuosity 46:59 Power of Practice 50:55 Sponsor: AG1 52:14 Tools for Focused Work & Learning; Distractions 1:00:17 Nutrition for Brain Health, Dementia; Critical Nutrients 1:06:56 Nutrient Timing, Supplementation; Omega-3s, Tool: Blood Tests 1:16:41 Sponsor: Function 1:18:19 Enhancing Brain Health, Nutrition & Supplements 1:23:10 GLP-1s, Peptides, Supplements & Evaluating Efficacy 1:32:56 Stimulants: Feeling vs Performance 1:37:18 Exercise & Enhancing Cognitive Function, Tool: Optimize Exercise Volume 1:43:18 Long-Term Cognitive Health & Exercise, HIIT 1:47:17 Sponsor: Rorra 1:48:31 Cortisol Benefits, Acute vs Chronic Stress 1:54:24 Resistance & Aerobic Exercise, Brain Gray & White Matter, Cognitive Health 2:03:37 Cognitive Decline, Dementia, Alzheimer's Disease, Modifiable Risk Factors 2:09:47 Shingles Vaccine & Dementia Risk; Tool: Avoid Illness for Cognitive Health 2:18:28 Concussion, Traumatic Brain Injury (TBI), Creatine 2:24:04 Treating TBI, Supplements, Physical Therapy 2:32:16 Strongman Competition 2:38:51 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.
2:41:25

The new Huberman Lab episode is out: Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood (Tommy Wood MD, PhD) 0:00 Tommy Wood 4:05 Neuroplasticity; Neurogenesis; Synaptic Pruning 11:11 Aging & Neuroplasticity; Familiar vs Novel Tasks 14:33 Protocols Book; Sponsor: David 16:49 Aging, Training & Processing Speed 21:56 Enhancing Neuroplasticity with Age, Tool: Motor & Cognitive Challenge 26:56 Learning New Skills, Dance, Sports, Arts; Psychological Benefits of Challenge 36:50 Flow, Clutch States; Virtuosity 46:59 Power of Practice 50:55 Sponsor: AG1 52:14 Tools for Focused Work & Learning; Distractions 1:00:17 Nutrition for Brain Health, Dementia; Critical Nutrients 1:06:56 Nutrient Timing, Supplementation; Omega-3s, Tool: Blood Tests 1:16:41 Sponsor: Function 1:18:19 Enhancing Brain Health, Nutrition & Supplements 1:23:10 GLP-1s, Peptides, Supplements & Evaluating Efficacy 1:32:56 Stimulants: Feeling vs Performance 1:37:18 Exercise & Enhancing Cognitive Function, Tool: Optimize Exercise Volume 1:43:18 Long-Term Cognitive Health & Exercise, HIIT 1:47:17 Sponsor: Rorra 1:48:31 Cortisol Benefits, Acute vs Chronic Stress 1:54:24 Resistance & Aerobic Exercise, Brain Gray & White Matter, Cognitive Health 2:03:37 Cognitive Decline, Dementia, Alzheimer's Disease, Modifiable Risk Factors 2:09:47 Shingles Vaccine & Dementia Risk; Tool: Avoid Illness for Cognitive Health 2:18:28 Concussion, Traumatic Brain Injury (TBI), Creatine 2:24:04 Treating TBI, Supplements, Physical Therapy 2:32:16 Strongman Competition 2:38:51 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

Andrew D. Huberman, Ph.D.

104,487 views • 11 days ago

Is there any amount of alcohol that is beneficial? My latest episode delves into its detrimental effects on brain volume loss, neuroinflammation risks via gut-brain axis disruption, and the credibility of mitigation strategies and hangover "cures." We also explore how alcohol affects brain function, sleep, glucose regulation, cardiovascular health, cancer risk, exercise adaptations, potentially heritable epigenetic changes, and more. Whether you avoid alcohol, drink a little too much, or fall somewhere in between, this comprehensive episode has valuable information for everyone. Timestamps: 0:00 - Introduction 2:19 - What does it mean to "have a drink"? 3:55 - Drinking frequency definitions 6:55 - How alcohol is metabolized 10:47 - How genetics affect alcohol metabolism 12:41 - Can alcoholism be inherited? 13:58 - How food affects alcohol metabolism 15:57 - Does age affect alcohol metabolism? 16:46 - How alcohol affects micronutrient absorption 21:22 - How alcohol affects gut health 23:15 - Alcohol elevates circulating LPS levels 26:09 - Gut health & alcohol use disorders 30:49 - Sick quitter & healthy user biases 33:57 - How alcohol impacts the brain 37:53 - Alcohol's effects on anxiety 42:09 - Brain volume loss from alcohol 44:16 - Alcohol facilitates vitamin B1 deficiency 46:00 - Alcohol promotes brain inflammation 47:16 - Dementia & Alzheimer's disease risk 53:19 - Impact on APOE4 carriers 57:28 - Alcohol and brain health mechanisms 1:01:11 - Is resveratrol in red wine beneficial? 1:05:50 - Detailing the sleep stages 1:09:11 - How alcohol impacts sleep 1:12:44 - Alcohol worsens sleep apnea 1:14:10 - Reducing impact on sleep 1:16:37 - Hangover symptoms & causes 1:20:56 - How different alcohol types affect hangover severity 1:22:22 - Treating hangovers with fruit 1:25:05 - Zinc, vitamin B3, & hangovers 1:26:05 - Managing hangovers with NSAIDs 1:26:46 - "Hair of the dog” for hangovers 1:27:05 - Liposomal glutathione, NAC, & hangovers 1:30:21 - Does ZBiotics credibly prevent hangovers? 1:32:43 - Dihydromyricetin (DHM) for hangovers 1:33:41 - Exercise & sauna for treating hangovers 1:34:47 - Does alcohol cause early death? 1:38:54 - Alcohol consumption in Blue Zones 1:52:18 - Genetics, alcohol, & cancer risk 1:55:10 - Can quitting alcohol lower cancer risk? 1:57:15 - Cancer-causing mechanisms 2:04:15 - Alcohol & cardiovascular disease (CVD) 2:11:42 - Mechanisms of cardiovascular disease 2:15:55 - Industry funding in alcohol research 2:17:54 - Type 2 diabetes risk 2:20:08 - How alcohol affects blood glucose 2:22:58 - Alcohol's impact on your waistline 2:26:04 - Why alcohol facilitates weight gain 2:28:37 - How alcohol impacts reproductive health 2:31:29 - Fertility impacts of alcohol in females 2:37:27 - How alcohol impacts fertility in males 2:39:03 - Preconception alcohol risks 2:41:44 - How alcohol affects testosterone in men 2:43:27 - Pre-pregnancy alcohol consumption risks 2:47:49 - Is red wine the healthiest option? 2:51:19 - Headaches after drinking red wine 2:52:20 - Alcohol & post-exercise recovery 2:56:08 - Does alcohol "blunt your gains"? 2:58:45 - How alcohol affects VO2 max 2:59:36 - Can exercise lessen alcohol cravings? 3:02:34 - FGF21, exercise, and alcohol intake 3:07:32 - Alcohol damage control tactics This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment.
3:15:46

Is there any amount of alcohol that is beneficial? My latest episode delves into its detrimental effects on brain volume loss, neuroinflammation risks via gut-brain axis disruption, and the credibility of mitigation strategies and hangover "cures." We also explore how alcohol affects brain function, sleep, glucose regulation, cardiovascular health, cancer risk, exercise adaptations, potentially heritable epigenetic changes, and more. Whether you avoid alcohol, drink a little too much, or fall somewhere in between, this comprehensive episode has valuable information for everyone. Timestamps: 0:00 - Introduction 2:19 - What does it mean to "have a drink"? 3:55 - Drinking frequency definitions 6:55 - How alcohol is metabolized 10:47 - How genetics affect alcohol metabolism 12:41 - Can alcoholism be inherited? 13:58 - How food affects alcohol metabolism 15:57 - Does age affect alcohol metabolism? 16:46 - How alcohol affects micronutrient absorption 21:22 - How alcohol affects gut health 23:15 - Alcohol elevates circulating LPS levels 26:09 - Gut health & alcohol use disorders 30:49 - Sick quitter & healthy user biases 33:57 - How alcohol impacts the brain 37:53 - Alcohol's effects on anxiety 42:09 - Brain volume loss from alcohol 44:16 - Alcohol facilitates vitamin B1 deficiency 46:00 - Alcohol promotes brain inflammation 47:16 - Dementia & Alzheimer's disease risk 53:19 - Impact on APOE4 carriers 57:28 - Alcohol and brain health mechanisms 1:01:11 - Is resveratrol in red wine beneficial? 1:05:50 - Detailing the sleep stages 1:09:11 - How alcohol impacts sleep 1:12:44 - Alcohol worsens sleep apnea 1:14:10 - Reducing impact on sleep 1:16:37 - Hangover symptoms & causes 1:20:56 - How different alcohol types affect hangover severity 1:22:22 - Treating hangovers with fruit 1:25:05 - Zinc, vitamin B3, & hangovers 1:26:05 - Managing hangovers with NSAIDs 1:26:46 - "Hair of the dog” for hangovers 1:27:05 - Liposomal glutathione, NAC, & hangovers 1:30:21 - Does ZBiotics credibly prevent hangovers? 1:32:43 - Dihydromyricetin (DHM) for hangovers 1:33:41 - Exercise & sauna for treating hangovers 1:34:47 - Does alcohol cause early death? 1:38:54 - Alcohol consumption in Blue Zones 1:52:18 - Genetics, alcohol, & cancer risk 1:55:10 - Can quitting alcohol lower cancer risk? 1:57:15 - Cancer-causing mechanisms 2:04:15 - Alcohol & cardiovascular disease (CVD) 2:11:42 - Mechanisms of cardiovascular disease 2:15:55 - Industry funding in alcohol research 2:17:54 - Type 2 diabetes risk 2:20:08 - How alcohol affects blood glucose 2:22:58 - Alcohol's impact on your waistline 2:26:04 - Why alcohol facilitates weight gain 2:28:37 - How alcohol impacts reproductive health 2:31:29 - Fertility impacts of alcohol in females 2:37:27 - How alcohol impacts fertility in males 2:39:03 - Preconception alcohol risks 2:41:44 - How alcohol affects testosterone in men 2:43:27 - Pre-pregnancy alcohol consumption risks 2:47:49 - Is red wine the healthiest option? 2:51:19 - Headaches after drinking red wine 2:52:20 - Alcohol & post-exercise recovery 2:56:08 - Does alcohol "blunt your gains"? 2:58:45 - How alcohol affects VO2 max 2:59:36 - Can exercise lessen alcohol cravings? 3:02:34 - FGF21, exercise, and alcohol intake 3:07:32 - Alcohol damage control tactics This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment.

Dr. Rhonda Patrick

154,859 views • 2 years ago

The new Huberman Lab episode is out: Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray (Tony Wyss-Coray) 0:00 Tony Wyss-Coray 3:00 Young vs Old Animals, Age-Related Disease 6:35 Blood Biomarkers, Young vs Old Humans, Alzheimer's Disease 12:50 Sponsors: David & LMNT 15:28 'Young Blood' Factors, Rejuvenation, Stem Cells 20:15 Blood Banking; Dracula 23:10 Rates of Aging in Organs, Age Gap & Disease Risk; Risk Profiles & Therapies 33:02 NAD Levels & Aging, NMN Supplements 36:44 Vitality vs Longevity; Periods of Accelerated Aging 43:17 Sponsors: AG1 & Roka 45:22 Sunlight; Youthful Blood Factors, Exercise & Brain Function, Fasting 51:25 Exercise, Injury & Inflammation 56:18 Pro-health Factors, Klotho, GDF11, Stem Cell Injection Risk 1:02:35 Platelet-Rich Plasma (PRP); Exosomes 1:05:43 Smoking, EMFs, Plastics, Long-Term Accumulation, Fresh Foods, Organic Food 1:11:28 Sponsor: Function 1:13:16 Intermittent Fasting, Long-Term Fasting, Snacking 1:19:07 Sleep; Cerebrospinal Fluid (CSF) Factors & Cognitive Function 1:24:44 Exercise Type & Longevity; Exercise Enjoyment 1:32:02 Lifestyle Factors & Alzheimer's Risk; Cognitive Exercise; Chocolate 1:37:05 Alcohol & Social Connection; US vs European Food Culture 1:40:50 Deliberate Deep Breathing; Wearables, Sunlight & Artificial Light 1:49:13 Future Projects 1:56:40 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.
1:59:13

The new Huberman Lab episode is out: Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray (Tony Wyss-Coray) 0:00 Tony Wyss-Coray 3:00 Young vs Old Animals, Age-Related Disease 6:35 Blood Biomarkers, Young vs Old Humans, Alzheimer's Disease 12:50 Sponsors: David & LMNT 15:28 'Young Blood' Factors, Rejuvenation, Stem Cells 20:15 Blood Banking; Dracula 23:10 Rates of Aging in Organs, Age Gap & Disease Risk; Risk Profiles & Therapies 33:02 NAD Levels & Aging, NMN Supplements 36:44 Vitality vs Longevity; Periods of Accelerated Aging 43:17 Sponsors: AG1 & Roka 45:22 Sunlight; Youthful Blood Factors, Exercise & Brain Function, Fasting 51:25 Exercise, Injury & Inflammation 56:18 Pro-health Factors, Klotho, GDF11, Stem Cell Injection Risk 1:02:35 Platelet-Rich Plasma (PRP); Exosomes 1:05:43 Smoking, EMFs, Plastics, Long-Term Accumulation, Fresh Foods, Organic Food 1:11:28 Sponsor: Function 1:13:16 Intermittent Fasting, Long-Term Fasting, Snacking 1:19:07 Sleep; Cerebrospinal Fluid (CSF) Factors & Cognitive Function 1:24:44 Exercise Type & Longevity; Exercise Enjoyment 1:32:02 Lifestyle Factors & Alzheimer's Risk; Cognitive Exercise; Chocolate 1:37:05 Alcohol & Social Connection; US vs European Food Culture 1:40:50 Deliberate Deep Breathing; Wearables, Sunlight & Artificial Light 1:49:13 Future Projects 1:56:40 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

Andrew D. Huberman, Ph.D.

432,394 views • 5 months ago

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging
2:39:14

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging

Dr. Rhonda Patrick

86,945 views • 1 month ago

NEW EPISODE WITH Peter Attia Can we age more slowly and evade or forestall the diseases of aging? In today’s episode, the brilliant Peter Attia equips us with some of his favorite strategies and tools designed to delay or potentially prevent cardiovascular disease, cancer, and Alzheimer’s disease, aiming to preserve health, longevity, and ultimately win the ‘centenarian olympics.’ TIMESTAMPS: (00:08:02) What is cholesterol? (00:15:03) Why ApoB is a superior predictor of cardiovascular disease over LDL particle number (00:33:31) Whether there’s an ApoB level low enough that it’s impossible to die from atherosclerosis (00:37:20) Which dietary factors increase ApoB (00:51:04) Whether or not low LDL is a risk for cancer – and a variety of other surprising facts about LDL biology you really can’t find anywhere else (00:56:52) How statins and other lipid-lowering pharmacotherapies work, including their side effects and costs (01:23:51) Statin alternatives pros & cons: PCSK9 inhibitors, ezetimibe, & bempedoic acid (01:36:35) How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it (01:52:28) Peter’s 80% zone 2 / 20% VO2 max training protocol (02:08:08) The danger of visceral fat and why it correlates with increased cancer risk (02:12:03) Benefits & risks of aggressive cancer screening (02:24:49) Recommended mammogram & ultrasound frequency for women (02:31:41) Radiation from CT scans & mammograms (02:37:27) Menopause (hormonal changes, hot flashes, sexual changes, & bone loss) & hormone replacement therapy (02:59:57) How hormone replacement affects dementia, cancer, & heart disease risk in women (03:05:35) Vitamin D: Sunlight vs. supplements & optimal levels (03:23:01) Is it safe for a woman who’s 10 years post-menopause to do HRT? (03:21:45) Why symptoms of low testosterone are often more important than the actual levels when deciding whether or not to go on TRT (03:28:07) Why Peter’s recommended TRT dosing schedule differs from the standard (03:37:00) Methods for lowering blood pressure: exercise, nitrates, hot tubs, & cocoa flavanols (03:49:44) Peter’s exercise, sleep, nutrition, & alcohol routines for optimizing longevity You can find Dr. Peter Attia's book "Outlive: The Science and Art of Longevity” here: Full episode available on YouTube and where ever podcasts can be downloaded:
3:00:10

NEW EPISODE WITH Peter Attia Can we age more slowly and evade or forestall the diseases of aging? In today’s episode, the brilliant Peter Attia equips us with some of his favorite strategies and tools designed to delay or potentially prevent cardiovascular disease, cancer, and Alzheimer’s disease, aiming to preserve health, longevity, and ultimately win the ‘centenarian olympics.’ TIMESTAMPS: (00:08:02) What is cholesterol? (00:15:03) Why ApoB is a superior predictor of cardiovascular disease over LDL particle number (00:33:31) Whether there’s an ApoB level low enough that it’s impossible to die from atherosclerosis (00:37:20) Which dietary factors increase ApoB (00:51:04) Whether or not low LDL is a risk for cancer – and a variety of other surprising facts about LDL biology you really can’t find anywhere else (00:56:52) How statins and other lipid-lowering pharmacotherapies work, including their side effects and costs (01:23:51) Statin alternatives pros & cons: PCSK9 inhibitors, ezetimibe, & bempedoic acid (01:36:35) How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it (01:52:28) Peter’s 80% zone 2 / 20% VO2 max training protocol (02:08:08) The danger of visceral fat and why it correlates with increased cancer risk (02:12:03) Benefits & risks of aggressive cancer screening (02:24:49) Recommended mammogram & ultrasound frequency for women (02:31:41) Radiation from CT scans & mammograms (02:37:27) Menopause (hormonal changes, hot flashes, sexual changes, & bone loss) & hormone replacement therapy (02:59:57) How hormone replacement affects dementia, cancer, & heart disease risk in women (03:05:35) Vitamin D: Sunlight vs. supplements & optimal levels (03:23:01) Is it safe for a woman who’s 10 years post-menopause to do HRT? (03:21:45) Why symptoms of low testosterone are often more important than the actual levels when deciding whether or not to go on TRT (03:28:07) Why Peter’s recommended TRT dosing schedule differs from the standard (03:37:00) Methods for lowering blood pressure: exercise, nitrates, hot tubs, & cocoa flavanols (03:49:44) Peter’s exercise, sleep, nutrition, & alcohol routines for optimizing longevity You can find Dr. Peter Attia's book "Outlive: The Science and Art of Longevity” here: Full episode available on YouTube and where ever podcasts can be downloaded:

Dr. Rhonda Patrick

340,320 views • 2 years ago

Most of us don’t have a slow metabolism, and are far from overtraining. The real issue is people underestimate their calorie intake, confuse discomfort with "failure," and just don't do the work. New episode with Dr. Layne Norton (Layne Norton, PhD), a Ph.D. scientist, professional bodybuilder, and champion powerlifter who deadlifts over 700 pounds. We discuss: • When to push to failure • Whether seed oils promote chronic disease (and how) • Why good habits beat perfectionism • Layne’s approach to eating, training, and supplementation. Plus, we tackle hot topics like the carnivore diet, artificial sweeteners, intermittent fasting, and more. This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 2:30 - Layne's coaching philosophy 12:22 - Why to start tracking calories (for at least 3 days) 15:24 - Why people mislead themselves about food intake 20:49 - Exercise vs. SSRIs 24:35 - Treat exercise like brushing your teeth 27:53 - Why old people should lift 31:34 - Should you train to failure? 44:50 - Exercise selection 54:29 - Is lifting heavy necessary? 55:37 - Barbell vs. hack squats for preventing falls 57:53 - Why lifting weights decreases lower back pain 59:26 - How to prevent and overcome training injuries 1:08:59 - Why 'exposure therapy' promotes recovery 1:12:47 - Why pain doesn't always indicate tissue injury 1:16:00 - Why and how to train after poor sleep 1:19:40 - Why menopause can cause weight gain 1:27:19 - Why it's never too late to start lifting weights 1:29:48 - Training tips for older people with joint pain 1:34:01 - Total protein intake vs. distribution 1:42:02 - Layne's daily protein distribution 1:44:27 - The shortcomings of nutrition studies 1:51:49 - Is consuming more than 1.6 g/kg of protein beneficial? 1:53:16 - Protein consumption in a calorie deficit 1:54:26 - Protein intake for endurance athletes 1:55:50 - How much protein does Layne eat? 1:56:54 - Are seed oils a predominant cause of disease? 2:01:15 - Saturated fat vs. seed oils 2:06:28 - Is the carnivore diet an LDL cholesterol catastrophe? 2:11:59 - Why heating seeds oil makes them inflammatory 2:18:16 - Is there a "big food" industry conspiracy? 2:24:00 - Sugar-sweetened beverages 2:28:00 - Can diet soda help you lose weight? 2:32:03 - Diet soda (cancer and microbiome) 2:42:07 - Why Layne rarely takes a strong position on early science 2:46:47 - Carnivore diet 2:59:35 - Time-restricted eating and fasting 3:10:21 - Layne's daily routine 3:14:38 - Layne's diet and supplements 3:16:21 - Why everyone should take creatine 3:20:32 - Rhodiola rosea 3:22:03 - Ashwagandha 3:23:37 - Promising supplements (need more evidence)
3:31:06

Most of us don’t have a slow metabolism, and are far from overtraining. The real issue is people underestimate their calorie intake, confuse discomfort with "failure," and just don't do the work. New episode with Dr. Layne Norton (Layne Norton, PhD), a Ph.D. scientist, professional bodybuilder, and champion powerlifter who deadlifts over 700 pounds. We discuss: • When to push to failure • Whether seed oils promote chronic disease (and how) • Why good habits beat perfectionism • Layne’s approach to eating, training, and supplementation. Plus, we tackle hot topics like the carnivore diet, artificial sweeteners, intermittent fasting, and more. This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 2:30 - Layne's coaching philosophy 12:22 - Why to start tracking calories (for at least 3 days) 15:24 - Why people mislead themselves about food intake 20:49 - Exercise vs. SSRIs 24:35 - Treat exercise like brushing your teeth 27:53 - Why old people should lift 31:34 - Should you train to failure? 44:50 - Exercise selection 54:29 - Is lifting heavy necessary? 55:37 - Barbell vs. hack squats for preventing falls 57:53 - Why lifting weights decreases lower back pain 59:26 - How to prevent and overcome training injuries 1:08:59 - Why 'exposure therapy' promotes recovery 1:12:47 - Why pain doesn't always indicate tissue injury 1:16:00 - Why and how to train after poor sleep 1:19:40 - Why menopause can cause weight gain 1:27:19 - Why it's never too late to start lifting weights 1:29:48 - Training tips for older people with joint pain 1:34:01 - Total protein intake vs. distribution 1:42:02 - Layne's daily protein distribution 1:44:27 - The shortcomings of nutrition studies 1:51:49 - Is consuming more than 1.6 g/kg of protein beneficial? 1:53:16 - Protein consumption in a calorie deficit 1:54:26 - Protein intake for endurance athletes 1:55:50 - How much protein does Layne eat? 1:56:54 - Are seed oils a predominant cause of disease? 2:01:15 - Saturated fat vs. seed oils 2:06:28 - Is the carnivore diet an LDL cholesterol catastrophe? 2:11:59 - Why heating seeds oil makes them inflammatory 2:18:16 - Is there a "big food" industry conspiracy? 2:24:00 - Sugar-sweetened beverages 2:28:00 - Can diet soda help you lose weight? 2:32:03 - Diet soda (cancer and microbiome) 2:42:07 - Why Layne rarely takes a strong position on early science 2:46:47 - Carnivore diet 2:59:35 - Time-restricted eating and fasting 3:10:21 - Layne's daily routine 3:14:38 - Layne's diet and supplements 3:16:21 - Why everyone should take creatine 3:20:32 - Rhodiola rosea 3:22:03 - Ashwagandha 3:23:37 - Promising supplements (need more evidence)

Dr. Rhonda Patrick

228,403 views • 1 year ago

New episode featuring Stanford professor, neurobiologist, and host of the incredibly popular Huberman Lab Podcast, Dr. Andrew Huberman (Andrew D. Huberman, Ph.D.). What makes Andrew truly exceptional is his ability to translate scientific findings into practical, actionable advice, enabling listeners to leverage new understandings of biology and neurobiology to improve their lives. In this episode, Dr. Huberman showcases his truly immense knowledge of the brain's dopamine system, which is incredibly central to many modern issues of motivation and attention that many of us struggle with. The public perception of Dr. Huberman's work often focuses on his unique distillations of protocols, but what I particularly enjoyed about this conversation was finding a common thread: the benefit of having an essential life philosophy of valuing "hard effort" over outcomes, something Andrew refers to as "forward center of mass." This podcast explains down to a neurobiological level why embracing discomfort can activate our motivation circuits, elevate dopamine and other catecholamine levels, and retrain brain regions like the anterior midcingulate cortex, ultimately growing our capacity for effort and striving at a fundamental level. A big thank you to Andrew for equipping us with this knowledge, enabling us to apply these insights for individual personal and professional growth. This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 2:37 - The neuromodulatory role of dopamine 4:29 - Driver of motivation vs. experiencing reward 9:35 - Why dopamine dynamics act as a "wave pool" 13:15 - Why dopamine neurons need a recovery period 18:32 - Why dopamine peaks without effort are dangerous 21:52 - The number one sign of a highly motivated individual 23:59 - Dopamine reward-prediction error 26:18 - How effort and anticipation influence dopamine release 28:21 - Does lacking motivation reflect dopamine system deficits? 33:00 - Why motivation has a 'warm-up' period 37:16 - Why to attach reward to effort itself 47:51 - Tips for fostering tenacity in children 50:05 - Visualization of negative outcomes (why to do it) 52:51 - How to overcome procrastination 58:51 - How exercise affects the dopamine system 1:03:35 - Cold exposure vs. drug highs 1:05:29 - The entrainment effect of same-time exercise 1:09:24 - Why you shouldn't rely on stimulants 1:16:52 - "Counting walls" during deliberate cold exposure 1:21:44 - Cold exposure parameters for increasing dopamine 1:24:18 - Cold plunge alternatives for replenishing dopamine 1:25:35 - Why Andrew limits most workouts to 80-85% intensity 1:28:37 - Using exercise & cold exposure as stimuli for the brain 1:31:08 - Why "hard efforts" retrain the brain to overcome 1:33:31 - tMS and ultrasound as neuromodulatory therapies 1:36:22 - What does Dr. Huberman think of Neuralink? 1:38:02 - Advantages of neuromodulation over pharmacotherapy 1:39:28 - Why non-sleep deep rest may replenish dopamine 1:49:45 - My experience trying NSDR after poor sleep 1:51:04 - The ‘body still, mind active’ state for creativity 1:54:15 - How to cultivate a healthy relationship with social media 2:00:44 - The unique psychosocial dynamics of X (formerly Twitter) 2:02:05 - Andrew's recommended daily use limit for Instagram 2:04:09 - Does Lex Fridman have a symbiotic relationship with X? 2:04:39 - Is screen time increasing the prevalence of ADHD? 2:06:20 - Why Andrew recommends setting social media constraints 2:09:32 - Is social media increasing divorce rates? 2:12:12 - How low solar angle sunlight affects the circadian rhythm 2:22:10 - Limiting the adverse effects of late-night artificial light 2:23:57 - The light bulb that mimics sunrise and sunset 2:25:09 - How to spike morning cortisol by 50% (and why that's good) 2:26:21 - What's the optimal time to view morning sunlight? 2:27:11 - Can light panels replace morning sunlight? 2:28:33 - Combatting laptop & phone use with long distance viewing 2:30:00 - Why two hours outdoors daily may prevent myopia 2:35:06 - Why Andrew recommends limiting alcohol to 0-2 drinks per week 2:43:09 - How alcohol affects the dopamine and serotonin systems 2:48:47 - Treating ADHD with drugs, supplements, & behaviors 2:53:30 - Why studies on school start age suggest ADHD is overdiagnosed 3:00:00 - Andrew's weekly workout routine 3:13:14 - Why a disciplined life is not a deprived life 3:05:43 - Andrew's diet & why his dinners are higher in carbs 3:06:39 - The science of the physiological sigh3:07:34 - Andrew's supplement routine 3:10:00 - Andrew's experimentation with peptides 3:15:10 - How Andrew processes sometimes negative feedback 3:20:30 - The volatility of interacting with internet crowds
3:24:33

New episode featuring Stanford professor, neurobiologist, and host of the incredibly popular Huberman Lab Podcast, Dr. Andrew Huberman (Andrew D. Huberman, Ph.D.). What makes Andrew truly exceptional is his ability to translate scientific findings into practical, actionable advice, enabling listeners to leverage new understandings of biology and neurobiology to improve their lives. In this episode, Dr. Huberman showcases his truly immense knowledge of the brain's dopamine system, which is incredibly central to many modern issues of motivation and attention that many of us struggle with. The public perception of Dr. Huberman's work often focuses on his unique distillations of protocols, but what I particularly enjoyed about this conversation was finding a common thread: the benefit of having an essential life philosophy of valuing "hard effort" over outcomes, something Andrew refers to as "forward center of mass." This podcast explains down to a neurobiological level why embracing discomfort can activate our motivation circuits, elevate dopamine and other catecholamine levels, and retrain brain regions like the anterior midcingulate cortex, ultimately growing our capacity for effort and striving at a fundamental level. A big thank you to Andrew for equipping us with this knowledge, enabling us to apply these insights for individual personal and professional growth. This episode is available on X, YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 2:37 - The neuromodulatory role of dopamine 4:29 - Driver of motivation vs. experiencing reward 9:35 - Why dopamine dynamics act as a "wave pool" 13:15 - Why dopamine neurons need a recovery period 18:32 - Why dopamine peaks without effort are dangerous 21:52 - The number one sign of a highly motivated individual 23:59 - Dopamine reward-prediction error 26:18 - How effort and anticipation influence dopamine release 28:21 - Does lacking motivation reflect dopamine system deficits? 33:00 - Why motivation has a 'warm-up' period 37:16 - Why to attach reward to effort itself 47:51 - Tips for fostering tenacity in children 50:05 - Visualization of negative outcomes (why to do it) 52:51 - How to overcome procrastination 58:51 - How exercise affects the dopamine system 1:03:35 - Cold exposure vs. drug highs 1:05:29 - The entrainment effect of same-time exercise 1:09:24 - Why you shouldn't rely on stimulants 1:16:52 - "Counting walls" during deliberate cold exposure 1:21:44 - Cold exposure parameters for increasing dopamine 1:24:18 - Cold plunge alternatives for replenishing dopamine 1:25:35 - Why Andrew limits most workouts to 80-85% intensity 1:28:37 - Using exercise & cold exposure as stimuli for the brain 1:31:08 - Why "hard efforts" retrain the brain to overcome 1:33:31 - tMS and ultrasound as neuromodulatory therapies 1:36:22 - What does Dr. Huberman think of Neuralink? 1:38:02 - Advantages of neuromodulation over pharmacotherapy 1:39:28 - Why non-sleep deep rest may replenish dopamine 1:49:45 - My experience trying NSDR after poor sleep 1:51:04 - The ‘body still, mind active’ state for creativity 1:54:15 - How to cultivate a healthy relationship with social media 2:00:44 - The unique psychosocial dynamics of X (formerly Twitter) 2:02:05 - Andrew's recommended daily use limit for Instagram 2:04:09 - Does Lex Fridman have a symbiotic relationship with X? 2:04:39 - Is screen time increasing the prevalence of ADHD? 2:06:20 - Why Andrew recommends setting social media constraints 2:09:32 - Is social media increasing divorce rates? 2:12:12 - How low solar angle sunlight affects the circadian rhythm 2:22:10 - Limiting the adverse effects of late-night artificial light 2:23:57 - The light bulb that mimics sunrise and sunset 2:25:09 - How to spike morning cortisol by 50% (and why that's good) 2:26:21 - What's the optimal time to view morning sunlight? 2:27:11 - Can light panels replace morning sunlight? 2:28:33 - Combatting laptop & phone use with long distance viewing 2:30:00 - Why two hours outdoors daily may prevent myopia 2:35:06 - Why Andrew recommends limiting alcohol to 0-2 drinks per week 2:43:09 - How alcohol affects the dopamine and serotonin systems 2:48:47 - Treating ADHD with drugs, supplements, & behaviors 2:53:30 - Why studies on school start age suggest ADHD is overdiagnosed 3:00:00 - Andrew's weekly workout routine 3:13:14 - Why a disciplined life is not a deprived life 3:05:43 - Andrew's diet & why his dinners are higher in carbs 3:06:39 - The science of the physiological sigh3:07:34 - Andrew's supplement routine 3:10:00 - Andrew's experimentation with peptides 3:15:10 - How Andrew processes sometimes negative feedback 3:20:30 - The volatility of interacting with internet crowds

Dr. Rhonda Patrick

333,877 views • 2 years ago

New episode on the science of protein. Protein is fundamental to our survival, fueling the processes that build, repair, and maintain every tissue in the body—including the brain. But how much is truly optimal, and are there risks to consuming too much? By the end of this episode, you'll have evidence-based tools to leverage protein for muscle, performance, and longevity. Episode 97 available now on X, YouTube, Spotify, and Apple Podcasts. Timestamps: 0:00 - Introduction 2:47 - Why muscle matters 5:12 - Why do we lose muscle? 6:46 - Negating anabolic resistance 7:39 - Why it's never too late to build muscle 8:20 - Requirements for overweight individuals 9:07 - Flaws of the RDA 10:27 - Optimal intake when resistance training 11:10 - What to do when losing weight 12:23 - Does protein harm healthy kidneys? 14:14 - How important is distribution? 16:26 - Debunking the "anabolic window" 18:03 - Benefits of pre-sleep intake 19:35 - Timing & distribution takeaways 20:16 - What are the best sources? 23:20 - Animal vs. plant protein 25:42 - Protein supplements 27:12 - Does high intake accelerate aging? 30:47 - Why exercise changes the story 33:17 - What we can learn from athletes 33:51 - Does high intake promote atherosclerosis? 36:06 - 8 key takeaways
40:09

New episode on the science of protein. Protein is fundamental to our survival, fueling the processes that build, repair, and maintain every tissue in the body—including the brain. But how much is truly optimal, and are there risks to consuming too much? By the end of this episode, you'll have evidence-based tools to leverage protein for muscle, performance, and longevity. Episode 97 available now on X, YouTube, Spotify, and Apple Podcasts. Timestamps: 0:00 - Introduction 2:47 - Why muscle matters 5:12 - Why do we lose muscle? 6:46 - Negating anabolic resistance 7:39 - Why it's never too late to build muscle 8:20 - Requirements for overweight individuals 9:07 - Flaws of the RDA 10:27 - Optimal intake when resistance training 11:10 - What to do when losing weight 12:23 - Does protein harm healthy kidneys? 14:14 - How important is distribution? 16:26 - Debunking the "anabolic window" 18:03 - Benefits of pre-sleep intake 19:35 - Timing & distribution takeaways 20:16 - What are the best sources? 23:20 - Animal vs. plant protein 25:42 - Protein supplements 27:12 - Does high intake accelerate aging? 30:47 - Why exercise changes the story 33:17 - What we can learn from athletes 33:51 - Does high intake promote atherosclerosis? 36:06 - 8 key takeaways

Dr. Rhonda Patrick

141,365 views • 1 year ago

The new Huberman Lab episode is out: The Best Vitality & Health Protocols | Dr. Rhonda Patrick (Dr. Rhonda Patrick) 0:00 Rhonda Patrick 2:40 Competition, Jumping Rope, Rope Flow 6:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 12:30 Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control 14:40 Sponsors: Our Place & Lingo 17:03 Phones While Training? 18:45 Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience 27:00 Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates 33:32 Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health 42:58 Sponsor: AG1 44:21 Tight Junctions, Gut, Neuroinflammation 47:26 L-glutamine, Immune System, Cancer Risk 54:55 N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress 1:00:08 Starch, Tool: Bedtime Fast & Cardiovascular Health 1:03:36 Cortisol, Intermittent Fasting Benefits 1:08:09 Cortisol, Train Fasted?; Hormones, Visceral Fat 1:13:35 Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body 1:21:13 Sponsor: LMNT 1:22:33 Cortisol & Sleep 1:25:42 Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? 1:36:47 Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy 1:45:06 Exercise After Poor Sleep?; Training Breaks 1:52:47 Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness 2:03:31 Sponsor: Function 2:05:16 Creatine, Dose, Resistance Training, Cognitive Function 2:17:43 Biology; Creatine; Supplement Safety 2:25:18 Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat 2:36:52 Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D 2:45:46 Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane 2:55:10 Microplastics 2:57:26 Sponsor: Mateina 2:58:28 BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources 3:06:28 L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet 3:15:20 Nattokinase; Microplastics, Water Bottles; Seed Oils 3:22:21 Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies 3:28:37 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.
3:31:07

The new Huberman Lab episode is out: The Best Vitality & Health Protocols | Dr. Rhonda Patrick (Dr. Rhonda Patrick) 0:00 Rhonda Patrick 2:40 Competition, Jumping Rope, Rope Flow 6:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 12:30 Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control 14:40 Sponsors: Our Place & Lingo 17:03 Phones While Training? 18:45 Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience 27:00 Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates 33:32 Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health 42:58 Sponsor: AG1 44:21 Tight Junctions, Gut, Neuroinflammation 47:26 L-glutamine, Immune System, Cancer Risk 54:55 N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress 1:00:08 Starch, Tool: Bedtime Fast & Cardiovascular Health 1:03:36 Cortisol, Intermittent Fasting Benefits 1:08:09 Cortisol, Train Fasted?; Hormones, Visceral Fat 1:13:35 Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body 1:21:13 Sponsor: LMNT 1:22:33 Cortisol & Sleep 1:25:42 Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? 1:36:47 Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy 1:45:06 Exercise After Poor Sleep?; Training Breaks 1:52:47 Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness 2:03:31 Sponsor: Function 2:05:16 Creatine, Dose, Resistance Training, Cognitive Function 2:17:43 Biology; Creatine; Supplement Safety 2:25:18 Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat 2:36:52 Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D 2:45:46 Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane 2:55:10 Microplastics 2:57:26 Sponsor: Mateina 2:58:28 BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources 3:06:28 L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet 3:15:20 Nattokinase; Microplastics, Water Bottles; Seed Oils 3:22:21 Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies 3:28:37 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

Andrew D. Huberman, Ph.D.

425,949 views • 4 months ago

Dr. Arthur Brooks has spent years studying happiness, meaning, and the habits that make life truly fulfilling. He makes a powerful case that happiness is not a feeling. It’s something deeper. Something built. In this episode, Dr. Arthur Brooks breaks down the science of happiness and explains why a good life is shaped by the three essential “macronutrients” of enjoyment, satisfaction, and meaning. He explains why pleasure alone is not enough, why struggle is necessary for fulfillment, and why many of the things we chase like money, status, comfort, and admiration, can quietly pull us away from what matters most. We also explore the hidden costs of modern technology, why boredom may actually be essential for reflection and purpose, and why service, beauty, and friendship are core ingredients of a meaningful life. Arthur shares practical ideas throughout, from his “reverse bucket list” to his mood-management protocol, tech hygiene rules, and strategies for avoiding relationship drift in marriage and friendship. If you want a richer framework for happiness—and practical tools for building more meaning, stronger relationships, and a more fulfilling life—this is an episode you won’t want to miss. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 2:04 - The happiness macronutrients 3:57 - Pleasure vs. enjoyment 8:08 - No struggle, no satisfaction 11:16 - The happiness paradox 13:38 - Why pleasure is better shared 16:17 - The lost art of boredom 20:47 - Striver's curse 24:19 - The four false idols 27:39 - What's secretly driving you? 37:10 - The reverse bucket list 39:19 - Training your gratitude muscle 44:01 - Raising grateful kids 46:29 - Emotional affect profiles 53:01 - Exercise as mood therapy 56:03 - Arthur's five-step daily protocol 1:00:19 - The meaning of life 1:03:56 - The left-brain trap 1:09:52 - Escaping the Matrix 1:14:50 - The beauty deficit 1:17:49 - Finding your ikigai 1:22:39 - When pain becomes growth 1:31:02 - Metacognition & emotional pain 1:33:37 - Reversing relationship drift 1:40:12 - Rethinking dating apps 1:45:16 - The friendship crisis 1:54:04 - Can happiness be learned? 1:57:14 - Pharmacological treatments 2:00:22 - Exercise vs. antidepressants 2:02:59 - The real value of a PhD 2:04:52 - Lifelong learning & aging 2:09:25 - Digital overload 2:11:52 - Curating your social feed 2:15:33 - Coping skills & happiness 2:16:21 - The power of love 2:17:51 - Real vs. deal marriages 2:19:23 - The second-half blueprint
2:29:04

Dr. Arthur Brooks has spent years studying happiness, meaning, and the habits that make life truly fulfilling. He makes a powerful case that happiness is not a feeling. It’s something deeper. Something built. In this episode, Dr. Arthur Brooks breaks down the science of happiness and explains why a good life is shaped by the three essential “macronutrients” of enjoyment, satisfaction, and meaning. He explains why pleasure alone is not enough, why struggle is necessary for fulfillment, and why many of the things we chase like money, status, comfort, and admiration, can quietly pull us away from what matters most. We also explore the hidden costs of modern technology, why boredom may actually be essential for reflection and purpose, and why service, beauty, and friendship are core ingredients of a meaningful life. Arthur shares practical ideas throughout, from his “reverse bucket list” to his mood-management protocol, tech hygiene rules, and strategies for avoiding relationship drift in marriage and friendship. If you want a richer framework for happiness—and practical tools for building more meaning, stronger relationships, and a more fulfilling life—this is an episode you won’t want to miss. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 2:04 - The happiness macronutrients 3:57 - Pleasure vs. enjoyment 8:08 - No struggle, no satisfaction 11:16 - The happiness paradox 13:38 - Why pleasure is better shared 16:17 - The lost art of boredom 20:47 - Striver's curse 24:19 - The four false idols 27:39 - What's secretly driving you? 37:10 - The reverse bucket list 39:19 - Training your gratitude muscle 44:01 - Raising grateful kids 46:29 - Emotional affect profiles 53:01 - Exercise as mood therapy 56:03 - Arthur's five-step daily protocol 1:00:19 - The meaning of life 1:03:56 - The left-brain trap 1:09:52 - Escaping the Matrix 1:14:50 - The beauty deficit 1:17:49 - Finding your ikigai 1:22:39 - When pain becomes growth 1:31:02 - Metacognition & emotional pain 1:33:37 - Reversing relationship drift 1:40:12 - Rethinking dating apps 1:45:16 - The friendship crisis 1:54:04 - Can happiness be learned? 1:57:14 - Pharmacological treatments 2:00:22 - Exercise vs. antidepressants 2:02:59 - The real value of a PhD 2:04:52 - Lifelong learning & aging 2:09:25 - Digital overload 2:11:52 - Curating your social feed 2:15:33 - Coping skills & happiness 2:16:21 - The power of love 2:17:51 - Real vs. deal marriages 2:19:23 - The second-half blueprint

Dr. Rhonda Patrick

143,497 views • 4 months ago

NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest
1:54:17

NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest

Dr. Rhonda Patrick

145,230 views • 5 months ago