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🚨It’s back… The Oreo vs Statin Experiment… 1/4) To catch you up, while a student at Harvard Medical School I conducted an experiment where I my LDL cholesterol TWICE as much with Oreo cookies as compared to high-dose statins, a viral experiment that was published in peer-review. The “Oreo...

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Nick Norwitz MD PhD

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54,291 次观看 • 7 个月前 •via X (Twitter)

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🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔
3:44

🚨#OreoVsStatin - PUBLISHED!🚨 OREO Cookie cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy! What you NEED to know... 👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol. 👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet Why Oreos? ... It's (productively) provocative! 😱 Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ... But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work! It's not 'just click bait' ... it's 'legit-bait' I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey. What you need to do... or should do... 🙏PRETTY PLEASE 🙏! 👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): 👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: ... doing so helps promote the work and provoke the discussion ... and feel free to tag in your favorite influencers (or least favorite 😉)... A HUGE thanks to the senior author and expert lipidologist William Cromwell, MD for his guiding wisdom, insightful thoughts, and always open and curious mind. And to Dave Feldman, my friend, research wife, and the '#LEM daddy' Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs). Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

Nick Norwitz MD PhD

3,217,614 次观看 • 2 年前

🚨 BILL GATES DAUGHTER JUST LAUNCHED A $35 MILLION “SOCIAL EXPERIMENT” — AND IT’S RAISING RED FLAGS As criticism surrounding Bill Gates continues online over his past ties to Jeffrey Epstein and controversial global remarks, his daughter Phoebe just stepped forward with a new platform, calling it a “personalized social shopping experiment.” $35 million behind it. And the word she chose? “Experiment.” Most people didn’t even know she was building in tech. Now she’s asking users to join in. Why frame it that way, especially right now?
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🚨 BILL GATES DAUGHTER JUST LAUNCHED A $35 MILLION “SOCIAL EXPERIMENT” — AND IT’S RAISING RED FLAGS As criticism surrounding Bill Gates continues online over his past ties to Jeffrey Epstein and controversial global remarks, his daughter Phoebe just stepped forward with a new platform, calling it a “personalized social shopping experiment.” $35 million behind it. And the word she chose? “Experiment.” Most people didn’t even know she was building in tech. Now she’s asking users to join in. Why frame it that way, especially right now?

HustleBitch

60,453 次观看 • 5 个月前

But here’s where it gets truly disturbing. Lemov revealed that when the experiment finally came to light, the backlash was swift—and in some cases, tragic. “But, so this is why there was an ethical debate when the experiment was published in 2014,” she said. One user, Lemov recalled, had a chilling reaction. “And on the Facebook page of the research group that that did the experiment, at least one user wrote in saying, could I ever find out if I was in that experiment.” “Because I was in the emergency room at that time with, you know, threatening to commit suicide, and I want to know if my feed was altered and maybe that pushed me over, you know, into that that state.” There was no way to know. “Of course, they could never know and it can’t be traced backwards. And other people had a similar response.” The scandal sparked an investigation by the British government, which considered sanctions over the international scope of the experiment. “And there was even an investigation by the British government about whether this should be sanctioned because it affected users internationally,” Lemov said. But in the end, there was no accountability. “Ultimately, there doesn’t seem to have been any sanctions that came out of in anyone associated with it, is mostly promoted.” No one punished. No warnings given. And we’re all left wondering: how many more experiments are happening right now—hidden in plain sight?
1:09

But here’s where it gets truly disturbing. Lemov revealed that when the experiment finally came to light, the backlash was swift—and in some cases, tragic. “But, so this is why there was an ethical debate when the experiment was published in 2014,” she said. One user, Lemov recalled, had a chilling reaction. “And on the Facebook page of the research group that that did the experiment, at least one user wrote in saying, could I ever find out if I was in that experiment.” “Because I was in the emergency room at that time with, you know, threatening to commit suicide, and I want to know if my feed was altered and maybe that pushed me over, you know, into that that state.” There was no way to know. “Of course, they could never know and it can’t be traced backwards. And other people had a similar response.” The scandal sparked an investigation by the British government, which considered sanctions over the international scope of the experiment. “And there was even an investigation by the British government about whether this should be sanctioned because it affected users internationally,” Lemov said. But in the end, there was no accountability. “Ultimately, there doesn’t seem to have been any sanctions that came out of in anyone associated with it, is mostly promoted.” No one punished. No warnings given. And we’re all left wondering: how many more experiments are happening right now—hidden in plain sight?

The Vigilant Fox 🦊

409,972 次观看 • 1 年前

Carlos Alcaraz says he initially wasn’t sure if he was cramping or if it was an issue with his adductor during his match against Zverev, ‘I just told what happened to the physio & he decided to take a medical’ “I didn’t think it was cramps at all at the beginning. I didn’t know exactly what it was. I ran to a forehand and started to feel it in the right adductor. That’s why I called the physio. Because it was just that moment, the rest of the legs.. the left leg was good. Not good but decent. After that with all the stress I didn’t know what was going on. I didn’t know if it was going to be worse or not. In that moment I just talked to the physio and said ‘Ok I just went to run to the forehand side and I started to feel the right adductor.’ He decided to take the medical time out and he did it. I just told what happened to the physio and he decided to take a medical.” (via Australian Open Press)
2:04

Carlos Alcaraz says he initially wasn’t sure if he was cramping or if it was an issue with his adductor during his match against Zverev, ‘I just told what happened to the physio & he decided to take a medical’ “I didn’t think it was cramps at all at the beginning. I didn’t know exactly what it was. I ran to a forehand and started to feel it in the right adductor. That’s why I called the physio. Because it was just that moment, the rest of the legs.. the left leg was good. Not good but decent. After that with all the stress I didn’t know what was going on. I didn’t know if it was going to be worse or not. In that moment I just talked to the physio and said ‘Ok I just went to run to the forehand side and I started to feel the right adductor.’ He decided to take the medical time out and he did it. I just told what happened to the physio and he decided to take a medical.” (via Australian Open Press)

The Tennis Letter

516,912 次观看 • 6 个月前

Did you know the first successful weather modification experiment was in 1905 in California where a Man called Charles Hatfield got paid by farmers to make it rain. Just imagine what those who want to play God with Earths weather can do now.
1:05

Did you know the first successful weather modification experiment was in 1905 in California where a Man called Charles Hatfield got paid by farmers to make it rain. Just imagine what those who want to play God with Earths weather can do now.

Concerned Citizen

52,190 次观看 • 6 个月前

My visuals for Eric Prydz' Holosphere 2.0!! This was my first big experiment in combining 3D and AI work, and it absolutely allowed me to push my visuals to the next level! 🔥 Also, massive shoutout to The Render Network. I wouldn't have been able to do it without you guys, and I ended up rendering 55+ shots within just a few days before final delivery! 🙏🫶
0:36

My visuals for Eric Prydz' Holosphere 2.0!! This was my first big experiment in combining 3D and AI work, and it absolutely allowed me to push my visuals to the next level! 🔥 Also, massive shoutout to The Render Network. I wouldn't have been able to do it without you guys, and I ended up rendering 55+ shots within just a few days before final delivery! 🙏🫶

David Ariew

26,928 次观看 • 1 年前

As promised, I open-sourced the app. Introducing Inka: AI Daily Journal for BOOX devices → ← It started as an experiment: a simple screen where you can write anything and the page writes back. I showed it to my son and he absolutely loved it. Then I realized I could turn this into a daily journal app, where you can write down your thoughts and get answers back. It's low-bandwidth communication, yes. But that's a feature, not a bug. I find myself focusing much better while drawing _random_ things on paper. And so I turned the one-screen experiment into a full app. You can configure the AI provider, persona, writing animation, handwriting font & style and even an experimental handwriting synthesis for a more realistic feel. Give it a try and let me know what you think.
0:34

As promised, I open-sourced the app. Introducing Inka: AI Daily Journal for BOOX devices → ← It started as an experiment: a simple screen where you can write anything and the page writes back. I showed it to my son and he absolutely loved it. Then I realized I could turn this into a daily journal app, where you can write down your thoughts and get answers back. It's low-bandwidth communication, yes. But that's a feature, not a bug. I find myself focusing much better while drawing _random_ things on paper. And so I turned the one-screen experiment into a full app. You can configure the AI provider, persona, writing animation, handwriting font & style and even an experimental handwriting synthesis for a more realistic feel. Give it a try and let me know what you think.

Daniel Nguyen

37,055 次观看 • 24 天前

What do you think of this? As much as I’d love to say this was so easy and brilliant it was the opposite. We had to actually rip it back out when 50% done because tiling was poor and not what I wanted standards wise and also the design wasn’t the best in my opinion. Back to the drawing board and re start. What a bloody job
1:04

What do you think of this? As much as I’d love to say this was so easy and brilliant it was the opposite. We had to actually rip it back out when 50% done because tiling was poor and not what I wanted standards wise and also the design wasn’t the best in my opinion. Back to the drawing board and re start. What a bloody job

Fraser Hoehle

31,399 次观看 • 1 年前

NEW: Brainwashing expert on Joe Rogan exposes the sinister Facebook experiment that manipulated 700,000 users—without their knowledge. This is very dark. Harvard professor Rebecca Lemov, an expert on mind control and emotional manipulation, joined Joe Rogan and laid out the disturbing details of a little-known experiment Facebook conducted in 2012: “There’s a famous Facebook experiment I read about that took place in 2012 and was published in 2014, where they announce that they’ve achieved, mass emotional contagion at scale,” she said. Lemov explained that the social media giant ran the test on 700,000 users—without telling them. “Whenever you go on the platform, you agree to be tested or AB testing. So this experiment exposed a group to a more—their newsfeed was altered in a negative direction emotionally, as measured by word counting software.” The results? Chilling. “And they discovered that that group that had a negative exposure also responded in a more negative way, as judged through their posts and likes and responses.” “The group that was exposed to a more positive newsfeed by altering the algorithm then had also a measurably statistically significant effect of more positive emotional response—and the control group was unaltered by this.” Facebook was’t just tracking behavior, they were engineering it at scale. And nobody was warned.
1:10

NEW: Brainwashing expert on Joe Rogan exposes the sinister Facebook experiment that manipulated 700,000 users—without their knowledge. This is very dark. Harvard professor Rebecca Lemov, an expert on mind control and emotional manipulation, joined Joe Rogan and laid out the disturbing details of a little-known experiment Facebook conducted in 2012: “There’s a famous Facebook experiment I read about that took place in 2012 and was published in 2014, where they announce that they’ve achieved, mass emotional contagion at scale,” she said. Lemov explained that the social media giant ran the test on 700,000 users—without telling them. “Whenever you go on the platform, you agree to be tested or AB testing. So this experiment exposed a group to a more—their newsfeed was altered in a negative direction emotionally, as measured by word counting software.” The results? Chilling. “And they discovered that that group that had a negative exposure also responded in a more negative way, as judged through their posts and likes and responses.” “The group that was exposed to a more positive newsfeed by altering the algorithm then had also a measurably statistically significant effect of more positive emotional response—and the control group was unaltered by this.” Facebook was’t just tracking behavior, they were engineering it at scale. And nobody was warned.

The Vigilant Fox 🦊

863,556 次观看 • 1 年前

Dr. Jay Bhattacharya isn’t letting China get away with it. He spoke to Laura Ingraham and pushed back hard on their attempt to blame the U.S. “It’s shocking, Laura. I guess, what can you do?” he said. Then he laid out the facts. “What happened was that the Chinese lab in Wuhan conducted some mad science experiments.” “Unfortunately, partly funded by the American government. In fact, by the agency that I can now currently lead. That experiment went astray. It leaked and caused the havoc that we faced for years.” “For China to now turn around and say well, the U.S. is to blame—well, I mean, it’s ridiculous, it’s absolutely ridiculous.” He unleashed the truth: “The Chinese were responsible for allowing these experiments to happen in a low security lab. It leaked. They covered it up. And that’s just a fact.”
0:43

Dr. Jay Bhattacharya isn’t letting China get away with it. He spoke to Laura Ingraham and pushed back hard on their attempt to blame the U.S. “It’s shocking, Laura. I guess, what can you do?” he said. Then he laid out the facts. “What happened was that the Chinese lab in Wuhan conducted some mad science experiments.” “Unfortunately, partly funded by the American government. In fact, by the agency that I can now currently lead. That experiment went astray. It leaked and caused the havoc that we faced for years.” “For China to now turn around and say well, the U.S. is to blame—well, I mean, it’s ridiculous, it’s absolutely ridiculous.” He unleashed the truth: “The Chinese were responsible for allowing these experiments to happen in a low security lab. It leaked. They covered it up. And that’s just a fact.”

Vigilant Fox 🦊

167,542 次观看 • 1 年前

minghao 🥹 🐻‍❄️ and i think it’s amazing that when you were asked what your dream was as a kid you could answer right away that you wanted to be a star 🎱 back then, i really did want to be a star 🐻‍❄️ exactly 🎱 but i think the reason i wanted to be a star wasn’t even for myself, it was for my mom because everything i learned was all because i wanted to see her smile. i wanted to show it to my mom. so honestly, even after debuting as seventeen i cared a lot about what others thought because of the environment i grew up in, it’s less like that now. that’s why i want to do more of what i actually want now.
0:49

minghao 🥹 🐻‍❄️ and i think it’s amazing that when you were asked what your dream was as a kid you could answer right away that you wanted to be a star 🎱 back then, i really did want to be a star 🐻‍❄️ exactly 🎱 but i think the reason i wanted to be a star wasn’t even for myself, it was for my mom because everything i learned was all because i wanted to see her smile. i wanted to show it to my mom. so honestly, even after debuting as seventeen i cared a lot about what others thought because of the environment i grew up in, it’s less like that now. that’s why i want to do more of what i actually want now.

𝗝𝗢.

14,428 次观看 • 1 个月前

OTD 28 years ago "The Strike" aired, and the world learned about "Festivus." We spoke with Dan O'Keefe whose father created Festivus. Dan was Not a fan of the episode, did Not want the episode to air, and to him, Festivus brings back deep rooted trauma. Dan explains: The way people adopted it, I didn’t see that coming. You gotta understand, I’ve been saying this for a while, yeah, that was my father, he was mentally ill and a drunk, but extremely brilliant. For whatever reason he invented this weird fucking extra holiday that was celebrated at random times. It did not have a set date. It was extremely upsetting. It was like borderline child endangerment, and it was not fun. So my brothers and I had this deal: you do not talk about it outside of the house, and we just try to pretend it’s not happening. But I didn’t pitch it, I didn’t want it to go in. I hoped it would fail and be edited out, and nevertheless, the damn thing survived. The reality is far weirder. I have the CDs that were remastered from the cassette tapes my dad used to make during the annual recording of this insanity, which is mostly him screaming about internal Reader’s Digest politics in a deep slur while my brothers are crying and my mom is telling him to simmer down. That was not something I agitated for, quite the reverse. So how do I feel about it taking off? I try to block it out. This holiday was basically an encapsulation of alcoholism and mental illness into one neat little wrapper. I was as surprised as anyone. I was not a booster of this. I was surprised it got on the air. I am beyond surprised that it seems to be something that has, to some extent, legs. There are still a few people who celebrate it. Good for them. I do not personally. I did my time on that in the ’70s and ’80s. Jerry Stiller made it fun. The real thing was terrifying, obviously, and you understood why George was not in favor of it. But he made it fun, and it was Jeff Schaffer’s joke—the idea to give it a pole. That was not the case. The real symbology of it was more peculiar and not as wholesome as an aluminum pole with a good strength-to-weight ratio.
0:33

OTD 28 years ago "The Strike" aired, and the world learned about "Festivus." We spoke with Dan O'Keefe whose father created Festivus. Dan was Not a fan of the episode, did Not want the episode to air, and to him, Festivus brings back deep rooted trauma. Dan explains: The way people adopted it, I didn’t see that coming. You gotta understand, I’ve been saying this for a while, yeah, that was my father, he was mentally ill and a drunk, but extremely brilliant. For whatever reason he invented this weird fucking extra holiday that was celebrated at random times. It did not have a set date. It was extremely upsetting. It was like borderline child endangerment, and it was not fun. So my brothers and I had this deal: you do not talk about it outside of the house, and we just try to pretend it’s not happening. But I didn’t pitch it, I didn’t want it to go in. I hoped it would fail and be edited out, and nevertheless, the damn thing survived. The reality is far weirder. I have the CDs that were remastered from the cassette tapes my dad used to make during the annual recording of this insanity, which is mostly him screaming about internal Reader’s Digest politics in a deep slur while my brothers are crying and my mom is telling him to simmer down. That was not something I agitated for, quite the reverse. So how do I feel about it taking off? I try to block it out. This holiday was basically an encapsulation of alcoholism and mental illness into one neat little wrapper. I was as surprised as anyone. I was not a booster of this. I was surprised it got on the air. I am beyond surprised that it seems to be something that has, to some extent, legs. There are still a few people who celebrate it. Good for them. I do not personally. I did my time on that in the ’70s and ’80s. Jerry Stiller made it fun. The real thing was terrifying, obviously, and you understood why George was not in favor of it. But he made it fun, and it was Jeff Schaffer’s joke—the idea to give it a pole. That was not the case. The real symbology of it was more peculiar and not as wholesome as an aluminum pole with a good strength-to-weight ratio.

This Podcast is Making Me Thirsty Seinfeld Podcast

103,005 次观看 • 7 个月前

“Skip and I would go at it with each other, and the minute we went to commercial, it was: ‘That was a good job. What’s up next?’” Stephen A Smith breaks down what it’s like to work with Skip Bayless.
5:59

“Skip and I would go at it with each other, and the minute we went to commercial, it was: ‘That was a good job. What’s up next?’” Stephen A Smith breaks down what it’s like to work with Skip Bayless.

The Arena: Gridiron

55,311 次观看 • 5 个月前

The Multi-Billion Dollar Lie: How LDL Became "The Bad Cholesterol" In a fascinating exchange on The Joe Rogan Experience, human biologist Gary Brecka deconstructed one of modern medicine's most entrenched narratives: the demonization of LDL cholesterol. Brecka argues the "LDL is bad" story was built on a flawed foundation of isolated science. Researchers observed a correlation—people with heart disease often had high LDL. But, crucially, they didn't solve for the context. What were their insulin levels? Fasting glucose? Inflammatory markers like CRP? The high LDL was often a fellow traveler in a body under metabolic distress from poor diet and lifestyle, not necessarily the sole villain. The proof, Brecka posits, is in the outcomes. If high LDL were a direct cause of mortality, then forcibly lowering it with statins should significantly extend life. "Lo and behold," he states, "we see no extension of mortality." So why does the narrative persist? Brecka points to a trillion-dollar industry and the rigid "Standard of Care." Physicians are trained and financially incentivized to operate within this box. The standard of care for high LDL is a statin. To practice outside of it risks their license, malpractice coverage, and career. Who defines this standard? Brecka is unequivocal: "Pharma dictates that that's the standard of care. They also dictate the reimbursement rates." The system, he explains, creates a herd mentality. It's not that doctors are trying to cause harm; they are practicing within a system designed to maintain a specific protocol, one that is incredibly profitable and legally protected. The conversation is a powerful reminder that true health requires looking at the whole system, not just an isolated biomarker. What are your thoughts on the role of standard of care in modern medicine?
3:55

The Multi-Billion Dollar Lie: How LDL Became "The Bad Cholesterol" In a fascinating exchange on The Joe Rogan Experience, human biologist Gary Brecka deconstructed one of modern medicine's most entrenched narratives: the demonization of LDL cholesterol. Brecka argues the "LDL is bad" story was built on a flawed foundation of isolated science. Researchers observed a correlation—people with heart disease often had high LDL. But, crucially, they didn't solve for the context. What were their insulin levels? Fasting glucose? Inflammatory markers like CRP? The high LDL was often a fellow traveler in a body under metabolic distress from poor diet and lifestyle, not necessarily the sole villain. The proof, Brecka posits, is in the outcomes. If high LDL were a direct cause of mortality, then forcibly lowering it with statins should significantly extend life. "Lo and behold," he states, "we see no extension of mortality." So why does the narrative persist? Brecka points to a trillion-dollar industry and the rigid "Standard of Care." Physicians are trained and financially incentivized to operate within this box. The standard of care for high LDL is a statin. To practice outside of it risks their license, malpractice coverage, and career. Who defines this standard? Brecka is unequivocal: "Pharma dictates that that's the standard of care. They also dictate the reimbursement rates." The system, he explains, creates a herd mentality. It's not that doctors are trying to cause harm; they are practicing within a system designed to maintain a specific protocol, one that is incredibly profitable and legally protected. The conversation is a powerful reminder that true health requires looking at the whole system, not just an isolated biomarker. What are your thoughts on the role of standard of care in modern medicine?

Camus

79,123 次观看 • 8 个月前

July 15th, 2015 was the very first time I used qualitative data to assess my sleep, life, work, and health. It was also the first time I began to see a calendar as a place to store data about myself. Asking how I felt and giving it a number created a deeper awareness that revealed more quantifiable insights over time. When I built Existence, I decided I did not want to do it for just the whole day. I wanted to see the quality of every block of time.
4:04

July 15th, 2015 was the very first time I used qualitative data to assess my sleep, life, work, and health. It was also the first time I began to see a calendar as a place to store data about myself. Asking how I felt and giving it a number created a deeper awareness that revealed more quantifiable insights over time. When I built Existence, I decided I did not want to do it for just the whole day. I wanted to see the quality of every block of time.

Rob Dyrdek

45,157 次观看 • 8 个月前

You know I like to ask provocative questions 🧐… Could a NEW 💊 DRUG for Fatty Liver impact LDL cholesterol in lean metabolically healthy people on a #keto diet? If so… HOW and what could we learn!? 👉 New exciting data in NEJM on a phase III trial for a thyroid receptor beta liver-targeting drug shows impressive results for reversing fatty liver In association, there are decreases in LDL-C, along with ApoB, ApoCIII, and even Lp(a) But what happens were we to put this same drug in a VERY different metabolic context? 🔨Would said drug hammer LDL-C in #LMHR into the floor simply because their LDL levels have so far to drop? OR could the opposite happen? ⚡️Could ramping up liver metabolism increase, rather than decrease, LDL-C in LMHR. I don’t know! But point being: CONTEXT, CONTEXT, CONTEXT. Just like OREO Cookie lowered LDL-C in #LMHR, when you change the metabolic context, sometimes you get surprising results And, it’s fair game to speculate (EMPHASIS: I AM SPECULATING) and pose bold ideas, provided we are CLEAR we can’t truly know the answers until we test. For more, see video: I, for one, think the NEJM data are promising for the indicated use case, and humbly share where my scientific mind ‘wanders’ when presented with these data, framed by my own field and interests NEJM paper: P.S. I know people are going to go "off" suggesting I'm recommending X, Y or Z or saying something about "dangers" of high LDL in #LMHR. I'm not. I'm just open-mindedly and transparently providing a provocative thought puzzle... if your emotions are stimulated, I did my job I suppose... if you let them get the better of you... that's on you 😜 cc Dave Feldman Adrian Soto-Mota (my #LEM bros!) William Cromwell, MD LipoFan Simon Hill MSc, BSc Matthew A. Nehs Dominic D'Agostino STEM-Talk
7:31

You know I like to ask provocative questions 🧐… Could a NEW 💊 DRUG for Fatty Liver impact LDL cholesterol in lean metabolically healthy people on a #keto diet? If so… HOW and what could we learn!? 👉 New exciting data in NEJM on a phase III trial for a thyroid receptor beta liver-targeting drug shows impressive results for reversing fatty liver In association, there are decreases in LDL-C, along with ApoB, ApoCIII, and even Lp(a) But what happens were we to put this same drug in a VERY different metabolic context? 🔨Would said drug hammer LDL-C in #LMHR into the floor simply because their LDL levels have so far to drop? OR could the opposite happen? ⚡️Could ramping up liver metabolism increase, rather than decrease, LDL-C in LMHR. I don’t know! But point being: CONTEXT, CONTEXT, CONTEXT. Just like OREO Cookie lowered LDL-C in #LMHR, when you change the metabolic context, sometimes you get surprising results And, it’s fair game to speculate (EMPHASIS: I AM SPECULATING) and pose bold ideas, provided we are CLEAR we can’t truly know the answers until we test. For more, see video: I, for one, think the NEJM data are promising for the indicated use case, and humbly share where my scientific mind ‘wanders’ when presented with these data, framed by my own field and interests NEJM paper: P.S. I know people are going to go "off" suggesting I'm recommending X, Y or Z or saying something about "dangers" of high LDL in #LMHR. I'm not. I'm just open-mindedly and transparently providing a provocative thought puzzle... if your emotions are stimulated, I did my job I suppose... if you let them get the better of you... that's on you 😜 cc Dave Feldman Adrian Soto-Mota (my #LEM bros!) William Cromwell, MD LipoFan Simon Hill MSc, BSc Matthew A. Nehs Dominic D'Agostino STEM-Talk

Nick Norwitz MD PhD

29,261 次观看 • 2 年前

I went from 92 to 98 miles an hour by adjusting my drop. When I used to think about the drop phase in my delivery, I thought I needed to drop as hard as I could into my back leg. So that’s what I did. I dropped in, got into a squat position, and powered myself out of it. That got me to the low to mid nineties. What got me to 96, 97, and 98 was learning to create linear momentum during the drop. I started moving down the mound instead of just dropping straight down. One of the biggest things that helped was dropping into the inside of my back foot. Before, I would drop into the sole of my back foot. That put me in a very vertical shin angle and I’d go straight down. Then I had to push out of it. The simple adjustment I made was dropping into the inside of my back foot. That put me in a position where my shin wasn’t as vertical. It created a force vector that helped me get down the mound and build linear momentum instead of just going straight down. That linear momentum wasn’t powered by me. It was powered by gravity. I was able to use gravity to my advantage and throw harder with less effort.
1:10

I went from 92 to 98 miles an hour by adjusting my drop. When I used to think about the drop phase in my delivery, I thought I needed to drop as hard as I could into my back leg. So that’s what I did. I dropped in, got into a squat position, and powered myself out of it. That got me to the low to mid nineties. What got me to 96, 97, and 98 was learning to create linear momentum during the drop. I started moving down the mound instead of just dropping straight down. One of the biggest things that helped was dropping into the inside of my back foot. Before, I would drop into the sole of my back foot. That put me in a very vertical shin angle and I’d go straight down. Then I had to push out of it. The simple adjustment I made was dropping into the inside of my back foot. That put me in a position where my shin wasn’t as vertical. It created a force vector that helped me get down the mound and build linear momentum instead of just going straight down. That linear momentum wasn’t powered by me. It was powered by gravity. I was able to use gravity to my advantage and throw harder with less effort.

Josh Gessner

30,075 次观看 • 5 个月前

I heard a great sermon today and at the end of the message an old hymn was sung that I wasn’t familiar with…but I loved what it said! Apparently it was written by a poet/hymnwriter in the late 1700s named Joseph Swain. I picked up my guitar and started singing my own version…and thought I’d share it with you as a reminder for us to “Look to Jesus”! Blessings on your day, scc
1:00

I heard a great sermon today and at the end of the message an old hymn was sung that I wasn’t familiar with…but I loved what it said! Apparently it was written by a poet/hymnwriter in the late 1700s named Joseph Swain. I picked up my guitar and started singing my own version…and thought I’d share it with you as a reminder for us to “Look to Jesus”! Blessings on your day, scc

Steven Curtis Chapman

26,893 次观看 • 2 年前