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In conversation with Andrew D. Huberman, Ph.D., Peter Attia explains why ApoB should be treated as a causal driver of heart disease, not just a risk marker: “There is no ambiguity that ApoB is causally related to atherosclerosis.” “LDL cholesterol or ApoB, causally related to atherosclerosis. Well, if that’s... show more

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🫀Is Causality Overrated? A Response to Peter Attia on Andrew D. Huberman, Ph.D. (Full Video for X) I wanted to respectfully address Dr. Peter Attia's views on causality, LDL, ApoB, and cardiovascular disease, offering a rebuttal to his position on the topic. I think he misses a big-picture point about what causality means and what it doesn’t when it comes to heart health. The TL;DR version is that “causality is not the logical equivalence of importance” and even if we identify a causal factor, it does not mean that factor should be treated. But let’s see if I can convince you. To that end I beg 10 minutes of your time if you share our passion for logical, responsible preventive care, metabolic health, and heart health. This is not an attempt to ‘dunk’ on anyone, but rather to catalyze a much-needed conversation in the realm of cardiology and cholesterol research. I hope you find this discussion respectful, thought-provoking, and an opportunity to expand the conversation. While I’m not expecting a response from Peter, consider this – at minimum – a time capsule and open invitation to evolve a dialogue that’s too long been siloed. (more information/links in first comment)

🫀Is Causality Overrated? A Response to Peter Attia on Andrew D. Huberman, Ph.D. (Full Video for X) I wanted to respectfully address Dr. Peter Attia's views on causality, LDL, ApoB, and cardiovascular disease, offering a rebuttal to his position on the topic. I think he misses a big-picture point about what causality means and what it doesn’t when it comes to heart health. The TL;DR version is that “causality is not the logical equivalence of importance” and even if we identify a causal factor, it does not mean that factor should be treated. But let’s see if I can convince you. To that end I beg 10 minutes of your time if you share our passion for logical, responsible preventive care, metabolic health, and heart health. This is not an attempt to ‘dunk’ on anyone, but rather to catalyze a much-needed conversation in the realm of cardiology and cholesterol research. I hope you find this discussion respectful, thought-provoking, and an opportunity to expand the conversation. While I’m not expecting a response from Peter, consider this – at minimum – a time capsule and open invitation to evolve a dialogue that’s too long been siloed. (more information/links in first comment)

Nick Norwitz MD PhD

37,902 Aufrufe • vor 11 Monaten

Dr. Paul Saladino reveals why the standard belief about LDL cholesterol is failing your heart health "Why do humans only develop atherosclerosis in arteries and not veins? The same amount of LDL cholesterol is circulating in my veins as in my arteries. It's a contiguous system. Veins don't develop atherosclerosis, only arteries" "Arteries are much more muscular because they must carry more pressure. When there's more pressure, there's more denuding of the endothelium, which means there's more damage just by being an artery because the pressure in there is higher" "My argument is apoB-containing particles like LDL are not atherosclerotic. You need endothelial damage to initiate atherosclerosis. Maybe they're arriving to the scene of the damage as part of the healing process—are they the firemen or are they the arsonist?"

Dr. Paul Saladino reveals why the standard belief about LDL cholesterol is failing your heart health "Why do humans only develop atherosclerosis in arteries and not veins? The same amount of LDL cholesterol is circulating in my veins as in my arteries. It's a contiguous system. Veins don't develop atherosclerosis, only arteries" "Arteries are much more muscular because they must carry more pressure. When there's more pressure, there's more denuding of the endothelium, which means there's more damage just by being an artery because the pressure in there is higher" "My argument is apoB-containing particles like LDL are not atherosclerotic. You need endothelial damage to initiate atherosclerosis. Maybe they're arriving to the scene of the damage as part of the healing process—are they the firemen or are they the arsonist?"

Health Almanac

14,371 Aufrufe • vor 1 Monat

"Just Because Cholesterol Is At The Scene Of The Crime, Doesn't Mean It's The Perpetrator." Dr Aseem Malhotra, Cardiologist "Cholesterol Is Not The Driver Of Atherosclerosis Plaque. Cholesterol Is The Firefighter, The First Responder." We find cholesterol in these fatty deposits in the inner lining of the artery, these plaques, but the cholesterol is also there with lots of immune cells. The damage to the lining of the inner artery is caused by lifestyle factors such as smoking, sugar & stress... And then the response to that damage to try & heal the artery is when you get these deposits & cholesterol is there. Cholesterol is not the driver, it just happens to be at the scene of the crime. Atherosclerosis is an inflammatory disease. Not a cholesterol disease or a statin deficiency. LDL is an important transport molecule involved in the immune system & contains vital heart nutrients like CoQ10, Vitamin E & antioxidants. True Causes of Inflammation & Atherosclerosis: Industrial Seed Oils Processed Sugar Carbohydrates Insulin Resistance Ultra Processed Foods Smoking Obesity Environmental Toxins Poor Sleep Low Vitamin D Levels Magnesium Deficiency K2 Deficiency Lack of Exercise Stress A low carbohydrate diet prioritizing nutrient dense animal foods, eliminating harmful seed oils & sugar, provides the best healthy cholesterol profile. This approach keeps Triglycerides low & HDL high, which is one of the best biomarkers for heart health. TG/HDL ratio optimally should be less than 2.0 & even better at 1.5 or less. 👇Low Cholesterol Increases Mortality👇 👇The Higher Your LDL, The Longer You Live👇 Speakers: Dr Aseem Malhotra & Gary Brecka

Valerie Anne Smith

85,331 Aufrufe • vor 1 Jahr

Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman

Cardiology Has an LDL Obsession. What to Measure Instead... 🔗New video: 👇1 min clip on LDL vs Insulin Resistance The landscape of atherosclerosis is changing. New drugs are lowering LDL, total cholesterol and ApoB lower and lower, while larger risk factors like insulin resistance, obesity, and diabetes persist. If you want a comparison, lipoprotein insulin resistance score (LP-IR). Because 1.0 is risk neutral, insulin resistance score is a more than 14X more powerful predictor of new coronary heart disease than LDL. But we know who gets all the attention. Answer: [See Clip] That’s not proportional medicine Do you agree? For more nuances see the video linked above. cc Benjamin Bikman Dave Feldman

Nick Norwitz MD PhD

77,831 Aufrufe • vor 6 Monaten

"The Higher Your LDL, The Longer You're Going To Live." Cardiologist Dr Aseem Malhotra & Study Co-Author. "The Greater The Financial Interest In A Given Field, The Less Likely The Research Findings Are to be True." "The Most Lucrative Drug In The History Of Medicine Are Statins." $19 Billion Dollar Profit Industry Totalling 818 Million Prescriptions Annually. "The Benefit Of Statins For Both Low Risk & High Risk Primary Prevention Is ONLY 1%...1 In 100." "There Is No Correlation Between Elevated LDL Level & Events Of Cardiovascular Disease. In Fact, It's The Inverse. There Is A Correlation Between Higher LDL Level & Longevity." "The Higher The LDL, The Longer You're Going To Live, Because It Has A Vital Role In Your Immune System." "Just Because Cholesterol Is At The Scene Of the Crime, Doesn't Mean It's The Perpetrator." Cholesterol is trying to clear the inflammation & put out the fire caused by other lifestyle issues in order to get the body to return to Homeostasis. Atherosclerosis Is An Inflammatory Disease, Not A Cholesterol Disease or A Statin Deficiency. A Fireman shows up to put out a fire. He's not the cause of the fire. Cholesterol shows up to put out the fire of Inflammation in the Arterial Wall. Cholesterol is not the cause of the Inflammation that turns to Plaque. Eliminate The Root of The Inflammation Which Causes The Damage & Atherosclerosis: Chronic Stress High Blood Pressure Type 2 Diabetes Obesity Smoking Sugar Consumption Carbohydrates/Insulin Resistance Ultra Processed Foods Seed Oils Environmental Toxins Poor Sleep Low Vitamin D Level Low Magnesium Level Lack of Exercise These Are All Modifiable Risk Factors. Most Chronic Disease Happens Within Us, It Does Not Happen To Us. 👇Dr Aseem Malhotra's Co Authored Analysis 👇 👇Higher LDL, Greater Longevity👇 👇LDL Does Not Cause Cardiovascular Disease👇 👇Full Episode: The Ultimate Human Podcast👇

"The Higher Your LDL, The Longer You're Going To Live." Cardiologist Dr Aseem Malhotra & Study Co-Author. "The Greater The Financial Interest In A Given Field, The Less Likely The Research Findings Are to be True." "The Most Lucrative Drug In The History Of Medicine Are Statins." $19 Billion Dollar Profit Industry Totalling 818 Million Prescriptions Annually. "The Benefit Of Statins For Both Low Risk & High Risk Primary Prevention Is ONLY 1%...1 In 100." "There Is No Correlation Between Elevated LDL Level & Events Of Cardiovascular Disease. In Fact, It's The Inverse. There Is A Correlation Between Higher LDL Level & Longevity." "The Higher The LDL, The Longer You're Going To Live, Because It Has A Vital Role In Your Immune System." "Just Because Cholesterol Is At The Scene Of the Crime, Doesn't Mean It's The Perpetrator." Cholesterol is trying to clear the inflammation & put out the fire caused by other lifestyle issues in order to get the body to return to Homeostasis. Atherosclerosis Is An Inflammatory Disease, Not A Cholesterol Disease or A Statin Deficiency. A Fireman shows up to put out a fire. He's not the cause of the fire. Cholesterol shows up to put out the fire of Inflammation in the Arterial Wall. Cholesterol is not the cause of the Inflammation that turns to Plaque. Eliminate The Root of The Inflammation Which Causes The Damage & Atherosclerosis: Chronic Stress High Blood Pressure Type 2 Diabetes Obesity Smoking Sugar Consumption Carbohydrates/Insulin Resistance Ultra Processed Foods Seed Oils Environmental Toxins Poor Sleep Low Vitamin D Level Low Magnesium Level Lack of Exercise These Are All Modifiable Risk Factors. Most Chronic Disease Happens Within Us, It Does Not Happen To Us. 👇Dr Aseem Malhotra's Co Authored Analysis 👇 👇Higher LDL, Greater Longevity👇 👇LDL Does Not Cause Cardiovascular Disease👇 👇Full Episode: The Ultimate Human Podcast👇

Valerie Anne Smith

204,369 Aufrufe • vor 1 Jahr

Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie Dave Feldman

Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie Dave Feldman

Nick Norwitz MD PhD

56,203 Aufrufe • vor 4 Monaten

Busting the cholesterol myth! Unless it’s ridiculously high (over 300) LDL cholesterol is not a major risk factor for heart disease. Dr Aseem Malhotra’s work shows there is no clear correlation between lowering LDL and preventing heart attacks. In the high risk groups over five years, Statins give a median increase in life expectancy of 4 days.

Busting the cholesterol myth! Unless it’s ridiculously high (over 300) LDL cholesterol is not a major risk factor for heart disease. Dr Aseem Malhotra’s work shows there is no clear correlation between lowering LDL and preventing heart attacks. In the high risk groups over five years, Statins give a median increase in life expectancy of 4 days.

Kat A 🌸

57,997 Aufrufe • vor 9 Monaten

"The Higher Your LDL, The Longer You're Going To Live." Dr Aseem Malhotra, Cardiologist "The Greater The Financial Interest In A Given Field, The Less Likely The Research Findings Are to be True." "The Most Lucrative Drug In The History Of Medicine Are Statins." $19 Billion Dollar Profit Industry Totalling 818 Million Prescriptions Annually. "The Benefit Of Statins For Both Low Risk & High Risk Primary Prevention Is ONLY 1%...1 In 100." "There Is No Correlation Between Elevated LDL Level & Events Of Cardiovascular Disease. In Fact, It's The Inverse. There Is A Correlation Between Higher LDL Level & Longevity." "The Higher The LDL, The Longer You're Going To Live, Because It Has A Vital Role In Your Immune System." "Just Because Cholesterol Is At The Scene Of the Crime, Doesn't Mean It's The Perpetrator." LDL serves an important & vital purpose for vibrant health. LDL contains the antioxidants Vitamin E, CoQ10 & Carotenoids that kill off free radicals. This reduces inflammation & oxidative damage, which are the true causes of cardiovascular disease. LDL is a transport molecule delivering cholesterol to repair the cell membrane of the arterial wall. LDL is preventive of disease & immune system protective. Cholesterol is trying to clear the inflammation & put out the fire caused by other lifestyle issues in order to get the body to return to Homeostasis. Atherosclerosis Is An Inflammatory Disease, Not A Cholesterol Disease or A Statin Deficiency. A Fireman shows up to put out a fire. He's not the cause of the fire. Cholesterol shows up to put out the fire of Inflammation in the Arterial Wall. Cholesterol is not the cause of the Inflammation that turns to Plaque. Eliminate The Root of The Inflammation Which Causes The Damage & Atherosclerosis: Industrial Seed Oils Processed Sugar Carbohydrates Insulin Resistance Ultra Processed Foods Smoking Obesity Environmental Toxins Poor Sleep Low Vitamin D Levels Magnesium Deficiency K2 Deficiency Lack of Exercise Stress These Are All Modifiable Risk Factors. Most Chronic Disease Happens Within Us, It Does Not Happen To Us. A low carbohydrate diet prioritizing nutrient dense animal foods, eliminating harmful seed oils & sugar, provides the best healthy cholesterol profile. This approach keeps Triglycerides low & HDL high, which is one of the best biomarkers for heart health. TG/HDL ratio optimally should be less than 2.0 & even better at 1.5 or less. 👇The Higher Your LDL, The Longer You Live👇 👇LDL Paradox: Higher LDL, Greater Longevity👇 👇LDL Does Not Cause Cardiovascular Disease👇 Speakers: Dr Aseem Malhotra & Gary Brecka Video: The Ultimate Human Podcast

Valerie Anne Smith

238,554 Aufrufe • vor 1 Jahr

I'm not a doctor and neither is this man but hundreds of hours of personal research lead me to agree with most of his cholesterol panel dissection. Total cholesterol: Fairly useless. LDL is not the boogeyman (although glycated LDL can be a problem) Triglycerides divided by HDL is the best predictor of heart disease risk in a cholesterol panel.

I'm not a doctor and neither is this man but hundreds of hours of personal research lead me to agree with most of his cholesterol panel dissection. Total cholesterol: Fairly useless. LDL is not the boogeyman (although glycated LDL can be a problem) Triglycerides divided by HDL is the best predictor of heart disease risk in a cholesterol panel.

Cary Kelly

56,240 Aufrufe • vor 4 Monaten

Where there is no risk, there is no adventure. If you take a risk and succeed, people say you’re adventurous. If you take a risk and fail, they’ll call you a fool. So you have to be ready to make a fool of yourself. That is when you can do adventure. #SadhguruWisdom

Where there is no risk, there is no adventure. If you take a risk and succeed, people say you’re adventurous. If you take a risk and fail, they’ll call you a fool. So you have to be ready to make a fool of yourself. That is when you can do adventure. #SadhguruWisdom

Sadhguru

32,018 Aufrufe • vor 1 Jahr

$The pathway to heart disease goes through the mitochondria. It's not LDL cholesterol, nor very fine LDL fraction, nor ApoB that best predicts risk of heart disease. It's blood glucose. Spikes in blood glucose cause glycation -- attachment of a glucose molecule to lipoprotiens -- that weaponizes cholesterol against your arteries. Smaller cholesterol particles are more susceptible to glycation, sure. BUT without the blood glucose spikes resulting from insulin resistance, there's no increased risk of heart disease. Someone should probably tell the statin pushers their days prescription royalties are soon coming to an end. h/t Paul Reynolds Dr. Ammous$

The pathway to heart disease goes through the mitochondria. It's not LDL cholesterol, nor very fine LDL fraction, nor ApoB that best predicts risk of heart disease. It's blood glucose. Spikes in blood glucose cause glycation -- attachment of a glucose molecule to lipoprotiens -- that weaponizes cholesterol against your arteries. Smaller cholesterol particles are more susceptible to glycation, sure. BUT without the blood glucose spikes resulting from insulin resistance, there's no increased risk of heart disease. Someone should probably tell the statin pushers their days prescription royalties are soon coming to an end. h/t Paul Reynolds Dr. Ammous

Thomas P Seager, PhD

50,291 Aufrufe • vor 1 Monat

2023. Bernie says there should not be billionaires, and is pressed on what his line is for exactly how much wealth he thinks someone should be able to have. "If there should not be billionaires, then that’s the line.” There it is. The magical number that Bernie has decreed as the maximum amount of individual success that should be allowed in America.

2023. Bernie says there should not be billionaires, and is pressed on what his line is for exactly how much wealth he thinks someone should be able to have. "If there should not be billionaires, then that’s the line.” There it is. The magical number that Bernie has decreed as the maximum amount of individual success that should be allowed in America.

Western Lensman

27,012 Aufrufe • vor 1 Monat

Why Are We Still Playing "Cholesterol Uno?" 🤔👇 (85 sec clip, link to full video below) "When faced with data showing that “optimal” LDL-C levels fail to prevent atherosclerosis, the final retreat is almost always the same: the LDL-C just wasn’t low enough. “Lower is better” the mantra goes. If a mean LDL of 57 mg/dL isn’t sufficient to make atherosclerosis an orphan disease, then the solution must be 40. Or 30. Or 20. Or even 10 mg/dL. Heck, let’s just try to hit zero like we’re playing cholesterol Uno… What this reflexive response reveals is the profound keyhole thinking that has come to dominate conventional cardiology Medicine has become so siloed and sub-specialized that success is often defined within the narrow boundaries of a single biomarker or organ system, rather than in terms of whole-person health. It is entirely possible—at least in theory—that taking a sledgehammer to LDL-C and ApoB, driving them as close to zero as possible, could further reduce cardiovascular events. But that framing dodges the far more important question: what are we trading? Because LDL-lowering therapies are not benign."

Why Are We Still Playing "Cholesterol Uno?" 🤔👇 (85 sec clip, link to full video below) "When faced with data showing that “optimal” LDL-C levels fail to prevent atherosclerosis, the final retreat is almost always the same: the LDL-C just wasn’t low enough. “Lower is better” the mantra goes. If a mean LDL of 57 mg/dL isn’t sufficient to make atherosclerosis an orphan disease, then the solution must be 40. Or 30. Or 20. Or even 10 mg/dL. Heck, let’s just try to hit zero like we’re playing cholesterol Uno… What this reflexive response reveals is the profound keyhole thinking that has come to dominate conventional cardiology Medicine has become so siloed and sub-specialized that success is often defined within the narrow boundaries of a single biomarker or organ system, rather than in terms of whole-person health. It is entirely possible—at least in theory—that taking a sledgehammer to LDL-C and ApoB, driving them as close to zero as possible, could further reduce cardiovascular events. But that framing dodges the far more important question: what are we trading? Because LDL-lowering therapies are not benign."

Nick Norwitz MD PhD

12,442 Aufrufe • vor 6 Monaten

Peter Thiel on how to never lose your job to AI in 2024: “It seems to be that AI is quite good at woke stuff.” “If you want to be a successful actor, you should be a little racist, or a little sexist, or just really funny— and you won’t have any risk of the AI replacing you.”

Peter Thiel on how to never lose your job to AI in 2024: “It seems to be that AI is quite good at woke stuff.” “If you want to be a successful actor, you should be a little racist, or a little sexist, or just really funny— and you won’t have any risk of the AI replacing you.”

Jawwwn

227,644 Aufrufe • vor 5 Monaten

“i don’t think it’s acceptable or reasonable to ask a driver who is also in a shot of a championship, in the very last race, to move over. (…) and if they lose out because of it, you just need to say the other guy did a better job. and that’s racing, that’s how it should be”

“i don’t think it’s acceptable or reasonable to ask a driver who is also in a shot of a championship, in the very last race, to move over. (…) and if they lose out because of it, you just need to say the other guy did a better job. and that’s racing, that’s how it should be”

🃏

250,295 Aufrufe • vor 8 Monaten

The corruption of our medical system goes much deeper than you think. Alan Cassels just exposed how the American Heart Association manipulates health guidelines to “sell sickness” and turn healthy people into patients for profit. “The new definition of ‘high cholesterol’ is almost 100 million Americans.” “This is a massive market.” “The reason is so obvious.” “Because there’s so much money in it.” “The American Heart Association came out with a new set of guidelines just earlier this month.” “They are a fascinating study in the creation of disease.” “The recommendations around when you should test somebody for high cholesterol have changed.” “Instead of just testing older people, we should be testing younger people.” “We should be screening children.” “We should be getting people to submit to a cholesterol test every 5 years.” “There are new cholesterol-lowering drugs.” “There are new ways to take healthy people and turn them into candidates for whom the drug would be prescribed.” “I think cholesterol is one of the most absurd examples of the selling of sickness.” “The danger of high cholesterol has not changed.” “It’s a small risk factor.” “If you take a cholesterol-lowering drug for 10 years, it might reduce your risk of having a heart attack or stroke by about 1%, if you’re lucky.” “About 20-25% of the people who take the drug will not be able to tolerate it because of adverse effects.” “We’re talking about a drug that has an extremely low yield and a high likelihood of being harmful.” Alan Cassels Jeffrey A Tucker

The corruption of our medical system goes much deeper than you think. Alan Cassels just exposed how the American Heart Association manipulates health guidelines to “sell sickness” and turn healthy people into patients for profit. “The new definition of ‘high cholesterol’ is almost 100 million Americans.” “This is a massive market.” “The reason is so obvious.” “Because there’s so much money in it.” “The American Heart Association came out with a new set of guidelines just earlier this month.” “They are a fascinating study in the creation of disease.” “The recommendations around when you should test somebody for high cholesterol have changed.” “Instead of just testing older people, we should be testing younger people.” “We should be screening children.” “We should be getting people to submit to a cholesterol test every 5 years.” “There are new cholesterol-lowering drugs.” “There are new ways to take healthy people and turn them into candidates for whom the drug would be prescribed.” “I think cholesterol is one of the most absurd examples of the selling of sickness.” “The danger of high cholesterol has not changed.” “It’s a small risk factor.” “If you take a cholesterol-lowering drug for 10 years, it might reduce your risk of having a heart attack or stroke by about 1%, if you’re lucky.” “About 20-25% of the people who take the drug will not be able to tolerate it because of adverse effects.” “We’re talking about a drug that has an extremely low yield and a high likelihood of being harmful.” Alan Cassels Jeffrey A Tucker

Brownstone Institute

138,544 Aufrufe • vor 11 Tagen

Bret Weinstein discusses the fearful response to risk, exploration and frontiers in the context of Pa Ingalls and the Little House on the Prairie series. Bret Weinstein explains, "life proceeds by finding frontiers, and that those frontiers are an indication of great potential profit at risk. You can't separate those things. That's what the market is, risk versus reward. If there isn't much risk, there won't be much reward. That's a part of the emergent feature of nature. And so you are effectively looking at three and a half billion years of evolution that produced the miracle that is you, and asking, well, wasn't there a lot of risk involved there? Why'd you all do it? And it's like, well, stop it. Speak for humanity. Nobody's inviting you to the frontier because you'd be useless and you'd be a hazard. But don't tell other people don't go to the frontier and don't mock them if it goes wrong. People who go to the frontier, understanding that there is risk, don't always do okay. But the ones that do are the ones that make history."

Bret Weinstein discusses the fearful response to risk, exploration and frontiers in the context of Pa Ingalls and the Little House on the Prairie series. Bret Weinstein explains, "life proceeds by finding frontiers, and that those frontiers are an indication of great potential profit at risk. You can't separate those things. That's what the market is, risk versus reward. If there isn't much risk, there won't be much reward. That's a part of the emergent feature of nature. And so you are effectively looking at three and a half billion years of evolution that produced the miracle that is you, and asking, well, wasn't there a lot of risk involved there? Why'd you all do it? And it's like, well, stop it. Speak for humanity. Nobody's inviting you to the frontier because you'd be useless and you'd be a hazard. But don't tell other people don't go to the frontier and don't mock them if it goes wrong. People who go to the frontier, understanding that there is risk, don't always do okay. But the ones that do are the ones that make history."

The DarkHorse Podcast

19,711 Aufrufe • vor 25 Tagen

Historian Niall Ferguson: Despite risks, overthrowing the regime in Iran would be a positive step for Iranians, the region, and the world. “Is there a risk to toppling Khamenei? Yeah, there is. Is there a risk to leaving the guy in power and whoever succeeds him when he finally croaks? There’s a big risk to that. I would say, on balance, it’s a bigger risk to leave this regime in place. It’s just shown what it’s capable of.”

Historian Niall Ferguson: Despite risks, overthrowing the regime in Iran would be a positive step for Iranians, the region, and the world. “Is there a risk to toppling Khamenei? Yeah, there is. Is there a risk to leaving the guy in power and whoever succeeds him when he finally croaks? There’s a big risk to that. I would say, on balance, it’s a bigger risk to leave this regime in place. It’s just shown what it’s capable of.”

Conversations with Coleman

25,815 Aufrufe • vor 7 Monaten