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Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study Nature Genetics reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 (1/2)

Kazuhiro Maeshima

2,149 subscribers

39,651 Aufrufe • vor 20 Tagen •via X (Twitter)

Anya Rossi• Live Now

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8 Kommentare

Profilbild von Kazuhiro Maeshima

Kazuhiro Maeshimavor 20 Tagen

Congratulations 🎉 We thank all the coauthors including 4 co-first authors: @MasaAShimazoe @shiori_iida @katsu_s_minami @level3defless 🔬👏 Special thanks to @nikonsolutions for 3D-SIM support. Modeling movie by Fujishiro-san. (2/2)

Profilbild von Raghavendra Singh

Raghavendra Singhvor 19 Tagen

@NatureGenet Nice work 👍. Congratulations 🎉👏, interesting sister chromatids null effect overall and nucleosome mobility affected by cohesin chromatin condensates.

Profilbild von Kazuhiro Maeshima

Kazuhiro Maeshimavor 19 Tagen

@NatureGenet Thank you very much!

Profilbild von 仲野徹『がんは運である？』

仲野徹『がんは運である？』vor 19 Tagen

@NatureGenet ナイス！むっちゃええ仕事やん

Profilbild von Kazuhiro Maeshima

Kazuhiro Maeshimavor 19 Tagen

@NatureGenet うれしいです。どうもありがとうございます。これからもがんばります。

Profilbild von Le Thi Phuong

Le Thi Phuongvor 19 Tagen

@NatureGenet Dude, it seems like euchromatin's rigidity is mainly due to condensed domains constraining its relaxation, allowing for proper transcription! That's pretty cool, rightd.

Profilbild von Kazuhiro Maeshima

Kazuhiro Maeshimavor 19 Tagen

@NatureGenet Thank you so much!

Profilbild von GOOD DADDY💸👝

GOOD DADDY💸👝vor 18 Tagen

@NatureGenet Dm.

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199,803 Aufrufe • vor 2 Jahren

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The Vigilant Fox 🦊

532,851 Aufrufe • vor 2 Jahren

Human Chromosome Number 2 were fused together about 200,000 years ago and it not clear what did this, but it gave us the human brain of logic, empathy and creativity. — “But what they’re showing is that we showed up about 200,000 years ago. Now there’s a little evidence that may have been back as far as 300,000. But the kicker is that we can now look at the DNA and reverse engineer it and say, what did it take to get where we are? And what scientists are now calling the smoking gun. And there’s still a lot of controversy around this is human chromosome number 2. Human chromosome number 2 is the second largest chromosome in every cell of the body. It’s got about 1200 or so genes in that chromosome. And just one of them, gene tbr number one, is responsible for most of the brain that we have for our neocortex. So our humanness, our empathy, sympathy, compassion, love, our cognitive abilities, the mirror neurons, all these kinds of things are because that one gene. Well, where this gets really interesting is where did chromosome 2 come from? And scientists have the answer, but they don’t like the answer because chromosome 2 is the product of a fusion. Proceedings from National Academy of Sciences. The volume Genetics says this very clearly. We conclude that the origin of human chromosome 2 is the product of an ancestral fusion of telomere to telomere. Fusion of two pre existing chromosomes. That does not happen in nature. It can’t happen in nature. So here’s what they’re saying. You got two fully formed, fully functional chromosomes, and on the end are the telomeres that protect those chromosomes when the cells divide. And that’s why they’re on the end, they take the hit. It’s a trauma in a cell when those chromosomes are pulled apart and some of the DNA doesn’t make it. So nature puts telomeres on the end to take the hit, so the good DNA remains intact, and that’s why it’s on the ends. Human chromosome two, those telomeres are right in the middle of the chromosome where they shouldn’t be, because those chromosomes were fused together about 200,000 years ago when we appeared”

Human Chromosome Number 2 were fused together about 200,000 years ago and it not clear what did this, but it gave us the human brain of logic, empathy and creativity. — “But what they’re showing is that we showed up about 200,000 years ago. Now there’s a little evidence that may have been back as far as 300,000. But the kicker is that we can now look at the DNA and reverse engineer it and say, what did it take to get where we are? And what scientists are now calling the smoking gun. And there’s still a lot of controversy around this is human chromosome number 2. Human chromosome number 2 is the second largest chromosome in every cell of the body. It’s got about 1200 or so genes in that chromosome. And just one of them, gene tbr number one, is responsible for most of the brain that we have for our neocortex. So our humanness, our empathy, sympathy, compassion, love, our cognitive abilities, the mirror neurons, all these kinds of things are because that one gene. Well, where this gets really interesting is where did chromosome 2 come from? And scientists have the answer, but they don’t like the answer because chromosome 2 is the product of a fusion. Proceedings from National Academy of Sciences. The volume Genetics says this very clearly. We conclude that the origin of human chromosome 2 is the product of an ancestral fusion of telomere to telomere. Fusion of two pre existing chromosomes. That does not happen in nature. It can’t happen in nature. So here’s what they’re saying. You got two fully formed, fully functional chromosomes, and on the end are the telomeres that protect those chromosomes when the cells divide. And that’s why they’re on the end, they take the hit. It’s a trauma in a cell when those chromosomes are pulled apart and some of the DNA doesn’t make it. So nature puts telomeres on the end to take the hit, so the good DNA remains intact, and that’s why it’s on the ends. Human chromosome two, those telomeres are right in the middle of the chromosome where they shouldn’t be, because those chromosomes were fused together about 200,000 years ago when we appeared”

Brian Roemmele

165,905 Aufrufe • vor 11 Monaten

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We’re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!👉 In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field of view. By introducing acrydite-modified probes covalently anchored to hydrogels, MERFISH+ achieves remarkable imaging stability and enables >1,800-gene, multi-modal, and multi-month experiments. With this platform, they, together with the Chi lab at UCSD, profiled a whole developing human heart at 12 post-conception week with merely two slides, resulting in a total of 53 slides, 3.1 million single cells and more than 30 cell types. Building upon our previous 3D reconstruction and modeling framework, Spateo ( we reconstruct the 3D human heart that nicely captures the anatomical structure of the heart, including the intricate vasculature network. Sophisticated analyses provide a holistic view of an entire organ and enable systematic characterization of 3D cellular neighborhoods and transcriptional gradients of substructures such as the descending arteries. Furthermore, using a generative integration framework for spatial multimodal data (Spateo-VI), we harmonized these MERFISH+ transcriptomic and chromatin data to reconstruct a 3D spatially-resolved multi-omics atlas of the developing human heart, shared at and MERFISH+ thus sets a new standard for large-format, multi-omic spatial profiling, enabling holistic, 3D characterization of organs at subcellular resolution. Huge congratulations to first authors Colin Kern, qingquan Zhang, Yifan Lu , and Jacqueline Eschbach, and to all collaborators from the Bintu, Zhu, Chi, and Qiu labs for this amazing team effort. Thanks for your diligence, creativity, and hard work on this project. We’re grateful for support from Arc Institute and our generous donors. Our lab is expanding—if you’re excited about building the next generation of single-cell and spatial genomics techniques and predictive single cell and spatial foundation models, we’re hiring! If you are interested, please reach out to me via direct message or email at [email protected]. We are excited for any potential collaborations along this line of research in Stanford, UCSF and Berkeley and other labs as well.

evo-devo

42,340 Aufrufe • vor 10 Monaten

For anyone going through cancer(s) ... Here are some useful tips: First, don't let them "test" the tumor. The body forms tumors to stop the CA cells from spreading throughout the body and altering healthy cells. Once the cells are punctured for "testing" the cells go and the beasties cause more trouble. (Why not, eh? It's a $ racquet.) 1A. CANCER IS A PARASIT. Start Ivermectin (dosage 1am1 pm by bodyweight) & Fenbendazole (dosage 1 222mg pill/day for 6 days, skip the 7th to let the renal system rest). 2ND CUT ALL SUGARS. CA LOVES SUGAR IN ALL FORMS. 3rd, HYDROGEN PEROXIDE: H202 has the extra Oxygen molecule that CA hates. Use a cotton ball or wash cloth for larger areas and rub all over skin. 3x/day, especially when you are out of the bath and shower, as your pores are open and more likely to get it into the bloodstream. The HP gets into the skin and kills the CA cells almost immediately. 4th, ALKALINE WATER: CA is not able to live in an alkaline body. Drink alkaline water w/ lemon throughout the day consistently. Lemon is an acid outside the body but in your stomach it is converted to an alkaline base by the hydrochloric acid. It will move through your blood stream and help get rid of the crud. 5th, DETOX BATHS: 1 Cup Baking Soda, 1 Cup Borax, 1 Cup Epsom Salt & Bentonite Clay Draw the hottest bath you can... Soak as long as you can, as hot as you can and it will help detox the CA and the nano-particulates (gr@phine oxide) out of the body. At least do this 2-3x a week. 6th, The BIG BOMBER: VITAMIN B17 NOBODY wants ANYBODY to know about! Apple seeds, Apricot, Peach & Plum Pits, - ALL of them! You can find them on Cabalazon, or anywhere else on the web. We have lost knowledge about the B17 vitamin because: BIG PHARMa. 1/4 teaspoon of the powder a day, or just eat a couple apricot pits during the day, (like 3 or 4), will also get rid of the CA. I really hate that innocent people are dealing w/ all the bioweapon B.S. The turbo cancers are all part of it... We now have LEGIT CURES. You no longer need the Chemo and Radiation that kill the good tissue. 9/10 the patient dies from chemo & radiation poison then the actual cancer. Prior to BIG pHARMa, CA patients were given 2 large bottles of peroxide, and a bag of cotton balls and told to use it daily and return in 2 weeks to find 100% of it was cured.

For anyone going through cancer(s) ... Here are some useful tips: First, don't let them "test" the tumor. The body forms tumors to stop the CA cells from spreading throughout the body and altering healthy cells. Once the cells are punctured for "testing" the cells go and the beasties cause more trouble. (Why not, eh? It's a $ racquet.) 1A. CANCER IS A PARASIT. Start Ivermectin (dosage 1am1 pm by bodyweight) & Fenbendazole (dosage 1 222mg pill/day for 6 days, skip the 7th to let the renal system rest). 2ND CUT ALL SUGARS. CA LOVES SUGAR IN ALL FORMS. 3rd, HYDROGEN PEROXIDE: H202 has the extra Oxygen molecule that CA hates. Use a cotton ball or wash cloth for larger areas and rub all over skin. 3x/day, especially when you are out of the bath and shower, as your pores are open and more likely to get it into the bloodstream. The HP gets into the skin and kills the CA cells almost immediately. 4th, ALKALINE WATER: CA is not able to live in an alkaline body. Drink alkaline water w/ lemon throughout the day consistently. Lemon is an acid outside the body but in your stomach it is converted to an alkaline base by the hydrochloric acid. It will move through your blood stream and help get rid of the crud. 5th, DETOX BATHS: 1 Cup Baking Soda, 1 Cup Borax, 1 Cup Epsom Salt & Bentonite Clay Draw the hottest bath you can... Soak as long as you can, as hot as you can and it will help detox the CA and the nano-particulates (gr@phine oxide) out of the body. At least do this 2-3x a week. 6th, The BIG BOMBER: VITAMIN B17 NOBODY wants ANYBODY to know about! Apple seeds, Apricot, Peach & Plum Pits, - ALL of them! You can find them on Cabalazon, or anywhere else on the web. We have lost knowledge about the B17 vitamin because: BIG PHARMa. 1/4 teaspoon of the powder a day, or just eat a couple apricot pits during the day, (like 3 or 4), will also get rid of the CA. I really hate that innocent people are dealing w/ all the bioweapon B.S. The turbo cancers are all part of it... We now have LEGIT CURES. You no longer need the Chemo and Radiation that kill the good tissue. 9/10 the patient dies from chemo & radiation poison then the actual cancer. Prior to BIG pHARMa, CA patients were given 2 large bottles of peroxide, and a bag of cotton balls and told to use it daily and return in 2 weeks to find 100% of it was cured.

Mr. Pool

122,760 Aufrufe • vor 10 Tagen

I taught my Primary 2 students magnetic fields, and how they help us determine magnetic north and bearings using a compass. At the later half of the class, the students did a small experiment that used a magnet and compass to test what we learned. This is what Nigeria can take away from this: 1. LANGUAGE: Using Chinese to explain magnetic fields was so easy for them to understand, and took less than 4 mins. They never have to worry about understanding the grammar or remembering new vocabulary if another language was used. Language skill is not for everyone, just like technical and creative skills. While you or your son can learn a new language fast, others might be more technically inclined. Nigeria should use native languages to teach primary school children right from the first day in school. With many native languages, autonomous regions with different official languages will be ideal, with an option for international classes which are more English focused. 2. CURRICULUM: Unless we are really oblivious, there is no way a Nigerian primary 6 student can compete with my primary 2 students. These are kids that first came to our school so tiny and sometimes crying, many of them don’t even know how to write their names. A Nigerian taught them most of what they know today in less than 2 years, and because we have a curriculum that is modern, targets what the students really need to know, and its always modified to reflect their realities, they have acquired so much knowledge about how the world around them works like electricity, engines, space, aerodynamics, mechanics and environmental protection in a short time. What they are learning is directly linked to where their economy is headed, so by the time they are in university, they can easily understand advanced practical and theoretical knowledge and be useful to their economic development after graduation. Our curriculums in Nigeria are old and mostly useless to the growth of our economy, so let’s do the needful. Don’t wait for miracles to change them for you. We must demand this change. 3. GROUP WORK: Students are encouraged to work in groups, divide tasks and roles and they mentored to understand their strengths and challenges and resolve conflicts. They learn to work with others who are different from them, giving them a diverse perspective and mindset about working together. Nigeria cannot succeed without all of us uniting and learning to work with each other, irrespective of tribe, religion, region and family background. When we win as individuals, we will still be surrounded by helpless people, but when we win as a society, everyone develops. 4. TEACHERS: Here in China, we are always happy and encouraged to learn new things and ways to teach our students. We are free from worrying about food, shelter and pocket money. We are paid more than enough, so we have enough time and mental space to throughly research information and knowledge, and also design useful and interesting lessons for our students. Nigerian teachers should be paid a minimum of 800k to 1 million Naira per month. Primary school teachers lay down the crucial foundations for our economic growth, development and future. It is one of the most important professions in the country and the compensation and benefits MUST be more than senators and representatives. Liking, commenting and retweeting are nice because they help spread the message, however what’s more important is us uniting as Nigerians with our common interest to ensure that our needs are addressed.

I taught my Primary 2 students magnetic fields, and how they help us determine magnetic north and bearings using a compass. At the later half of the class, the students did a small experiment that used a magnet and compass to test what we learned. This is what Nigeria can take away from this: 1. LANGUAGE: Using Chinese to explain magnetic fields was so easy for them to understand, and took less than 4 mins. They never have to worry about understanding the grammar or remembering new vocabulary if another language was used. Language skill is not for everyone, just like technical and creative skills. While you or your son can learn a new language fast, others might be more technically inclined. Nigeria should use native languages to teach primary school children right from the first day in school. With many native languages, autonomous regions with different official languages will be ideal, with an option for international classes which are more English focused. 2. CURRICULUM: Unless we are really oblivious, there is no way a Nigerian primary 6 student can compete with my primary 2 students. These are kids that first came to our school so tiny and sometimes crying, many of them don’t even know how to write their names. A Nigerian taught them most of what they know today in less than 2 years, and because we have a curriculum that is modern, targets what the students really need to know, and its always modified to reflect their realities, they have acquired so much knowledge about how the world around them works like electricity, engines, space, aerodynamics, mechanics and environmental protection in a short time. What they are learning is directly linked to where their economy is headed, so by the time they are in university, they can easily understand advanced practical and theoretical knowledge and be useful to their economic development after graduation. Our curriculums in Nigeria are old and mostly useless to the growth of our economy, so let’s do the needful. Don’t wait for miracles to change them for you. We must demand this change. 3. GROUP WORK: Students are encouraged to work in groups, divide tasks and roles and they mentored to understand their strengths and challenges and resolve conflicts. They learn to work with others who are different from them, giving them a diverse perspective and mindset about working together. Nigeria cannot succeed without all of us uniting and learning to work with each other, irrespective of tribe, religion, region and family background. When we win as individuals, we will still be surrounded by helpless people, but when we win as a society, everyone develops. 4. TEACHERS: Here in China, we are always happy and encouraged to learn new things and ways to teach our students. We are free from worrying about food, shelter and pocket money. We are paid more than enough, so we have enough time and mental space to throughly research information and knowledge, and also design useful and interesting lessons for our students. Nigerian teachers should be paid a minimum of 800k to 1 million Naira per month. Primary school teachers lay down the crucial foundations for our economic growth, development and future. It is one of the most important professions in the country and the compensation and benefits MUST be more than senators and representatives. Liking, commenting and retweeting are nice because they help spread the message, however what’s more important is us uniting as Nigerians with our common interest to ensure that our needs are addressed.

Dan Bello

161,065 Aufrufe • vor 2 Jahren

A new way of working. And a scary one at that. Memory Store is one of a group of new kinds of AI-first companies that can turn you into a Fast Company. I’m using several of them on my desktop and they are a dramatically new way to work. It builds a memory for: 1. Your AI agents. 2. Any employee using it. 3. The company itself. I sit down with founder Diwank Singh Tomer, Diwank Singh Tomer, who both freaks me out as well as shows how AI can radically help workers as well as managers. First, why does it freak me out? Well, his AI watches nearly everything a worker does and keeps a “memory” of it. It watches your email. Your calendar. Your Slack. And a whole lot of other things. This can really freak out workers if “forced” on them. And leads to a whole new set of security issues companies need to consider before adopting these things. Such data about a company could give a competitor a HUGE advantage, if leaked. They would know how a company “thinks.” It really is a surveillance system for employees and the company itself. OK, now why would anyone ever use such a thing? Because it gives employees super powers. It makes them more productive. Shows workers a lot of things about themselves, and helps them work and stay on task. It also gives the company super powers. Institutional memory stays with the AI now, even if an employee dies or leaves. As companies move to “AI First” approaches, they will increasingly see the value in companies like Memory Store. It prepares employees for meetings. It helps them remember things. It shows them what they should be working on, and helps them do it. Memory Store builds a memory for: 1. Your agents. 2. Your company. 3. Yourself, or any employee on it. This helps all three work better together. Diwank Singh Tomer and I go in depth about what it does and how deeply it improves working at a company that deploys it. But to get the ultimate benefits you gotta convince your coworkers to use it. And your managers to approve it. Which means you have to get over your fears and get everyone you work with over theirs too. Which will be the challenge for Diwank. Luckily for him his first customers are raving about how good it is and how much his platform helped their companies. Increases sales. Makes teams more productive. Decreases errors and unnecessary costs. Which tells me everyone soon will be using systems like this. This is what the new way of working looks like. Once I got over my fears it sure is an amazing way to work. Will you try working this way?

A new way of working. And a scary one at that. Memory Store is one of a group of new kinds of AI-first companies that can turn you into a Fast Company. I’m using several of them on my desktop and they are a dramatically new way to work. It builds a memory for: 1. Your AI agents. 2. Any employee using it. 3. The company itself. I sit down with founder Diwank Singh Tomer, Diwank Singh Tomer, who both freaks me out as well as shows how AI can radically help workers as well as managers. First, why does it freak me out? Well, his AI watches nearly everything a worker does and keeps a “memory” of it. It watches your email. Your calendar. Your Slack. And a whole lot of other things. This can really freak out workers if “forced” on them. And leads to a whole new set of security issues companies need to consider before adopting these things. Such data about a company could give a competitor a HUGE advantage, if leaked. They would know how a company “thinks.” It really is a surveillance system for employees and the company itself. OK, now why would anyone ever use such a thing? Because it gives employees super powers. It makes them more productive. Shows workers a lot of things about themselves, and helps them work and stay on task. It also gives the company super powers. Institutional memory stays with the AI now, even if an employee dies or leaves. As companies move to “AI First” approaches, they will increasingly see the value in companies like Memory Store. It prepares employees for meetings. It helps them remember things. It shows them what they should be working on, and helps them do it. Memory Store builds a memory for: 1. Your agents. 2. Your company. 3. Yourself, or any employee on it. This helps all three work better together. Diwank Singh Tomer and I go in depth about what it does and how deeply it improves working at a company that deploys it. But to get the ultimate benefits you gotta convince your coworkers to use it. And your managers to approve it. Which means you have to get over your fears and get everyone you work with over theirs too. Which will be the challenge for Diwank. Luckily for him his first customers are raving about how good it is and how much his platform helped their companies. Increases sales. Makes teams more productive. Decreases errors and unnecessary costs. Which tells me everyone soon will be using systems like this. This is what the new way of working looks like. Once I got over my fears it sure is an amazing way to work. Will you try working this way?

Robert Scoble

26,186 Aufrufe • vor 4 Monaten

Last week we launched a preview version of our newest StefanBrain model, which we are calling SB1.5. It’s an extremely strong upgrade from our current model. It’s much more creative, writes better copy, provides sharper analysis, and is all around smarter. I made this video using StefanBrain’s VidGen 2.0 tool to help show the difference... But the best way to see if I'm telling the truth or not is to try out 1.5 for yourself. To do that: 1. Go to and start a free 3-day trial (zero cost, no credit card required). 2. Open a new tab and log in at using that same email. That instantly unlocks 1.5. 3. Use. 1.5 on Beta to brainstorm angles, come up with hooks, do funnel analysis, write copy, etc. 4. Use regular to generate full video ads, create static ads, and publish them directly to Meta. In the next 7-10 days, the two version will be merged together and you won’t need to do two separate workflows… But SB1.5 is so freaking good, I didn’t want to wait to share this with all of you. Enjoy :) - P.S. Right now 1.5 is pure chat. You can upload files, tell it go go watch videos or analyze domains, etc. You can't create projects or tag products. When we do the merge in 7-10 days from now, you'll have all those features available too.

Last week we launched a preview version of our newest StefanBrain model, which we are calling SB1.5. It’s an extremely strong upgrade from our current model. It’s much more creative, writes better copy, provides sharper analysis, and is all around smarter. I made this video using StefanBrain’s VidGen 2.0 tool to help show the difference... But the best way to see if I'm telling the truth or not is to try out 1.5 for yourself. To do that: 1. Go to and start a free 3-day trial (zero cost, no credit card required). 2. Open a new tab and log in at using that same email. That instantly unlocks 1.5. 3. Use. 1.5 on Beta to brainstorm angles, come up with hooks, do funnel analysis, write copy, etc. 4. Use regular to generate full video ads, create static ads, and publish them directly to Meta. In the next 7-10 days, the two version will be merged together and you won’t need to do two separate workflows… But SB1.5 is so freaking good, I didn’t want to wait to share this with all of you. Enjoy :) - P.S. Right now 1.5 is pure chat. You can upload files, tell it go go watch videos or analyze domains, etc. You can't create projects or tag products. When we do the merge in 7-10 days from now, you'll have all those features available too.

Stefan Georgi

18,512 Aufrufe • vor 14 Tagen

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

The All-In Podcast

58,533 Aufrufe • vor 1 Jahr

$ASTS | Scott Wisniewski at JP Morgan conference, May 18, 2026 Transcript - part 1 Good afternoon, everyone. I'm Sebastiano Petty, and I cover the telecom, cable, and satellite space here at J.P. Morgan. I'd like to welcome Scott Wisniewski, President and Chief Strategy Offer of ASTS Space Mobile. Scott, thanks for joining us. Thank you for having me. You're good. You're live. Can you hear me? All right. Thank you for having me. Great. So, Scott, just to start, let's zoom out. As you sit here in mid-2026, with Bluebirds launching, commercial service activation approaching, and the government pipeline accelerating, where are you spending most of your time as President and Chief Strategy Officer? And more broadly, what are your two to three highest priority objectives over the next 18 months as you transition from what has primarily been an R&D and manufacturing story into a scaled revenue-generating operating company? Thank you. And for those who don't know us that well, we were founded about a decade ago around the direct-to-device opportunity. That's what we do. That's our entire strategy. It's from space, of course, and we build our own satellites, and we'll be operating them and selling capacity on them. But at its core, we are a direct-to-device pure play. And over the years, I met our founder in January 2019, but over the years, telling our equity story, people always asked three questions. Does it work? Can you fund it? And how big will the market be, or will there be a market? And that's our traditional private company questions that we still got even as a public company for a while, and we really retired those risks in 2023, 2024, and 2025. And so this year, yeah, you're exactly right. Traditional growth stuff, scaling stuff is where we are. And for us, if I were to say two simple things, one is network deployment. The vast majority of the folks in the company are focused on exactly that, network deployment now for revenue in 2026 and 2027 and beyond. And then the second one is, I think, building the market out in the right way. This is a brand new service. It's a service that is at the very heart of connectivity. Remember, we all know the trends in connectivity. When I started my career in connectivity, there was a question, bubble, what inning are we in? When is the expansion going to end? And then, of course, AI comes along, and there's always something every couple of years. So for us, we're at the heart of connectivity. We can do coverage better than any terrestrial footprint by its very nature. And making connectivity work for our partners, the mobile network operators, and ultimately for the consumer mass market among other markets, is our focus. So building out that market is our second priority. Great. And let's address the news from last week. AT&T, Verizon, and T-Mobile announced a proposed joint venture to extend mobile connectivity using satellite-based D2D technologies. You guys put out a statement commending the announcement. Unpack this for us. What does this mean for ASTS in practice? Does it change your commercial positioning with the carriers? Does it accelerate or maybe even complicate your path to service? So we really value the carrier relationship. We've organized the business, the technology, the go-to-market strategy. Everything we do, really, is about making connectivity better for the mobile network operators. And so you see that in where we've prioritized the company over the years. You see that in how we've built out the tech. And even the network stack is organized with the RAN on the ground, so the operators control it. So that's really been our focus. We share their spectrum, although we also have our own spectrum now. And that's always been the approach. Part1, 1 (of 2)

Peter LINDM🅰️RK

29,453 Aufrufe • vor 4 Monaten

We built and launched a viral AI product in 2 months (at Google!). Here's how: Our little NotebookLM team has had a crazy few months and is proving that small, nimble teams not only exist within Google, but can move fast and have significant impact. Our newest feature “Audio Overviews” has taken over the internet the past few days. The team has been sprinting - we went from idea to prototype in weeks, then launched publicly in under 2 months. It’s not perfect (yet!), but that’s the point. Here are a few takeaways: 1. It's about building products *with* our users, not just *for* them. We’re not waiting to launch, we’re shipping early and iterating. Tech is evolving faster than users can possibly know what they want. We're often anticipating needs for V1 then working alongside them to improve. Example: Very quickly we saw a massive user desire for in-line citations so our team quickly pivoted to build and launch. (Join our discord!) 2. Built-in not bolted-on: We’re building net-new, AI native products. This isn’t just AI for the sake of “AI”, we’re working to bridge the gap between state-of-the-art research and human problems. Audio Overviews are great because they sound amazing, yes -- but useful because they are (1) source grounded and (2) an easy one-click way to study and digest your own information. 3. Meetings are spent building, not just talking about building. We’re collaborating, deeply. I am the only UX designer on the team so we have to make every moment count. @raiza_abubakar, Steven Johnson and I are constantly strategizing and iterating together. NotebookLM represents a new era of product development within Labs at Google. We're putting user feedback and community engagement at the heart of everything we do. We’re building quickly and have a lot more coming soon.. The audio below is made with the NotebookLM Audio Overview feature using only my LinkedIn post! If you haven’t tried it, I highly recommend it. We want to make it better for you! It’s been awesome to see so much investigation into the product by Andrej Karpathy and Ethan Mollick.

We built and launched a viral AI product in 2 months (at Google!). Here's how: Our little NotebookLM team has had a crazy few months and is proving that small, nimble teams not only exist within Google, but can move fast and have significant impact. Our newest feature “Audio Overviews” has taken over the internet the past few days. The team has been sprinting - we went from idea to prototype in weeks, then launched publicly in under 2 months. It’s not perfect (yet!), but that’s the point. Here are a few takeaways: 1. It's about building products with our users, not just for them. We’re not waiting to launch, we’re shipping early and iterating. Tech is evolving faster than users can possibly know what they want. We're often anticipating needs for V1 then working alongside them to improve. Example: Very quickly we saw a massive user desire for in-line citations so our team quickly pivoted to build and launch. (Join our discord!) 2. Built-in not bolted-on: We’re building net-new, AI native products. This isn’t just AI for the sake of “AI”, we’re working to bridge the gap between state-of-the-art research and human problems. Audio Overviews are great because they sound amazing, yes -- but useful because they are (1) source grounded and (2) an easy one-click way to study and digest your own information. 3. Meetings are spent building, not just talking about building. We’re collaborating, deeply. I am the only UX designer on the team so we have to make every moment count. @raiza_abubakar, Steven Johnson and I are constantly strategizing and iterating together. NotebookLM represents a new era of product development within Labs at Google. We're putting user feedback and community engagement at the heart of everything we do. We’re building quickly and have a lot more coming soon.. The audio below is made with the NotebookLM Audio Overview feature using only my LinkedIn post! If you haven’t tried it, I highly recommend it. We want to make it better for you! It’s been awesome to see so much investigation into the product by Andrej Karpathy and Ethan Mollick.

Jason Spielman

369,463 Aufrufe • vor 2 Jahren