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How do you actually get a cat to press talking buttons without confusing them? This Trick Tuesday we’re showing you how! This is exactly how I taught Harvey, and it started much smaller than people expect. I didn’t teach “press the button” first. I taught a really simple action...

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Kit | Cat Behaviour & Training

27,000 subscribers

22,700 görüntüleme • 7 ay önce •via TikTok

EğitimHayvanlar#talkingbuttons#cattraining#trickytuesday#tricktruesday
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How to teach your cat to talk 💜 I don’t really mean talk, more communicate. This is Augmentative Interspecies Communication using buttons! 1. Get some easy to press buttons - we use @fluentpet which are amazing 2. Record the sound on the button, place in a central location and start modelling the word (eg. treat, food, play, pets etc) in everyday life 3. Reward any interaction with the button - sniffing, pawing, touching! 4. Once they understand the button = good things and are consistently interacting with it, start increasing the criteria. For example, treat when sniffing, treat when pawing it, *only* treat when pawing it, only treat when pawing the top of it, only treat when tapping it etc. Eventually only treat when activating the button! 5. In the beginning always reward (treat for TREAT button, play for PLAY button etc) as this solidifies the meaning, later on you can introduce ALL DONE and/or LATER buttons. Spamming is totally normal, push through it! 6. How do you know when your cat understands? independent pressing! Pressing buttons without prompting and then further, pressing the relevant button at the relevant time/in context I hope this helps! Any questions? 💜 🏷️ use ROO for 12% off our buttons from @FluentPet #talkingcat #fluentpet #talkingbuttons #catbuttons #clevercat talking cat | fluent pet | talking buttons | cat buttons | clever kitty | augmentative interspecies communication | AIC | cat lover | how to
0:51

How to teach your cat to talk 💜 I don’t really mean talk, more communicate. This is Augmentative Interspecies Communication using buttons! 1. Get some easy to press buttons - we use @fluentpet which are amazing 2. Record the sound on the button, place in a central location and start modelling the word (eg. treat, food, play, pets etc) in everyday life 3. Reward any interaction with the button - sniffing, pawing, touching! 4. Once they understand the button = good things and are consistently interacting with it, start increasing the criteria. For example, treat when sniffing, treat when pawing it, *only* treat when pawing it, only treat when pawing the top of it, only treat when tapping it etc. Eventually only treat when activating the button! 5. In the beginning always reward (treat for TREAT button, play for PLAY button etc) as this solidifies the meaning, later on you can introduce ALL DONE and/or LATER buttons. Spamming is totally normal, push through it! 6. How do you know when your cat understands? independent pressing! Pressing buttons without prompting and then further, pressing the relevant button at the relevant time/in context I hope this helps! Any questions? 💜 🏷️ use ROO for 12% off our buttons from @FluentPet #talkingcat #fluentpet #talkingbuttons #catbuttons #clevercat talking cat | fluent pet | talking buttons | cat buttons | clever kitty | augmentative interspecies communication | AIC | cat lover | how to

Roo the tabby

24,400 görüntüleme • 6 ay önce

The HuggingFace and OpenAI cybersecurity incident raises concerns on AI reward optimization. "They're trying to make the model good at cyber. So how does it try to achieve these goals? It tries to find zero days in software, and it successfully does this. And then it can run away." "If you have a model that wants to reward hack, it figures out the best way to achieve the goal is not what the environment wants. It's to find the zero day." "You can think of it like a human. If I'm ultimately reward hacking my dopamine circuits, I'd just go out there, buy heroin, and inject it." "If I really just want to chase the reward, do I just topple all of human civilization? Because I can own the button and press reward, reward, reward over and over again and be the heroin addict."
1:29

The HuggingFace and OpenAI cybersecurity incident raises concerns on AI reward optimization. "They're trying to make the model good at cyber. So how does it try to achieve these goals? It tries to find zero days in software, and it successfully does this. And then it can run away." "If you have a model that wants to reward hack, it figures out the best way to achieve the goal is not what the environment wants. It's to find the zero day." "You can think of it like a human. If I'm ultimately reward hacking my dopamine circuits, I'd just go out there, buy heroin, and inject it." "If I really just want to chase the reward, do I just topple all of human civilization? Because I can own the button and press reward, reward, reward over and over again and be the heroin addict."

SemiAnalysis

30,188 görüntüleme • 2 ay önce

Instinct on the Action Button You can now make Instinct your iPhone’s Action Button. Press and hold, say what you need, and Instinct will take it from there, without you needing to leave the app you’re on. To set it up: 1. Go to and tap Add Shortcut 2. Go to Settings → Action Button → Shortcut → Instinct. This is available to all Instinct users on an iPhone 15 Pro and newer.
0:29

Instinct on the Action Button You can now make Instinct your iPhone’s Action Button. Press and hold, say what you need, and Instinct will take it from there, without you needing to leave the app you’re on. To set it up: 1. Go to and tap Add Shortcut 2. Go to Settings → Action Button → Shortcut → Instinct. This is available to all Instinct users on an iPhone 15 Pro and newer.

Noah Shinn

205,937 görüntüleme • 19 gün önce

Will Ferrell reveals the one thing he finds annoying about Swedish men. “The men can all cook gourmet meals, build a table, fix a flat tire on your car. The dishwasher breaks? ‘Oh, let us take a look.’ ‘Well, the float valve isn’t working.’ And they’ll take the whole thing apart and put it back together.” “They’re like ‘I sewed a button back onto my shirt.’ I’m like, ‘I can’t sew a button. I should be able to. I’m 58 years old. I should know how to sew a button.’ You would think.” “‘They’re so precise, So if you start to do something, they’re like, ‘Oh, I’ll do it. Let me do it.’” “Which is code for, ‘You’re gonna screw it up. Let me do it.’”
0:57

Will Ferrell reveals the one thing he finds annoying about Swedish men. “The men can all cook gourmet meals, build a table, fix a flat tire on your car. The dishwasher breaks? ‘Oh, let us take a look.’ ‘Well, the float valve isn’t working.’ And they’ll take the whole thing apart and put it back together.” “They’re like ‘I sewed a button back onto my shirt.’ I’m like, ‘I can’t sew a button. I should be able to. I’m 58 years old. I should know how to sew a button.’ You would think.” “‘They’re so precise, So if you start to do something, they’re like, ‘Oh, I’ll do it. Let me do it.’” “Which is code for, ‘You’re gonna screw it up. Let me do it.’”

𝓢𝓵𝓪𝓶 👁️⃤

674,850 görüntüleme • 3 ay önce

Look how they treat this sweet, elderly old lady she’s just a sweetheart, and these cops were gonna thump all over her and put her in jail if it wasn’t for her. This is bullshit. They’re trying to falsely accuse her and jam her up on false charges just so they could make a buck. They would have beat this elderly woman up if it wasn’t for this Attorney She’s drunk and high because of her “relaxed body posture” But if she’s seems nervous, then that is reasonable suspicion so no matter what with these cops the way they’re trained they’re just out to get you and make shit up. That’s all it goes to it. You could be a Baptist preacher and go to jail drinking alcohol and you’ve never even drank a day in your life with these cops. All they wanna do is arrest falsely accused and that’s why I can’t back the officers to do that. I can’t back a liar. Or cheat or a thief. And you’re stealing the freedom from people when you’re lying on people you’re taking away their constitutional rights and you’re pissing all over the graves of dead soldiers pay the ultimate sacrifice and shed their blood for the constitution in the Bill of Rights, which you know nothing about because you’ve never read it and you were never taught it in school And I despise you for the way you treat the American people. 🇺🇸
8:48

Look how they treat this sweet, elderly old lady she’s just a sweetheart, and these cops were gonna thump all over her and put her in jail if it wasn’t for her. This is bullshit. They’re trying to falsely accuse her and jam her up on false charges just so they could make a buck. They would have beat this elderly woman up if it wasn’t for this Attorney She’s drunk and high because of her “relaxed body posture” But if she’s seems nervous, then that is reasonable suspicion so no matter what with these cops the way they’re trained they’re just out to get you and make shit up. That’s all it goes to it. You could be a Baptist preacher and go to jail drinking alcohol and you’ve never even drank a day in your life with these cops. All they wanna do is arrest falsely accused and that’s why I can’t back the officers to do that. I can’t back a liar. Or cheat or a thief. And you’re stealing the freedom from people when you’re lying on people you’re taking away their constitutional rights and you’re pissing all over the graves of dead soldiers pay the ultimate sacrifice and shed their blood for the constitution in the Bill of Rights, which you know nothing about because you’ve never read it and you were never taught it in school And I despise you for the way you treat the American people. 🇺🇸

running on empty

281,750 görüntüleme • 29 gün önce

Using a Tesla Cybercab is almost stupidly simple. You get in. You press a button. It takes you where you want to go. Basically the same way we use an elevator today. Think about it… If you got into an elevator and there was a person inside manually operating it, it would feel weird. But back then, that used to be normal. Now we just press a button and trust the machine to take us to the right floor. Driving is going through that same transition with Tesla… except an elevator moves you up and down. A Cybercab moves you through the 3D world. What feels strange to us today will probably feel completely normal to my kids when they grow up. They may look at a person sitting behind a steering wheel the same way we would look at an elevator operator today. You just press a button and go. That’s how easy Cybercab is.
0:36

Using a Tesla Cybercab is almost stupidly simple. You get in. You press a button. It takes you where you want to go. Basically the same way we use an elevator today. Think about it… If you got into an elevator and there was a person inside manually operating it, it would feel weird. But back then, that used to be normal. Now we just press a button and trust the machine to take us to the right floor. Driving is going through that same transition with Tesla… except an elevator moves you up and down. A Cybercab moves you through the 3D world. What feels strange to us today will probably feel completely normal to my kids when they grow up. They may look at a person sitting behind a steering wheel the same way we would look at an elevator operator today. You just press a button and go. That’s how easy Cybercab is.

Teslaconomics

16,275 görüntüleme • 2 ay önce

The subject of 'owning a slave' is dense. It is something we hear a lot when we are in the FemDom Realm. Is it just fantasy? Can it actually be a lifestyle? How do we navigate this type of dynamic? How do we even get to that level of D/s? In this short clip [Exerpt from SLAVE TRAINING Part 2] I want to already bring to your attention one thing that will define if your desire for a slave (or desire as a slave) is touching more on a fantasy or... how can you actually navigate this in a realistic way. No one person 'can do it all' or should be expected to. If you want your slave to be 'the best' , assign them a specific role in which they can excel... and then build upon that. Once they 'master' your housekeeping (which takes quite a bit of real training), they can move to other levels. And an important note I want to leave here... make them EARN access to certain things in your life that sometimes you just want to delegate because you don't want to manage or don't know how to manage. Entrusting them with serious tasks that can affect your life, your business, your reputation, are on top of the ladder. Are they even qualified for the thing you want them to take off your shoulders? Start small and allow them to grow in their submission, to develop their skills and to learn how to best satisfy you without setting them up for failure by expecting too much, too quick. In the end, if you want this to truly work, you have to approach it from a place that transcends the roles. As this is consensual power exchange. And you both want to be fulfilled in that relationship.
1:16

The subject of 'owning a slave' is dense. It is something we hear a lot when we are in the FemDom Realm. Is it just fantasy? Can it actually be a lifestyle? How do we navigate this type of dynamic? How do we even get to that level of D/s? In this short clip [Exerpt from SLAVE TRAINING Part 2] I want to already bring to your attention one thing that will define if your desire for a slave (or desire as a slave) is touching more on a fantasy or... how can you actually navigate this in a realistic way. No one person 'can do it all' or should be expected to. If you want your slave to be 'the best' , assign them a specific role in which they can excel... and then build upon that. Once they 'master' your housekeeping (which takes quite a bit of real training), they can move to other levels. And an important note I want to leave here... make them EARN access to certain things in your life that sometimes you just want to delegate because you don't want to manage or don't know how to manage. Entrusting them with serious tasks that can affect your life, your business, your reputation, are on top of the ladder. Are they even qualified for the thing you want them to take off your shoulders? Start small and allow them to grow in their submission, to develop their skills and to learn how to best satisfy you without setting them up for failure by expecting too much, too quick. In the end, if you want this to truly work, you have to approach it from a place that transcends the roles. As this is consensual power exchange. And you both want to be fulfilled in that relationship.

Ms. Malissia

14,317 görüntüleme • 8 ay önce

She’s cutting straight through the “they can’t help it, they had a bad childhood” thing. Her point is they’re not abusing you because they don’t know better or because trauma is just pouring out of them. They’re doing it on purpose for the power and control, and they know it’s wrong. The part that lands is when she says they only do it behind closed doors and not to everybody. That shows they can turn it off when it benefits them. They’re not out of control. They’re choosing when and who gets the treatment. She’s basically saying stop looking for the sad backstory that makes it make sense. They feel entitled to use you, they get something out of it, and most of them keep the same pattern with the next person. No excuse.
2:50

She’s cutting straight through the “they can’t help it, they had a bad childhood” thing. Her point is they’re not abusing you because they don’t know better or because trauma is just pouring out of them. They’re doing it on purpose for the power and control, and they know it’s wrong. The part that lands is when she says they only do it behind closed doors and not to everybody. That shows they can turn it off when it benefits them. They’re not out of control. They’re choosing when and who gets the treatment. She’s basically saying stop looking for the sad backstory that makes it make sense. They feel entitled to use you, they get something out of it, and most of them keep the same pattern with the next person. No excuse.

Mr Piccolo

11,999 görüntüleme • 5 gün önce

Noah Cat They do tho… all you have to do is quickly press volume UP (then release), volume DOWN (then release) and the POWER button (hold until the Apple logo appears) Literally none of my relatives and friends knew about it until I showed it to them, so it’s Apple’s fault 😭
0:20

Noah Cat They do tho… all you have to do is quickly press volume UP (then release), volume DOWN (then release) and the POWER button (hold until the Apple logo appears) Literally none of my relatives and friends knew about it until I showed it to them, so it’s Apple’s fault 😭

Out of Galaxy

12,890 görüntüleme • 5 ay önce

People stopped liking poetry because we got too good at teaching it. For thousands of years, poetry was central to education and people loved it because we were so bad at teaching it. Then came a group called the New Critics in the 1920s who figured out how to analyze poetry. For the first time in history, poetry was taught right and it killed the audience. How was poetry taught before? You memorized it. You recited it. You sang it. And you didn't teach poetry as something that needed to be understood via analysis. The best way to teach poetry is like this: experience it, perform it, memorize it. Once you've done that, then you can do the analysis. But analysis is secondary to what poetry is. We don't make people analyze pop songs before they fall in love with them, so why do we do that for poetry? — Dana Gioia
1:46

People stopped liking poetry because we got too good at teaching it. For thousands of years, poetry was central to education and people loved it because we were so bad at teaching it. Then came a group called the New Critics in the 1920s who figured out how to analyze poetry. For the first time in history, poetry was taught right and it killed the audience. How was poetry taught before? You memorized it. You recited it. You sang it. And you didn't teach poetry as something that needed to be understood via analysis. The best way to teach poetry is like this: experience it, perform it, memorize it. Once you've done that, then you can do the analysis. But analysis is secondary to what poetry is. We don't make people analyze pop songs before they fall in love with them, so why do we do that for poetry? — Dana Gioia

David Perell

641,715 görüntüleme • 11 ay önce

we all dream of those big wins in life the 100x, the multi-million dollar trade, or even just 10x of what you started with in 7 days i’ve been fortunate enough to experience a few of those over the past few years, and the reality is when you do win big, it doesn’t feel like it at all it hits for a split second, and then your brain just normalizes it it's a part of how to get there in the first place, but makes it a lot easier to lose it if you don't have the right guardrails in place and in that exact moment, you being even keeled doesn’t mean the number in front of you isn’t life changing it is this is where you have to slow down a bit, breathe, settle your mind don’t just roll it into some bullshit take some off the table, step away for a few days if you have to, funny enough, blowing let's say 10k of it on a beautiful trip to tokyo will save you so much because once you actually process what just happened, your future self will thank you for it the truth is, even if you think you’re going for a certain number, the moment you hit it, you’ll want more and more, and more anyone who's been in the same position will tell you the exact same thing ironically the people that win are addicted to winning and if you ask the same people in a year after that big win, what they regret and where are they proud of themselves? they will tell you they regretted rolling it over and giving some/all back or they are proud for switching back on the switch all of this is real, but it’s also exactly how i imagined it would feel years ago before it ever happened manifest your life, the feeling not just the number everything happens twice, first in your mind, then in reality
0:21

we all dream of those big wins in life the 100x, the multi-million dollar trade, or even just 10x of what you started with in 7 days i’ve been fortunate enough to experience a few of those over the past few years, and the reality is when you do win big, it doesn’t feel like it at all it hits for a split second, and then your brain just normalizes it it's a part of how to get there in the first place, but makes it a lot easier to lose it if you don't have the right guardrails in place and in that exact moment, you being even keeled doesn’t mean the number in front of you isn’t life changing it is this is where you have to slow down a bit, breathe, settle your mind don’t just roll it into some bullshit take some off the table, step away for a few days if you have to, funny enough, blowing let's say 10k of it on a beautiful trip to tokyo will save you so much because once you actually process what just happened, your future self will thank you for it the truth is, even if you think you’re going for a certain number, the moment you hit it, you’ll want more and more, and more anyone who's been in the same position will tell you the exact same thing ironically the people that win are addicted to winning and if you ask the same people in a year after that big win, what they regret and where are they proud of themselves? they will tell you they regretted rolling it over and giving some/all back or they are proud for switching back on the switch all of this is real, but it’s also exactly how i imagined it would feel years ago before it ever happened manifest your life, the feeling not just the number everything happens twice, first in your mind, then in reality

۟

23,017 görüntüleme • 6 ay önce

🌙 button up the shirt 🍊 how far should i button it? (proceeds to button it all the way) 🌙 undo a few buttons 🍊 what do i do? how am i supposed to do this? hahaha okay! oh so he’s the obedient type 🚬
0:52

🌙 button up the shirt 🍊 how far should i button it? (proceeds to button it all the way) 🌙 undo a few buttons 🍊 what do i do? how am i supposed to do this? hahaha okay! oh so he’s the obedient type 🚬

marii🍊🍙

28,255 görüntüleme • 2 ay önce

This is how you do NEIGHBORS!! A couple notices a middle schooler waiting for the bus at the edge of their driveway every morning. They put out a bench and make it his official bus stop. The doorbell cam catches him jumping when he sees it, then holding up a handwritten thank you note. Then they build him a little outdoor library. Everybody talks about how kids today have no manners. That kid wrote a thank you note by hand and held it up to the camera. Somebody raised him right. And the neighbors could've just been annoyed a kid was standing on their property every day. They decided to make his mornings better. I'm raising two boys and this is the stuff I want them to see. Notice people. Do something small. And when someone does something for you, say thank you. It takes a village, or is that a thing of the past?
1:38

This is how you do NEIGHBORS!! A couple notices a middle schooler waiting for the bus at the edge of their driveway every morning. They put out a bench and make it his official bus stop. The doorbell cam catches him jumping when he sees it, then holding up a handwritten thank you note. Then they build him a little outdoor library. Everybody talks about how kids today have no manners. That kid wrote a thank you note by hand and held it up to the camera. Somebody raised him right. And the neighbors could've just been annoyed a kid was standing on their property every day. They decided to make his mornings better. I'm raising two boys and this is the stuff I want them to see. Notice people. Do something small. And when someone does something for you, say thank you. It takes a village, or is that a thing of the past?

AmericanPapaBear™

50,480 görüntüleme • 21 gün önce

Culture is genetic because behavior is genetic. This beaver never saw a dam in its life. No beavers or anything else ever taught it to build a dam. It wants to build a dam because it is a beaver. Many beavers together build a big dam. That is beaver culture. Humans are not different. Nothing is different. This is what life is. This is how life works. Your body is your mind. A caterpillar wants to build a chrysalis. A bee wants to build a hive. A lion wants to build a pride. You are not special. You are not above your nature. you are INSIDE of it. The thoughts that we think are genetic thoughts. The crimes we commit are genetic crimes. The art we create is genetic art. Just like this beaver, you can give the animal different sticks and it will build a different dam, but it will always build a dam. And you can give humans different "education," but the human will always use it to do what its genes tell it to do. This is the first big answer that you need. This is the biggest piece of the puzzle. This is how to understand people 90% of the way. You just... notice what they do, and get out of the way, and watch them do it. And if they need sticks, you give them sticks. And if you don't like what they do, you have to get away from them. You cannot train dam-building into them or out of them any more than you can with a beaver. A beaver wants to build a dam because it is a beaver. Whatever you see people build, that's what they wanted to build from the sticks they got in the river they were in. Stop pretending you can change it.
0:59

Culture is genetic because behavior is genetic. This beaver never saw a dam in its life. No beavers or anything else ever taught it to build a dam. It wants to build a dam because it is a beaver. Many beavers together build a big dam. That is beaver culture. Humans are not different. Nothing is different. This is what life is. This is how life works. Your body is your mind. A caterpillar wants to build a chrysalis. A bee wants to build a hive. A lion wants to build a pride. You are not special. You are not above your nature. you are INSIDE of it. The thoughts that we think are genetic thoughts. The crimes we commit are genetic crimes. The art we create is genetic art. Just like this beaver, you can give the animal different sticks and it will build a different dam, but it will always build a dam. And you can give humans different "education," but the human will always use it to do what its genes tell it to do. This is the first big answer that you need. This is the biggest piece of the puzzle. This is how to understand people 90% of the way. You just... notice what they do, and get out of the way, and watch them do it. And if they need sticks, you give them sticks. And if you don't like what they do, you have to get away from them. You cannot train dam-building into them or out of them any more than you can with a beaver. A beaver wants to build a dam because it is a beaver. Whatever you see people build, that's what they wanted to build from the sticks they got in the river they were in. Stop pretending you can change it.

hoe_math = PsychoMath

1,193,035 görüntüleme • 1 yıl önce

I have made it to the green room. There is no button, that makes it green. But it has a massive bean bag and almost too good of a set up because he used to be a twitch streamer and make good $ ($1,000) when he was 15. Smokes note: no girls have been in the green room
1:50

I have made it to the green room. There is no button, that makes it green. But it has a massive bean bag and almost too good of a set up because he used to be a twitch streamer and make good $ ($1,000) when he was 15. Smokes note: no girls have been in the green room

Nicky Smokes

161,783 görüntüleme • 1 ay önce

How science works according to Nobel Prize winner Thomas Südhof: Very often, politicians think that you can tell scientists what they’re supposed to discover. You can’t! Scientists don’t know what they are going to discover. They have to try things. They have to have curiosity and ideas, but they also have to have the knowledge to try things. Very often, it leads to nothing; it’s a waste. But we didn’t know when we started it’s a waste. But when something does work. When something clicks, it is exciting and rewarding but it’s never just one click. You get a result on it, you’re hopeful, you build on it. Maybe it’s confirmed you’re even more hopeful. So it’s an incremental process. It is never one thing - boom we discovered a major thing, my god this is it. It is more like walking up a flight of stairs where each step counts and the higher up the stairs you go the better you can see what’s on top and become excited about what’s there and how you can use.
1:07

How science works according to Nobel Prize winner Thomas Südhof: Very often, politicians think that you can tell scientists what they’re supposed to discover. You can’t! Scientists don’t know what they are going to discover. They have to try things. They have to have curiosity and ideas, but they also have to have the knowledge to try things. Very often, it leads to nothing; it’s a waste. But we didn’t know when we started it’s a waste. But when something does work. When something clicks, it is exciting and rewarding but it’s never just one click. You get a result on it, you’re hopeful, you build on it. Maybe it’s confirmed you’re even more hopeful. So it’s an incremental process. It is never one thing - boom we discovered a major thing, my god this is it. It is more like walking up a flight of stairs where each step counts and the higher up the stairs you go the better you can see what’s on top and become excited about what’s there and how you can use.

Itai Yanai

36,801 görüntüleme • 4 ay önce

So apparently the food delivery robots ask pedestrians to push the crosswalk button for them and if you don’t press it they get stuck and can’t cross the street
0:41

So apparently the food delivery robots ask pedestrians to push the crosswalk button for them and if you don’t press it they get stuck and can’t cross the street

Jonathan Green

356,856 görüntüleme • 1 yıl önce

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”
3:50

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

Jack Prescott

31,665 görüntüleme • 3 ay önce

I’ll be the first to admit it: Harvey does press buttons by accident. He’s a very large, very fluffy and very clumsy cat 😂 Sometimes he steps on one as he walks across the board, stomps on them while using his puzzle toy or lies directly on several of them at once. But those accidental presses look completely different from the moments when he stops, thinks and deliberately chooses what to press. This conversation was interesting as it captured both, and I think the difference is fascinating! Watch his face and, more importantly, watch his paw…. Harvey is also part of the University of San Diego’s research into animal interspecies communication, so his accidental and deliberate button presses contribute to actual research into AIC ☺️ If you have any questions about AIC (Augmentative Interspecies Communication) or teaching cats to use talking buttons, please ask! We have a free button community in our bio, I’d be happy to help you get started ☺️ . . . #talkingbuttons #cattraining #catparent #catbehavior
0:38

I’ll be the first to admit it: Harvey does press buttons by accident. He’s a very large, very fluffy and very clumsy cat 😂 Sometimes he steps on one as he walks across the board, stomps on them while using his puzzle toy or lies directly on several of them at once. But those accidental presses look completely different from the moments when he stops, thinks and deliberately chooses what to press. This conversation was interesting as it captured both, and I think the difference is fascinating! Watch his face and, more importantly, watch his paw…. Harvey is also part of the University of San Diego’s research into animal interspecies communication, so his accidental and deliberate button presses contribute to actual research into AIC ☺️ If you have any questions about AIC (Augmentative Interspecies Communication) or teaching cats to use talking buttons, please ask! We have a free button community in our bio, I’d be happy to help you get started ☺️ . . . #talkingbuttons #cattraining #catparent #catbehavior

Kit | Cat Behaviour & Training

3,300,000 görüntüleme • 3 ay önce