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Interesting approach for acne treatment: engineer bacteria to work like Accutane, but locally (and without all the nasty side effects)! Modified C. Acnes bacteria secrete NGAL to kill sebocytes & thus sebum production. They engraft on mice skin & produce NGAL there.

Julia Bauman

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43,123 görüntüleme • 2 yıl önce •via X (Twitter)

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Julia Bauman2 yıl önce

Paper is in @NatureBiotech from @marcguellc @NastassiaKn @Synbio_Lab_UPF :

Julia Bauman profil fotoğrafı

Julia Bauman2 yıl önce

@marcguellc @NastassiaKn @Synbio_Lab_UPF Shoutout to @marthaluchow for making this video happen!

Jason Kelly profil fotoğrafı

Jason Kelly2 yıl önce

cool!!

Sina K, MD. profil fotoğrafı

Sina K, MD.2 yıl önce

The paper has this nice delivery system by C acnes but I could find very few papers on targeting LCN2/NGAL for acne treatment/sebum reduction other than the initial papers by Thiboutot and Nelson ...

Nick Albertini profil fotoğrafı

Nick Albertini2 yıl önce

@NatureBiotech What could possibly go wrong?! Contamination of non-consenting non-treated people, direct evolution into something hostile... Yep, no problems here!

Nick Albertini profil fotoğrafı

Nick Albertini2 yıl önce

Taking bets on how many people treated this way get MRSA infections due to lowered readiness of skin cytokine defense.... takers?

Michael McLeod 🐙 🐦 profil fotoğrafı

Michael McLeod 🐙 🐦2 yıl önce

@NatureBiotech Intuitive idea.

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So Accutane nuked your gut… That acne drug may clear your skin - but at what cost? It carpet bombs the bacteria keeping you healthy. Drugs like Accutane or Isotretinoin may appear to temporarily “fix” the problem of your acne (which has other underlying causes)… but with long term consequences. A guy at my recent Sol meetup details how he’s still dealing with poor amounts of beneficial bacteria in his system, years later. Your gut microbiome is your second brain. It controls your mood and your ability to absorb nutrients. Accutane leaves it in pieces. Luckily, the fix is straightforward - but it may be a bit stinky if you’re not used to it. This is what I recommend! Put simply, you need to cultivate bacteria in foods by fermenting them, then consume those foods. My top picks: ⁃ Raw kefir. Billions of living probiotics in every glass. More potent than any supplement in a plastic bottle. ⁃ Fermented meat. High meat, aged salami, fermented fish. An ancestrally consistent delicacy praised for its health giving properties. ⁃ Stinky raw blue cheese. Those mold cultures aren't only tasty - they're actually medicinal. Roquefort, Gorgonzola, Stilton. The funkier the better. Fermented foods work because they're alive. They repopulate your gut with the bacteria that antibiotics destroy. They come with their own enzymes. They're pre-digested and bioavailable. Our ancestors didn't need probiotic capsules, they simply ate food that was teeming with life. So, if you’ve taken big Pharma medications in the past, now is the time you replenish! Start slow, eat small amounts and then build up. Let the bacteria thrive - what you’ll notice is that you will begin to crave these foods and normal processed “foods” will disgust you. This is your microbiome repopulating.

So Accutane nuked your gut… That acne drug may clear your skin - but at what cost? It carpet bombs the bacteria keeping you healthy. Drugs like Accutane or Isotretinoin may appear to temporarily “fix” the problem of your acne (which has other underlying causes)… but with long term consequences. A guy at my recent Sol meetup details how he’s still dealing with poor amounts of beneficial bacteria in his system, years later. Your gut microbiome is your second brain. It controls your mood and your ability to absorb nutrients. Accutane leaves it in pieces. Luckily, the fix is straightforward - but it may be a bit stinky if you’re not used to it. This is what I recommend! Put simply, you need to cultivate bacteria in foods by fermenting them, then consume those foods. My top picks: ⁃ Raw kefir. Billions of living probiotics in every glass. More potent than any supplement in a plastic bottle. ⁃ Fermented meat. High meat, aged salami, fermented fish. An ancestrally consistent delicacy praised for its health giving properties. ⁃ Stinky raw blue cheese. Those mold cultures aren't only tasty - they're actually medicinal. Roquefort, Gorgonzola, Stilton. The funkier the better. Fermented foods work because they're alive. They repopulate your gut with the bacteria that antibiotics destroy. They come with their own enzymes. They're pre-digested and bioavailable. Our ancestors didn't need probiotic capsules, they simply ate food that was teeming with life. So, if you’ve taken big Pharma medications in the past, now is the time you replenish! Start slow, eat small amounts and then build up. Let the bacteria thrive - what you’ll notice is that you will begin to crave these foods and normal processed “foods” will disgust you. This is your microbiome repopulating.

⚡️🌞 Sol Brah 🌞🐬

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Hexumllite says all skincare is cope and the only things that actually work are Accutane or DHT blockers “All these skincare products are just people with good skin jerking themselves off after they get a glow from the fucking oiliness. For people that actually have skin disorders, it’s just straight bullshit. I see this whole thing like, ‘Oh, I take tretinoin,’ but they already had good skin to begin with” “Go on YouTube right now and look up tretinoin transformations. You can’t find one where the guy actually goes from having acne to having clear skin. People that already have good skin already take care of their health, jerking themselves off like, ‘Oh, my skin’s glowing because of GHK-Cu.’ It’s like, bitch, your skin was already glowing”

Hexumllite says all skincare is cope and the only things that actually work are Accutane or DHT blockers “All these skincare products are just people with good skin jerking themselves off after they get a glow from the fucking oiliness. For people that actually have skin disorders, it’s just straight bullshit. I see this whole thing like, ‘Oh, I take tretinoin,’ but they already had good skin to begin with” “Go on YouTube right now and look up tretinoin transformations. You can’t find one where the guy actually goes from having acne to having clear skin. People that already have good skin already take care of their health, jerking themselves off like, ‘Oh, my skin’s glowing because of GHK-Cu.’ It’s like, bitch, your skin was already glowing”

Mikli

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Dr. Abhishek Shukla (Geriatrician) explained an important fact about sweat and body odor. Many people think sweat itself smells bad, but this is not true. Sweat, in its pure form, is actually odorless. It has no foul smell at all. This is the first thing everyone should understand clearly. Then why does sweat sometimes cause such a strong smell from the body, socks, or shoes? The answer lies in the bacteria living on our skin. Our skin naturally has millions of bacteria. When sweat comes out, it contains water along with some proteins and fats. These bacteria use those proteins and fats as food. During digestion, they produce certain by-products, and these by-products are what create the bad smell. The strength of body odor depends on three major things — the type of sweat gland, the kind of bacteria on the skin, and external factors like food, lifestyle, and environment. There are two main sweat glands in our body: 1. Eccrine glands These are present on exposed parts of the body like the face, hands, and forehead. They mainly produce water and salt. Their main job is to cool the body. In hot weather, sweat evaporates from the skin, taking heat away and reducing body temperature. This sweat usually causes very little odor. 2. Apocrine glands These are found mainly in the armpits and groin area. They become active after puberty and during stress or anxiety. The sweat from these glands is thicker and richer in proteins and fats. Because of this, bacteria get more food and produce stronger-smelling compounds. The common bacteria involved are Staphylococcus and Corynebacterium. They break down sweat and produce chemicals like propionic acid, which creates a sour or pungent smell. Food also affects body odor. Onion, garlic, and spicy foods can change the smell of sweat. Stress can also increase odor because it activates apocrine glands. So remember: Heat → Eccrine glands → Water + Salt → Less odor Stress → Apocrine glands → Protein + Fat → More odor These are the basic facts behind sweat smell. In the next part, we will discuss how to prevent it.#bodyodour #hyperhidrosis #excesssweat #miradry #odour #underarmsweat #antisweating #nosweat #feelconfident #permanent #spiderveins #isclerotherapyinjections

Dr. Abhishek Shukla (Geriatrician) explained an important fact about sweat and body odor. Many people think sweat itself smells bad, but this is not true. Sweat, in its pure form, is actually odorless. It has no foul smell at all. This is the first thing everyone should understand clearly. Then why does sweat sometimes cause such a strong smell from the body, socks, or shoes? The answer lies in the bacteria living on our skin. Our skin naturally has millions of bacteria. When sweat comes out, it contains water along with some proteins and fats. These bacteria use those proteins and fats as food. During digestion, they produce certain by-products, and these by-products are what create the bad smell. The strength of body odor depends on three major things — the type of sweat gland, the kind of bacteria on the skin, and external factors like food, lifestyle, and environment. There are two main sweat glands in our body: 1. Eccrine glands These are present on exposed parts of the body like the face, hands, and forehead. They mainly produce water and salt. Their main job is to cool the body. In hot weather, sweat evaporates from the skin, taking heat away and reducing body temperature. This sweat usually causes very little odor. 2. Apocrine glands These are found mainly in the armpits and groin area. They become active after puberty and during stress or anxiety. The sweat from these glands is thicker and richer in proteins and fats. Because of this, bacteria get more food and produce stronger-smelling compounds. The common bacteria involved are Staphylococcus and Corynebacterium. They break down sweat and produce chemicals like propionic acid, which creates a sour or pungent smell. Food also affects body odor. Onion, garlic, and spicy foods can change the smell of sweat. Stress can also increase odor because it activates apocrine glands. So remember: Heat → Eccrine glands → Water + Salt → Less odor Stress → Apocrine glands → Protein + Fat → More odor These are the basic facts behind sweat smell. In the next part, we will discuss how to prevent it.#bodyodour #hyperhidrosis #excesssweat #miradry #odour #underarmsweat #antisweating #nosweat #feelconfident #permanent #spiderveins #isclerotherapyinjections

Association of International Doctors. (India).

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BREAKING: People Against Genocide are blocking all entry to Ultra I&C, a key supplier to Elbit's Israeli drone factory in Leicester. They used modified suitcases to lock on and shut down the site for as long as possible. "Direct action will continue undeterred"

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This Texas homeowner catches ICE on his property without any reason to be there since he & his family are all U.S citizens! He caught them sneaking around his property & came out & told them to get the F off his property. They said they were looking for someone,but had no name!

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Wall Street Apes

57,542 görüntüleme • 2 ay önce

MAYE MUSK: "The media has to change, and the politicians have to change and stop being mean & nasty, and dishonest. They used to always hate on Elon Musk for 15 years, but I trusted them with the other news but then, I realized, no, they are dishonest in all aspects."

MAYE MUSK: "The media has to change, and the politicians have to change and stop being mean & nasty, and dishonest. They used to always hate on Elon Musk for 15 years, but I trusted them with the other news but then, I realized, no, they are dishonest in all aspects."

DogeDesigner

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MAYE MUSK: "The media has to change, and the politicians have to change and stop being mean & nasty, and dishonest. They used to always hate on Elon Musk for 15 years, but I trusted them with the other news but then, I realized, no, they are dishonest in all aspects."

MAYE MUSK: "The media has to change, and the politicians have to change and stop being mean & nasty, and dishonest. They used to always hate on Elon Musk for 15 years, but I trusted them with the other news but then, I realized, no, they are dishonest in all aspects."

DogeDesigner

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"Antibacterial Mouthwash Causes High Blood Pressure." Dr Nathan Bryan, PhD Long Term Daily Use Leads To Diabetes, Heart Disease & Cancer. Mouthwash Kills 99.9% Of All Bacteria, Just Like An Antibiotic & That's Bad News For Your Microbiome. "2 out of 3 use mouthwash everyday, 2 out of 3 have high blood pressure. Mouthwash is causal for Hypertension." "When you eradicate these essential commensal Nitrate reducing bacteria, it causes an increase in blood pressure." "The bacteria that live on & in the human body outnumber human cells 10 to 1. This is an entire ecology of symbiosis, these bacteria providing metabolic benefits to the human host. We cannot produce Nitric Oxide without the oral microbiome bacteria." "When these bacteria are killed off, from the mouth all the way down to the anus, production of Nitric Oxide is stopped. The oral microbiome is just as essential as the gut microbiome." Cardiovascular Health & Blood Pressure rely on Nitric Oxide production. In one of many studies, normal non hypertensive adults used mouthwash everyday for 7 days. At the end of 7 days, blood pressure readings went up into hypertensive ranges. Nitric oxide is considered one of the most important molecules produced in humans. This molecule controls oxygen & nutrient delivery to every cell in the body, it regulates cellular communication & is antimicrobial to protect our body from invading pathogens. Loss of nitric oxide production is recognized as the earliest event in the onset & progression of all chronic diseases, including the number 1 killer of men and women worldwide, cardiovascular disease. Mouthwash contains antibacterial ingredients, which kills oral microbes critical for nitric oxide formation & in turn, predisposes people to metabolic disorders including diabetes. Removal of 99.9% of oral bacteria also encourages mitochondrial cell mutation leading to cancer. Steps To Full Nitric Oxide Production & Protection: 1: Eliminate antiseptic/antibacterial mouthwash & antibacterial/fluoride toothpaste. 2: Get moderate physical exercise. Exercise stimulates the production of nitric oxide. 3: Prioritize animal foods rich in L-Arginine & Nitrates, which are the building blocks to Nitric Oxide conversion in the oral microbiome. 4: Encourage stomach acid production necessary for nutrient absorption by eliminating all acid reducing products like Proton Pump Inhibitors, Antacids, Baking Soda, etc. 👇Mouthwash Causes Hypertension👇 👇Mouthwash Causes Diabetes👇 👇Mouthwash Detrimental To Heart Health👇 👇Antibacterial Mouthwash Causes Cancer👇 Speakers: Dr Nathan Bryan & Max Lugavere Podcast: The Genius Life

"Antibacterial Mouthwash Causes High Blood Pressure." Dr Nathan Bryan, PhD Long Term Daily Use Leads To Diabetes, Heart Disease & Cancer. Mouthwash Kills 99.9% Of All Bacteria, Just Like An Antibiotic & That's Bad News For Your Microbiome. "2 out of 3 use mouthwash everyday, 2 out of 3 have high blood pressure. Mouthwash is causal for Hypertension." "When you eradicate these essential commensal Nitrate reducing bacteria, it causes an increase in blood pressure." "The bacteria that live on & in the human body outnumber human cells 10 to 1. This is an entire ecology of symbiosis, these bacteria providing metabolic benefits to the human host. We cannot produce Nitric Oxide without the oral microbiome bacteria." "When these bacteria are killed off, from the mouth all the way down to the anus, production of Nitric Oxide is stopped. The oral microbiome is just as essential as the gut microbiome." Cardiovascular Health & Blood Pressure rely on Nitric Oxide production. In one of many studies, normal non hypertensive adults used mouthwash everyday for 7 days. At the end of 7 days, blood pressure readings went up into hypertensive ranges. Nitric oxide is considered one of the most important molecules produced in humans. This molecule controls oxygen & nutrient delivery to every cell in the body, it regulates cellular communication & is antimicrobial to protect our body from invading pathogens. Loss of nitric oxide production is recognized as the earliest event in the onset & progression of all chronic diseases, including the number 1 killer of men and women worldwide, cardiovascular disease. Mouthwash contains antibacterial ingredients, which kills oral microbes critical for nitric oxide formation & in turn, predisposes people to metabolic disorders including diabetes. Removal of 99.9% of oral bacteria also encourages mitochondrial cell mutation leading to cancer. Steps To Full Nitric Oxide Production & Protection: 1: Eliminate antiseptic/antibacterial mouthwash & antibacterial/fluoride toothpaste. 2: Get moderate physical exercise. Exercise stimulates the production of nitric oxide. 3: Prioritize animal foods rich in L-Arginine & Nitrates, which are the building blocks to Nitric Oxide conversion in the oral microbiome. 4: Encourage stomach acid production necessary for nutrient absorption by eliminating all acid reducing products like Proton Pump Inhibitors, Antacids, Baking Soda, etc. 👇Mouthwash Causes Hypertension👇 👇Mouthwash Causes Diabetes👇 👇Mouthwash Detrimental To Heart Health👇 👇Antibacterial Mouthwash Causes Cancer👇 Speakers: Dr Nathan Bryan & Max Lugavere Podcast: The Genius Life

Valerie Anne Smith

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Adrian Lyne on what made "Unfaithful" (2002) interesting: "I remember on 'Unfaithful' (2002), there was a feeling from the studio at that time that they had to have a bad marriage in order for the relationship to work. But there would’ve been no drama in that at all. What was interesting was the fact that it was a good marriage and she had no reason at all to f**k around, but she did. So I like the arbitrary thing of that." (Adrian Lyne's interview with Todd Gilchrist, AV Club, 2022)

Adrian Lyne on what made "Unfaithful" (2002) interesting: "I remember on 'Unfaithful' (2002), there was a feeling from the studio at that time that they had to have a bad marriage in order for the relationship to work. But there would’ve been no drama in that at all. What was interesting was the fact that it was a good marriage and she had no reason at all to f**k around, but she did. So I like the arbitrary thing of that." (Adrian Lyne's interview with Todd Gilchrist, AV Club, 2022)

DepressedBergman

525,781 görüntüleme • 4 ay önce

"They can't force you to have a digital ID." "But here's the catch—they don't need to force you. They just need to make life impossible without it." "So although there will be no law saying that you must, you just can't work without it, eat without it, bank without it, travel without it, and so on and so forth... You are forced by exclusion." "You can disagree with the agenda on principle all you like. But if you're not in a practical position to resist it, you'll be forced to comply through exclusion." "For example, you may disagree on principle with a policy that mandates digital IDs to access the food system. But if you're not in a practical position to feed yourself without said system, then you're going to be hard pressed to not submit." "You do still need to have access to land, independent water, energy and food production, and a like-minded community. With these five things in place, you can resist the mainstream agenda on principle and in practice."

"They can't force you to have a digital ID." "But here's the catch—they don't need to force you. They just need to make life impossible without it." "So although there will be no law saying that you must, you just can't work without it, eat without it, bank without it, travel without it, and so on and so forth... You are forced by exclusion." "You can disagree with the agenda on principle all you like. But if you're not in a practical position to resist it, you'll be forced to comply through exclusion." "For example, you may disagree on principle with a policy that mandates digital IDs to access the food system. But if you're not in a practical position to feed yourself without said system, then you're going to be hard pressed to not submit." "You do still need to have access to land, independent water, energy and food production, and a like-minded community. With these five things in place, you can resist the mainstream agenda on principle and in practice."

Wide Awake Media

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All of Syracuse is rooting for Kiyan. The talent is definitely there but there are aspects of his game that he does need to work on like his defense & getting stronger which will all improve. As Trevor Cooney said, G Mac’s system should be great for him 🍊

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Etan Thomas

29,114 görüntüleme • 3 ay önce

Ryan also described cases where patients remained on chemotherapy for extended periods without eliminating their cancer. In one example, a patient underwent chemotherapy for two years! The treatment kept the cancer “at bay,” meaning it did not progress, but it also did not resolve. During that time, they experienced side effects including weight loss, hair loss, and loss of appetite. Eventually, they stopped chemotherapy and turned to a different approach. According to Ryan, that included B17, vitamin C, enzymes, and dietary changes. He described the sequence of improvements—appetite returning, weight gain, and reduced pain. And over time, the cancer was no longer present. Across these cases, the pattern is clear: patients diagnosed with cancer, often after exhausting or struggling with conventional treatment, move to a combined approach centered on B17, nutrition, and metabolic support—and then report a reversal in their condition. That pattern is what people should be paying attention to, and why Ryan encourages individuals to look into the Richardson protocol he described and the supplements that support it.

Ryan also described cases where patients remained on chemotherapy for extended periods without eliminating their cancer. In one example, a patient underwent chemotherapy for two years! The treatment kept the cancer “at bay,” meaning it did not progress, but it also did not resolve. During that time, they experienced side effects including weight loss, hair loss, and loss of appetite. Eventually, they stopped chemotherapy and turned to a different approach. According to Ryan, that included B17, vitamin C, enzymes, and dietary changes. He described the sequence of improvements—appetite returning, weight gain, and reduced pain. And over time, the cancer was no longer present. Across these cases, the pattern is clear: patients diagnosed with cancer, often after exhausting or struggling with conventional treatment, move to a combined approach centered on B17, nutrition, and metabolic support—and then report a reversal in their condition. That pattern is what people should be paying attention to, and why Ryan encourages individuals to look into the Richardson protocol he described and the supplements that support it.

The Vigilant Fox 🦊

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Ran a super quick test here with the AI Voice "Callum" (who is weirdly over expressive), and just had GPT write a fake script based on the horse's names and feed it in. I did a quick mix and added effects. Would still take a decent amount of work to get it all synced up on timestamps for production quality but yeah, seems like the AI voices are about ready...

Ran a super quick test here with the AI Voice "Callum" (who is weirdly over expressive), and just had GPT write a fake script based on the horse's names and feed it in. I did a quick mix and added effects. Would still take a decent amount of work to get it all synced up on timestamps for production quality but yeah, seems like the AI voices are about ready...

ian c

10,549 görüntüleme • 1 yıl önce

🐰 you’re asking if i’ve fully recovered? of course, i fully recovered! as soon as the doctor scraped the inflammation and put on the albothyl…all the symptoms disappeared within 30 minutes! my throat stopped hurting, my fever completely went down and my butt stopped hurting too 🤣 🐰 “what a great doctor” they’re really a great doctor…all the members go to that ent when we have a cold or are sick and that doctor is really good! all the members go there. 🐰 (the treatment) there hurts a lot so whenever any of the members go there, they come back after shedding tears…the doctor makes you pour out all kinds of pain for an effective treatment but all the members always feel completely fine once they come back from the treatment so whenever the members go to that hospital, we’re like “ah i’m so scared, i don’t want to go” but after the treatment, we’re like “wow what a great doctor”

🐰 you’re asking if i’ve fully recovered? of course, i fully recovered! as soon as the doctor scraped the inflammation and put on the albothyl…all the symptoms disappeared within 30 minutes! my throat stopped hurting, my fever completely went down and my butt stopped hurting too 🤣 🐰 “what a great doctor” they’re really a great doctor…all the members go to that ent when we have a cold or are sick and that doctor is really good! all the members go there. 🐰 (the treatment) there hurts a lot so whenever any of the members go there, they come back after shedding tears…the doctor makes you pour out all kinds of pain for an effective treatment but all the members always feel completely fine once they come back from the treatment so whenever the members go to that hospital, we’re like “ah i’m so scared, i don’t want to go” but after the treatment, we’re like “wow what a great doctor”

💬

48,928 görüntüleme • 4 ay önce

the fact that it wasnt easy to gather a lot of artists & each of the artists might have different schedules but they all readily agreed on to participate for Bin. And just like Jinjin said, Bin indeed lived a great life 🥹

the fact that it wasnt easy to gather a lot of artists & each of the artists might have different schedules but they all readily agreed on to participate for Bin. And just like Jinjin said, Bin indeed lived a great life 🥹

마리 ✶

48,036 görüntüleme • 1 yıl önce

a part of me is like, stop playing the victim, but another part of me say, he is absolutely right. they all benefited and capitalized from scandoval. got whatever they could out of tom & ariana. tossed them both to the side. i feel bad for tom in a way. #PUMPRULES | #THEVALLEY

a part of me is like, stop playing the victim, but another part of me say, he is absolutely right. they all benefited and capitalized from scandoval. got whatever they could out of tom & ariana. tossed them both to the side. i feel bad for tom in a way. #PUMPRULES | #THEVALLEY

penthouse papi

171,133 görüntüleme • 1 yıl önce