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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio

11,666 görüntüleme • 1 yıl önce •via X (Twitter)

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What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan

Markus J. Buehler

47,242 görüntüleme • 2 yıl önce

The best exercise for the brain you’ve probably never seen. According to Michael J. Lavery’s book “Whole Brain Power”, using a 4-pound sledge hammer to bounce a golf ball up and down dramatically amplifies both your neurological and physical demands Massive Central Nervous System (CNS) Activation The sheer weight of a 4-lb sledge forces the CNS to fire at a much higher intensity. To keep a lively golf ball bouncing on a heavy, rigid piece of steel, your brain has to send incredibly powerful, rapid-fire signals to your muscles. This level of resistance forces maximum motor unit recruitment, teaching your nervous system to fire more efficiently under tension. Elite Grip and Forearm Strength Lavery heavily emphasizes the link between hand/grip strength and brain health, viewing the hands as the direct external extension of the central nervous system. Bouncing a ball requires a loose, reactive wrist to absorb and redirect impact, but holding a 4-lb hammer requires immense isometric grip strength. Managing that weight leverages extreme stress onto the forearms, wrists, and fingers, building dense, functional grip strength that standard lifting rarely touches. Accelerated Neuroplasticity via Forced Focus With a light hammer, you can cheat the movement or rely on casual reflexes. With a 4-lb sledge, there is zero room for error. The high penalty for a missed bounce (the heavy hammer dropping or completely throwing off your rhythm) forces the brain into a state of hyper-vigilance and deep cognitive focus. This intense concentration triggers a higher release of acetylcholine and dopamine, the exact neurotransmitters required to stimulate neuroplasticity and forge new neural pathways. Overcoming Hemispheric Dominance (Ambidexterity) When you transition the 4-lb sledge to your non-dominant hand, the challenge scales exponentially. Because the non-dominant hemisphere of your brain isn't used to managing that much weight combined with fine motor precision, the drill forces rapid communication across the corpus callosum (the bridge connecting the left and right sides of the brain). It quickly exposes and corrects deep-seated muscular and neurological imbalances between your two sides. Cortical Mapping and Joint Stability Holding a heavy weight at the end of a lever arm requires all the stabilizing micro-muscles in your wrist, elbow, and shoulder rotator cuff to fire simultaneously. This builds incredible joint integrity while expanding your brain’s "cortical map"—its internal blueprint of where your body is in space (proprioception). Benefits: - Maximum Central Nervous System Recruitment - Dense Grip and Forearm Strength - Forced Cognitive Focus & Neuroplasticity - Rapid Dual-Hemisphere Brain Activation - Enhanced Proprioception & Joint Integrity - Growth Hormone (GH) and Testosterone - “ Fountain of Youth" Endorphins - Dopamine and Acetylcholine - Insulin Sensitivity and Blood Sugar Regulation

Thor Torrens

417,853 görüntüleme • 3 ay önce

How many times have you been told to “take it down a notch,” “calm down,” or “just relax” — while your heart races, your mind never powers down, and you live with a short fuse that embarrasses you later? You’re stuck in persistent fight-or-flight: anxious over small things, irritable, and unable to settle. The world blames you — “it’s just who you are,” try medication, manage it better. You’ve pointed fingers at people, money, family, politics, EMF, 5G, or blue light. You’ve tried therapy, breathing, supplements… yet the underlying tension always returns. This isn’t a mindset problem or personality flaw. It’s mechanical. The real culprit? Accumulated trauma — acquired, consecutive, and layered — creating a literal “vice-grip” compression on your central nervous system through your spine. Picture your nervous system as a perfectly solved Rubik’s Cube. The first major trauma adds the initial “turn,” misaligning the upper cervical spine (C1-C2). This compresses the brainstem, disrupts neural flow, cerebrospinal fluid, and electrical balance. Your entire spine immediately compensates with global adaptations — posture shifts, muscle contractions, even compensatory scoliosis — to protect the brainstem. Every new trauma stacks another layer on an already scrambled cube. These layers don’t reset; they compound dysfunction from a vulnerable position, tightening the vice grip and locking in deeper survival patterns. You become literally and figuratively wound up in chronic sympathetic dominance. This concept traces to the early 1900s with Dr. Richard VanRumpt’s pioneering work on layered subluxations. Yet most modern chiropractic treats the spine as something that simply “fell apart,” forcing alignment and hoping it holds. Without addressing the layered trauma and protective adaptations, results are temporary. The body reflexively returns to its survival pattern. The Stacking Effect produces stubborn symptoms: constant fight-or-flight, inhibited vagus nerve (poor digestion, inflammation, emotional dysregulation), and electrical dysfunction no willpower or medication can permanently fix. These aren’t “in your head” — they’re locked behind mechanical compression. The solution is precise and elegant. The YES Test (Your Electrical Systems Test) uses reflex analysis to “run the codes” on your nervous system, revealing the exact top layer — the most recent turn on your Rubik’s Cube. A highly gentle, vector-specific Master Reset then unlocks that layer. Often so subtle you barely feel it, yet the body responds immediately. Once released, your spine unwinds naturally — like a tightly twisted rubber band releasing twist by twist through normal daily movement. Layers clear in reverse chronological order. Compensatory patterns dissolve. Normal CNS communication returns. Homeostasis is restored. The process is elegant, automatic, and can be permanent (as long as no major new trauma occurs). I know this is true because I lived wired, anxious, and unable to relax for years — until this addressed the root mechanical cause. Hundreds upon hundreds of others (approximately 4,000 people) have experienced similar profound shifts. Your nervous system is electrical by design. Compressed wiring creates symptoms and dis-ease. Remove the compression at the source, and function, health, and true calm return. You don’t have to stay wound up. The constant fight-or-flight isn’t who you truly are — it’s simply the current mechanical state you’re stuck in. You can be solved. Your body is waiting to unwind. Link in next post

Dr. C ⭐️⭐️⭐️

43,596 görüntüleme • 4 ay önce

Shocking Covid-19 Hospital Protocols: Unvaccinated Patients Targeted for Deadly Treatments A disturbing pattern has emerged from hospitals across the U.S.—unvaccinated Covid-19 patients were subjected to aggressive, profit-driven protocols that often led to fatal outcomes. Dr. Brian Hooker reveals what patients and grieving families witnessed firsthand: 🔹 Vaccination Status Determined Care – The first question asked in hospitals wasn’t about symptoms, but “Are you vaccinated?” Unvaccinated patients were funneled into a dangerous, pre-set protocol with higher mortality rates. 🔹 Remdesivir: A Deadly Cash Cow – This failed Ebola drug (with questionable efficacy) was pushed aggressively. Why? Gilead Sciences and the NIH held the patent, meaning huge profits for hospitals via reimbursement. Studies showed organ failure risks, yet it remained the go-to treatment. 🔹 The Lethal Progression 1️⃣ Remdesivir → Kidney/liver damage 2️⃣ Oxygen (CPAP/BiPAP) → Further complications 3️⃣ Mechanical Ventilation → Often a death sentence 4️⃣ ICU Sedation Cocktails (Propofol, Fentanyl, Morphine) → Patients chemically restrained, sometimes in four-point restraints if they resisted. Result? Countless preventable deaths—families devastated, while hospitals profited at every step. “This wasn’t medicine—it was a business model built on desperation,” says Dr. Hooker. “Patients were denied early treatments (like ivermectin) in favor of a protocol designed to maximize billing, not healing.” The evidence is clear: We must investigate these deadly hospital protocols and hold those responsible accountable.

Camus

104,381 görüntüleme • 1 yıl önce

Cable Zercher Slant Board Squat This is a very cool exercise I have started doing with the following beneficial mechanics: - Slant Board (Heels Elevated): The incline shifts your center of gravity forward, allowing for greater knee flexion, a deeper squat for those with limited mobility and a more upright torso. This puts an extreme emphasis on the quadriceps, particularly the vastus medialis (VMO) or teardrop muscle. - Zercher Position: Holding the load in the crooks of your elbows forces your upper back and core to work harder to prevent the weight from pulling your torso forward. This is a very natural force pattern that has great carryover to real life applications. - Safety/Stability: The cable acts as a guide, making it easier to maintain your balance on the slant board while focusing entirely on the muscle contraction, good for those who want to push the legs with a bit more “safety” than a free weight squat. Unlike a barbell where the tension changes through the range of motion (getting "easier" at the top), the cable provides constant mechanical tension throughout the entire squat. It is an exceptional movement for building teardrop quad definition and improving knee stability, as well as core bracing. I like to do it 6 or so sets, high volume repetitions - pyramiding up from low weight to high with minimal rest times - focusing on achieving the most brutal lactic acid build up that I can in the legs, done at the start of a workout. Even though the weight isn’t hugely high on the cable machine, it still packs a massive punch. Try it out! Wearing Sol Dept. 100% cotton sol shorts and drinking Aurum ancient mineral salts in my water

⚡️🌞 Sol Brah 🌞🐬

67,763 görüntüleme • 7 ay önce

It's quantum biorisonance fused with artificial intelligence-based diagnostics, scale frequency therapy, and zero-point field harmonies. Think of it as an MRI, an artificial intelligence-based surgeon, and a cellular regeneration system all rolled into one. HOW DOES THAT WORK? 1. FULL BODY QUANTUM SCAN Scan your biofield, the energetic model of your body Detects abnormalities at the subatomic level, long before symptoms appear Quantum sensors read your body like a hyper-dimensional fingerprint 2. TIME REVERSAL CELLPHONE •Tap into your original DNA pattern •Use field harmonies to "remind" your cells of their ideal state •It doesn't just heal, it restores 3. ZERO POINT ENERGY CAMP •It draws unlimited energy from quantum emptiness •Cells absorb this energy to accelerate repair and restore harmony •This is not "energy healing", this is quantum engineering of the fields 4. CORRECTION OF SCALAR FREQUENCY •Sends targeted scalar waves to reprogram damaged cells •Think of frequent acupuncture: no needles, just light and precision •Tumors, inflammation, scar tissue? •Neutralize yourself WHO CONTROLS THIS TECHNOLOGY? •Classified military medical programs •Independent scientific divisions •The same forces behind quantum finance, defense via artificial intelligence, and free energy. It's all connected. WHY NOW? Why the financial recovery, the boom of quantum computing, and the collapse of healthcare tech suppression are converging. They made fun of medbeds to make you laugh. But now they'll throw them like a miracle when the old world collapses. This is not science fiction. It's classified technology infiltrating public reality. The future is not about pills and surgery. It's about energy, frequency, and restoration of the original project. Follow 👉👉👉

Q(MEGA_TRUMP)

53,411 görüntüleme • 11 ay önce

(Phil Schneider + Ancient Knowledge + Modern Developments) If Phil Schneider was reporting what he believed to be true, and if ancient traditions were describing encounters as they understood them, how would the full picture look if it were internally consistent?🛸💫🐉👽🧠 Phil Schneider was not fundamentally saying “aliens secretly rule the world.” He was making a narrower and more destabilizing claim: Certain human institutions became aware of non-human intelligences or advanced technologies long ago, entered into secrecy-based arrangements, and reorganized power, infrastructure, and knowledge around classification rather than public legitimacy. The shift was not ideological, but structural: Power moved from shared authority → compartmentalized control. Connection to Ancient Traditions Across African, Egyptian, Sumerian, and Mesoamerican traditions, a consistent pattern appears: •Civilization is introduced, not invented •Knowledge comes from “others” (Nommo, Oannes, Chitauri, Serpent beings) •These beings are non-human, biologically distinct, often amphibious or subterranean •Authority is associated with anatomy: head shape, gaze, luminosity, longevity Hypothetically, ancient cultures preserved memories of encounters with advanced beings using the only frameworks available to them: myth, ritual, and anatomical symbolism. Why the Head shape, False Beard, and Anatomy Matters Cranial elongation, headdresses, and ritual beards become acts of imitation and lineage signaling. Credo Mutwa’s claim of a chin-growth or “beard” can be read as a remembered biological feature later reduced to symbolic regalia. Defacement of beards and facial features then reads not as vandalism, but as erasure of implication. Where Phil’s Underground Claims Fit Phil’s testimony introduces a modern continuation of the same pattern: •Non-human intelligences are not only “from the sky” •They are associated with subterranean environments •Some underground infrastructure is pre-existing •Advanced material science is involved •Presence is long-term, not episodic In this model, ancient “underworld” myths and serpent gods are not metaphors, but environmental descriptions filtered through mythic language. 5. Advanced Boring & Underground Bases Phil described tunneling that vitrifies rock, leaving glassy, sealed walls via non-mechanical excavation. Hypothetically, this could reflect: •Exposure to classified high-energy excavation research •Plasma or thermal boring concepts •Nuclear excavation studies (which historically existed) •Or partial repetition of briefings without full context The effects he described are real in physics. The interpretive leap is not the engineering — it is the attribution of non-human collaboration. Why This Resonates Today Governments now admit UAPs exist without explanation. Classified programs remain opaque. Whistleblowers are marginalized. Ancient cultures are being reassessed as more sophisticated than assumed. It feels like denial followed by partial admission — not confirmation, but resonance. Why Institutions Reject the Implications If humanity is not alone, civilization was externally influenced, and governments are not fully sovereign, then religious authority, political legitimacy, and public trust destabilize. Institutions respond with silence, reframing, delay, and minimization — not necessarily because of aliens, but because loss of control is unacceptable.

Jack

28,633 görüntüleme • 7 ay önce

Ask anyone who’s taken a course in Ordinary Differential Equations (ODEs) what a solution to an ODE represents geometrically, and most of them won’t have a clean answer. When I first took ordinary differential equations, the pattern was always the same. Early on it turns into a speedrun of methods: separation of variables, integrating factors, variation of parameters, Bernoulli, exact equations. Then pretty quickly the course slides into hammer-picking. Spot the form, apply the recipe, move on. Too mechanical! And the real problem is what you don’t walk away with. You leave with a toolkit, but without a feel for what a differential equation even is, especially geometrically. That matters because in real modeling the equations you meet are rarely nice enough to reward memorised recipes. So you get trained to solve toy forms, while the actual subject stays blurry. The behavior. The flow. The shape of solutions. It wasn't until I watched the first lecture of Professor Arthur Mattuck that I realized I didn’t actually know what a solution to a differential equation represents geometrically. His point is almost embarrassingly simple. A first-order ODE is a slope field, and a solution is a curve that stays tangent to that field everywhere. The math breakdown: Write the ODE as dy/dx = f(x,y). At each point (x,y), attach a tiny line segment with slope f(x,y). A function y = y₁(x) is a solution exactly when its graph follows those slopes. At every x, the slope of the curve equals the slope prescribed by the field at the point on the curve. That’s the one line that ties both viewpoints together: y₁′(x) = f(x, y₁(x)). So solving the ODE and drawing an integral curve are the same statement in two languages. Once you see that, you stop obsessing over whether you can write y(x) in closed form. You start asking the questions that actually matter. Where do solutions flow. Where do they get trapped. Where do they blow up. Where does existence or uniqueness fail because the field isn’t even defined? That’s the perspective shift I wish every ODE course forces early. It’s also why I keep pairing math with animation. #DifferentialEquations #ODEs #VectorFields #AppliedMathematics #Mathematics #

Mathelirium

40,841 görüntüleme • 6 ay önce

SOMETHING BIG IS COMING: AMERICA'S LARGEST MIDEAST BUILDUP SINCE 2003 ACCELERATES NOW U.S. forces are executing a major transatlantic push that is visible to the entire world right now. Nine KC-46A Pegasus tankers have crossed the Strait of Gibraltar eastward from Lajes Field in the Azores, refueling and escorting roughly twelve Marine Corps F/A-18C/D Hornets from VMFA-312 “Checkerboards.” This is no isolated flight—it is the latest wave in the largest sustained U.S. military buildup in the Middle East since the 2003 Iraq invasion. THE TRANSIT DETAILS ➡️ The tankers operated under standard ADOBE callsigns used for long-range CORONET fighter transit missions. ➡️ They departed after staging at the critical mid-Atlantic hub of Lajes Field in Portugal’s Azores. ➡️ The Hornets belong to the elite VMFA-312 squadron based at MCAS Beaufort, South Carolina. THE FORWARD FORCE ALREADY IN PLACE ➡️ Dozens of additional U.S. refueling aircraft, both KC-46A Pegasus and KC-135 Stratotankers, sit ready at Israel’s Ben Gurion Airport. ➡️ Fighters including F-22 Raptors, F-15Es, and F-16s have already relocated to bases in Israel and Jordan. ➡️ Multiple carrier strike groups, such as USS Abraham Lincoln and USS Gerald R. Ford, provide a powerful two-carrier presence in theater. THE STRATEGIC REACH EXPANDING ➡️ Thousands more Marines are en route via amphibious ships and Marine Expeditionary Units toward the Gulf of Oman and Red Sea. ➡️ This air bridge multiplies U.S. capability for extended patrols and force projection deep into CENTCOM’s area. ➡️ The movement targets enhanced operations around the Persian Gulf, Strait of Hormuz, and Red Sea. THE BIGGER CONTEXT ➡️ The pattern has run nonstop since late January 2026 amid heightened tensions and operations involving Iran. ➡️ Everything remains fully observable in real time through open-source flight tracking and plane spotters. ➡️ This is sustained reinforcement at the highest posture levels seen in years. #USAirpowerSurge #MarineCheckerboards #MideastBuildup #KC46Tankers #CORONETMission #CENTCOMReinforcement #PersianGulfPosture

Mark

42,170 görüntüleme • 4 ay önce

HERMES AGENT RUNS MONITORING, RESEARCH, LEAD DETECTION, AND COMPETITIVE ANALYSIS ON AUTOPILOT. AND KNOWS WHEN NOT TO SPEND YOUR TOKENS. the biggest unlock most people skip: Hermes cron jobs can decide ON THEIR OWN whether the LLM should wake up. WAKE AGENT — THE $0 GATE every cron job can run a Python script first. the script checks: did anything actually change? nothing changed: → script outputs {"wakeAgent": false} → LLM stays asleep → zero tokens spent something changed: → script outputs {"wakeAgent": true} → agent wakes up and handles it three gate patterns from official docs: → file-change: compare file mtime to last run. no change? sleep. → external-flag: another process drops a ready file. no flag? sleep. → HTTP-check: ping a URL, diff the response. same as last time? sleep. real example: monitor AWS costs every hour. script pulls current spend from AWS API. no spike? agent sleeps. zero cost. costs jump 40%? agent wakes, reports to Slack, takes action through Stripe MCP. you run 20 monitoring jobs a day. 18 of them find nothing. you pay for 2. NO AGENT — PURE SCRIPT, ZERO LLM some jobs don't need reasoning at all. TLS checks. uptime pings. disk alerts. heartbeats. hermes cron edit --no-agent --script check_health.py script runs. stdout goes straight to Telegram, Discord, or Slack. no LLM involved. flip any job between modes: hermes cron edit --agent # add LLM hermes cron edit --no-agent # remove LLM free monitoring that lives inside the same ecosystem as your agent. 4 MORE USE CASES THIS UNLOCKS: COMPETITIVE ANALYSIS weekly cron with script that diffs competitor pages. agent only analyzes actual changes. updates your tracking file and PRD skill automatically. PRD AS A SKILL save product requirements as a skill, not a document. skills load on demand into fresh context. documents drift. skills stay sharp. CONTENT REPURPOSING hand a video script to the agent. it drafts X and LinkedIn posts in your voice. writes to a review folder. you approve via Telegram. LEAD DETECTION webhook monitors inbox. agent spots potential leads. drafts responses using your business context. schedules meetings from your calendar. the pattern across all of these: scripts handle the mechanical work for free. the agent only spends tokens on reasoning that requires judgment. comment CRON and I'll send you 5 ready-to-paste cron configs with wakeAgent and no_agent patterns. full Hermes SOUL.MD guide 👇

YanXbt

96,056 görüntüleme • 2 ay önce

AgiBot has formally unveiled its G2 humanoid robot, a system designed to transition into various industries and liberate humans from repetitive labor. G2 features high-performance joints, precision torque sensors, and an advanced spatial perception system, supporting quick deployment and multi-modal voice interaction. ► Factory Floor Performance: The G2 is engineered to industrial standards. In a safety belt lock production line, robots collaborate with human workers, performing tasks like pressing lock cores. The G2 collects production data to continuously train and iterate models (local server deployment ensures data privacy), steadily improving its operational ability. ► Mobility & Safety: The G2 navigates narrow factory aisles using dual LiDAR and full-panorama vision for environment sensing and collision detection. Its chassis is designed to overcome common obstacles (speed bumps, elevator gaps). It supports 24/7 continuous operation via autonomous return-to-charge and battery swapping. ► Humanoid Design Advantage: The G2's design includes a three-degree-of-freedom flexible waist, allowing it to mimic natural human movements like bending and side-leaning. This dramatically expands its operational workspace and enables seamless integration into existing human-centric production lines without costly modifications. ► Advanced Dexterity & Learning (Lab): The new G02 arm is the world's first cross-moment arm, featuring high-precision joint torque sensors that allow it to precisely sense external forces and adjust stiffness, mimicking human hand compliance. Using Real-Machine Reinforcement Learning (RL), the G2 can learn complex, delicate tasks like memory stick insertion in about one hour with minimal human intervention. ► Logistics & Grasping: In logistics sorting, the G2 uses a 19-degree-of-freedom mechanical dexterous hand (20N maximum fingertip force; 35kg capacity for hard objects) equipped with 3D tactile sensors to ensure it grasps securely without damaging items. Its full-body articulation (waist and legs) aids grasping and posture adjustment. ► Model & Data: G2's intelligence is powered by the Go-One Large Embodied Model (VLA architecture: Vision-Language-Latent Action) and the GE-One World Model (vision-centric predictive modeling), trained using the AgiBot Word true-machine dataset (over 500k downloads). ► Service & Interaction: The G2 is deployed as a guide/receptionist in settings like art museums. It uses its high-DOF head, arms, and waist to point to exhibits, maintains eye contact while navigating difficult spaces (chassis walks forward, body faces backward), handles specialized and random queries, and uses proactive safety features (stops movement, issues warnings) when people get too close.

RoboHub🤖

46,733 görüntüleme • 10 ay önce

🚨 BREAKING: BILLIONS of allegedly Fake $GME Shares Just Hit a MASSIVE Settlement Wall! 🚨 They created the synthetics. Now, the structure is forcing them to answer for it. 🧵👇 🕵️‍♂️ THE PLAYERS: Ryan Cohen & the HoldCo. Diamond-handed, long-term holders. 💎👐 VS. Every Market Maker, Swap Desk, and Naked Short still sitting on a mountain of phantom paper. 🧻📉 🔥 THE PATTERN: The Game Has Changed Assume the premise: Billions of fake and naked GameStop shares were printed via market maker exemptions, FTDs, and shadow swaps. But under a true HoldCo? Checkmate. ♟️ Only DELIVERABLE shares can be tendered into the new parent company. ✅ Legitimate shares move upstairs into Teddy. 🧸 ❌ Synthetic positions cannot be delivered. The broker that printed them? They still owe. 💸 The Warrants = The Ultimate Filter. 🎟️ 59 MILLION $GMEWS become allocation tickets for actual holders. Synthetic equity does not automatically carry matching warrants. Real holders convert. The fakes do not follow on the same terms. They get left in the dust. 💨 📊 THE EVIDENCE IS IN PLAIN SIGHT Swaps referencing GameStop are staring down a massive Corporate Action Event. The underlying asset is changing as GameStop becomes an operating subsidiary. Counterparties MUST: 1️⃣ Settle 2️⃣ Terminate 3️⃣ Completely re-paper those contracts 📝 A clean HoldCo isolates the $20 BILLION credit line and brings outside capital to the parent level. Legacy synthetic counts that existed against the old float suddenly sit MISMATCHED against the new capital structure. How does a mismatch resolve? Delivery, cash settlement, or FORCED CLOSE-OUT. 💥 Look at the OCC: They’ve already shifted warrant settlement to broker-to-broker with written officer attestations and strict buy-in language. The infrastructure for non-standard resolution is ALREADY PLUGGED IN. 🔌⚡ 🛡️ THE WALL STREET COVERUP They’ll call it a "normal merger." 🤡 They’ll ignore the delivery crisis. 🙈 They’ll pretend synthetic shares can just roll forward forever. THE STRUCTURE DOES NOT ALLOW IT. Real shares move. Phantom paper collides head-on with a historic settlement event. 🧱🏎️💨 📅 THE CLIMAX The pressure cooker explodes the exact second the tender and warrant exchange opens. 🌋 👇 DO YOUR PART: 🔁 RETWEET this so every single holder sees the mechanical risk to the fakes! 💬 REPLY with how many real shares you actually hold! 🏷️ TAG the accounts still pretending synthetics are risk-free! (Credit the original HoldCo mapping masterclass to Goatbeardz 🐐) #GME #Teddy #NakedShorts #MOASS #GameStop #BBBYQ #MMTLP ⚠️ Entertainment purposes only • DYOR ⚠️

Eronima

15,157 görüntüleme • 27 gün önce

When I first took ordinary differential equations, the pattern was always the same. Week 1 turns into a speedrun of methods: separation of variables, integrating factors, variation of parameters, Bernoulli, exact equations… and by Week 2 or 3 the course has quietly degenerated into hammer-picking. Spot the form, apply the recipe, move on. Mechanical! Fuuuuck!😫😫😫😫 The problem is what you don’t walk away with. You leave with a toolkit, but without a feel for what a differential equation even is, especially geometrically. And that’s a big deal, because in real modeling the equations you meet are rarely nice enough to reward memorized recipes. So you end up trained to solve toy forms, while the actual subject...the behavior, the flow, the shape of solutions stays blurry. This is why I’m biased toward the old-timers. Their old-school way of doing things always surprises me:...they’ll spend time on one idea until it sticks, instead of sprinting through a syllabus checklist. One lecture from them and you start noticing a contrast. A lot of modern teaching feels like "finish the content,". You get marched through techniques, but you’re not left with a single thought that keeps bothering you later...the kind of thought that actually pushes you toward research-level curiosity. MIT OpenCourseWare’s Professor Arthur Mattuck did that to me in his very first ODE lecture. One lecture, and your whole relationship with dy/dx = f(x,y) changes. In this segment, Prof. Mattuck is basically saying: A first-order ODE is a slope field, and a solution is a curve that moves everywhere tangent to that field. The math breakdown Write the ODE as dy/dx = f(x,y). At each point (x,y) you attach a tiny line segment with slope f(x,y). A function y = y₁(x) is a solution exactly when its graph follows those slopes:. At every x, the slope of the curve equals the slope prescribed by the field at the point on the curve. That’s the single line that unifies both viewpoints: y₁′(x) = f(x, y₁(x)). So solving the ODE and drawing an integral curve are the same statement in two languages!👌🏻 Once you see that, you can stop obsessing over whether you can write y(x) in closed form. You can start asking the questions that matter: where do solutions flow, where do they get trapped, where do they blow up, and where does existence/uniqueness fail just because the field isn’t even defined? That’s the perspective shift I wish every ODE course forces early and it’s exactly why I keep pairing math with animation. #DifferentialEquations #ODEs #VectorFields #MathAnimation #Mathematics

Mathelirium

53,338 görüntüleme • 7 ay önce

🚨🇮🇷Real Reason Pentagon Is Losing Sleep: Iranian Top Drones Tehran has developed a diverse fleet of strike drones designed for different combat roles. In addition to the famous Shaheds, here are the top-notch Iranian drones that keep Pentagon planners awake at night: 1️⃣ Mohajer-6 — The tactical backbone of Iran's proxy forces. This drone is a battlefield multiplier, equipped with electro-optical sensors and capable of firing the Almas anti-tank missile with pinpoint accuracy. It has been exported and used in conflicts from the Caucasus to the Red Sea, systematically destroying armored vehicles and fortifications; 2️⃣ Mohajer-10 — The next evolution in strike capability. It boasts triple the range (2,000 km) and double the flight endurance (24 hours) of its predecessor. Most critically, it can carry a 300 kg payload, including up to six smart bombs or cruise missiles, allowing it to saturate small sections of an air defense network; 3️⃣ Kaman-22 — Iran's "wide-body" combat drone. With a 3,000 km range, it can reach the furthest US outposts. It carries a 300 kg payload of air-to-ground missiles and glide bombs, designed to hit command centers and radar sites deep behind enemy lines, far from the front; 4️⃣ Karrar — The jet-powered speed demon. Unlike propeller drones, the Karrar races to its target at high subsonic speeds. It can be configured as a swarm leader or as a "mini-cruise missile" itself, carrying a 225 kg warhead to strike time-sensitive targets before defenses can react; 5️⃣ Fotros — The heavy hitter. With a 2,000 km range and a 30-hour flight time, it carries up to six missiles. Its large airframe allows for powerful, advanced communication relays, meaning it can guide other drones or missiles to their targets while staying outside the immediate kill zone; 6️⃣ Arash-2 — A loitering munition specifically designed to hunt radars. Once a US Patriot or THAAD battery turns on its radar, the Arash-2, with a range exceeding 1,000 km, can home in on that emission and destroy the system, effectively blinding the base's air defense; 7️⃣ Hadid-110 (Dalaho) — A jet-powered stealth loitering munition fresh from real combat. It hits 510 km/h with a radar cross-section below 0.02 square meters, evading F-15E and E-3C detection. With a 350 km range and a 30 kg warhead, it precisely targets Persian Gulf infrastructure, slipping past Western defenses silently; 8️⃣ Meraj-521 — A man-portable loitering munition that fits in a backpack. With a 5 km range and interchangeable 500g-1kg warheads, it silently strikes bunkers and armor via live video feed. Launched in swarms from ground or air, it dismantles fortified positions without exposing a single soldier to return fire.

𝐃𝐚𝐯𝐢𝐝 𝐙 🇷🇺🇮🇪

63,109 görüntüleme • 5 ay önce

Excited to share our new work. Over the past decade, single-cell genomics has transformed our ability to map cellular systems. But a major question remains: Can we predict how perturbations reshape cellular trajectories over time? In 2018, we first showed that it is possible to predict cellular responses to perturbations — ranging from disease signals to chemical treatments — even in unseen contexts. In 2022, we introduced CPA (MSB 2022; NeurIPS 2022), extending this idea to predict responses to unseen chemical and genetic perturbations, including their combinations. Since then, the field of perturbation modeling has grown enormously. The community has pushed the space forward with many creative ideas and powerful models. It’s exciting to see how fast things are moving — even though many fundamental challenges remain. One of the biggest is that cells are not static. They move through trajectories during development, immune responses, and disease. Yet most current models still predict perturbation effects within a single state, rather than how early perturbations propagate across future states and reshape downstream outcomes. To address this, we developed PerturbGen, a trajectory-aware generative AI model that predicts how genetic perturbations reshape downstream cellular states. Huge credit to the people who made this work possible. Thanks to co-first authors Kevin Ly, Adib Miraki, Tomoya Isobe, AmirHoss3in Vahidi, Delshad Vaghari & Anthony Rostron. Special recognition to Kevin Ly and Adib Miraki for driving this work over the finish line. Grateful for our outstanding collaborators from Haniffa Lab, Bertie Gottgens lab Gosia Trynka and many others — a true cross-institute effort across Cambridge Stem Cell Institute, Open Targets ,Wellcome Sanger Institute and Cambridge University.🎉 PerturbGen learns transcriptional dynamics across cellular trajectories. By introducing perturbations at an early source state, it can simulate how these effects propagate into future states along differentiation trajectories. Scaling this across genes enables the creation of dynamic in silico perturbation atlases — maps of how perturbations reshape biological trajectories over time. We explored this idea across three biological questions. First, in a human in vivo LPS immune challenge, PerturbGen predicted that perturbing a transient IL1B signal dampens downstream inflammatory programs in myeloid cells, with pathway changes reversing signatures observed in an independent IL-1β stimulation experiment. Second, in human hematopoiesis, PerturbGen predicted transcriptional responses to CRISPR transcription factor knockouts and enabled construction of perturbation atlases revealing lineage- and age-specific regulatory programs. These programs could also be linked to human genetics and blood diseases, including recapitulation of signatures associated with ETV6-related thrombocytopenia. Finally, we asked whether perturbation modeling could help improve complex tissue models. We built a dynamic perturbation atlas of human skin organoids to identify perturbations that could guideorganoid cells towardhuman fetal skin states. PerturbGen prioritized activation of Wnt signaling via GSK3β inhibition. Experimental validation confirmed the prediction: treatment with CHIR99021 induced stromal gene programs and shifted organoid fibroblasts toward transcriptional states observed in fetal skin stroma. Together, these results show how trajectory-aware perturbation modeling can connect gene perturbations to developmental programs, human genetics, disease mechanisms, and experimental interventions. More broadly, we think these point toward a future where single-cell atlases become predictive systems. As atlases expand across tissues, developmental windows, and modalities, models like PerturbGen could enable dynamic, virtual perturbation atlases— allowing us to simulate interventions, generate hypotheses, and design experiments before stepping into the lab. Preprint Code Excited to see how the community builds on this work.

Mo Lotfollahi

17,137 görüntüleme • 5 ay önce

🚨It’s 3:00 a.m. in Iran, and here are my 9 key, detailed observations on the current state of protests—based on regime media, on-the-ground testimonies, and additional sources [January 16]: 🧵👇 1⃣Regime Threat Signaling & Escalation of Rhetoric: Iran’s Chief of Staff of the Armed Forces claimed that security forces exercised “restraint” by not using live ammunition, asserting that had they chosen to do so, protests could have been crushed “within two hours.” In parallel, Tehran’s Friday prayer leader Ahmad Khatami openly called for the execution of detained protesters and the arrest of anyone who supported the protests in any form—underscoring a sharp escalation in official rhetoric toward mass punishment. 2⃣ Arrest Campaign, Forced Confessions & Narrative Control: Regime media reported widespread arrests of alleged “media and field leaders” in cities including Shahriar/Qods, Rafsanjan, North Khorasan, Kerman, Kermanshah, Tehran, and Bandar Abbas—an apparent effort to reduce a nationwide uprising to a handful of directed networks. Authorities also claimed to have arrested a “terrorist team” at the border and released a new wave of forced confessions using language such as “turning protests into war,” widely believed to be extracted under coercion or torture. The regime further alleged the arrest of “3,000 terrorist affiliates” and announced the detention of an individual in Rasht accused of cooperating with Mossad. With street protests temporarily suppressed, the regime’s focus has shifted to mass arrests and televised confessions. 3⃣ De Facto Martial Law: A de facto state of martial law continues across many cities. Drone surveillance remains constant, jamming is widespread, and Tehran effectively turns into a ghost city by late afternoon. Reflecting deep regime anxiety over public gatherings, the football federation authorized a major match to proceed in Tehran, only without spectators. 4⃣Collapse of the ‘Reformist vs. Hardliner’ Divide: Coverage by so-called reformist and hardline media has become indistinguishable. Political figures once portrayed as “moderates” have dropped any pretense: former president Mohammad Khatami described the protests as a “large, organized conspiracy” against Iran’s national unity, while the current "reformist" president claimed that people took to the streets to defend the system and defeat the protesters. Years of certain DC analysts attempting to market regime reformists as a viable "alternative" now appear increasingly detached from reality. 5⃣ Ground Reports via Starlink & Human Rights Crisis: Internet freedom activists who speak with their sources on the ground through Starlink describe a catastrophic situation inside Iran: several women imprisoned in Fashafuyeh have reportedly been convicted on charges of moharebeh (“waging war against God”), which can carry the death penalty. Reports also include wounded protesters being handed over to security forces and the militarization of medical facilities. Gunfire was reported in Babol; drone flights are constant; jamming is pervasive; and burial sites such as Kahrizak and Behesht-e Zahra are under heavy security with tightly controlled ceremonies. Many Iranians express growing frustration over mixed and contradictory signals from the United States regarding humanitarian intervention. 6⃣ Voices from Inside & Collective Mourning: One witness inside Iran said: “The Prince underestimated how powerful his words would be on the ground. This was the first time entire families came out—grandparents to grandchildren. If people hadn’t been massacred, the regime would have ended that Friday.” In a haunting message, the mother of Dorsa Sattari wrote: “I am Dorsa Sattari’s mother. I am the mother of Iran. They shot my daughter. I buried her in our own yard—tell the world she is safe. I will lay beside her soon.” At the same time, messages from Iranians abroad who have just learned of the deaths of their young siblings are flooding Persian Twitter, turning it into a space of collective grief and suppressed rage. 7⃣ Opposition & Political Alternative: Today, Crown Prince Reza Pahlavi held a press conference attended by roughly 100 journalists and activists, outlining a vision for Iran’s future. As usual, VOA Persian was absent. He urged the international community to intensify economic, political, and even military pressure on Tehran to assist protesters in overthrowing the Islamic Republic, and emphasized the existence of a transition plan and a prepared team for a post-regime period. A journalist from Iran International remarked: “You can’t imagine how rare it is, as an Iranian journalist, to feel pride at a press event.” 8⃣ International Dimension & U.S. Posture: Internationally, Donald Trump stated that no Arab country had persuaded him against striking Iran, adding, “I convinced myself.” Coupled with the continued U.S. military posture in the region, Trump’s past emphasis on enforcing red lines, and his pattern of strategic media signaling ahead of strikes on Iranian nuclear sites, speculation about a potential attack remains high. Analysts note that while uncertainty persists, the likelihood of military action remains significant. 9⃣ Outlook: The regime is currently prioritizing repression, mass arrests, and punishment. Meanwhile, CP Reza Pahlavi has called for rooftop chants rather than street protests, scheduled for Saturday through Monday (Jan. 17–19) at 8:00 p.m. While a rapid return to large-scale street demonstrations appears unlikely in the near term, Iranian society remains in a holding pattern—awaiting an international military or strategic shift that could fundamentally alter the balance against the regime.

Navid Mohebbi نوید محبی

37,603 görüntüleme • 7 ay önce