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David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And...

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John Cumbers

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21,184 次观看 • 4 个月前 •via X (Twitter)

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David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:23

David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

841,064 次观看 • 4 个月前

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:04

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

84,263 次观看 • 4 个月前

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.
0:27

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

John Cumbers

55,280 次观看 • 4 个月前

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:
1:29

David Sinclair's lab may have just found the $100 pill that reverses aging. Over the holidays, his team ran what he calls a "hail mary experiment." They gave old mice a "longevity" cocktail three times a week for 4 weeks. He didn't reveal what's in it - only that it contained molecules that work on the four longevity pathways that control the epigenome. They weren't expecting any significant results. Yet every treated mice came back physiologically younger while the controls didn't. Biological age clocks confirmed the reversal. This changes the trajectory for longevity medicine. The gene therapy his company is taking into human trials costs over $10 million to manufacture per batch. It requires a direct injection into the target organ. These oral molecules cost roughly $100 for a month's course. If they're able to put these molecules into a pill that patients can take instead of them using a multi-million dollar gene therapy, they'd save a ton of money. "Imagine in 10 years you just take a pill for 4 weeks and you get younger. That's what we're headed towards. I can see how this is going to happen." The proof of concept exists in animals. Now it's a race to get it into humans. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. You won't want to miss it:

John Cumbers

56,136 次观看 • 3 个月前

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
3:56

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,231,954 次观看 • 16 天前

Dr. David Sinclair was one of the most well-known advocates for drinking red wine. His reason was because red wine contains resveratrol, a molecule linked in longevity. He drank red wine because of it every day. Then he read data that changed his mind. Studies show that people who drink even one glass of alcohol a day tend to have smaller brain size. And the more you drink, the smaller your brain gets. The trend line was clear. Now he just takes resveratrol as a pure supplement. (about a gram mixed with olive oil or yogurt so his body can absorb it) He says since quitting he has mental clarity he has not felt since his 20s. PS. David Sinclair (David Sinclair) is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. You won't want to miss it. Tickets available now:
1:08

Dr. David Sinclair was one of the most well-known advocates for drinking red wine. His reason was because red wine contains resveratrol, a molecule linked in longevity. He drank red wine because of it every day. Then he read data that changed his mind. Studies show that people who drink even one glass of alcohol a day tend to have smaller brain size. And the more you drink, the smaller your brain gets. The trend line was clear. Now he just takes resveratrol as a pure supplement. (about a gram mixed with olive oil or yogurt so his body can absorb it) He says since quitting he has mental clarity he has not felt since his 20s. PS. David Sinclair (David Sinclair) is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. You won't want to miss it. Tickets available now:

John Cumbers

71,922 次观看 • 4 个月前

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.
1:24

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

John Cumbers

157,553 次观看 • 4 个月前

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:
1:43

David Sinclair believes: “If even if you slow aging by one year… for the US, that’s an extra $38 trillion because people are not sick and productive. If you extend that over 10 years, that’s $360+ trillion.” The reason is simple. Healthier people work longer, produce more, and cost less to treat. Improve the lifespan and vitality of a population and you directly improve the GDP and economy of an entire country. But there's an urgency here most people are missing. In 1960, the US had 25 babies per thousand people. Today it's around 10. As Sinclair puts it: "For the first time, more than half of the American states produced fewer babies than people died." A country's greatest asset isn't tech, oil, or gold - it's human productivity. And that resource is dwindling. Sinclair sees only two options: "Replace them with robots or keep people alive and healthy." - David Sinclair —— David Sinclair is at SynBioBeta this year—discussing the science of reversing aging. If longevity is your world, the investors, partners and scientists shaping this future will be in the room. Four days, 2,000 people. Grab your ticket:

John Cumbers

27,280 次观看 • 5 个月前

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair
1:45

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

John Cumbers

203,250 次观看 • 5 个月前

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair
2:59

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

Goku

32,589 次观看 • 5 个月前

New: Joe Rogan is visibly concerned when longevity scientist David Sinclair reveals that the first potential human age-reversal technology is already being tested in humans: ROGAN: “This sounds like the beginning of a horror movie.” SINCLAIR: “I admit it is science fiction, and I even have to pinch myself that it’s actually happening.” “The first potential human age-reversal technology is in people right now.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “ER-100 is the drug we put into people that makes them younger, and then they work like they were young again.” ROGAN: “Horror movie.” SINCLAIR: “This trial is FDA approved.” ROGAN: “Oh great they never f*ck anything up.” SINCLAIR: “I don’t see an old person anymore on the street. I just see a person that needs to be rebooted.”
5:29

New: Joe Rogan is visibly concerned when longevity scientist David Sinclair reveals that the first potential human age-reversal technology is already being tested in humans: ROGAN: “This sounds like the beginning of a horror movie.” SINCLAIR: “I admit it is science fiction, and I even have to pinch myself that it’s actually happening.” “The first potential human age-reversal technology is in people right now.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “ER-100 is the drug we put into people that makes them younger, and then they work like they were young again.” ROGAN: “Horror movie.” SINCLAIR: “This trial is FDA approved.” ROGAN: “Oh great they never f*ck anything up.” SINCLAIR: “I don’t see an old person anymore on the street. I just see a person that needs to be rebooted.”

Fan Commentary: Joe Rogan Recaps

27,492 次观看 • 16 天前

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

John Cumbers

417,802 次观看 • 5 个月前

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

Goku

985,946 次观看 • 5 个月前

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair
2:35

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

John Cumbers

305,874 次观看 • 5 个月前

Rapamycin Longevity Lab is proud to announce that the world-leading researcher Brian Kennedy (Brian Kennedy) will join the lab as a scientific advisor. We are also thrilled to welcome Kamil Pabis (Kamil Pabis), a great researcher from Brian’s lab, who will take on the role of scientific lead at Rapamycin Longevity Lab. Together, we will evaluate and explore the opportunities of using Pump Science as a platform to accelerate and fund longevity research in a new way. Now in mid September we are launching three promising longevity interventions on the platform. More details about this will be shared in the coming week. A very warm welcome to Brian and Kamil! We look forward to pushing the boundaries of longevity science together!
0:55

Rapamycin Longevity Lab is proud to announce that the world-leading researcher Brian Kennedy (Brian Kennedy) will join the lab as a scientific advisor. We are also thrilled to welcome Kamil Pabis (Kamil Pabis), a great researcher from Brian’s lab, who will take on the role of scientific lead at Rapamycin Longevity Lab. Together, we will evaluate and explore the opportunities of using Pump Science as a platform to accelerate and fund longevity research in a new way. Now in mid September we are launching three promising longevity interventions on the platform. More details about this will be shared in the coming week. A very warm welcome to Brian and Kamil! We look forward to pushing the boundaries of longevity science together!

Krister Kauppi - Rapamycin Longevity Lab

23,559 次观看 • 11 个月前

🇺🇸 HARVARD BEGINS TO REVERSE ALZHEIMER'S Professor of Genetics at Harvard, David Sinclair: "Curing blindness is a big deal. We didn't choose the eye because it was going to work; we chose it because it was difficult. If it's going to work in the eye, I think it's likely to work in other tissues. We can cure Alzheimer's in, or at least reverse large aspects of Alzheimer's, in a mouse now. Hopefully, reversing the age of the human brain will have the same effect, which means that memories will come back, and the ability to learn will come back. I'm saying that the eye is just the beginning." Source: Tsarathustra
1:22

🇺🇸 HARVARD BEGINS TO REVERSE ALZHEIMER'S Professor of Genetics at Harvard, David Sinclair: "Curing blindness is a big deal. We didn't choose the eye because it was going to work; we chose it because it was difficult. If it's going to work in the eye, I think it's likely to work in other tissues. We can cure Alzheimer's in, or at least reverse large aspects of Alzheimer's, in a mouse now. Hopefully, reversing the age of the human brain will have the same effect, which means that memories will come back, and the ability to learn will come back. I'm saying that the eye is just the beginning." Source: Tsarathustra

Mario Nawfal

411,616 次观看 • 2 年前

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”
6:19

Joe Rogan has his mind blown when anti-aging genius David Sinclair says his lab has a top secret drink that successfully makes old mice stronger and smarter in just 4 weeks: SINCLAIR: “The drink has three components in its formula which are top secret.” ROGAN: “You can’t tell us what’s in the drink?” SINCLAIR: “My lab is sworn to secrecy.” ROGAN: “So how are the mice responding to the drink?” SINCLAIR: “The mice get younger.” “Within those four weeks, they get better physically, mentally.” “In normal old mice we see them fitter, stronger, and they’ve shown better memory.” ROGAN: “How long did it take for them to get these results?” SINCLAIR: “They run around the cage in a month’s time. It worked in just four weeks.” ROGAN: “That’s amazing.” SINCLAIR: “Imagine a world where if I’m successful, you can put a cream on your face and you literally get younger.”

Fan Commentary: Joe Rogan Recaps

24,517 次观看 • 16 天前

Joe Rogan is mindblown after Harvard scientist David Sinclair reveals that Lebron James might be able to play in the NBA until he’s 60 years old with cutting edge age-reversal technology and that the FDA are the only ones preventing it from happening: SINCLAIR: “We’re going to be in a world where we can rebuild parts of the body, including joints.” ROGAN: “Have you had any successful studies yet that can prove this?” SINCLAIR: “A group in China just tested our technology and put it into mice that had bad joints.” “The results were the that it regrew their bones and joints back to normal.” ROGAN: “Woahhh.” SINCLAIR: “We’re also looking at curing back injuries and arthritis.” ROGAN: “That would be phenomenal. I know so many people who are struggling with arthritis.” SINCLAIR: “Yeah this drink is going to be an absolute game changer for athletes.” ROGAN: “We’re going to have super soldiers in every sport.” “There’s going to be people in every sport that could do what Michael Jordan did and leap from halfway across the basketball court and dunk.” SINCLAIR: “Yeah it’s going to be insane.” ROGAN: “Can we start testing this on humans? Let’s try it on 80 year olds.” SINCLAIR: “The FDA forbids that.” ROGAN: “That’s why we need to get rid of the FDA.”
2:20

Joe Rogan is mindblown after Harvard scientist David Sinclair reveals that Lebron James might be able to play in the NBA until he’s 60 years old with cutting edge age-reversal technology and that the FDA are the only ones preventing it from happening: SINCLAIR: “We’re going to be in a world where we can rebuild parts of the body, including joints.” ROGAN: “Have you had any successful studies yet that can prove this?” SINCLAIR: “A group in China just tested our technology and put it into mice that had bad joints.” “The results were the that it regrew their bones and joints back to normal.” ROGAN: “Woahhh.” SINCLAIR: “We’re also looking at curing back injuries and arthritis.” ROGAN: “That would be phenomenal. I know so many people who are struggling with arthritis.” SINCLAIR: “Yeah this drink is going to be an absolute game changer for athletes.” ROGAN: “We’re going to have super soldiers in every sport.” “There’s going to be people in every sport that could do what Michael Jordan did and leap from halfway across the basketball court and dunk.” SINCLAIR: “Yeah it’s going to be insane.” ROGAN: “Can we start testing this on humans? Let’s try it on 80 year olds.” SINCLAIR: “The FDA forbids that.” ROGAN: “That’s why we need to get rid of the FDA.”

Fan Commentary: Joe Rogan Recaps

14,738 次观看 • 13 天前

Joe Rogan is stunned by a theory that could completely rewrite human history: an advanced civilization may have existed LONG before recorded history. ROGAN: “There was a very advanced civilization that existed on Earth tens of thousands of years ago.” ROGAN: “We were probably wiped out by a comet impact, and what we have today is a rebuild of civilization.” ROGAN: “There’s not a linear progression from caveman to us.” ROGAN: “When you look at the Sumerian kings list, it gets very weird because there’s kings that reign for thousands of years.” ROGAN: “And then you have the flood. After the flood, the age of these people drops pretty dramatically.” ROGAN: “Is this just myth? Poor recordkeeping? Or had they achieved something we don’t understand?” ROGAN: “They had achieved incredibly complex structures like the pyramids.” ROGAN: “How did they move these 500-ton stones from hundreds of miles away? We don’t really know.” ROGAN: “Had they also gotten involved in genetic engineering?” ROGAN: “Had they figured out a way to extend lifespan?” Then Sinclair takes the idea even further. SINCLAIR: “Imagine if you had 500 years to do research, not just 57 years.” SINCLAIR: “Imagine if you could continue learning and growing.” SINCLAIR: “You would get so much done.” SINCLAIR: “The exponential increase in technological innovation that we would have in this society would be absolutely mind-blowing.” SINCLAIR: “If we do have extension of human lifespan… how will you think about your life if being 100 is still your prime?” SINCLAIR: “You might have multiple lifetimes, multiple marriages, multiple families.” SINCLAIR: “That will happen. It’s not really a question of if anymore.”
5:13

Joe Rogan is stunned by a theory that could completely rewrite human history: an advanced civilization may have existed LONG before recorded history. ROGAN: “There was a very advanced civilization that existed on Earth tens of thousands of years ago.” ROGAN: “We were probably wiped out by a comet impact, and what we have today is a rebuild of civilization.” ROGAN: “There’s not a linear progression from caveman to us.” ROGAN: “When you look at the Sumerian kings list, it gets very weird because there’s kings that reign for thousands of years.” ROGAN: “And then you have the flood. After the flood, the age of these people drops pretty dramatically.” ROGAN: “Is this just myth? Poor recordkeeping? Or had they achieved something we don’t understand?” ROGAN: “They had achieved incredibly complex structures like the pyramids.” ROGAN: “How did they move these 500-ton stones from hundreds of miles away? We don’t really know.” ROGAN: “Had they also gotten involved in genetic engineering?” ROGAN: “Had they figured out a way to extend lifespan?” Then Sinclair takes the idea even further. SINCLAIR: “Imagine if you had 500 years to do research, not just 57 years.” SINCLAIR: “Imagine if you could continue learning and growing.” SINCLAIR: “You would get so much done.” SINCLAIR: “The exponential increase in technological innovation that we would have in this society would be absolutely mind-blowing.” SINCLAIR: “If we do have extension of human lifespan… how will you think about your life if being 100 is still your prime?” SINCLAIR: “You might have multiple lifetimes, multiple marriages, multiple families.” SINCLAIR: “That will happen. It’s not really a question of if anymore.”

gomi

121,301 次观看 • 14 天前

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair
1:36

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair

John Cumbers

231,590 次观看 • 4 个月前