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Long-term live-cell super-res microscopy! 👉🏻our new preprint ( reports >6h STED imaging of ER dynamics in live cells with seconds time resolution. It combines low-light imaging and NN-assisted denoising🔬

HeilemannLab (👉🏻 heilemannlab.bsky.social)

1,121 subscribers

18,635 次观看 • 2 年前 •via X (Twitter)

健康养生教育科学技术

Anya Rossi• Live Now

Private livecam show

10 条评论

HeilemannLab (👉🏻 heilemannlab.bsky.social) 的头像

HeilemannLab (👉🏻 heilemannlab.bsky.social)2 年前

This approach enables ultra-fast scanning, minimizing photobleaching and phototoxicity. With that, we were able to record 3D-STED videos of ER structural rearrangements👇🏻

HeilemannLab (👉🏻 heilemannlab.bsky.social) 的头像

HeilemannLab (👉🏻 heilemannlab.bsky.social)2 年前

We used the RCAN-UNet introduced by our colleagues ( and tailored it for long-term live-cell imaging of low-light STED data.

HeilemannLab (👉🏻 heilemannlab.bsky.social) 的头像

HeilemannLab (👉🏻 heilemannlab.bsky.social)2 年前

We thank @dfg_public for funding this research in the frame of the @sfb1177 @goetheuni

Andy Moore 的头像

Andy Moore2 年前

This looks so good.

HeilemannLab (👉🏻 heilemannlab.bsky.social) 的头像

HeilemannLab (👉🏻 heilemannlab.bsky.social)2 年前

Thank you, Andy 🙏

Luc Reym⌬nd 的头像

Luc Reym⌬nd2 年前

Congrats! Looks terrific. SiR-chloroalkane performs superbly.

Till Stephan 的头像

Till Stephan2 年前

Congrats! The future of superres is live!

HeilemannLab (👉🏻 heilemannlab.bsky.social) 的头像

HeilemannLab (👉🏻 heilemannlab.bsky.social)2 年前

Absolutely!

Jon Lane 的头像

Jon Lane2 年前

This is lovely. Puts into context all those years I spent recording ER dynamics in frog egg extracts by VE-DIC with an S-VHS......

Bond079, PhD 的头像

Bond079, PhD2 年前

The way ER dynamics happen is totally mesmerizing 😊

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This means clinicians can visualize fine structures such as microcalcifications in arteries, small lesions in soft tissues, or the intricate architecture of bones. This level of detail was previously unattainable with traditional CT. When combined with molecular imaging, this ultra-high resolution allows for the precise localization and characterization of disease at very early stages, which is essential for early diagnosis and intervention. • Functional Imaging Capabilities: PCCT also excels as a functional imaging modality. By capturing energy-resolved information, PCCT can provide insights into tissue functionality and dynamic physiological processes. For instance, it can detect changes in blood flow, tissue perfusion, and oxygenation without the need for additional contrast agents or scans. 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387,977 次观看 • 7 个月前

📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf). A major accomplishment by YangJoon Kim co-led by Merlin Lange with experiments by Shruthi VijayKumar #Zebrahub-Multiome is a sequel to our transcriptomic and imaging atlas of zebrafish development. #zebrafish #development #ATACseq #cell #biology #sequencing Chan Zuckerberg Biohub Network #CZBiohubSF Biohub Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...

📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish development. Integrating scATAC-seq and scRNA-seq from 94,000+ cells, we map gene regulatory networks across six key stages of embryogenesis (10 to 24 hpf). A major accomplishment by YangJoon Kim co-led by Merlin Lange with experiments by Shruthi VijayKumar #Zebrahub-Multiome is a sequel to our transcriptomic and imaging atlas of zebrafish development. #zebrafish #development #ATACseq #cell #biology #sequencing Chan Zuckerberg Biohub Network #CZBiohubSF Biohub Note: We sent two preprints simultaneously yesterday, and this is the first one to come out... I will append to this thread when the second one is out...

Loïc A. Royer 💻🔬⚗️

39,790 次观看 • 1 年前

From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).

From 3D imaging to therapy Using our DISCO tissue clearing and whole organ 3D imaging platform, we revealed skull to meninges microchannels connecting calvarial bone marrow with the brain borders in mice (Cai...Ertürk, Nature Neuroscience,2018, We then extended this biology to humans, discovering distinct skull bone marrow programs and structural skull meninges connections in health and neurological disease (Kolabas...Ertürk, Cell, 2023). Now, a new study reports a first therapeutic application of this route: intracalvariosseous (calvarial) injection of drug loaded albumin nanoparticles to “hijack” calvarial immune cells, which then migrate via skull meninges microchannels to CNS lesions, bypassing the blood brain barrier and improving outcomes in stroke models, with encouraging clinical feasibility data (Gao et al., Cell, 2026) We are proud that DISCO enabled biology that is now turning into concrete therapeutic strategies for devastating neurological diseases. More to come. #DISCO #TissueClearing #Neuroimmunology #Stroke #Nanomedicine #DrugDelivery #BBB #CNS Refs (for linking in comments): Cai et al. Nat Neuroscience, Kolabas et al. Cell 2023, the video from Gao et al. Cell 2026 (online Jan 16, 2026).

Ali Max Erturk

15,901 次观看 • 6 个月前

🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form Please also send your application to: farida.hellal@med.uni-muenchen.de CC: ali.ertuerk@med.uni-muenchen.de 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form Please also send your application to: [email protected] CC: [email protected] 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

Ali Max Erturk

14,751 次观看 • 7 个月前

Exciting results in lung cancer today. It is my belief that treating lymphopenia in patients with low NK and T cell count, is as essential as treating anemia (low red blood cells count) or neutropenia (low neutrophil count) which occurs as a consequence of chemotherapy, independent of tumor types. This will herald in the paradigm change of treating the immune system itself and allow the immune system to cure the cancer, regardless of its anatomical location. The long-term survival in patients with bladder cancer and now in lung cancer provide evidence of the potential validity of this hypothesis, with ANKTVIA as the foundation of the Bioshield platform.

Exciting results in lung cancer today. It is my belief that treating lymphopenia in patients with low NK and T cell count, is as essential as treating anemia (low red blood cells count) or neutropenia (low neutrophil count) which occurs as a consequence of chemotherapy, independent of tumor types. This will herald in the paradigm change of treating the immune system itself and allow the immune system to cure the cancer, regardless of its anatomical location. The long-term survival in patients with bladder cancer and now in lung cancer provide evidence of the potential validity of this hypothesis, with ANKTVIA as the foundation of the Bioshield platform.

Dr. Pat Soon-Shiong

43,436 次观看 • 10 个月前

Today, we're announcing an expansion of Vantor’s industry-leading imaging constellation—eliminating a long-standing tradeoff between accurate, high-resolution imagery and high-frequency monitoring. For the first time, both come together in a single commercial system. 20 cm-class imaging. Global revisits as often as every 15 minutes. This expansion introduces two new satellite classes: 🛰️ Vantor Vantage™, next-generation 20 cm-class imaging satellites delivering the highest commercial resolution on orbit, coming online as early as 2029 🛰️ Vantor Pulse™, a fleet of 40 cm-class satellites designed for persistent, high-frequency monitoring, coming online as early as 2027 These new satellites build on the strength of the Vantor constellation—including our WorldView Legion satellites, which already deliver the most accurate, high-resolution imagery on orbit. By increasing capacity and refresh rates, the expansion reinforces the spatial foundation behind our Tensorglobe spatial intelligence platform, powering a real-time, AI-ready view of the world in 2D and 3D. These capabilities automate the full intelligence cycle within customer environments, enabling a new level of sovereign capability that helps governments and businesses detect change, track activity, and act faster. 👉 Read the full announcement here: Total clarity from space to ground.

Today, we're announcing an expansion of Vantor’s industry-leading imaging constellation—eliminating a long-standing tradeoff between accurate, high-resolution imagery and high-frequency monitoring. For the first time, both come together in a single commercial system. 20 cm-class imaging. Global revisits as often as every 15 minutes. This expansion introduces two new satellite classes: 🛰️ Vantor Vantage™, next-generation 20 cm-class imaging satellites delivering the highest commercial resolution on orbit, coming online as early as 2029 🛰️ Vantor Pulse™, a fleet of 40 cm-class satellites designed for persistent, high-frequency monitoring, coming online as early as 2027 These new satellites build on the strength of the Vantor constellation—including our WorldView Legion satellites, which already deliver the most accurate, high-resolution imagery on orbit. By increasing capacity and refresh rates, the expansion reinforces the spatial foundation behind our Tensorglobe spatial intelligence platform, powering a real-time, AI-ready view of the world in 2D and 3D. These capabilities automate the full intelligence cycle within customer environments, enabling a new level of sovereign capability that helps governments and businesses detect change, track activity, and act faster. 👉 Read the full announcement here: Total clarity from space to ground.

Vantor

24,722 次观看 • 3 个月前

🐼 Technology is giving conservation a powerful new edge in the Qinling Mountains! Rangers at the Shaanxi Foping National Nature Reserve recently spotted a wild giant panda during a routine patrol, first detecting its heat signature with a drone's thermal imaging before confirming it through visible-light footage. Home to one of the highest densities of wild giant pandas in China—about one panda per 1.5 sq km—the reserve now combines infrared cameras, video surveillance and 24/7 smart monitoring to protect these iconic animals in real time.

🐼 Technology is giving conservation a powerful new edge in the Qinling Mountains! Rangers at the Shaanxi Foping National Nature Reserve recently spotted a wild giant panda during a routine patrol, first detecting its heat signature with a drone's thermal imaging before confirming it through visible-light footage. Home to one of the highest densities of wild giant pandas in China—about one panda per 1.5 sq km—the reserve now combines infrared cameras, video surveillance and 24/7 smart monitoring to protect these iconic animals in real time.

Green China

43,443 次观看 • 1 个月前

After our hiatus, we're returning tonight to @SystemUpdate_ at our regular time: 7pm ET, live only on Rumble. Our return is in conjunction with a new, long-planned, exciting major ad campaign we're launching today to show what our program has done and where we're taking it:

After our hiatus, we're returning tonight to @SystemUpdate_ at our regular time: 7pm ET, live only on Rumble. Our return is in conjunction with a new, long-planned, exciting major ad campaign we're launching today to show what our program has done and where we're taking it:

Glenn Greenwald

13,792,154 次观看 • 3 年前