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Need a bit of community input: We’re currently working on the melee system for PMC. Internally, we’re debating between a few options: Left click lets you perform a 3-hit combo if you spam it. Right now, if you attack from a narrow angle behind an enemy, you perform a... backstab that one-shots them (similar to Dark Souls). However, we’re wondering if it might be better to replace that with a heavy attack that you can charge up using right click instead. Alternatively, we could implement both, but that would require more budget—you know how it goes. Note: Animations are still WIP, and FX haven’t been implemented yet. Context: This is also important for PvE balance.show more

Beautiful Light

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26,509 次观看 • 11 个月前 •via X (Twitter)

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3D AI animations are blowing up right now if your still working a job and want to get into that first stage of online money or you already have a brand and need people making content like this for you this is one of the easiest plays right now > it goes super viral > it's exceptionally easy to make > it can be completely automated (we built tools for this) > it converts well i’m looking to connect with as many talented creators as possible, we’re getting more client requests than we can currently handle that's why i created a full step-by-step blueprint on how to create videos like that reply "AI" + RT and i'll send you the full breakdown so you can create those too (must be following so i can DM)

MAX

47,195 次观看 • 5 个月前

McGowan: It’s like when you play monopoly and somebody has all of the hotels on the whole board, and it doesn't matter if you're playing the game right, it doesn't matter if you're doing what you're supposed to do, it doesn't matter if you get the education, if you get the job, you are still always going to lose. That is where we are in America right now, and that is not how we should want to be. And I'm saying capitalism is a wonderful system if it is working, it is not currently working for the American people.

McGowan: It’s like when you play monopoly and somebody has all of the hotels on the whole board, and it doesn't matter if you're playing the game right, it doesn't matter if you're doing what you're supposed to do, it doesn't matter if you get the education, if you get the job, you are still always going to lose. That is where we are in America right now, and that is not how we should want to be. And I'm saying capitalism is a wonderful system if it is working, it is not currently working for the American people.

Acyn

66,101 次观看 • 19 天前

It is with a heavy heart that we sadly have to announce… that we are LYING TO YOU, WE’RE NOT SAD, IF ANYTHING, WE’RE THE OPPOSITE, YOU KNOW WHY? SLAP BATTLES IS OFFICIALLY PART OF THE GAMES EVENT! we have some exclusive, never before seen footage of what we’ve been cooking up

It is with a heavy heart that we sadly have to announce… that we are LYING TO YOU, WE’RE NOT SAD, IF ANYTHING, WE’RE THE OPPOSITE, YOU KNOW WHY? SLAP BATTLES IS OFFICIALLY PART OF THE GAMES EVENT! we have some exclusive, never before seen footage of what we’ve been cooking up

Slap Battles

72,234 次观看 • 2 年前

Sky News Interviewer: There were seven other people killed in that attack… Is the IDF’s position that all five of those journalists who were killed were also working for Hamas or are they just collateral damage? IDF’s Nadav Shoshani: We’re we’re looking into further details of the incidents… about additional people — we’re still looking into the incident and we’ll hopefully be able to provide more information soon. Interviewer: But clearly you must have understood that there was a risk if you’re going to drop a bomb into a tent containing a load of journalists that more than the one that you are trying to attack would would perish. Shoshani: Well, we conduct our operations and as you see, he wasn’t with his family and we try and conduct our operations in a way that goes after terrorists in the most minimal way. Interviewer: Killing eight people when you’re aiming for one, is that— is that the most minimal way, killing eight if you’re aiming for one?

Sky News Interviewer: There were seven other people killed in that attack… Is the IDF’s position that all five of those journalists who were killed were also working for Hamas or are they just collateral damage? IDF’s Nadav Shoshani: We’re we’re looking into further details of the incidents… about additional people — we’re still looking into the incident and we’ll hopefully be able to provide more information soon. Interviewer: But clearly you must have understood that there was a risk if you’re going to drop a bomb into a tent containing a load of journalists that more than the one that you are trying to attack would would perish. Shoshani: Well, we conduct our operations and as you see, he wasn’t with his family and we try and conduct our operations in a way that goes after terrorists in the most minimal way. Interviewer: Killing eight people when you’re aiming for one, is that— is that the most minimal way, killing eight if you’re aiming for one?

Drop Site

22,937 次观看 • 1 年前

Ethan Evans (ex-Amazon VP) on his Director promo: "So I said, my career is very important to me. I need to understand how important it is to Amazon because if it's not as important to Amazon as it is to me, I need to think about that. And you know, I need to think about that isn't a direct threat. But you laughed. Everyone understands. But I'm not doing it in a way that is easily easy for him to push back on. See, if I say, well, if it's not as important to you, making it personal with him, if it's not important to you as it is to me, then I might quit. That's a threat. And all managers are going to be like, hey, you can't extort me, right? That isn't how it works right? He pushed the promotion through." Ethan Evans Ryan: "When you say that wording, I feel the effects of extortion a bit, right? But I couldn't, I could not label it extortion."

Ethan Evans (ex-Amazon VP) on his Director promo: "So I said, my career is very important to me. I need to understand how important it is to Amazon because if it's not as important to Amazon as it is to me, I need to think about that. And you know, I need to think about that isn't a direct threat. But you laughed. Everyone understands. But I'm not doing it in a way that is easily easy for him to push back on. See, if I say, well, if it's not as important to you, making it personal with him, if it's not important to you as it is to me, then I might quit. That's a threat. And all managers are going to be like, hey, you can't extort me, right? That isn't how it works right? He pushed the promotion through." Ethan Evans Ryan: "When you say that wording, I feel the effects of extortion a bit, right? But I couldn't, I could not label it extortion."

Ryan Peterman

106,328 次观看 • 5 个月前

RFK Jr. says HHS is working to find a cure for Alpha Gal. The tick disease that can make you allergic to red meat for life. “One bite from a lone star tick, and you could have a lifetime allergy to red meat.” “50% of the population of Martha’s Vineyard now has alpha gal.” “We’re also working on medicines that can prevent Alpha Gal and have the promise of actually curing it.” “One of those medicines is almost ready.” “We’re fast tracking it.” “We’re doing the studies over the next two years to see if we can actually reverse this devastating disease.”

RFK Jr. says HHS is working to find a cure for Alpha Gal. The tick disease that can make you allergic to red meat for life. “One bite from a lone star tick, and you could have a lifetime allergy to red meat.” “50% of the population of Martha’s Vineyard now has alpha gal.” “We’re also working on medicines that can prevent Alpha Gal and have the promise of actually curing it.” “One of those medicines is almost ready.” “We’re fast tracking it.” “We’re doing the studies over the next two years to see if we can actually reverse this devastating disease.”

End Tribalism in Politics

1,298,127 次观看 • 3 个月前

Jordan Peterson: "If you can't fix your room, you can't fix your life" "Why should you even bother improving yourself? The answer is something like: so you don't suffer anymore stupidly than you have to. And maybe so others don't have to either. It's not some casual self-help doctrine. If you don't organize yourself properly, you'll pay for it. In a big way. And so will the people around you." Peterson continues: "You can say, 'Well, I don't care about that.' But that's actually not true, you do care about it. Because if you're in pain, you will care about it. It's very rare that you can find someone in excruciating pain who would say, 'Well, it would be no better if I was out of this.' Pain brings the idea that it would be better if it didn't exist along with it. It's incontrovertible." On how to start: "Look around for something that bothers you and see if you can fix it. You can do this in a room. Sit in your bedroom and think: 'If I wanted to spend ten minutes making this room better, what would I have to do?' You have to ask yourself that, it's a genuine question. And things will pop out. There's a stack of papers bugging you. Some rubbish behind your computer monitor you haven't attended to for six months. Cables tangled up." He explains why this matters: "If you were coming to see me for psychotherapy, the easiest thing would be to get you to organize your room. You think, is that psychotherapy? It depends on how you conceive the limits of your being. Start where you can start. If something announces itself as in need of repair that you could repair, fix it. Fix a hundred things like that, your life will be a lot different." On fixing what you repeat every day: "People tend to think of their daily routines as trivial. You get up, brush your teeth, have breakfast. Those probably constitute 50% of your life. People think, they're mundane, I don't need to pay attention to them. No, that's exactly wrong. The things you do every day are the most important things you do. Hands down. Just do the arithmetic." On staying within your competence: "Sometimes you don't know how to fix something. Imagine you're walking down the street and there's a guy who's alcoholic and schizophrenic and has been homeless for ten years. That's a problem. It would be good if you could fix it, but you haven't got a clue. You walk around that and go find something you could fix. Just because something announces itself as in need of repair doesn't mean it's you, right then and there, who should repair it. You have to have some humility. You don't walk up to a helicopter that isn't working and just start tinkering away." Peterson shares the key insight: "As soon as you give your mind a genuine aim, it'll reconfigure the world in keeping with that aim. That's actually how you see to begin with. You've all seen the video where you watch basketballs being tossed back and forth, and while you're doing that, a gorilla walks into the middle of the video and you don't see it. If you thought about that experiment for five years, that would be about the right amount of time to spend thinking about it." He explains what it reveals: "What it shows you is that you see what you aim at. If you can get one thing through your head, that would be a good one. You see what you aim at. One inference you might draw from that is: be careful what you aim at. What you aim at determines the way the world manifests itself to you. So if the world is manifesting itself in a very negative way, one thing to ask is: are you aiming at the right thing?"

Jordan Peterson: "If you can't fix your room, you can't fix your life" "Why should you even bother improving yourself? The answer is something like: so you don't suffer anymore stupidly than you have to. And maybe so others don't have to either. It's not some casual self-help doctrine. If you don't organize yourself properly, you'll pay for it. In a big way. And so will the people around you." Peterson continues: "You can say, 'Well, I don't care about that.' But that's actually not true, you do care about it. Because if you're in pain, you will care about it. It's very rare that you can find someone in excruciating pain who would say, 'Well, it would be no better if I was out of this.' Pain brings the idea that it would be better if it didn't exist along with it. It's incontrovertible." On how to start: "Look around for something that bothers you and see if you can fix it. You can do this in a room. Sit in your bedroom and think: 'If I wanted to spend ten minutes making this room better, what would I have to do?' You have to ask yourself that, it's a genuine question. And things will pop out. There's a stack of papers bugging you. Some rubbish behind your computer monitor you haven't attended to for six months. Cables tangled up." He explains why this matters: "If you were coming to see me for psychotherapy, the easiest thing would be to get you to organize your room. You think, is that psychotherapy? It depends on how you conceive the limits of your being. Start where you can start. If something announces itself as in need of repair that you could repair, fix it. Fix a hundred things like that, your life will be a lot different." On fixing what you repeat every day: "People tend to think of their daily routines as trivial. You get up, brush your teeth, have breakfast. Those probably constitute 50% of your life. People think, they're mundane, I don't need to pay attention to them. No, that's exactly wrong. The things you do every day are the most important things you do. Hands down. Just do the arithmetic." On staying within your competence: "Sometimes you don't know how to fix something. Imagine you're walking down the street and there's a guy who's alcoholic and schizophrenic and has been homeless for ten years. That's a problem. It would be good if you could fix it, but you haven't got a clue. You walk around that and go find something you could fix. Just because something announces itself as in need of repair doesn't mean it's you, right then and there, who should repair it. You have to have some humility. You don't walk up to a helicopter that isn't working and just start tinkering away." Peterson shares the key insight: "As soon as you give your mind a genuine aim, it'll reconfigure the world in keeping with that aim. That's actually how you see to begin with. You've all seen the video where you watch basketballs being tossed back and forth, and while you're doing that, a gorilla walks into the middle of the video and you don't see it. If you thought about that experiment for five years, that would be about the right amount of time to spend thinking about it." He explains what it reveals: "What it shows you is that you see what you aim at. If you can get one thing through your head, that would be a good one. You see what you aim at. One inference you might draw from that is: be careful what you aim at. What you aim at determines the way the world manifests itself to you. So if the world is manifesting itself in a very negative way, one thing to ask is: are you aiming at the right thing?"

Jaynit

68,799 次观看 • 5 个月前

🚨 WOW! HHS Sec. Robert F. Kennedy Jr. DROPS this line on an insufferable Democrat representative "If you want just a SOUNDBYTE that you can come in here, you can get that and you did it!" "But if you actually want to SOLVE the problem, call me — because we're aligned on the issue of getting good food to children and we think that we're doing a good job of it." "We could do a better job, but come and tell us how we can do a better job and that would be something we could all profit from."

🚨 WOW! HHS Sec. Robert F. Kennedy Jr. DROPS this line on an insufferable Democrat representative "If you want just a SOUNDBYTE that you can come in here, you can get that and you did it!" "But if you actually want to SOLVE the problem, call me — because we're aligned on the issue of getting good food to children and we think that we're doing a good job of it." "We could do a better job, but come and tell us how we can do a better job and that would be something we could all profit from."

Eric Daugherty

119,089 次观看 • 5 个月前

Kevin Durant says Jalen Brunson won the championship and is still out $100 million Speedy: “Brunson famously turned down a hundred… Would you do that?” KD: “I don’t think I would be advised to do that. I would have got talked out of it. I probably would have been like, ‘All right, I’m cool with it.’ I’d have sat down and talked to all my people like I usually do, Rich, all my friends. Like, ‘What? Are you serious? Why do you need to take that risk when this dude’s a billionaire?’” “Nobody would do that. If you just throw that on the table and say right now, make a choice, nobody would turn that down.” “But if you sat down and thought about it and they put everything on the table, ‘this will happen in four years if you do this, this is how the team could be built, we could for sure win a chip’, it sounds good when you sell it to somebody that way.” Speedy: “But they still win a chip. Is he ever really going to recoup it?” KD: “There’s always going to be a hundred that you don’t have. Even if you get it back, it’s like, well, I still could’ve had an extra hundred. Even if you give me a hundred again.” (via Boardroom, ft. Kevin Durant)

Kevin Durant says Jalen Brunson won the championship and is still out $100 million Speedy: “Brunson famously turned down a hundred… Would you do that?” KD: “I don’t think I would be advised to do that. I would have got talked out of it. I probably would have been like, ‘All right, I’m cool with it.’ I’d have sat down and talked to all my people like I usually do, Rich, all my friends. Like, ‘What? Are you serious? Why do you need to take that risk when this dude’s a billionaire?’” “Nobody would do that. If you just throw that on the table and say right now, make a choice, nobody would turn that down.” “But if you sat down and thought about it and they put everything on the table, ‘this will happen in four years if you do this, this is how the team could be built, we could for sure win a chip’, it sounds good when you sell it to somebody that way.” Speedy: “But they still win a chip. Is he ever really going to recoup it?” KD: “There’s always going to be a hundred that you don’t have. Even if you get it back, it’s like, well, I still could’ve had an extra hundred. Even if you give me a hundred again.” (via Boardroom, ft. Kevin Durant)

katsu

477,500 次观看 • 24 天前

"In the Ukrainian army, you have this score system. You need to kill people. And if you attack, for instance, a civilian car, you can claim, oh, some military was there. If you attack a bus, you say, oh, one military officer was inside. They just need to have enough points." Victor Bout and Rick Sanchez discuss a brand-new strategy that Europe has implemented against Russia. The whole world can see it now. Yet, they all still blindly believe they can beat the rap.

Margarita Simonyan

18,585 次观看 • 1 个月前

.President Donald J. Trump on Iran: "I guess you could define it any way you want, but certainly we’re beating them up really badly. They have to be beaten up. We’re hitting them very, very hard. We’re hitting every single thing that they have along the shore, along the waterfront. If you look at the Strait of Hormuz... We have to keep it open. I was going to charge a fee, but instead [Gulf States] would rather spend a lot of money in the United States, which frankly, is better."

.President Donald J. Trump on Iran: "I guess you could define it any way you want, but certainly we’re beating them up really badly. They have to be beaten up. We’re hitting them very, very hard. We’re hitting every single thing that they have along the shore, along the waterfront. If you look at the Strait of Hormuz... We have to keep it open. I was going to charge a fee, but instead [Gulf States] would rather spend a lot of money in the United States, which frankly, is better."

Rapid Response 47

91,200 次观看 • 2 个月前

$I hear so often from the Dommes I work with that they struggle with people online fetichizing them and simply seeing them for how sexy and beautiful they are. They project their fantasies and their desires onto you. That stops immediately once you move the attention from you to them. From 'look at me' to 'I see you'. What does that look like? When you create content, think of them and what this scene or that narrative is evoking. What will they learn from you? What they want is not to passively watch how sexy you are, but for you to train them, to give them instructions, to teach them, to guide them, to be in charge, to command them. This is not being an object but the main subject. The Authority figure. How is your content already doing that. The sexy photos can still be there, they are important to already capture des attention. But what you do with that attention once you have it, is where the power dynamic is established. Positioning yourself as more than a stunning Goddess, but actually a woman who has a voice, opinions, perspective, a philosophy, a way to doing things, teaching them what you like, how you like it, why you like it, already makes them want to be that for you. You hold the attention, you hold the power, so you direct it. And for that, you want them to know you get them and you know what lives within them... that creates the desire for you to be the one exposing it. You instantly build trust. Not because you demanded it, but because you earned it: you showed them you know what you are doing. You have experience, you understand them. They are not told to come see you, they are seduced into it. They desire it. And they will work for it. This will attract better clients (real subs) and instead of you trying to get their attention, they will work to earn yours. If you want to learn more about power dynamics, building a brand as a Pro or the psychology behind BDSM, you can now access all my trainings and classes in one place for a fraction of the cost of The Dominatrix Academy. And you can reinvest the total amount towards the Program. Message me [SECRET] for the details. This offer is not available on my website.$

I hear so often from the Dommes I work with that they struggle with people online fetichizing them and simply seeing them for how sexy and beautiful they are. They project their fantasies and their desires onto you. That stops immediately once you move the attention from you to them. From 'look at me' to 'I see you'. What does that look like? When you create content, think of them and what this scene or that narrative is evoking. What will they learn from you? What they want is not to passively watch how sexy you are, but for you to train them, to give them instructions, to teach them, to guide them, to be in charge, to command them. This is not being an object but the main subject. The Authority figure. How is your content already doing that. The sexy photos can still be there, they are important to already capture des attention. But what you do with that attention once you have it, is where the power dynamic is established. Positioning yourself as more than a stunning Goddess, but actually a woman who has a voice, opinions, perspective, a philosophy, a way to doing things, teaching them what you like, how you like it, why you like it, already makes them want to be that for you. You hold the attention, you hold the power, so you direct it. And for that, you want them to know you get them and you know what lives within them... that creates the desire for you to be the one exposing it. You instantly build trust. Not because you demanded it, but because you earned it: you showed them you know what you are doing. You have experience, you understand them. They are not told to come see you, they are seduced into it. They desire it. And they will work for it. This will attract better clients (real subs) and instead of you trying to get their attention, they will work to earn yours. If you want to learn more about power dynamics, building a brand as a Pro or the psychology behind BDSM, you can now access all my trainings and classes in one place for a fraction of the cost of The Dominatrix Academy. And you can reinvest the total amount towards the Program. Message me [SECRET] for the details. This offer is not available on my website.

Ms. Malissia

17,098 次观看 • 4 个月前

#CHANYEOL: "You might think exercising is hard, but even if it's not working out inside a gym, just like going for a walk..i think it's good for my mental health to keep moving my body. And one more thing, it would be nice if you have a hobby. For example..well, I'm also guilty of it, but we use our handphones alot. I also do this everyday..you know what I mean, right? We keep scrolling down like this. Ofcourse, time spent like that is nice too..but, say for example, playing musical instruments. I think it would really be nicer if we have a hobby that can make us use that time more efficiently"

#CHANYEOL: "You might think exercising is hard, but even if it's not working out inside a gym, just like going for a walk..i think it's good for my mental health to keep moving my body. And one more thing, it would be nice if you have a hobby. For example..well, I'm also guilty of it, but we use our handphones alot. I also do this everyday..you know what I mean, right? We keep scrolling down like this. Ofcourse, time spent like that is nice too..but, say for example, playing musical instruments. I think it would really be nicer if we have a hobby that can make us use that time more efficiently"

NLNL 🍒🔥

109,817 次观看 • 2 年前

What do a cover model and a scientist know about homesteading? You guessed it… absolutely nothing 😂 Lol. Seriously though. We’re doing our best to break away from social constructs. But not only that… We’re on a mission to make the world a better place, hopefully inspiring you to become more self-sufficient 🌿 What’s been YOUR favorite part so far? It’s the llamas for me 😂 If you haven’t tuned in yet, go give it a watch on CarbonTV ! We hope to keep you inspired and well-entertained 😂

What do a cover model and a scientist know about homesteading? You guessed it… absolutely nothing 😂 Lol. Seriously though. We’re doing our best to break away from social constructs. But not only that… We’re on a mission to make the world a better place, hopefully inspiring you to become more self-sufficient 🌿 What’s been YOUR favorite part so far? It’s the llamas for me 😂 If you haven’t tuned in yet, go give it a watch on CarbonTV ! We hope to keep you inspired and well-entertained 😂

Janna Breslin

23,635 次观看 • 2 年前

Gilbert Arenas says if Cleveland trades for James Harden makes them a finals contender “You have Donovan Mitchell that is a leading scorer. They have a great balance attack know you add James Harden who defers to a star and if he starts playing bad we know he can turn it up and do what he does. So you got a guy that can do both any moment in time. I really believe if he goes to Cleveland they will be favorite to make it out the east” (Via Gil’s Arena)

Gilbert Arenas says if Cleveland trades for James Harden makes them a finals contender “You have Donovan Mitchell that is a leading scorer. They have a great balance attack know you add James Harden who defers to a star and if he starts playing bad we know he can turn it up and do what he does. So you got a guy that can do both any moment in time. I really believe if he goes to Cleveland they will be favorite to make it out the east” (Via Gil’s Arena)

NBA Courtside

124,134 次观看 • 7 个月前

🤷‍♂️ Seattle Sounders head coach Brian Schmetzer isn’t ready to hit the panic button on the club after a historic 5 straight losses. “We’re still successful. I understand everybody is calling for more signing and one hand I might say we probably should. But on the other hand, if your resources are such, we’re not going to go out right now in this window and replace 5 guys to a group that started of 7-3-3. We’re just not going to do that.” Do you agree with Coach?

🤷‍♂️ Seattle Sounders head coach Brian Schmetzer isn’t ready to hit the panic button on the club after a historic 5 straight losses. “We’re still successful. I understand everybody is calling for more signing and one hand I might say we probably should. But on the other hand, if your resources are such, we’re not going to go out right now in this window and replace 5 guys to a group that started of 7-3-3. We’re just not going to do that.” Do you agree with Coach?

Noah Riffe

17,934 次观看 • 1 个月前

American Farmer Heads Into The Grocery Store To Warn Americans About What You’re Eating Popular Name Brand Foods Contain In Their Ingredients Antibiotics Only Available By Prescription Right Alongside “Wood Fibers” “This is a farm boy. We're in a grocery store today to look up some things that might be or may not be in your foods. One of them is called natamycin. Know what that is? That is a medicine by prescription, and it's in a lot of your foods. And I'll take you and show you what what's going on here. See that brand name right there? You flip this over. If you look real close, you can see it. See it? Sure is. That is a medicine by prescription. It is in a great many of shredded cheeses. They use, if you can see here on this list, you will be able to see that it has Natamycin in that. See that brand name? America's favorite. Let's see what it has to offer. Lookie right there. Natamycin. Wonder what's up with that. And for those of you that's on a diet and you think eating protein products like these breakfast sausage winners are good for you, well, let's take a look at that. How about that crap? Oh my gosh. Now that may not seem like much to you, but that nadamycin, well, that's an antifungus medicine by prescription. Yep. It's for your eyes a lot of times. Now they're putting it in our food right along with wood cellulose products. Yep. When you see cellulose, you know you're getting wood fibers. And what they're using that for is a preservative, and they're using that as an anti caking and anti fungus. They're putting antibiotics right in your food. This is a farm boy, thought you'd like to know that.”

Wall Street Apes

1,233,561 次观看 • 2 年前

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

Jack Prescott

31,665 次观看 • 1 个月前