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I am delighted to share our latest paper on the Integrator complex assembly and association with transcription factors. Great work by Michal Razew, Angelique Fraudeau, Moritz Pfleiderer and Romain Linares EMBL EMBL Grenoble

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Wojtek Galej

1,131 subscribers

18,747 Aufrufe • vor 2 Jahren •via X (Twitter)

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Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

We used #cryoEM to determine structures of the two Integrator sub-complexes, which allowed modelling of the fully assembled integrator bound to paused RNA polymerase II.

Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

We employed @GoogleDeepMind #AlphaFold2 to screen potential protein-protein interactions between Integrator subunits and over 1500 transcription factors. Candidate hits were validated experimentally by proteomics, mass photometry and pull-down analysis.

Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

We identified ZNF655 as a novel factor associating with the integrator and potentially modulating transcription attenuation.

Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

Also, check out recent complementary studies from Stefani Jonas @Fei_Xavier_Chen @isaac_fianu and @mpgpresident

Profilbild von Juha Huiskonen
Juha Huiskonenvor 2 Jahren

@brettcollins100 @MichalRazew @MorPfl @embl @EMBLGrenoble Nice work!

Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

@MichalRazew @MorPfl @embl @EMBLGrenoble Thanks Alexey!

Profilbild von Claudio Alfieri
Claudio Alfierivor 2 Jahren

@MichalRazew @MorPfl @embl @EMBLGrenoble Many congratulations @WojtekGalej and coauthors, great work!

Profilbild von Wojtek Galej
Wojtek Galejvor 2 Jahren

@MichalRazew @MorPfl @embl @EMBLGrenoble Thanks Claudio!

Profilbild von Rajiv Ranjan Singh
Rajiv Ranjan Singhvor 2 Jahren

@MichalRazew @MorPfl @embl @EMBLGrenoble This is awesome!!

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