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MOTSc (peptide) explained 16 amino acid peptide derived from mitochondrial DNA. Its sequence is: MRWQEMGYIFYPRKLR

Michael Morelli

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111,726 görüntüleme • 3 ay önce •via X (Twitter)

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New Huang lab publication at Nature. Our newly developed technique: transient Pore Analyte Looping (tPAL) now achieves “chop and measure” nanopore sequencing of peptide, in an amino acid by amino acid manner.

New Huang lab publication at Nature. Our newly developed technique: transient Pore Analyte Looping (tPAL) now achieves “chop and measure” nanopore sequencing of peptide, in an amino acid by amino acid manner.

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Bryan Johnson reveals sex peptide and ozempic are good and improve sexual tension ‘PT141 is a sex peptide that works on the brain of men and women to increase dopamine response peptide are very interesting’ ‘One of the peptide I take is cerebrolysin it’s from pig brain and people take it for Alzheimer’s’ ‘The problem with peptide if your going to do something measure it you always want to measure’

Bryan Johnson reveals sex peptide and ozempic are good and improve sexual tension ‘PT141 is a sex peptide that works on the brain of men and women to increase dopamine response peptide are very interesting’ ‘One of the peptide I take is cerebrolysin it’s from pig brain and people take it for Alzheimer’s’ ‘The problem with peptide if your going to do something measure it you always want to measure’

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Mizkif explained how his friend built a peptide empire off one legal LOOPHOLE and made $400,000,000 in revenue from it 😳💉 "The powder is legal, but powder plus water equals the peptide, and that's illegal." "They buy these powders for $3 or $4 and sell them for $50."

Mizkif explained how his friend built a peptide empire off one legal LOOPHOLE and made $400,000,000 in revenue from it 😳💉 "The powder is legal, but powder plus water equals the peptide, and that's illegal." "They buy these powders for $3 or $4 and sell them for $50."

midaqih

456,125 görüntüleme • 14 gün önce

$HIMS THE PEPTIDE SUPPLY CHAIN --- JUST 5 COMPANIES IN CHINA CONTROL ~90% OF THE AMINO ACIDS 🤯 Mansi: "Before any peptide is produced, you need its API, which stands for 'active pharmaceutical ingredient', and right now China supplies most of the world's API" "The top 5 companies in China control around 90% of the protected amino acids, which is essentially the raw building block of a peptide." "You can't attach raw amino acids to each other. That's a very volatile and chaotic process... The error rate tends to compound every time you attach one amino acid to the other. So for example, BPC-157 sits at around 15 amino acids, and it tends to come out correct around 75% of the time. And Semaglutide (Ozempic) sits at 31 amino acids, and that comes out correct around 50% of the time." "This is why China wins: because they have this at massive scale to compensate for these efficiency issues." "CordenPharma in Colorado is the largest in the US. They have around 10,000 liter of SPPS reactor capacity." "But in China there's a company called WuXi AppTec, which has 100,000 liters of capacity... more than 10x larger than *the largest* synthesis plant here in the United States."

$HIMS THE PEPTIDE SUPPLY CHAIN --- JUST 5 COMPANIES IN CHINA CONTROL ~90% OF THE AMINO ACIDS 🤯 Mansi: "Before any peptide is produced, you need its API, which stands for 'active pharmaceutical ingredient', and right now China supplies most of the world's API" "The top 5 companies in China control around 90% of the protected amino acids, which is essentially the raw building block of a peptide." "You can't attach raw amino acids to each other. That's a very volatile and chaotic process... The error rate tends to compound every time you attach one amino acid to the other. So for example, BPC-157 sits at around 15 amino acids, and it tends to come out correct around 75% of the time. And Semaglutide (Ozempic) sits at 31 amino acids, and that comes out correct around 50% of the time." "This is why China wins: because they have this at massive scale to compensate for these efficiency issues." "CordenPharma in Colorado is the largest in the US. They have around 10,000 liter of SPPS reactor capacity." "But in China there's a company called WuXi AppTec, which has 100,000 liters of capacity... more than 10x larger than the largest synthesis plant here in the United States."

Hims House

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This lady claimed men aren't "givers of life," citing mitochondrial DNA. She argued that since this "powerhouse" DNA comes only from the mother's egg, life is fundamentally female-driven.

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Clavicular was pitched a new app by its founders on stream but wasn’t impressed with the business model. One of the founders later went on X, claiming the clip would “go viral” once the company is worth $1B and Clavicular is “DEAD from a peptide OD.“😳

Clavicular was pitched a new app by its founders on stream but wasn’t impressed with the business model. One of the founders later went on X, claiming the clip would “go viral” once the company is worth $1B and Clavicular is “DEAD from a peptide OD.“😳

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Everything worth knowing about the most underrated mitochondrial peptide in the space. My SS-31 masterclass. 00:00 Intro 02:45 The FDA approval story and what it means for peptides 03:18 Why SS-31 is different from every other peptide 06:02 Nearly every chronic disease of aging involves this 10:46 How SS-31 actually works 11:12 Why no receptor means no desensitization 13:36 Who SS-31 is for 15:34 The three tier dosing ladder 24:24 Why SS-31 must come before MOTS-c 29:18 How to stack it correctly 32:26 Troubleshooting when you feel nothing 36:54 Long COVID, TRT, athletic performance use cases

Everything worth knowing about the most underrated mitochondrial peptide in the space. My SS-31 masterclass. 00:00 Intro 02:45 The FDA approval story and what it means for peptides 03:18 Why SS-31 is different from every other peptide 06:02 Nearly every chronic disease of aging involves this 10:46 How SS-31 actually works 11:12 Why no receptor means no desensitization 13:36 Who SS-31 is for 15:34 The three tier dosing ladder 24:24 Why SS-31 must come before MOTS-c 29:18 How to stack it correctly 32:26 Troubleshooting when you feel nothing 36:54 Long COVID, TRT, athletic performance use cases

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$HIMS $LLY $NVO 🚨 BREAKING: Noom is acquiring a 503A pharmacy to prepare for the peptide boom We sat down with Geoff Cook (Noom CEO) to discuss why vertical integration is so important, how large the peptide market is going to be, and the evolving dynamics between telehealth platforms and big pharma A great episode with one of the best CEOs in the game - thanks again, Geoff! 00:00 - Why pharma needs DTC platforms 03:03 - Noom's 90% revenue growth 05:01 - Why Noom bought Tailor Made Compounding 07:29 - The case for vertical integration 08:56 - Compounded GLP-1s aren't going anywhere 16:48 - The Hims-Novo deal 19:08 - Noom's pitch to next-gen pharma 24:24 - Peptide market sizing 25:33 - Why GLP-1 users will buy peptides first 27:22 - Ten million potential peptide patients 👀 30:09 - When will legalization happen? 31:09 - Tracking the FDA green list 34:26 - Who wins when peptides go legal? 37:58 - Why Noom won't rush peptide launch 39:33 - Geoff's BPC-157 ski injury recovery 46:42 - Expanding at-home labs past 30 biomarkers 52:47 - Noom IPO coming?! Not financial, legal, or medical advice

$HIMS $LLY $NVO 🚨 BREAKING: Noom is acquiring a 503A pharmacy to prepare for the peptide boom We sat down with Geoff Cook (Noom CEO) to discuss why vertical integration is so important, how large the peptide market is going to be, and the evolving dynamics between telehealth platforms and big pharma A great episode with one of the best CEOs in the game - thanks again, Geoff! 00:00 - Why pharma needs DTC platforms 03:03 - Noom's 90% revenue growth 05:01 - Why Noom bought Tailor Made Compounding 07:29 - The case for vertical integration 08:56 - Compounded GLP-1s aren't going anywhere 16:48 - The Hims-Novo deal 19:08 - Noom's pitch to next-gen pharma 24:24 - Peptide market sizing 25:33 - Why GLP-1 users will buy peptides first 27:22 - Ten million potential peptide patients 👀 30:09 - When will legalization happen? 31:09 - Tracking the FDA green list 34:26 - Who wins when peptides go legal? 37:58 - Why Noom won't rush peptide launch 39:33 - Geoff's BPC-157 ski injury recovery 46:42 - Expanding at-home labs past 30 biomarkers 52:47 - Noom IPO coming?! Not financial, legal, or medical advice

Hims House

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Where BPC-157 peptide comes from and how it affects the body: - Croatian research group in the '90s isolated BPC-157 from a much larger 40,000-unit peptide naturally found in the gut - it is 15 amino acids long and is not something the body produces on its own. - Researchers theorized the stomach contained a cytoprotective compound after Pavlov's gastric juice experiments showed healing effects on GI tissue. - BPC-157 accelerates repair by upregulating VEGF signaling (new blood vessel formation), boosting nitric oxide synthesis, and increasing growth hormone receptors on tendons. - Corticosteroids normally halt wound healing - BPC-157 administered alongside them maintained or even improved healing outcomes in animal models. - In mouse models, BPC-157 reduced intoxication, blunted alcohol withdrawal symptoms, and appears to modulate dopaminergic signaling - effects that get far less attention than its musculoskeletal uses. Abud Bakri MD on Andrew D. Huberman, Ph.D.

Where BPC-157 peptide comes from and how it affects the body: - Croatian research group in the '90s isolated BPC-157 from a much larger 40,000-unit peptide naturally found in the gut - it is 15 amino acids long and is not something the body produces on its own. - Researchers theorized the stomach contained a cytoprotective compound after Pavlov's gastric juice experiments showed healing effects on GI tissue. - BPC-157 accelerates repair by upregulating VEGF signaling (new blood vessel formation), boosting nitric oxide synthesis, and increasing growth hormone receptors on tendons. - Corticosteroids normally halt wound healing - BPC-157 administered alongside them maintained or even improved healing outcomes in animal models. - In mouse models, BPC-157 reduced intoxication, blunted alcohol withdrawal symptoms, and appears to modulate dopaminergic signaling - effects that get far less attention than its musculoskeletal uses. Abud Bakri MD on Andrew D. Huberman, Ph.D.

Huberman Lab Clips

97,189 görüntüleme • 2 ay önce

Unpopular Opinion: the most promising peptide is not a GLP-1, it’s Tesamorelin. While its little brother, Sermorelin, increases growth hormone, Tesamorelin increases IGF-1 as well, which reduces visceral fat around your organs. It also enhances: - recovery - sleep - skin/hair

Unpopular Opinion: the most promising peptide is not a GLP-1, it’s Tesamorelin. While its little brother, Sermorelin, increases growth hormone, Tesamorelin increases IGF-1 as well, which reduces visceral fat around your organs. It also enhances: - recovery - sleep - skin/hair

Dr. Cameron Maximus🤴🏻 🥷🏻 🧙🏻‍♂️ 🤵‍♂️

34,778 görüntüleme • 3 ay önce

Top 5 advances in medicine this week (🧵) 𝟏. 𝟖 𝐡𝐞𝐚𝐥𝐭𝐡𝐲 𝐛𝐢𝐫𝐭𝐡𝐬 𝐟𝐫𝐨𝐦 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Women with mitochondrial disease can pass the condition to their children – because mitochondria, and the DNA it carries, are exclusively passed from mothers to children This technique uses mitochondrial 𝘥𝘰𝘯𝘢𝘵𝘪𝘰𝘯, where 𝘯𝘶𝘤𝘭𝘦𝘢𝘳 DNA comes from parents but 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 DNA comes from a healthy donor All 8 babies are developing normally, and all have healthy (or mostly healthy) mitochondria – the oldest is just over 2! Source:

Top 5 advances in medicine this week (🧵) 𝟏. 𝟖 𝐡𝐞𝐚𝐥𝐭𝐡𝐲 𝐛𝐢𝐫𝐭𝐡𝐬 𝐟𝐫𝐨𝐦 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Women with mitochondrial disease can pass the condition to their children – because mitochondria, and the DNA it carries, are exclusively passed from mothers to children This technique uses mitochondrial 𝘥𝘰𝘯𝘢𝘵𝘪𝘰𝘯, where 𝘯𝘶𝘤𝘭𝘦𝘢𝘳 DNA comes from parents but 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 DNA comes from a healthy donor All 8 babies are developing normally, and all have healthy (or mostly healthy) mitochondria – the oldest is just over 2! Source:

Samuel Hume

13,572 görüntüleme • 1 yıl önce

Kearney Disinformation Correction Yesterday, Aidan Kearney attempted to attack the lack of canine DNA detected on John's clothing by tweeting two misleading claims. 1. Canine Swab Collection Kearney Disinformation: Michael Proctor was the source of DNA collected. Factual Information: The swabs were neither from Proctor's body nor collected by him. The swabs were collected by Maureen Hartnett at the MSP crime lab from John's shirt per instructions of Teri Kuhn at UC Davis and were received packaged appropriately. 2. Inhibitors Caused The Lack of Canine DNA Kearney Disinformation: There were inhibitors on John's clothing that masked the presence of canine DNA. Factual Information: UC Davis was asked to perform two tests: a nuclear DNA test which would be used to identify a specific animal and, if the nuclear DNA test failed to yield results, a mitochondrial DNA test called Meat ID to determine presence of DNA from a variety of species. Nuclear DNA is found in the nucleus of the cell and only 2 copies exist whereas mitochondrial DNA is found in the cytoplasm and is significantly more abundant with hundreds of thousands of copies. Nuclear DNA tests are far more accurate in determining the exact source, ie one dog from another dog, whereas mitochondrial DNA is less specific but will be able to determine if DNA from a specific animal species is present. In this case, the presence of DNA from 12 different animal species, including canine and pig, was tested. The results of the QPCR testing for nuclear DNA were that the swabs "did not indicate the presence of canine (nuclear) DNA, but did indicate the presence of inhibitors. This result is obtained when 1. Canine DNA is degraded, 2. The DNA is obscured by inhibitors, or 3. There is no nuclear DNA present." The less specific test using mitochondrial DNA, Meat ID, was then completed. This test showed no canine DNA and further, showed no inhibitors. In other words, had canine DNA been present, it would have been identified on the Meat ID mitochondrial testing since there were no inhibitors. The below video contains questioning from both the defense and prosecution supporting the identified factual information.

Kearney Disinformation Correction Yesterday, Aidan Kearney attempted to attack the lack of canine DNA detected on John's clothing by tweeting two misleading claims. 1. Canine Swab Collection Kearney Disinformation: Michael Proctor was the source of DNA collected. Factual Information: The swabs were neither from Proctor's body nor collected by him. The swabs were collected by Maureen Hartnett at the MSP crime lab from John's shirt per instructions of Teri Kuhn at UC Davis and were received packaged appropriately. 2. Inhibitors Caused The Lack of Canine DNA Kearney Disinformation: There were inhibitors on John's clothing that masked the presence of canine DNA. Factual Information: UC Davis was asked to perform two tests: a nuclear DNA test which would be used to identify a specific animal and, if the nuclear DNA test failed to yield results, a mitochondrial DNA test called Meat ID to determine presence of DNA from a variety of species. Nuclear DNA is found in the nucleus of the cell and only 2 copies exist whereas mitochondrial DNA is found in the cytoplasm and is significantly more abundant with hundreds of thousands of copies. Nuclear DNA tests are far more accurate in determining the exact source, ie one dog from another dog, whereas mitochondrial DNA is less specific but will be able to determine if DNA from a specific animal species is present. In this case, the presence of DNA from 12 different animal species, including canine and pig, was tested. The results of the QPCR testing for nuclear DNA were that the swabs "did not indicate the presence of canine (nuclear) DNA, but did indicate the presence of inhibitors. This result is obtained when 1. Canine DNA is degraded, 2. The DNA is obscured by inhibitors, or 3. There is no nuclear DNA present." The less specific test using mitochondrial DNA, Meat ID, was then completed. This test showed no canine DNA and further, showed no inhibitors. In other words, had canine DNA been present, it would have been identified on the Meat ID mitochondrial testing since there were no inhibitors. The below video contains questioning from both the defense and prosecution supporting the identified factual information.

Julie Carpenter

10,660 görüntüleme • 1 yıl önce

NEW!🚨 😳 Chinese Fentanyl dealers are now rebranding themselves as peptide providers. A new investigation reveals that fentanyl dealers are now selling peptides that are not up to standard used in regular supplements, skin care products & even legitimate pharmaceutical drugs. On top of that there is a booming peptide market that is unregulated & millions of Americans are injecting these peptides but have no idea where they are coming from. Even though peptides are a promising medical breakthrough, many providers are not transparent about their source We need MAHA on this case ASAP!

NEW!🚨 😳 Chinese Fentanyl dealers are now rebranding themselves as peptide providers. A new investigation reveals that fentanyl dealers are now selling peptides that are not up to standard used in regular supplements, skin care products & even legitimate pharmaceutical drugs. On top of that there is a booming peptide market that is unregulated & millions of Americans are injecting these peptides but have no idea where they are coming from. Even though peptides are a promising medical breakthrough, many providers are not transparent about their source We need MAHA on this case ASAP!

Melissa Tate

19,211 görüntüleme • 21 gün önce