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How would one-and-done cholesterol medicines be priced? What about a subscription model, as suggested by Lilly's CEO - pay monthly if cholesterol is still low; don't pay if it's not? Sek Kathiresan MD explains how he thinks about it - less a drug, more a molecular surgical procedure:

Samuel Hume

61,574 subscribers

11,776 просмотров • 1 месяц назад •via X (Twitter)

Anya Rossi• Live Now

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Комментарии: 3

Фото профиля Samuel Hume

Samuel Hume1 месяц назад

Watch the full version on Youtube!

Фото профиля sciqst

sciqst1 месяц назад

@skathire The “molecular surgery” framing makes outcome-based pricing interesting, but who carries the risk if LDL rebounds years later—or the patient changes insurers? I’d dig through the evidence with Sci-Quest, a platform for biomedical literature reviews:

Фото профиля iandanforth 🦋 @iandanforth.bsky.social

iandanforth 🦋 @iandanforth.bsky.social1 месяц назад

@skathire Life imitating art

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How would a one-and-done cholesterol-lowering medicine fit in with the other therapies? It's all about choice. In surveys with patients: 40% choose daily pills (like enlicitide) 5-6% choose twice-monthly injections (like evolocumab) 14% choose twice-yearly injections (like inclisiran) ~33% choose the one-time treatment (Verve-102) With the pioneer of the technology, Sek Kathiresan MD:

How would a one-and-done cholesterol-lowering medicine fit in with the other therapies? It's all about choice. In surveys with patients: 40% choose daily pills (like enlicitide) 5-6% choose twice-monthly injections (like evolocumab) 14% choose twice-yearly injections (like inclisiran) ~33% choose the one-time treatment (Verve-102) With the pioneer of the technology, Sek Kathiresan MD:

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The corruption of our medical system goes much deeper than you think. Alan Cassels just exposed how the American Heart Association manipulates health guidelines to “sell sickness” and turn healthy people into patients for profit. “The new definition of ‘high cholesterol’ is almost 100 million Americans.” “This is a massive market.” “The reason is so obvious.” “Because there’s so much money in it.” “The American Heart Association came out with a new set of guidelines just earlier this month.” “They are a fascinating study in the creation of disease.” “The recommendations around when you should test somebody for high cholesterol have changed.” “Instead of just testing older people, we should be testing younger people.” “We should be screening children.” “We should be getting people to submit to a cholesterol test every 5 years.” “There are new cholesterol-lowering drugs.” “There are new ways to take healthy people and turn them into candidates for whom the drug would be prescribed.” “I think cholesterol is one of the most absurd examples of the selling of sickness.” “The danger of high cholesterol has not changed.” “It’s a small risk factor.” “If you take a cholesterol-lowering drug for 10 years, it might reduce your risk of having a heart attack or stroke by about 1%, if you’re lucky.” “About 20-25% of the people who take the drug will not be able to tolerate it because of adverse effects.” “We’re talking about a drug that has an extremely low yield and a high likelihood of being harmful.” Alan Cassels Jeffrey A Tucker

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