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I'm convinced everyone aged 30+ needs to watch this exchange between longevity experts Peter Attia & Andrew Huberman. Understanding this may extend your lifespan by 10 years. Let me explain in simple language 👇:

2,235,346 Aufrufe • vor 2 Jahren •via X (Twitter)

29 Kommentare

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

The first key to living longer is to prevent the main causes of death. These are: - Heart disease - Metabolic disease - Neurodegeneration - Cancer

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Exercise is clinically proven to reduce All-Cause Mortality (ACM), i.e. death from any kind of disease by 500%. This is not a headline. It's a fact. Humans as a species evolved to live an active life outdoors. It's not surprising that exercising has such life-altering effects.

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Sean Kellyvor 2 Jahren

It took me a 4-year biomedical engineering degree and 10+ years of experiments to perfect my exercise routine. Here's what I've implemented 👇

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

1. Less Cardio - Say "No" to Running Running more than 5 miles at a time is highly inflammatory, injury-inducing, and detrimental to mobility. If your goal is to lose fat, there are far more effective ways to achieve it than running.

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Sean Kellyvor 2 Jahren

What I do instead: I have traded in 4-5 days per week of long runs to 1 day per week of a moderate run. Then I integrate cardio into my strength training routines. Note: Long cardio sessions and endurance workouts are good for the brain but not good for the body/inflammation

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Cardio absolutely has a place in your exercise routine. It's important to heart health & overall performance. But most people will largely benefit if they exercise MORE strength training and less cardio. Or at least combine the two.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

2. Lift Weights 4-5x/wk Lifting helps me improve my quality of life today, extend my health span & look the way I want to look (in this order). Specifically I: - Rotate muscle groups - Focus on compound > isolation exercises - Do 5-10 minutes of mobility training before/after

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

My workout routines are significantly geared towards building a strong posterior chain (legs, back & butt). I swear by my leg days & ensure that I train my glutes, quads, and hamstrings every week. A strong posterior chain is key to overall functional strength. Butt > Abs ;)

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Sean Kellyvor 2 Jahren

Right now I'm following @fillymarcus's Functional Bodybuilding program 👇🏻 It's a full-body program that helps me cycle through a range of workouts and intensity levels. Also includes warm-up and cool-down exercises for improving mobility.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Exercise is only the first key to unlock longevity The second key is having great relationships. Since 1938, Harvard studied what makes people flourish. It’s the longest in-depth longitudinal study on human life ever done, and it led to a simple and profound conclusion:

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Good relationships lead to great health We don’t prioritize relationships first. Consider the fact that the average American in 2018 spent 11 hours/day on solitary activities such as watching television and listening to the radio The result? We have a loneliness epidemic today

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Sean Kellyvor 2 Jahren

Studies have found that loneliness is just as lethal as smoking 15 cigarettes per day. So how can you solve it? Connections online and through devices seem to be poor replacements for the emotional and psychological sustenance we get from being around others.

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Sean Kellyvor 2 Jahren

Social media and video games are like the diet soda of our emotional well-being—it tastes like we’re hanging out with people, but there are no emotional calories. And in this case, no emotional calorie is a bad thing… it’s starving us. So how to make friends IRL?

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Sean Kellyvor 2 Jahren

Research shows that it’s far more useful to tackle feelings of loneliness by pursuing social groups rather than one-on-one interactions. The easiest way to join a group? Find an activity. The more participatory and active the group, the better.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Also, listen to this 80-second clip of Andrew Huberman and you'll likely grow deeper social bonds with your loved ones and people you meet 👇

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

3rd area: HEALTH TESTS But why are health tests so important for longevity? Because ~300 people die EVERY DAY prematurely because they don't identify symptoms soon enough.

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Sean Kellyvor 2 Jahren

I recommend this protocol to my family & friends because I would be crushed if they died too early from a preventable health condition. Here's a detailed thread I wrote a couple of months back on what tests you should have annually.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

4th area: Your diet A smart diet is one that helps you meet your macros while matching your lifestyle.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

My ground rule is 1 g of protein per pound of body weight. That's close to 200 grams of protein/day in my case. I'm able to hit this goal thanks to two protein-packed smoothies/day (w/ 40g+ protein each). I travel a lot, so this fits my lifestyle & ensures protein compliance.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

Studies reveal our bodies can absorb more than 25g of protein in a single go, especially after a hard workout. So, incorporate smoothies that give you 25+ gms of protein in one go.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

I consume lots of good fats: almonds, walnuts, and extra virgin olive oil. Since I'm an ectomorph (it helps to understand your body type), I can get away with not counting my calories and eating nutrient-rich foods. Besides, I hate counting calories and don't ever plan to.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

I rarely consume carbs alone. That's because having them alone is one of the worst things you can do for your body/blood sugar. This is especially true for high glycemic carbs. I also found that I have gluten sensitivity, so I no longer eat it. Gluten isn't great for anyone.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

5th Area: Sleep I now work out LESS than before. I take 1-2 days off every week and avoid pushing myself on days when I'm not at my best energy-wise. More rest is the easiest way to improve your health, focus and paradoxically, be more productive at work.

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Sean Kellyvor 2 Jahren

I have an elaborate night-time routine, a sleep toolkit, and a few thumb rules to get better sleep every night: - No alcohol on weekdays - Eat 3 hrs before bed - No emails/texts 2 hours prior to bed - Wake up w/o an alarm - Journal negative thoughts

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

I also aim to create the perfect sleep environment & hit a @eightsleep score of 95+ most days - Optimal sleep temp of 68°F or 20°C - Lightly stuffed pillow - White noise machine - MZOO sleep mask - Temperature-controlled mattress - Mouth-tape I sleep 50% better now.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

To recap, here are 5 areas you need to focus on optimizing in order to be fit late into life: 1. Exercise 2. Relationships 3. Regular health tests 4. Diet 5. Sleep Nail these and live a long, energized, healthy life.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

If you liked this, retweet the quote below. Follow me @seanpk for more threads on human performance, entrepreneurship, and investing.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

A bit about me: 20 years ago, I was a broke biomedical engineering college student trying to get my first biz off the ground. Since then, I’ve grown six 7-figure businesses, three 8-figure businesses & raised $50M+ in VC. I'm also a General Partner at The Family Fund.

Profilbild von Sean Kelly
Sean Kellyvor 2 Jahren

And I do all of this while prioritizing my health, traveling for fun every month & not grinding 247. I go deeper into everything I’ve learned about building businesses, investing & founder performance in my newsletter. Join thousands of founders here:

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Why I'm More Convinced Than Ever About Longevity Escape Velocity by 2030 Friends, many of you have been asking if I still believe we'll reach longevity escape velocity (LEV) by 2030, especially with all the recent AI breakthroughs dominating the headlines. My answer? Not only do I still believe it – I'm more convinced than ever. Let me share why this isn't wishful thinking but a rational conclusion based on converging evidence. We don't need to achieve immortality right away – we just need to add more than one year of lifespan per calendar year to buy time for even better solutions. The animal models already prove this is possible. We've extended the lifespans of mice (complex mammals!) by 30-50% using various therapies. The telomerase gene therapy alone extended mouse lifespan by 24% – equivalent to adding 30 human years. Imagine going from a max lifespan of 120 to 150 from a single treatment! Even more impressive, partial reprogramming using Yamanaka factors doubled the remaining lifespan of older mice. Applied to humans, this could dramatically extend our lives even starting in middle age. I'm 39 now – if something similar worked for me, it could potentially push my life expectancy well beyond 120 years. But here's where it gets really exciting: AI and quantum computing. These technologies are completely transforming how we approach longevity research. The computational barriers that previously made it impossible to simulate complete biological systems, metabolomes, or proteomes are rapidly falling. AI is accelerating drug discovery, deepening our genetic understanding, and enabling personalized medicine approaches that were purely science fiction just years ago. Tools like AlphaFold, AlphaProteo, and Deep Research aren't just making research 20% faster – they're making it 2,000% faster! World-leading experts are now saying that these technologies will likely cure essentially all diseases within the next 10-15 years. Cancer, heart disease, Alzheimer's – they're all computational problems at their core, and our computational power is exploding. What does this mean for you personally? In the immediate term, you can already improve your healthspan with existing compounds (I've started NAD+ precursors myself and noticed improvements). Within a few years, simple but effective anti-aging compounds like rapamycin (used carefully) will become more accessible. Looking further ahead, I expect we'll see comprehensive rejuvenation therapies becoming commonplace as we approach 2045. Imagine a sequence of treatments – perhaps once every 5-10 years – that dials your biological age back by 10-20 years. And each time you "kick the can down the road," the technology will have advanced even further. The biggest obstacle isn't scientific or technical – it's human. Regulatory systems like the FDA haven't even classified aging as a disease yet (though they happily medicalize other natural processes like pregnancy). There's also a strange cultural acceptance of death that resembles a death wish when you really examine it. I'd love to hear your thoughts on this topic in our community. Are you optimistic about LEV by 2030? What aspects of longevity research excite you most? And what steps are you taking today to extend your own healthspan while we wait for these breakthrough technologies?

David Shapiro (L/0)

35,264 Aufrufe • vor 1 Jahr