eLife - the journal

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The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity

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eLife - the journal

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This 'important' Tools and Resources paper establishes a robust live-imaging toolkit to characterize excitatory and inhibitory synaptic dynamics during neuronal development. The methodology and quantitative data are 'convincing' and well validated.

Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes.

A new transparent killifish line called klara, generated using #CRISPR/Cas9, can significantly simplify explorations of development, senescence, ageing and regeneration.

Evidence of artefactual calcium microwaves during calcium imaging of neurons in the hippocampus.

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.

Enhanced single RNA imaging reveals dynamic gene expression in live animals.

Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X.

Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell-derived cardiomyocytes.

The path we take while walking on rugged terrain can be mathematically predicted. 🔗

Researchers have developed Opto-RhoGEFs, an optimised optogenetic toolbox to reversibly control Rho GTPase activity, advancing the ability to manipulate the barrier between endothelial cells.

An imaging system with an ultra-wide field of view allows scientists to track millions of cells at once in large 3D tissues and embryos.

Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

Controlling the forces needed to move around is pretty complicated for soft-bodied organisms. Researchers have implemented a new technique for measuring these crawling forces with nanonewton precision in fruit fly larvae.

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

Generating active T1 transitions through mechanochemical feedback.

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For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron.

The centrosome decides which branch extending from the body of microglia will successfully engulf and clear away dead neurons.

Enhanced single RNA imaging reveals dynamic gene expression in live animals.

When a fish beats its tail, it produces vortices in the water that other fish could take advantage of to save energy while swimming. ​​

Can you infer cause and effect between genes without disturbing the cell? 🧬 This study shows how natural “noise” in gene expression can reveal directed gene–gene interactions.

Researchers have uncovered surprising findings on the assembly of microtubules in vitro.

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

A novel method for imaging glutamate receptors in situ via #CryoET.

Using solely extracellular action potential recordings, researchers provide a noninvasive method for functional imaging of cortical and spinal axons.

This study presents new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment.

Structural insights into actin isoforms #CryoEM

“This fundamental work provides a creative and thoughtful analysis of rodent foraging behavior” Mice can take shortcuts to find food, demonstrating their ability to make a mental map of their surroundings.

The components of a synapse revealed by expansion microscopy of a single synaptic contact.

Retinal motion statistics during natural locomotion.

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio

What makes one member of the species behave differently from another? It's a core problem in behavioural #neuroscience. This valuable study seeks an answer for the specific case of the fruit fly expressing preferences for one odour over another.

When a fish beats its tail, it produces vortices in the water that other fish could take advantage of to save energy while swimming.