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Long-term live-cell super-res microscopy! 👉🏻our new preprint ( reports >6h STED imaging of ER dynamics in live cells with seconds time resolution. It combines low-light imaging and NN-assisted denoising🔬

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HeilemannLab (👉🏻 heilemannlab.bsky.social)

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18,635 görüntüleme • 2 yıl önce •via X (Twitter)

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HeilemannLab (👉🏻 heilemannlab.bsky.social)2 yıl önce

This approach enables ultra-fast scanning, minimizing photobleaching and phototoxicity. With that, we were able to record 3D-STED videos of ER structural rearrangements👇🏻

HeilemannLab (👉🏻 heilemannlab.bsky.social) profil fotoğrafı
HeilemannLab (👉🏻 heilemannlab.bsky.social)2 yıl önce

We used the RCAN-UNet introduced by our colleagues ( and tailored it for long-term live-cell imaging of low-light STED data.

HeilemannLab (👉🏻 heilemannlab.bsky.social) profil fotoğrafı
HeilemannLab (👉🏻 heilemannlab.bsky.social)2 yıl önce

We thank @dfg_public for funding this research in the frame of the @sfb1177 @goetheuni

Andy Moore profil fotoğrafı
Andy Moore2 yıl önce

This looks so good.

HeilemannLab (👉🏻 heilemannlab.bsky.social) profil fotoğrafı
HeilemannLab (👉🏻 heilemannlab.bsky.social)2 yıl önce

Thank you, Andy 🙏

Luc Reym⌬nd profil fotoğrafı
Luc Reym⌬nd2 yıl önce

Congrats! Looks terrific. SiR-chloroalkane performs superbly.

Till Stephan profil fotoğrafı
Till Stephan2 yıl önce

Congrats! The future of superres is live!

HeilemannLab (👉🏻 heilemannlab.bsky.social) profil fotoğrafı
HeilemannLab (👉🏻 heilemannlab.bsky.social)2 yıl önce

Absolutely!

Jon Lane profil fotoğrafı
Jon Lane2 yıl önce

This is lovely. Puts into context all those years I spent recording ER dynamics in frog egg extracts by VE-DIC with an S-VHS......

Bond079, PhD profil fotoğrafı
Bond079, PhD2 yıl önce

The way ER dynamics happen is totally mesmerizing 😊

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PHOTON COUNTING CT is NOT a better CT It is a NEW imaging modality Photon Counting CT (PCCT) represents a transformative leap in medical imaging, not only as a molecular imaging modality but also as a technology offering ultra-high resolution and functional imaging capabilities. It is fundamentally more than just an enhanced version of traditional CT—PCCT introduces new ways of seeing and understanding the human body, providing critical insights at the molecular, structural, and functional levels. This positions PCCT as a unique imaging modality that requires a fresh approach to technical implementation, operational workflows, and financial planning. Despite the larger upfront investment, PCCT’s ability to drastically reduce downstream healthcare costs makes it a highly valuable investment in the long run. 1. 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📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf). A major accomplishment by YangJoon Kim co-led by Merlin Lange with experiments by Shruthi VijayKumar #Zebrahub-Multiome is a sequel to our transcriptomic and imaging atlas of zebrafish development. #zebrafish #development #ATACseq #cell #biology #sequencing Chan Zuckerberg Biohub Network #CZBiohubSF Biohub Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...
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📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf). A major accomplishment by YangJoon Kim co-led by Merlin Lange with experiments by Shruthi VijayKumar #Zebrahub-Multiome is a sequel to our transcriptomic and imaging atlas of zebrafish development. #zebrafish #development #ATACseq #cell #biology #sequencing Chan Zuckerberg Biohub Network #CZBiohubSF Biohub Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...

Loïc A. Royer 💻🔬⚗️

39,790 görüntüleme • 1 yıl önce

From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).
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From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).

Ali Max Erturk

15,912 görüntüleme • 6 ay önce

🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form Please also send your application to: farida.hellal@med.uni-muenchen.de CC: ali.ertuerk@med.uni-muenchen.de 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich
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🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form Please also send your application to: [email protected] CC: [email protected] 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

Ali Max Erturk

14,781 görüntüleme • 7 ay önce

Exciting results in lung cancer today. It is my belief that treating lymphopenia in patients with low NK and T cell count, is as essential as treating anemia (low red blood cells count) or neutropenia (low neutrophil count) which occurs as a consequence of chemotherapy, independent of tumor types. This will herald in the paradigm change of treating the immune system itself and allow the immune system to cure the cancer, regardless of its anatomical location. The long-term survival in patients with bladder cancer and now in lung cancer provide evidence of the potential validity of this hypothesis, with ANKTVIA as the foundation of the Bioshield platform.
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Exciting results in lung cancer today. It is my belief that treating lymphopenia in patients with low NK and T cell count, is as essential as treating anemia (low red blood cells count) or neutropenia (low neutrophil count) which occurs as a consequence of chemotherapy, independent of tumor types. This will herald in the paradigm change of treating the immune system itself and allow the immune system to cure the cancer, regardless of its anatomical location. The long-term survival in patients with bladder cancer and now in lung cancer provide evidence of the potential validity of this hypothesis, with ANKTVIA as the foundation of the Bioshield platform.

Dr. Pat Soon-Shiong

43,436 görüntüleme • 11 ay önce

Today, we're announcing an expansion of Vantor’s industry-leading imaging constellation—eliminating a long-standing tradeoff between accurate, high-resolution imagery and high-frequency monitoring. For the first time, both come together in a single commercial system. 20 cm-class imaging. Global revisits as often as every 15 minutes. This expansion introduces two new satellite classes: 🛰️ Vantor Vantage™, next-generation 20 cm-class imaging satellites delivering the highest commercial resolution on orbit, coming online as early as 2029 🛰️ Vantor Pulse™, a fleet of 40 cm-class satellites designed for persistent, high-frequency monitoring, coming online as early as 2027 These new satellites build on the strength of the Vantor constellation—including our WorldView Legion satellites, which already deliver the most accurate, high-resolution imagery on orbit. By increasing capacity and refresh rates, the expansion reinforces the spatial foundation behind our Tensorglobe spatial intelligence platform, powering a real-time, AI-ready view of the world in 2D and 3D. These capabilities automate the full intelligence cycle within customer environments, enabling a new level of sovereign capability that helps governments and businesses detect change, track activity, and act faster. 👉 Read the full announcement here: Total clarity from space to ground.
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Today, we're announcing an expansion of Vantor’s industry-leading imaging constellation—eliminating a long-standing tradeoff between accurate, high-resolution imagery and high-frequency monitoring. For the first time, both come together in a single commercial system. 20 cm-class imaging. Global revisits as often as every 15 minutes. This expansion introduces two new satellite classes: 🛰️ Vantor Vantage™, next-generation 20 cm-class imaging satellites delivering the highest commercial resolution on orbit, coming online as early as 2029 🛰️ Vantor Pulse™, a fleet of 40 cm-class satellites designed for persistent, high-frequency monitoring, coming online as early as 2027 These new satellites build on the strength of the Vantor constellation—including our WorldView Legion satellites, which already deliver the most accurate, high-resolution imagery on orbit. By increasing capacity and refresh rates, the expansion reinforces the spatial foundation behind our Tensorglobe spatial intelligence platform, powering a real-time, AI-ready view of the world in 2D and 3D. These capabilities automate the full intelligence cycle within customer environments, enabling a new level of sovereign capability that helps governments and businesses detect change, track activity, and act faster. 👉 Read the full announcement here: Total clarity from space to ground.

Vantor

24,722 görüntüleme • 4 ay önce

🐼 Technology is giving conservation a powerful new edge in the Qinling Mountains! Rangers at the Shaanxi Foping National Nature Reserve recently spotted a wild giant panda during a routine patrol, first detecting its heat signature with a drone's thermal imaging before confirming it through visible-light footage. Home to one of the highest densities of wild giant pandas in China—about one panda per 1.5 sq km—the reserve now combines infrared cameras, video surveillance and 24/7 smart monitoring to protect these iconic animals in real time.
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🐼 Technology is giving conservation a powerful new edge in the Qinling Mountains! Rangers at the Shaanxi Foping National Nature Reserve recently spotted a wild giant panda during a routine patrol, first detecting its heat signature with a drone's thermal imaging before confirming it through visible-light footage. Home to one of the highest densities of wild giant pandas in China—about one panda per 1.5 sq km—the reserve now combines infrared cameras, video surveillance and 24/7 smart monitoring to protect these iconic animals in real time.

Green China

43,443 görüntüleme • 1 ay önce

After our hiatus, we're returning tonight to @SystemUpdate_ at our regular time: 7pm ET, live only on Rumble. Our return is in conjunction with a new, long-planned, exciting major ad campaign we're launching today to show what our program has done and where we're taking it:
1:30

After our hiatus, we're returning tonight to @SystemUpdate_ at our regular time: 7pm ET, live only on Rumble. Our return is in conjunction with a new, long-planned, exciting major ad campaign we're launching today to show what our program has done and where we're taking it:

Glenn Greenwald

13,792,157 görüntüleme • 3 yıl önce