Loading video...

Video Failed to Load

There was a problem loading this video. This could be due to a temporary network issue or the video might be unavailable.

#HighlightOfTheWeek Cosolvent molecular dynamics are an increasingly popular form of MD simulations where small molecule cosolvents are added to the system, helping to identify cryptic and allosteric pockets in proteins. #compchem

JCIM & JCTC Journals

10,327 subscribers

11,287 views • 1 year ago •via X (Twitter)

Education Science & Technology News & Politics #HighlightOfTheWeek #compchem

Anya Rossi• Live Now

Private livecam show

0 Comments

No comments available

Comments from the original post will appear here

Related Videos

#HighlightOfTheWeek Intramolecular proton transfer in glycine obtained using enhanced-sampling molecular dynamics simulations and deep learning potentials. #compchem

#HighlightOfTheWeek Intramolecular proton transfer in glycine obtained using enhanced-sampling molecular dynamics simulations and deep learning potentials. #compchem

JCIM & JCTC Journals

11,412 views • 2 years ago

Molecular dynamics simulations in mixed reality! With Luciano Abriata and Lucien Krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! Three.js #WebXR #Quest3

Molecular dynamics simulations in mixed reality! With Luciano Abriata and Lucien Krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! Three.js #WebXR #Quest3

Fabio Cortes

269,101 views • 1 year ago

Introducing LiteFold Dynamo. For the first time, you can now run 100ns+ molecular dynamics simulations at LiteFold. Molecular dynamics is one of the last steps before researchers validate in wet labs. At LiteFold, run multiple simulations, manage them, get insights, and view trajectories in real time within the platform. Check it out, it's free. Links in the comments.

Introducing LiteFold Dynamo. For the first time, you can now run 100ns+ molecular dynamics simulations at LiteFold. Molecular dynamics is one of the last steps before researchers validate in wet labs. At LiteFold, run multiple simulations, manage them, get insights, and view trajectories in real time within the platform. Check it out, it's free. Links in the comments.

LiteFold

12,375 views • 8 months ago

@Tkexpress11: Virtual simulations from gaming are likely to increasingly be used in real-world applications.

@Tkexpress11: Virtual simulations from gaming are likely to increasingly be used in real-world applications.

a16z

26,576 views • 1 year ago

How pockets are added to shirts

How pockets are added to shirts

Science girl

5,315,568 views • 1 year ago

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,517 views • 6 months ago

This is the Bacterial Flagellum. An amazingly sophisticated molecular nano-machine, requiring at least 30-50 separate proteins, engineered to precision perfection for function. Remove any one of those parts, and the entire system fails. Clear evidence of the Design in Life.

This is the Bacterial Flagellum. An amazingly sophisticated molecular nano-machine, requiring at least 30-50 separate proteins, engineered to precision perfection for function. Remove any one of those parts, and the entire system fails. Clear evidence of the Design in Life.

Divinely Designed

13,659 views • 6 months ago

BERNIE: “I worry we are increasingly becoming an oligarchic form of society, where a very small # of people control our economy + have huge influence over both political parties. if there was ever a time to stand up for working families and prevent authoritarianism, this is it.”

BERNIE: “I worry we are increasingly becoming an oligarchic form of society, where a very small # of people control our economy + have huge influence over both political parties. if there was ever a time to stand up for working families and prevent authoritarianism, this is it.”

The Tennessee Holler

46,725 views • 8 months ago

Videos showcasing simple utilities or small everyday "hacks" are becoming increasingly popular on the internet.

Videos showcasing simple utilities or small everyday "hacks" are becoming increasingly popular on the internet.

Tips2Home 🏡

27,929 views • 3 months ago

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,877 views • 6 months ago

Earbuds are small, in-ear audio devices designed for personal listening. They come in wired and wireless (Bluetooth) versions, with wireless models becoming increasingly popular due to their convenience and portability.

Earbuds are small, in-ear audio devices designed for personal listening. They come in wired and wireless (Bluetooth) versions, with wireless models becoming increasingly popular due to their convenience and portability.

HOW THINGS WORK

120,033 views • 1 year ago

Labour is on the side of young people and it is becoming increasingly clear which parties are not. The increase in the minimum wage and the Youth Guarantee are vital in our plan to deliver change and put more money in the pockets of working people.

Labour is on the side of young people and it is becoming increasingly clear which parties are not. The increase in the minimum wage and the Youth Guarantee are vital in our plan to deliver change and put more money in the pockets of working people.

David Lammy

90,377 views • 8 months ago

While using the bathroom an astronaut notices something strange, after waste is processed in a sealed system small crystals are supposed to form on the inner wall of the toilet, but this time there's nothing there.

While using the bathroom an astronaut notices something strange, after waste is processed in a sealed system small crystals are supposed to form on the inner wall of the toilet, but this time there's nothing there.

𝕲𝖇𝖊𝖓𝖌𝖆 ☮️🕊️✌️

69,225 views • 1 month ago

The same women who feared that Trump would impose a dystopian ‘Handmaid’s Tale’-like system, where women were forced to wear colored attire to identify them, are the same women now voluntarily donning blue bracelets as a form of self-identification. Amazing.

The same women who feared that Trump would impose a dystopian ‘Handmaid’s Tale’-like system, where women were forced to wear colored attire to identify them, are the same women now voluntarily donning blue bracelets as a form of self-identification. Amazing.

ZNO 🇺🇸

414,340 views • 1 year ago

Mockler: Young people are having trouble accumulating capital in the form of housing or in the form of investing. And due to that, you see a lot of younger people turning against the system. We're not loyal to a system that hasn't been loyal to us.

Mockler: Young people are having trouble accumulating capital in the form of housing or in the form of investing. And due to that, you see a lot of younger people turning against the system. We're not loyal to a system that hasn't been loyal to us.

Acyn

165,666 views • 7 months ago

And this is where the dynamics are supposed to find balance but naaa

And this is where the dynamics are supposed to find balance but naaa

Dr. God Abeg ooo

22,012 views • 1 year ago

The full scale of the earthquakes in Venezuela is only beginning to emerge. IOM is working to identify where needs are greatest, helping ensure emergency assistance reaches people affected by the earthquakes as quickly as possible.

The full scale of the earthquakes in Venezuela is only beginning to emerge. IOM is working to identify where needs are greatest, helping ensure emergency assistance reaches people affected by the earthquakes as quickly as possible.

IOM - UN Migration 🇺🇳

17,703 views • 10 days ago