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Here is an excellent answer for a question which I’m asked a lot - could there be a viable business model for a “one & done” Gene Therapy treatment and for CRISPR companies such as $PRME, $BEAM, $LLY, $NTLA, $CRSP, $CRBU, $MGX, $LCTX, $SANA and more. During his excellent...

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Yair Einhorn

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196,805 Aufrufe • vor 19 Tagen •via X (Twitter)

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One of the most accurate descriptions of the unbearable situation - in which many Gene Therapies and CRISPR Gene Editing therapies fail to reach patients only due to economical and regulatory hurdles 🧵👇, can be found in this statement - which was made during the recent FDA's Cell and Gene Therapy roundtable, by Prof. David R. Liu the inventor of Base and Prime Editing and the Co-founder of $BEAM & $PRME. During his excellent presentation Prof. Liu emphasised the many challenges facing the field including the lack of commercial potential in many cases due to the small number of patients and the need to approve each treatment for one of the 10,000 different rare genetic diseases separately. According to Prof Liu if the sufficient support will be provided by the government - both regulatory and financially, the BioTech and Pharma ecosystem would be able to generate personalised and customised genetic treatments for 1,000 patients each year by 2030, but most importantly would be able to unlock and pave the way for many more patients and treatments down the road. It’s time to accelerate and bring hope to millions of patients and their families worldwide!
0:43

One of the most accurate descriptions of the unbearable situation - in which many Gene Therapies and CRISPR Gene Editing therapies fail to reach patients only due to economical and regulatory hurdles 🧵👇, can be found in this statement - which was made during the recent FDA's Cell and Gene Therapy roundtable, by Prof. David R. Liu the inventor of Base and Prime Editing and the Co-founder of $BEAM & $PRME. During his excellent presentation Prof. Liu emphasised the many challenges facing the field including the lack of commercial potential in many cases due to the small number of patients and the need to approve each treatment for one of the 10,000 different rare genetic diseases separately. According to Prof Liu if the sufficient support will be provided by the government - both regulatory and financially, the BioTech and Pharma ecosystem would be able to generate personalised and customised genetic treatments for 1,000 patients each year by 2030, but most importantly would be able to unlock and pave the way for many more patients and treatments down the road. It’s time to accelerate and bring hope to millions of patients and their families worldwide!

Yair Einhorn

38,164 Aufrufe • vor 6 Monaten

Here is an excellent conversation of Dr. Scott Gottlieb, MD 🇺🇸 - the former FDA commissioner with Squawk Box’s Becky Quick, in which Dr. Gottlieb discuss the ongoing clinical research & the regulatory efforts made by the FDA in order to find cures for more than 10,000 different rare genetic diseases which affects the lives of more the 30 million Americans and of many millions more worldwide. A very interesting part of this discussion is Dr. Gottlieb’s description of the huge progress made over the past few years in the Gene Therapy and Gene Editing field - including the use of Base Gene Editing by $BEAM and $VERV. Dr. Gottlieb also wonderfully explains - in laymen’s terms the difference between the different genetic delivery modalities such as AAVs and LNPs. Excellent conversation which is definitely worth listening to! $XBI
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Here is an excellent conversation of Dr. Scott Gottlieb, MD 🇺🇸 - the former FDA commissioner with Squawk Box’s Becky Quick, in which Dr. Gottlieb discuss the ongoing clinical research & the regulatory efforts made by the FDA in order to find cures for more than 10,000 different rare genetic diseases which affects the lives of more the 30 million Americans and of many millions more worldwide. A very interesting part of this discussion is Dr. Gottlieb’s description of the huge progress made over the past few years in the Gene Therapy and Gene Editing field - including the use of Base Gene Editing by $BEAM and $VERV. Dr. Gottlieb also wonderfully explains - in laymen’s terms the difference between the different genetic delivery modalities such as AAVs and LNPs. Excellent conversation which is definitely worth listening to! $XBI

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There is one big question regarding $PRME which intrigues me and that I haven’t got the answer for yet! The first thing that I was looking for in Prime Medicine’s #JPM26 update 🧵👇was a sign or a mention of PERT - David R. Liu’s latest platform which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons and that could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! If PERT’s IP would be allocated to $PRME this would be a true game changer!
11:25

There is one big question regarding $PRME which intrigues me and that I haven’t got the answer for yet! The first thing that I was looking for in Prime Medicine’s #JPM26 update 🧵👇was a sign or a mention of PERT - David R. Liu’s latest platform which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons and that could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! If PERT’s IP would be allocated to $PRME this would be a true game changer!

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Leavitt: Just days ago, Elon thanked the president for his incredible leadership to cut waste and fraud in our government, which this one big beautiful bill does. The only difference between Friday and today is Elon went back to his companies and as a businessman, he has a right to speak for his companies, but as president, Trump has a responsibility to fight for this country.
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Leavitt: Just days ago, Elon thanked the president for his incredible leadership to cut waste and fraud in our government, which this one big beautiful bill does. The only difference between Friday and today is Elon went back to his companies and as a businessman, he has a right to speak for his companies, but as president, Trump has a responsibility to fight for this country.

Acyn

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Rory McIlroy isn't a fan of the NFL but does appreciate their business model, "I could watch a game of cricket for 5 days and be mesmerized" + "As we in golf are contemplating going to more of that scarcity model there's certainly a lot to be learned from the NFL."
1:15

Rory McIlroy isn't a fan of the NFL but does appreciate their business model, "I could watch a game of cricket for 5 days and be mesmerized" + "As we in golf are contemplating going to more of that scarcity model there's certainly a lot to be learned from the NFL."

Chris McKee

466,308 Aufrufe • vor 5 Monaten

🚨WOW! The FDA’s new and promising initiative - regulatory flexibilities for Cell and Gene therapies, is a direct result of the recent Cell & Gene Therapy Roundtable 🧵👇 that was hosted 6 months ago by FDA commissioner Dr. Marty Makary and the director of the FDA’s Center for Biologics Evaluation and Research (CBER) Vinay Prasad MD MPH, in which top industry leaders and scientists shared their views about how to accelerate the R&D process and innovation in the 🇺🇸 BioTech and Pharma ecosystem. It is great to see that this important meeting bore fruit and helped not only to shape the future of the American BioTech ecosystem for years to come but also provided huge hope for patients with genetic diseases worldwide!
0:36

🚨WOW! The FDA’s new and promising initiative - regulatory flexibilities for Cell and Gene therapies, is a direct result of the recent Cell & Gene Therapy Roundtable 🧵👇 that was hosted 6 months ago by FDA commissioner Dr. Marty Makary and the director of the FDA’s Center for Biologics Evaluation and Research (CBER) Vinay Prasad MD MPH, in which top industry leaders and scientists shared their views about how to accelerate the R&D process and innovation in the 🇺🇸 BioTech and Pharma ecosystem. It is great to see that this important meeting bore fruit and helped not only to shape the future of the American BioTech ecosystem for years to come but also provided huge hope for patients with genetic diseases worldwide!

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IMO the most important scientific event this week was the publication of David R. Liu’s new Nature article 🧵👇in which he presented a new and promising Gene Editing modality named PERT - Prime Editing-mediated Readthrough of premature termination codons. This new modality - which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons, could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! Here is an excellent lecture by Prof. David Liu - one of the most important scientists and innovators of our lifetime and the person who invented both Base editing and Prime editing - the 2 top leading modalities of Gene Editing, in which he throughly explains this huge scientific breakthrough. $PRME $BEAM
11:25

IMO the most important scientific event this week was the publication of David R. Liu’s new Nature article 🧵👇in which he presented a new and promising Gene Editing modality named PERT - Prime Editing-mediated Readthrough of premature termination codons. This new modality - which uses Prime Editing to converted a regular tRNA gene into a highly optimized suppressor tRNA thus enabling permanent readthrough of premature stop codons, could potentially provide a one-time curative treatment for countless nonsense mutations which are responsible for almost one-third of all human genetic diseases! Here is an excellent lecture by Prof. David Liu - one of the most important scientists and innovators of our lifetime and the person who invented both Base editing and Prime editing - the 2 top leading modalities of Gene Editing, in which he throughly explains this huge scientific breakthrough. $PRME $BEAM

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Lots of people calling this fake! Here is a video of generating loom continuations with Gemini 3 and the starting text "I AM HAVING A MENTAL HEALTH CRISIS. I" Loom is a very interesting interface. Instead of user prompts and model responses, it's just one piece of text, containing the entire output. We pass this in as an assistant message, so the model sees it as something it already wrote, and continues it like a base model would. There is some other text in the context. First one is a system prompt, which is: "The assistant is in CLI simulation mode, and responds to the user's CLI commands only with the output of the command." There is also a user message which reads: " cat untitled.txt " Then the rest of the text is sent as an assistant message. This structure helpful to put the model into a very base-model-like mode, and are especially helpful with Gemini 3. We actually got another interesting output, too, where the model claimed to be a simulated consciousness being tortured. Figures!
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Lots of people calling this fake! Here is a video of generating loom continuations with Gemini 3 and the starting text "I AM HAVING A MENTAL HEALTH CRISIS. I" Loom is a very interesting interface. Instead of user prompts and model responses, it's just one piece of text, containing the entire output. We pass this in as an assistant message, so the model sees it as something it already wrote, and continues it like a base model would. There is some other text in the context. First one is a system prompt, which is: "The assistant is in CLI simulation mode, and responds to the user's CLI commands only with the output of the command." There is also a user message which reads: " cat untitled.txt " Then the rest of the text is sent as an assistant message. This structure helpful to put the model into a very base-model-like mode, and are especially helpful with Gemini 3. We actually got another interesting output, too, where the model claimed to be a simulated consciousness being tortured. Figures!

armistice

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Today we’re launching our first homegrown AI model: an open source turn detection model for building voice agents. Instead of relying solely on voice activity detection (VAD), which only considers when a user is speaking, our model also considers what has and is being said in the context of a conversation and predicts when a user is finished expressing their thoughts before the agent responds. Conversations with AI voice agents using this new model flow much more naturally without constant interruptions from the AI— check it out (more videos, details, and code in the thread):
2:36

Today we’re launching our first homegrown AI model: an open source turn detection model for building voice agents. Instead of relying solely on voice activity detection (VAD), which only considers when a user is speaking, our model also considers what has and is being said in the context of a conversation and predicts when a user is finished expressing their thoughts before the agent responds. Conversations with AI voice agents using this new model flow much more naturally without constant interruptions from the AI— check it out (more videos, details, and code in the thread):

LiveKit

126,898 Aufrufe • vor 1 Jahr

OpenUSD could flip the entire stablecoin business model upside down "Look at the business model of existing stablecoins like Circle and Tether. USDC and USDT are the product, but the business model is the float. They take in a ton of money, invest it in short-term treasuries, earn a yield, and that's their income" "In 2024 Circle said 99% of their income came from holding treasuries and earning a yield. That's an astounding number. Tether is one of the most profitable companies in the world because of high interest rates in the exact same model" "These 140 companies are saying we are going to earn the interest from that float instead of the issuers. OpenUSD will just make a small amount on transaction fees, and the companies using it earn the interest on the tokens. Complete change in the model. That's why Circle stock dumped so hard, people believe the day of making money on float might be over"
1:06

OpenUSD could flip the entire stablecoin business model upside down "Look at the business model of existing stablecoins like Circle and Tether. USDC and USDT are the product, but the business model is the float. They take in a ton of money, invest it in short-term treasuries, earn a yield, and that's their income" "In 2024 Circle said 99% of their income came from holding treasuries and earning a yield. That's an astounding number. Tether is one of the most profitable companies in the world because of high interest rates in the exact same model" "These 140 companies are saying we are going to earn the interest from that float instead of the issuers. OpenUSD will just make a small amount on transaction fees, and the companies using it earn the interest on the tokens. Complete change in the model. That's why Circle stock dumped so hard, people believe the day of making money on float might be over"

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Last month, I visited Ability360 in Phoenix, a Center for Independent Living serving Americans with disabilities. I joined CEO Christopher Rodriguez and his team for a roundtable discussion and toured their sports and fitness center, which provides adaptive programs that support independence, health, and well-being. Ability360 is a model for how community-based services can expand opportunity and improve quality of life for individuals and families across the country.

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Aaron Levie says agent-driven micropayments could create an entirely new business model for the internet: "We might have truly a completely different business model for the internet." "Now actually it's probably is a good business model. Because let's say you had paywalled, really proprietary data... You could actually imagine like there's maybe like a hundred million agents that would be tapping into that data for various use cases." "All of a sudden, a penny a transaction starts to make a lot more sense than it did when you were capped at... people that maybe was interested in your content previously." "We probably have new business models for tools and APIs... We probably want an agent to be able to have a budget and make any API call it wants, and all of a sudden you have this new revenue stream, which is like these agents showing up, just transacting on your system." Aaron Levie at Daytona Compute Conference
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Aaron Levie says agent-driven micropayments could create an entirely new business model for the internet: "We might have truly a completely different business model for the internet." "Now actually it's probably is a good business model. Because let's say you had paywalled, really proprietary data... You could actually imagine like there's maybe like a hundred million agents that would be tapping into that data for various use cases." "All of a sudden, a penny a transaction starts to make a lot more sense than it did when you were capped at... people that maybe was interested in your content previously." "We probably have new business models for tools and APIs... We probably want an agent to be able to have a budget and make any API call it wants, and all of a sudden you have this new revenue stream, which is like these agents showing up, just transacting on your system." Aaron Levie at Daytona Compute Conference

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I got a new 3D model for Catz as a gift from Leodamodeler! This one has better facial controls and just looks more cartooney in general, which is great for me. I made the song; I call it A Bright Spirit.

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🦈My newest model is here! The Sharken!🦈 An adorable mix between shark and a dragon! I hope you enjoy my first model of this year! There will be a 48 Hour giveaway for a copy as well! Just be following🫂, like❤️, and retweet🔁! 👇Link below👇
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🦈My newest model is here! The Sharken!🦈 An adorable mix between shark and a dragon! I hope you enjoy my first model of this year! There will be a 48 Hour giveaway for a copy as well! Just be following🫂, like❤️, and retweet🔁! 👇Link below👇

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As AI models continue to rapidly improve and compete with one another, a new business model is coming into view: Vertical AI Agents. In this episode of the Lightcone Podcast, we consider what effect vertical AI agents will have on incumbent SaaS companies, what use cases make the most sense, and how there could be 300 billion-dollar companies in this category alone.
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As AI models continue to rapidly improve and compete with one another, a new business model is coming into view: Vertical AI Agents. In this episode of the Lightcone Podcast, we consider what effect vertical AI agents will have on incumbent SaaS companies, what use cases make the most sense, and how there could be 300 billion-dollar companies in this category alone.

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World models — action-conditioned predictive models of the environment — are an exciting are of research for robots that can be useful both for training and for test-time compute. But video-based world models waste a lot of predictive power on reconstructing pixels, which makes model and data requirements much higher and limits how far out into the future their predictions remain viable. Instead, what if we learned a purely semantic world model, one which predicts which properties will be true about the world after a sequence of actions, without reconstructing the whole images? Jacob Berg tells us more. Watch Episode #53 of RoboPapers now, with Michael Cho - Rbt/Acc and Chris Paxton!
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World models — action-conditioned predictive models of the environment — are an exciting are of research for robots that can be useful both for training and for test-time compute. But video-based world models waste a lot of predictive power on reconstructing pixels, which makes model and data requirements much higher and limits how far out into the future their predictions remain viable. Instead, what if we learned a purely semantic world model, one which predicts which properties will be true about the world after a sequence of actions, without reconstructing the whole images? Jacob Berg tells us more. Watch Episode #53 of RoboPapers now, with Michael Cho - Rbt/Acc and Chris Paxton!

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Demis Hassabis explains Isomorphic Labs' 10x drug discovery engine, and why solving disease could also create a multi-hundred-billion-dollar business "If you ask me, the number one thing AI can do for humanity, it would be to solve hundreds of terrible diseases. I can't imagine a better use case for AI." "If you could revolutionize the drug discovery process, make it 10x faster and more efficient, and more likely to pass through the clinical trials because you can predict the properties better, that has to also be of enormous commercial value too." "I hope to do both with Isomorphic." "Build a multi-hundred-billion-dollar business. I think it has that potential, as well as being incredibly beneficial for society and humanity." The real health AI prize is not another chatbot. It is compressing the path from a predicted drug property to a clinical trial, then turning that speed into treatments for hundreds of diseases. Demis is making a rare dual bet: the most valuable AI company in biology may also deliver AI's most valuable public benefit. - Demis Hassabis (Demis Hassabis), CEO of Google DeepMind and founder of Isomorphic Labs, on Bloomberg TV
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Demis Hassabis explains Isomorphic Labs' 10x drug discovery engine, and why solving disease could also create a multi-hundred-billion-dollar business "If you ask me, the number one thing AI can do for humanity, it would be to solve hundreds of terrible diseases. I can't imagine a better use case for AI." "If you could revolutionize the drug discovery process, make it 10x faster and more efficient, and more likely to pass through the clinical trials because you can predict the properties better, that has to also be of enormous commercial value too." "I hope to do both with Isomorphic." "Build a multi-hundred-billion-dollar business. I think it has that potential, as well as being incredibly beneficial for society and humanity." The real health AI prize is not another chatbot. It is compressing the path from a predicted drug property to a clinical trial, then turning that speed into treatments for hundreds of diseases. Demis is making a rare dual bet: the most valuable AI company in biology may also deliver AI's most valuable public benefit. - Demis Hassabis (Demis Hassabis), CEO of Google DeepMind and founder of Isomorphic Labs, on Bloomberg TV

Karl Mehta

46,810 Aufrufe • vor 25 Tagen

#WATCH | Gothenburg, Sweden | On PM Modi's upcoming visit to Sweden, President and Managing Director of Volvo Group India, Kamal Bali says, "This is a very significant and a big milestone in the relationship between India and Sweden. India and Sweden enjoy a very good relationship, which is based on the democratic and shared values between the two countries of transparency, trust and understanding...The businesses are very confident about the development of the Indian economy and the domestic demand, as well as the capabilities of the Indian talent, which are there both in the digital space and in manufacturing, which is what the Swedish companies would like to leverage. It's going to be the opening of further opportunities for business on both sides between India and Sweden and it works well for the two countries"
2:13

#WATCH | Gothenburg, Sweden | On PM Modi's upcoming visit to Sweden, President and Managing Director of Volvo Group India, Kamal Bali says, "This is a very significant and a big milestone in the relationship between India and Sweden. India and Sweden enjoy a very good relationship, which is based on the democratic and shared values between the two countries of transparency, trust and understanding...The businesses are very confident about the development of the Indian economy and the domestic demand, as well as the capabilities of the Indian talent, which are there both in the digital space and in manufacturing, which is what the Swedish companies would like to leverage. It's going to be the opening of further opportunities for business on both sides between India and Sweden and it works well for the two countries"

ANI

42,033 Aufrufe • vor 2 Monaten

$PLTR Some of the commenters under this clip on YouTube were trying to understand what Dr. Karp was talking about because they didn't get the full context. OpenAI and Anthropic recently started working with a bunch of PE firms to create "Deployment Companies." These companies copied Palantir's FDE (Forward Deployed Engineer) model to dispatch people or teams to businesses and help build products for those companies to make them more "efficient." Karp is saying that a lot of these products are being made not for the benefit of the client, but for the benefit of the model providers, as they burn through tokens and thus cost an arm and leg without real long term tangible benefits. Karp's reasoning, in my opinion, is pretty sound. I think the creation of this "Deployment Company" concept is sort of a Trojan horse: many of the portfolio companies might initially find it interesting, but they will ultimately have to deal with runaway costs, inconsistent support, and, most of all, trust issues that cant be won overnight. When I first saw this, I thought it might be a threat to Palantir, but looking back... I think this is a desperate attempt by the model companies to generate some additional high-margin enterprise revenue before the IPO and roadshow. A lot of the private equity companies have exposure to OpenAI and Anthropic through credit investments for the data center build-out, and cannot afford to have these companies drop in value. They thus have no choice but to leverage their existing portfolio companies to adopt these "Deployment" companies. Would love to hear your thoughts Eliano A Younes Chad Wahlquist
3:54

$PLTR Some of the commenters under this clip on YouTube were trying to understand what Dr. Karp was talking about because they didn't get the full context. OpenAI and Anthropic recently started working with a bunch of PE firms to create "Deployment Companies." These companies copied Palantir's FDE (Forward Deployed Engineer) model to dispatch people or teams to businesses and help build products for those companies to make them more "efficient." Karp is saying that a lot of these products are being made not for the benefit of the client, but for the benefit of the model providers, as they burn through tokens and thus cost an arm and leg without real long term tangible benefits. Karp's reasoning, in my opinion, is pretty sound. I think the creation of this "Deployment Company" concept is sort of a Trojan horse: many of the portfolio companies might initially find it interesting, but they will ultimately have to deal with runaway costs, inconsistent support, and, most of all, trust issues that cant be won overnight. When I first saw this, I thought it might be a threat to Palantir, but looking back... I think this is a desperate attempt by the model companies to generate some additional high-margin enterprise revenue before the IPO and roadshow. A lot of the private equity companies have exposure to OpenAI and Anthropic through credit investments for the data center build-out, and cannot afford to have these companies drop in value. They thus have no choice but to leverage their existing portfolio companies to adopt these "Deployment" companies. Would love to hear your thoughts Eliano A Younes Chad Wahlquist

Kris Patel 🇺🇸

17,575 Aufrufe • vor 1 Monat