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Introducing Interactive Cell Biology, a complete course solution—no textbook needed. In partnership with Macmillan Learning, delivered through Achieve. Check it out today! Visit: to learn more. #cell #biology #education #animation

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Smart Biology

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44,046 Aufrufe • vor 1 Jahr •via X (Twitter)

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Dive into the world of Mathematical Quantum Theory! 🌊📚 Explore our curated list of must-read books! Click the banner below to discover more & use code "MATH25" for 25% OFF! #QuantumMath #MathBooks #BookLovers

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From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).

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