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16,665 次观看 • 2 个月前 •via X (Twitter)

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The Woman Who Said “No” and Saved a Generation ​In 1960, a 46-year-old pharmacologist named Dr. Frances Oldham Kelsey started her first day at the FDA. Within five weeks, she was handed an application that seemed like a "formality." ​The drug was Kevadon (Thalidomide). It was already a massive success in Europe, marketed as a "wonder drug" for pregnant women suffering from morning sickness. Most expected her to sign off immediately. ​But Frances felt something wasn't right. ​She noticed the clinical data was vague. There was almost no evidence showing how the drug affected a developing fetus. While the pharmaceutical company, Richardson-Merrell, pressured her to rush the approval, she stood her ground. ​The Pressure Was Suffocating ​For 19 months, the company relentlessly hounded her. They: ​Visited her office over 50 times. ​Called her "unreasonable" and "stubborn." ​Complained to her supervisors, trying to go over her head. ​Had doctors write letters demanding she release the drug. ​Can you imagine the weight on her shoulders? A new employee standing up to a corporate giant and an entire industry. But her mantra was simple: "Show me the data." ​A Devastating Discovery ​By November 1961, the world’s worst fears came true. In Germany and Australia, babies were being born with Phocomelia—severe limb malformations. Some were born with flipper-like hands attached to their shoulders; others had no limbs at all. ​Thousands of babies were born with these deformities, and thousands more were stillborn. Thalidomide was the cause. ​The Silent Hero ​Because Dr. Kelsey refused to be bullied, the damage in the United States was largely contained. She didn't just do her job; she protected the future. ​On August 7, 1962, President John F. Kennedy awarded her the President’s Award for Distinguished Federal Civilian Service. She was only the second woman to ever receive it. ​We often talk about "changing the world." Dr. Kelsey changed it with one word: No. ​Sometimes, being "stubborn" is the most heroic thing you can be. ​What do you think of Dr. Kelsey's story? Does it inspire you to stand firm in your convictions, even when the world is pushing back?

PeachProof

45,630 次观看 • 4 个月前

China’s message is basically: If you can compete, compete. Stop whining. The West spent decades enjoying globalization while hollowing out its own manufacturing base and calling it efficiency. Now that Chinese products are more competitive, suddenly we hear: “China shock.” “China squeeze.” “Overcapacity.” “Unfair competition.” Translation: We were allowed to deindustrialize ourselves. China is not allowed to industrialize successfully. And the hypocrisy goes far beyond China. China does not only export finished goods. It exports machinery, components, power equipment, solar panels, batteries, industrial systems and the tools that allow poorer countries to build factories in the first place. For much of the Global South, industrialization is not an academic debate. It begins with one brutally practical question: Can we afford the machines? Chinese manufacturing lowered that threshold. So when Western governments demand that China “make room” by weakening its own industries, they are not merely trying to protect Western companies. They are also trying to make industrialization more expensive for countries that are still trying to escape poverty. If Europe and America want stronger industries, build them. Compete. Invest. Innovate. You do not get to ask the world to stop moving forward just to protect Western corporate giant babies that spent decades growing fat on cheap labor, cheap resources, and the underdevelopment of poorer countries. The world does not owe your complacency a subsidy. And development is not something the West gets to ration.

𝘊𝘰𝘳𝘳𝘪𝘯𝘦

48,009 次观看 • 27 天前

🚨CABBAGE PATCH KIDS WHAT HAVE I TOLD YOU IT’S DARKER THAN WHAT WE’VE HAVR BEEN TOLD. Dark truth behind Cabbage Patch Kids may ruin your childhood Cabbage Patch Kids were a controversial child commodity. The alleged 'USP' of the Cabbage Patch collection was the official ownership documentation that they came with - including birth certificates and adoption papers. The idea was formed by original owner Xavier Roberts, whose line of pinched-nose, close-eyed dolls was first and foremost called 'Little People'. And apparently, that's because the wacky businessman wanted owners to see them as just that - little people, as opposed to dolls. So much so, that he actually purchased a property in Cleveland, Georgia and set up the fictional 'birthplace' of his babies, which he alarmingly named the Babyland General Hospital. It gets weirder, because the alleged infant health facility still exists, attracting countless fans of the macabre year upon year. Staff working at the toy store in its prime were referred to as doctors and nurses to add to the notion of the dolls being delivered. According to a downright eerie fairytale of how the brand name idea came about - which is still listed on the toy firm's website - as a child, owner Xavier was reportedly approached while playing in the garden by a bee-bunny hybrid creature. A young Xavier then claimed to have followed the 'adorable' critter to a field of cabbages where more 'bunnybees' were sprouting tiny babies out of the vegetables, as well as fully grown boy named Otis, who told him he needed to help all the new Cabbage Patch babies find their homes... According to the official website, there is a rather eerie and sinister fairytale about how they became known as "Cabbage Patch Kids". It says that as a child, Xavier was playing in the garden when a bee-bunny hybrid creature approached him, and Xavier followed it to a field of cabbages. The bunnybee creatures were "sprouting tiny babies out of the vegetables". Xavier also came across a boy called Otis, who told him he needed to help all of the Cabbage Kids find their forever homes. Writer Sarah Baird took to X to share her strange visit to an American Cabbage Patch 'hospital' where dolls 'give birth' and adopters have to sign an oath to take their newborn dolly home. Kicking off a thread that left readers gobsmacked, she said: "A few weeks ago we were camping in the north Georgia mountains and happened to drive past a bunch of signs for 'babyland general hospital' where cabbage patch dolls are 'born' so we decided to check it out as kitschy fun…" Detailing the unusual way in which the Cabbage Patch Kids are 'born' in the facility, Baird explained: "We were absolutely not prepared to witness the ceremony of a 'licensed patch nurse' helping a giant, led-light covered tree called 'mother cabbage' give 'birth' to a cabbage patch doll!" Just when you thought things couldn't get much more bizzare, the writer revealed that the birthing procedure was far more serious than you'd expect for a children's toy, with a dedicated 'nurse' on deck to ensure the whole birth runs smoothly. According to Baird, Cabbage Patch-related puns were even thrown into the mix during the birth. She wrote: "The 'nurse' kept calling out mother cabbage’s dilation as 'five leaves apart, seven leaves apart, nine leaves apart' until she eventually announced that mother cabbage had to have a 'leaves-iotomy' (like an episiotomy) in order to deliver the baby…" No expenses were spared when offering the mother doll 'pain relief', either: "The nurse gave mother cabbage a shot of 'imagicillin' to help her 'relax before, during and after labor and delivery," Baird explained Per The Mirror News

SANTINO

19,408 次观看 • 2 个月前

Q: Is it better to target a small market or a large one? In the clip below, Peter Thiel (billionaire venture capitalist and co-founder of PayPal and Palantir) describes his framework for evaluating markets: “It’s always a big mistake going after a giant market on day 1. That’s typically evidence that you haven’t defined the categories correctly, and there’s going to be too much competition.” He continues: “Almost all of the successful companies in Silicon Valley had some model of starting with small markets and expanding.” Amazon started with books eBay started with Pez dispensers and Beanie Babies PayPal started with power-sellers on eBay Facebook started with Harvard “What’s very counterintuitive about many of these companies is that they often start with markets so small that most people don’t think they’re valuable at all.” The opposite of this is companies that start out targeting really big markets, and he uses clean tech companies in 2005-2008 trying to capture a small percentage of a trillion dollar market as an example. “Once you’re a minnow in a vast ocean, that’s not a good place to be. It means you have tons of competitors, and you don’t even know who all of the competitors are.” As Thiel puts it: “You want to be a one-of-a-kind company where it’s the only one in a small ecosystem… large existing markets typically mean you have tons of competition and it’s very hard to differentiate.” You can then expand concentrically from there.

Michael McGuiness

1,534,816 次观看 • 3 年前

Q: Is it better to target a small market or a large one? In the clip below, Peter Thiel (billionaire venture capitalist and co-founder of PayPal and Palantir) describes his framework for evaluating markets: “It’s always a big mistake going after a giant market on day 1. That’s typically evidence that you haven’t defined the categories correctly, and there’s going to be too much competition.” He continues: “Almost all of the successful companies in Silicon Valley had some model of starting with small markets and expanding.” Amazon started with books eBay started with Pez dispensers and Beanie Babies PayPal started with power-sellers on eBay Facebook started with Harvard “What’s very counterintuitive about many of these companies is that they often start with markets so small that most people don’t think they’re valuable at all.” The opposite of this is companies that start out targeting really big markets, and he used clean tech companies in 2005-2008 trying to capture a small percentage of a trillion-dollar market as an example. “Once you’re a minnow in a vast ocean, that’s not a good place to be. It means you have tons of competitors, and you don’t even know who all of the competitors are.” As Thiel puts it: “You want to be a one-of-a-kind company where it’s the only one in a small ecosystem… large existing markets typically mean you have tons of competition and it’s very hard to differentiate.” You can then expand concentrically from there. Follow Startup Archive for more tactical startup advice!

Startup Archive

84,096 次观看 • 2 年前