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I interviewed Aubrey de Grey on why neither billionaires nor AI will solve aging. And why a single mouse breakthrough could be the ChatGPT moment for longevity. 0:00 - Longevity Field 20 Years On 08:58 - Are Billionaires Getting It Wrong? 17:13 - Bryan Johnson vs Peter Thiel 23:42...

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Mgoes (bio/acc 🤖💉)

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45,429 Aufrufe • vor 7 Monaten •via X (Twitter)

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MR SHIFT 🦁

265,222 Aufrufe • vor 1 Jahr

NEW POD | EP 72 How Long Will This Bear Market Last? qw & Imran Timestamps: 0:56 State of the Market 3:23 Is Anyone Bullish? 4:08 Tariffs & the Economy 10:09 Crypto Sentiment Divergence 13:18 Ethena and Ondo Launching Their Own Layer 1 15:55 Regulation and Counterparty Risk 18:28 Tokenizing $COIN on Base 19:49 Stablecoins 20:41 Robinhood & Kalshi 22:12 State of AI 22:25 Manus AI 26:02 China vs. US AI Video Models 28:55 Localized LLMs & Privacy 29:44 Apple Intelligence & Privacy Issues 32:02 Using Localized LLMs 32:51 Global Paranoia About Privacy 34:14 Vibe Coding 39:53 Tokenizing Startups and Equity 42:49 BYD's New 1,000kw EV Charging Technology 45:42 Robotics 49:48 Crypto and Robotics 53:23 AI and Robotics in the Workforce 54:26 Where are we headed? Link ↓
59:46

NEW POD | EP 72 How Long Will This Bear Market Last? qw & Imran Timestamps: 0:56 State of the Market 3:23 Is Anyone Bullish? 4:08 Tariffs & the Economy 10:09 Crypto Sentiment Divergence 13:18 Ethena and Ondo Launching Their Own Layer 1 15:55 Regulation and Counterparty Risk 18:28 Tokenizing $COIN on Base 19:49 Stablecoins 20:41 Robinhood & Kalshi 22:12 State of AI 22:25 Manus AI 26:02 China vs. US AI Video Models 28:55 Localized LLMs & Privacy 29:44 Apple Intelligence & Privacy Issues 32:02 Using Localized LLMs 32:51 Global Paranoia About Privacy 34:14 Vibe Coding 39:53 Tokenizing Startups and Equity 42:49 BYD's New 1,000kw EV Charging Technology 45:42 Robotics 49:48 Crypto and Robotics 53:23 AI and Robotics in the Workforce 54:26 Where are we headed? Link ↓

Good Game

12,078 Aufrufe • vor 1 Jahr

The Sam Altman Interview You know him as the CEO of OpenAI — but he's also an avid writer. We spoke not once but twice about how Sam captures ideas, clarifies his thinking, edits his writing, decides what to work on, and uses ChatGPT. Timestamps: 1:47 Will LLMs change how we write? 8:39 How does Sam use ChatGPT? 11:26 How Sam became less anxious 17:24 Sam once dreamed of being a novelist 18:37 Lessons from Peter Thiel 21:35 Lessons from Paul Graham 26:02 The book Sam Altman wants to write 28:37 Advice for startup founders 30:20 How Y Combinator shapes OpenAI 35:55 How Sam chose to work on AGI 37:35 Writing strategy memos at OpenAI 41:34 Why isn’t ChatGPT a better storyteller? 44:20 Sam's obsessive note-taking method 47:12 Will AI put writers out of work?
48:38

The Sam Altman Interview You know him as the CEO of OpenAI — but he's also an avid writer. We spoke not once but twice about how Sam captures ideas, clarifies his thinking, edits his writing, decides what to work on, and uses ChatGPT. Timestamps: 1:47 Will LLMs change how we write? 8:39 How does Sam use ChatGPT? 11:26 How Sam became less anxious 17:24 Sam once dreamed of being a novelist 18:37 Lessons from Peter Thiel 21:35 Lessons from Paul Graham 26:02 The book Sam Altman wants to write 28:37 Advice for startup founders 30:20 How Y Combinator shapes OpenAI 35:55 How Sam chose to work on AGI 37:35 Writing strategy memos at OpenAI 41:34 Why isn’t ChatGPT a better storyteller? 44:20 Sam's obsessive note-taking method 47:12 Will AI put writers out of work?

David Perell

239,789 Aufrufe • vor 1 Jahr

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS
47:57

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS

Daniel Shur

29,517 Aufrufe • vor 9 Monaten

A deep dive conversation with Dan Shipper 📧 on how AI can (actually) improve your life. We explore the human side of AI: why producing good work still requires taste, how coordinating agents can fry your attention and why automation actually creates more work for humans. Timestamps: 0:38 Annie Dillard, art + writing 4:14 Can AI deepen human craft? 5:43 The slot-machine effect of AI agents 6:55 Dan's “house phone” experiment 8:01 What AI can actually help us create 13:55 AI as a non-specific amplifier 17:23 Why AI companies mishandled the story 19:36 Will AI destroy jobs? 22:35 AI as “frozen competence” 26:11 Are human-AI centaurs temporary? 31:34 Career advice for the AI era 37:19 The skills that matter now 40:08 Every 🪨 as an AI research lab 42:25 The coherence problem 45:25 Rapid-fire questions 48:00 Super-intelligence by 2030? 50:44 Life after superintelligence 52:07 The questions Dan is living 53:02 Give yourself permission
53:26

A deep dive conversation with Dan Shipper 📧 on how AI can (actually) improve your life. We explore the human side of AI: why producing good work still requires taste, how coordinating agents can fry your attention and why automation actually creates more work for humans. Timestamps: 0:38 Annie Dillard, art + writing 4:14 Can AI deepen human craft? 5:43 The slot-machine effect of AI agents 6:55 Dan's “house phone” experiment 8:01 What AI can actually help us create 13:55 AI as a non-specific amplifier 17:23 Why AI companies mishandled the story 19:36 Will AI destroy jobs? 22:35 AI as “frozen competence” 26:11 Are human-AI centaurs temporary? 31:34 Career advice for the AI era 37:19 The skills that matter now 40:08 Every 🪨 as an AI research lab 42:25 The coherence problem 45:25 Rapid-fire questions 48:00 Super-intelligence by 2030? 50:44 Life after superintelligence 52:07 The questions Dan is living 53:02 Give yourself permission

Jonny Miller

94,051 Aufrufe • vor 25 Tagen

New Limit just raised $435 million. This is, in part, because they've had a massive breakthrough on reversing the age of the liver with their new brand of genetic reprogramming drugs. For the first time, NewLimit's co-founder and president Jacob Kimmel details the company's breakthrough here. We also get into the longevity and bio-tech fields more broadly to explain where aging science and AI are heading. If nothing else, come to see some mice get drunk. The Core Memory podcast is available wherever you pod, and I'll put the YouTube link down below in the replies. Our show is sponsored by Brex and SendCutSend. They are both wise and benevolent. Timestamps 0:00 Intro 3:50 What Is Epigenetic Reprogramming? 7:16 Growing a Whole Animal From One Old Cell 13:06 Meet Ambrosia, the AI Hunting for Youth 22:44 $435 Million and the Race to Human Trials 29:26 The Drunk Mice That Skip the Hangover 36:48 Inside the First Human Trial 43:14 Will There Ever Be a Hangover Pen? 49:39 Beyond the Liver: The Delivery Problem 1:03:27 Answering the Skeptics 1:12:42 Will OpenAI Become a Drug Company? 1:23:53 The Health Story Bigger Than AI? 1:35:00 How Far Behind Is the US vs China? 1:53:10 Can We Build Computers From Neurons?
2:00:28

New Limit just raised $435 million. This is, in part, because they've had a massive breakthrough on reversing the age of the liver with their new brand of genetic reprogramming drugs. For the first time, NewLimit's co-founder and president Jacob Kimmel details the company's breakthrough here. We also get into the longevity and bio-tech fields more broadly to explain where aging science and AI are heading. If nothing else, come to see some mice get drunk. The Core Memory podcast is available wherever you pod, and I'll put the YouTube link down below in the replies. Our show is sponsored by Brex and SendCutSend. They are both wise and benevolent. Timestamps 0:00 Intro 3:50 What Is Epigenetic Reprogramming? 7:16 Growing a Whole Animal From One Old Cell 13:06 Meet Ambrosia, the AI Hunting for Youth 22:44 $435 Million and the Race to Human Trials 29:26 The Drunk Mice That Skip the Hangover 36:48 Inside the First Human Trial 43:14 Will There Ever Be a Hangover Pen? 49:39 Beyond the Liver: The Delivery Problem 1:03:27 Answering the Skeptics 1:12:42 Will OpenAI Become a Drug Company? 1:23:53 The Health Story Bigger Than AI? 1:35:00 How Far Behind Is the US vs China? 1:53:10 Can We Build Computers From Neurons?

Ashlee Vance

93,172 Aufrufe • vor 2 Monaten

My dear friend, Vlad Tenev, changed the landscape of investing forever! The rise of the retail investor is largely due to Robinhood's success... and in this new Journey Man, we discuss it all... Enjoy! 00:00 - Intro 00:53 - Introducing Vlad Tenev of Robinhood 01:27 - Why Take on Wall Street? 01:54 - Robinhood’s Zero-Fee Origin Story 02:53 - Inspiration from Instagram and Uber 04:24 - Reimagining Trading for Mobile 05:05 - The Challenge of Disrupting Finance 05:42 - Why Everything Is Hard 06:34 - Early Wrong Assumptions 07:42 - Raising Capital with a Small Vision 08:48 - Funding Robinhood on AngelList 09:50 - Early Investors Changed Their Lives 10:38 - The Crypto Explosion Begins 11:07 - Considering a Bitcoin Exchange First 12:17 - Bitcoin’s Early Skepticism and Growth 13:08 - Robinhood Launches Crypto in 2018 14:03 - 2020: Crypto Revenue Surges Overnight 15:04 - The Challenge of Crypto Cyclicality 16:11 - Staffing a Volatile Business 17:10 - Building Robinhood’s Lean Crypto Team 18:46 - Robinhood’s First Crypto Event Coming 19:38 - Where TradFi Meets DeFi 20:34 - Tokenizing Everything 21:09 - Robinhood’s Vision for Crypto + Finance 21:47 - Thoughts on Crypto Options Demand 23:04 - Why Crypto Options Haven’t Taken Off 24:09 - Millennials and the Speculative Economy 25:22 - Democratizing Trading for Everyone 26:08 - Why Buy-and-Hold Doesn’t Work for All 27:15 - Trading vs Investing: A Matter of Wealth 28:01 - Trading as a Skill Anyone Can Build 29:13 - Robinhood’s Role in Onboarding Millions 30:06 - The Fed's Role and Retail Insight 31:03 - The Rise of the Retail Macro Trader 32:17 - Helping Users Succeed with Robinhood Strategies 33:35 - Power of Community and the Hive Mind 34:55 - Will AI Disrupt Community Too? 36:14 - Technological Waves and Investor Opportunity 37:10 - Human Purpose in an AI World 37:52 - Tokenizing Human Connection 38:28 - Creators, Platforms, and Future-Proofing 39:26 - Vlad’s Long-Term View of the Future 40:05 - Financial Services at the Heart of Disruption 41:14 - If AI Replaces Jobs, What Happens to Investing? 42:25 - Entering the Economic Singularity 43:31 - What Happens When AIs Win the Markets? 44:16 - AI's Role in Capital and Markets 45:07 - Will AI Eliminate Human Emotion from Markets? 46:06 - HFT: The Original AI Traders 47:20 - AI and Long-Term Probabilistic Forecasting 48:48 - GPUs, Gaming, and the Origins of AI 50:01 - Nvidia, CUDA, and Wall Street Arms Races 51:04 - Flash Boys and Microwave Trading 51:54 - Will AI Costs Go to Zero? 52:52 - Lower Cost, Higher Usage 53:41 - Robinhood’s UX Won’t Be Just a Chatbox 55:16 - Cortex: AI-Powered Features at Robinhood 56:54 - Tokenization and the Future of Asset Management 57:44 - Crowdsourced, Tokenized Hedge Funds 58:48 - Portability of Tokenized Assets 59:39 - Blockchain as the New Rails of Finance 01:00:09 - The Trump Token and Capital Formation 01:01:00 - Capital Access Unlocks Innovation 01:01:49 - Why Crypto Needs Regulatory Clarity 01:03:17 - From Meme Coins to Real Assets 01:04:17 - Crypto's Path to $100 Trillion? 01:05:15 - The Financial System Will Run on Blockchains 01:06:00 - Platform Layer vs Application Layer Wealth 01:06:29 - AI Raises Money and Launches Tokens 01:07:39 - AIs Creating Software and Capital Formation 01:08:00 - Final Thoughts: A Wild Future Ahead 01:08:20 - When Will Vlad Buy a CryptoPunk? 01:08:51 - Wrapping Up: AI, Crypto, and the Road Ahead
1:09:53

My dear friend, Vlad Tenev, changed the landscape of investing forever! The rise of the retail investor is largely due to Robinhood's success... and in this new Journey Man, we discuss it all... Enjoy! 00:00 - Intro 00:53 - Introducing Vlad Tenev of Robinhood 01:27 - Why Take on Wall Street? 01:54 - Robinhood’s Zero-Fee Origin Story 02:53 - Inspiration from Instagram and Uber 04:24 - Reimagining Trading for Mobile 05:05 - The Challenge of Disrupting Finance 05:42 - Why Everything Is Hard 06:34 - Early Wrong Assumptions 07:42 - Raising Capital with a Small Vision 08:48 - Funding Robinhood on AngelList 09:50 - Early Investors Changed Their Lives 10:38 - The Crypto Explosion Begins 11:07 - Considering a Bitcoin Exchange First 12:17 - Bitcoin’s Early Skepticism and Growth 13:08 - Robinhood Launches Crypto in 2018 14:03 - 2020: Crypto Revenue Surges Overnight 15:04 - The Challenge of Crypto Cyclicality 16:11 - Staffing a Volatile Business 17:10 - Building Robinhood’s Lean Crypto Team 18:46 - Robinhood’s First Crypto Event Coming 19:38 - Where TradFi Meets DeFi 20:34 - Tokenizing Everything 21:09 - Robinhood’s Vision for Crypto + Finance 21:47 - Thoughts on Crypto Options Demand 23:04 - Why Crypto Options Haven’t Taken Off 24:09 - Millennials and the Speculative Economy 25:22 - Democratizing Trading for Everyone 26:08 - Why Buy-and-Hold Doesn’t Work for All 27:15 - Trading vs Investing: A Matter of Wealth 28:01 - Trading as a Skill Anyone Can Build 29:13 - Robinhood’s Role in Onboarding Millions 30:06 - The Fed's Role and Retail Insight 31:03 - The Rise of the Retail Macro Trader 32:17 - Helping Users Succeed with Robinhood Strategies 33:35 - Power of Community and the Hive Mind 34:55 - Will AI Disrupt Community Too? 36:14 - Technological Waves and Investor Opportunity 37:10 - Human Purpose in an AI World 37:52 - Tokenizing Human Connection 38:28 - Creators, Platforms, and Future-Proofing 39:26 - Vlad’s Long-Term View of the Future 40:05 - Financial Services at the Heart of Disruption 41:14 - If AI Replaces Jobs, What Happens to Investing? 42:25 - Entering the Economic Singularity 43:31 - What Happens When AIs Win the Markets? 44:16 - AI's Role in Capital and Markets 45:07 - Will AI Eliminate Human Emotion from Markets? 46:06 - HFT: The Original AI Traders 47:20 - AI and Long-Term Probabilistic Forecasting 48:48 - GPUs, Gaming, and the Origins of AI 50:01 - Nvidia, CUDA, and Wall Street Arms Races 51:04 - Flash Boys and Microwave Trading 51:54 - Will AI Costs Go to Zero? 52:52 - Lower Cost, Higher Usage 53:41 - Robinhood’s UX Won’t Be Just a Chatbox 55:16 - Cortex: AI-Powered Features at Robinhood 56:54 - Tokenization and the Future of Asset Management 57:44 - Crowdsourced, Tokenized Hedge Funds 58:48 - Portability of Tokenized Assets 59:39 - Blockchain as the New Rails of Finance 01:00:09 - The Trump Token and Capital Formation 01:01:00 - Capital Access Unlocks Innovation 01:01:49 - Why Crypto Needs Regulatory Clarity 01:03:17 - From Meme Coins to Real Assets 01:04:17 - Crypto's Path to $100 Trillion? 01:05:15 - The Financial System Will Run on Blockchains 01:06:00 - Platform Layer vs Application Layer Wealth 01:06:29 - AI Raises Money and Launches Tokens 01:07:39 - AIs Creating Software and Capital Formation 01:08:00 - Final Thoughts: A Wild Future Ahead 01:08:20 - When Will Vlad Buy a CryptoPunk? 01:08:51 - Wrapping Up: AI, Crypto, and the Road Ahead

Raoul Pal

172,640 Aufrufe • vor 1 Jahr

Is there a Christian revival going on in America? Cliffe Knechtle would know. He’s been preaching on college campuses for 45 years. (0:00) Moral Relativism Is Running Rampant (8:23) The Tragedy of Transgenderism (17:54) Protestantism vs. Catholicism vs. Orthodoxy (25:12) Cliffe’s Greatest Challenge (28:12) The Importance of Self-Discipline (29:43) Cliffe’s Biggest Debates (34:54) Why Is the Old Testament So Violent? (44:49) The Emotional Fragility of Young America (48:44) Why Secularists Hate Christianity (53:52) The Demonic Forces at Work In the World (56:05) Judas, Pharaoh, and Free Will (1:03:03) Are People Inherently Good? (1:07:28) Cliffe’s Thoughts on Gay Marriage (1:11:34) Cliffe’s Response to Abortion (1:19:15) The Dangers of Self-Righteousness (1:27:21) Who Really Are God’s Chosen People? (1:34:18) The Continuous Rise of Christian Persecution (1:37:58) Is Cliffe Ever Worried for His Safety? (1:38:49) More and More People Are Converting to Christianity (1:39:48) Is Divorce a Sin? (1:41:36) Drugs and Alcoholism (1:45:28) Is Cliffe Hopeful for America’s Future? Includes Paid Partnerships.
1:48:16

Is there a Christian revival going on in America? Cliffe Knechtle would know. He’s been preaching on college campuses for 45 years. (0:00) Moral Relativism Is Running Rampant (8:23) The Tragedy of Transgenderism (17:54) Protestantism vs. Catholicism vs. Orthodoxy (25:12) Cliffe’s Greatest Challenge (28:12) The Importance of Self-Discipline (29:43) Cliffe’s Biggest Debates (34:54) Why Is the Old Testament So Violent? (44:49) The Emotional Fragility of Young America (48:44) Why Secularists Hate Christianity (53:52) The Demonic Forces at Work In the World (56:05) Judas, Pharaoh, and Free Will (1:03:03) Are People Inherently Good? (1:07:28) Cliffe’s Thoughts on Gay Marriage (1:11:34) Cliffe’s Response to Abortion (1:19:15) The Dangers of Self-Righteousness (1:27:21) Who Really Are God’s Chosen People? (1:34:18) The Continuous Rise of Christian Persecution (1:37:58) Is Cliffe Ever Worried for His Safety? (1:38:49) More and More People Are Converting to Christianity (1:39:48) Is Divorce a Sin? (1:41:36) Drugs and Alcoholism (1:45:28) Is Cliffe Hopeful for America’s Future? Includes Paid Partnerships.

Tucker Carlson

2,725,926 Aufrufe • vor 1 Jahr