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GLP-1 Confession #50 Reta is so powerful đŸ’Ș I literally can’t overcome its effects. The experiment may have to come to a halt. I’ve been pushing hard — eating everything in sight during this reverse diet phase, heavy lifting, high protein, trying to hold onto muscle while leaning out
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11,558 görĂŒntĂŒleme ‱ 24 gĂŒn önce ‱via X (Twitter)

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There's a question that keeps coming up: is retatrutide better than tirzepatide? In my experience, this is the wrong question. It's like asking whether steak or chicken is better. Steak is arguably more nutrient-dense, but some people do better on chicken, and there's no reason you wouldn't vary your protein sources. It's the same with GLPs. It's not either/or, you have to experiment. > Tirzepatide is a dual agonist. It hits GLP-1 and GIP receptors. > Retatrutide is a triple agonist. It hits GLP-1, GIP, and glucagon receptors. That glucagon piece is the key difference. It changes how your body uses fuel in a way tirzepatide simply doesn't. In clinical trials, retatrutide produced 24% average weight loss in 48 weeks. Tirzepatide produced 21% in 72 weeks. Reta produced better results in almost half the time. The glucagon receptor drives thermogenesis and fat oxidation, which you don't get with a dual agonist. But retatrutide comes with a tradeoff. It raises resting heart rate by 5-10 BPM, driven by the glucagon receptor, and happens at every dose level. Reta peaks around week 24 and reverses when you stop. This doesn't happen with tirzepatide. And that's exactly why you shouldn't be on either of these indefinitely. The problem is that most people are scared to cycle off because they've heard the horror stories about weight rebound. As a result, they stay on way too long. This isn't medical advice, but I believe the right approach is to be 12-16 weeks on, 8-10 weeks off. You cycle, monitor, and adjust. If you don't know how to properly come off a GLP, you have no business being on one. On top of that, if you're running the experiment but not tracking it, you're wasting it. - Get labs done: fasting insulin, blood glucose, A1C, etc. - Wear a tracker: monitor heart rate and HRV These compounds impact metabolic markers that matter way more than bodyweight. If you have weight to lose and you're interested in GLPs, run at least one cycle of each. See how your body responds to retatrutide. Then see how it responds to tirzepatide. Compare the data, and that's how you'll find what works. Because in performance healthcare, data wins, not the math. Comment "FATLOSS" below, and I'll send you my 70-page Peptide Bible. P.S. None of this is medical advice nor a recommendation.

Michael Morelli

39,309 görĂŒntĂŒleme ‱ 3 ay önce

RETATRUTIDE is NOT JUST for WEIGHT LOSS
 
and the fact that that’s what everyone is obsessing over tells me we’re still missing the point. 🙃 Because what I’m looking at? It’s not just the scale. It’s what’s happening underneath it. We’re talking 24% body weight reduction in trials
 sure. BUT ALSO: 47% drop in inflammatory markers in 12 weeks. 2.1% drop in HbA1c. 42% reduction in visceral fat (the dangerous kind hugging your organs). đŸ« And then it gets uncomfortable
 31% lower cardiovascular mortality. 28% fewer heart attacks. 22% fewer strokes. Like
 pause there. Because if this was just about weight loss
 those numbers wouldn’t exist. This is metabolism. This is inflammation. This is mitochondrial signaling. 🧬 And THIS is where I start side-eyeing the narrative. Because you’ve been told this is about “calories” and “willpower.” Meanwhile your body is sitting there like— “Hey
 I’m inflamed. I’m insulin resistant. I’m storing for a reason.” 👀 And instead of asking why
 We’ve been handed drugs and told to shrink. But here’s the part nobody’s talking about
 What happens when you stop? With semaglutide (Ozempic)
 about 72% of people regain the weight. Tirzepatide? Around 60%. Retatrutide? ONLY 5–10%. That’s not a small difference. That’s a completely different conversation. Because now we’re NOT just talking about weight suppression
 We’re talking about whether the terrain (esp hormones and body talk) actually changed. And if you’ve ever felt like you’re doing everything right
 but your body keeps pulling you back
 this matters more than you think. Because your body isn’t trying to sabotage you. It’s responding to something deeper. If you want me to break down what this actually means
 and how peptides are shifting the entire conversation— Comment PEPTIDES and I’ll send you the full breakdown. 💡 #peptides #biohacking #womenshealth #hormones #healthandwellbeing

Dr Diane Kazer

78,474 görĂŒntĂŒleme ‱ 3 ay önce

Everyone keeps telling her to eat less fat so her body will burn stored fat. But it is not working. And there is a reason for that. When you come from a background of insulin resistance your body has literally lost the ability to tap into stored fat. Elevated insulin for extended periods shoves glucose into your fat cells and locks it behind closed doors. Your liver is still running around looking for glucose because that is all it has ever known. You cannot fix that by eating less fat. You fix it by flooding your body with fat. I am talking 150 to 200 grams a day. You have to force your liver to stop looking for glucose and finally accept fat as its fuel source. That is not maintenance eating. That is metabolic retraining. And before you close this post let me remind you what fat actually does for your body. Your brain is nearly 60% fat. Every single one of your hormones is made from fat. Your cell membranes are made from fat. Fat carries your fat soluble vitamins, A, D, E and K, without fat you cannot absorb them at all. Fat keeps you satiated, stabilizes your mood, gives you steady energy, and keeps your hormones balanced. Fat is not the enemy. Fat is literally the building material your body runs on. About 70% of your calories should be coming from fat. That is not a typo. Once your liver concedes and fat becomes the rule of the land that is fat adaptation. And THAT is when you can start pulling back on dietary fat slightly and let your body tap into its own stores. That is when the weight really starts moving. I know it sounds completely backwards. I lived on low fat my entire life and ballooned to 330 pounds eating way too many carbohydrates. It took me months to unlearn everything I had been taught. The answer has always been fat. It will always be fat.👑

Queen of Carni

18,088 görĂŒntĂŒleme ‱ 4 ay önce

Up to 30% of the weight lost while dieting can come from lean muscle mass—but the right training and nutrition can help you preserve muscle, which is key for metabolic health and reducing the risk of sarcopenia. You can lose fat and gain muscle at the same time—a process called body recomposition—if you train and eat strategically. The most important factor is resistance training. Lifting heavy 2–3 times per week is essential for maintaining and building muscle while losing fat. Without it, muscle mass inevitably declines. Nutrition also plays a major role. Eating in a slight calorie deficit—around 10–20% below maintenance—allows for steady fat loss without sacrificing muscle, energy levels, or training performance. Protein intake is another key priority. Research shows that consuming 1.8 to 2.2 grams of protein per kilogram of body weight per day is optimal for muscle retention and growth during a calorie deficit, and going even higher may provide additional benefits. Beyond training and nutrition, recovery is just as crucial. Adequate sleep, stress management, and tracking progress help ensure you’re making real, sustainable changes. Get this right and you have a powerful strategy to build muscle and lose fat. If you want to learn more about optimizing body recomposition, improving VO2 max, and enhancing brain health, tune into the latest episode of the FoundMyFitness podcast, where and I break it all down with insights from top experts. Link to the full episode on YouTube:

Dr. Rhonda Patrick

120,402 görĂŒntĂŒleme ‱ 1 yıl önce

you don’t need whey protein because it’s unnatural” is genuinely one of the worst takes floating around indian households. let me be clear. 1 scoop gives you roughly 25g of protein in minutes. your dal, sabzi, and roti combined don’t even come close to what your body actually needs to function properly. whey protein isn’t some lab-created poison. it’s literally milk protein separated out. if paneer is natural, whey is natural. the only difference is whey actually works faster and doesn’t come loaded with extra fat. here’s the real problem. most indians, especially vegetarians, are surviving on maybe 30-40g of protein daily when they need double that just to maintain basic health. and the solution is sitting right there but people won’t touch it because someone said it’s western or chemicals. (by the way you can consume protein from other sources, fair enough but i'm accounting for ease and bioavailability as well) whenever i travel constantly. trains, hotels, random cities. i don’t have to stress about breakfast because i can tear open a packet, mix it in 200ml water, and get 25g of protein that keeps me sorted till afternoon. if you can afford it and especially if you’re vegetarian, stop making protein harder than it needs to be. add a scoop to your breakfast or post-workout and watch your energy, recovery, and overall health improve. also this isn’t about bodybuilding. this is about not being protein-starved in a carb-heavy culture. make sense?

Abhi Rajput | Men Fat Loss Coach

15,554 görĂŒntĂŒleme ‱ 7 ay önce