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🇺🇸 NEURALINK'S FIRST PATIENT SHINES IN MRBEAST VID Noland Arbaugh, Neuralink's pioneering implant recipient, popped up in MrBeast's newest video. He's showing off mind-controlled feats while the team's grinding on restoring movement, speech, vision, hearing, memory, and beyond in these super early stages. Source: Neura Pod – Neuralink

80,400 Aufrufe • vor 8 Monaten •via X (Twitter)

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i don't think people realize what just happened with brain implants in china for the first time in history, a brain implant has been approved for commercial sale. you can actually buy one. it's called neo. costs around $15,000. the question everyone asks first: does it actually work? here's what the implant does. a coin-sized chip gets placed on the surface of the brain, right over the area that controls movement. when a paralyzed patient imagines moving their hand, the chip reads that signal, sends it to a computer, and the computer drives a mechanical glove that moves for them picking up objects, gripping utensils, handling daily tasks. all from thought alone. the whole surgery takes an hour and 40 minutes. surgeons thin the skull, open a small window, and place two electrodes directly on the surface of the brain. then they close it up, patients go home within a week. 32 patients with spinal cord injuries were implanted in a clinical trial led by huashan hospital > ALL 32 regained the ability to grab objects through the glove. > 100% improvement rate. > zero adverse side effects. no other brain implant company on earth has received approval to sell their device commercially. elon's neuralink is still in clinical trials. side effects from their more invasive approach have stalled any path to regulatory clearance. china is the only country where you can buy a brain implant right now. this is by design. months before the approval, china published a national policy document with 17 steps to dominate the brain implant industry within 5 years. they want brain-reading devices to be as common as hearing aids. headbands, visors, earpieces that pick up brain signals... all mass-produced for consumers. and the government is coordinating the whole thing. funding the research, building the manufacturing, clearing the regulatory path, all at once. the West is moving painfully slow in comparison...still running controlled trials one patient group at a time. china already has a commercial product, a 72-year-old moving his leg on state television, and a national playbook to own the entire category.

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KanekoaTheGreat

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Mario Nawfal

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The Tale of Two Contagions In 2019, German psychiatrists observed a sudden surge of adolescent girls presenting to clinics with abrupt-onset Tourette-like tics. This immediately raised alarm bells. Tourette’s typically affects boys and begins in early childhood. This was an entirely new patient population. Researchers quickly identified the index case: Jan Zimmermann, a young Tourette sufferer, whose YouTube channel had recently exploded in popularity. The girls displayed the exact same symptoms as Jan: the same outbursts and catchphrases. The phenomenon soon migrated to TikTok, where it spread like wildfire. Researchers coined a new term for what they were observing: mass social media–induced illness — a modern iteration of the long-recognized phenomenon of mass sociogenic illness. Yet, in 2014, when paediatric gender clinics across the Western world began to fill with adolescent girls — another entirely new patient population — “gender-affirming” clinicians didn’t even bother to look for the trigger. And it wouldn’t have taken much effort to find. All it required was a glance at the cultural messaging of the time. Because 2014 was the year Time magazine put Laverne Cox on its cover with the headline: The Transgender Tipping Point: America’s Next Civil Rights Frontier. And with that, the modern trans rights movement launched. Trans-identified celebrities were everywhere, trans characters appeared in children’s books and television shows, trans influencers proliferated with astonishing speed online, and schools began teaching gender identity ideology as if it were scientific fact. And in a perfect-storm scenario, smartphones and social media exploded in popularity, creating the ideal super-spreading environment for this seductive idea to go viral. The message adolescents received was simple: If you hate your body, that could mean you’re trans. And right on cue, legions of confused adolescents who hated their developing bodies began showing up at gender clinics believing themselves to be trans. Just like the TikTok tics. A mass social media–induced illness. Except on this occasion, instead of scrambling to contain the epidemic, doctors picked up their syringes and scalpels and set about permanently medicalising the innocent youth caught up in this powerful cultural storm. And activists marched in the streets demanding that these young people be allowed to sacrifice their health, fertility, and body parts — while swiftly demonising anyone who dared point out the obvious parallels to social contagions of the past.

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The totalitarianism we warned of is happening. The European Union is at this moment forcing big tech companies to secretly engage in mass censorship. Google and Facebook are, apparently, going along with it. Only Elon Musk’s X, among the major platforms, is resisting. A few hours ago, Musk said, “The European Commission offered 𝕏 an illegal secret deal: if we quietly censored speech without telling anyone, they would not fine us. The other platforms accepted that deal. 𝕏 did not.” And so now, the EU is preparing to punish X with massive fines — up to 6% of total global revenue. I can't imagine a more egregious form of foreign interference in our domestic affairs than foreign governments demanding mass secret censorship for ideological and political purposes. Most terrifying is the apparently direct involvement of government intelligence and security agencies, and their intermediaries, in demanding censorship. This is all happening at the very moment that the same governments, including our own, warn of Russian disinformation through spam accounts that hardly anybody ever sees. Don’t be fooled by what is happening. Governments and former intelligence officials in Europe, Australia, Israel, Brazil, and Ukraine and other nations are not only demanding censorship but also often spreading their own disinformation. For example, the EU claims that there is more false information on X than on other platforms, and more censorship would reduce it. This is false. Only X has the open-source Community Notes system, which allows for real-time corrections to false information. A recent study in JAMA, the Journal of American Medicine, found that 97.5% of the Community Notes were entirely accurate, 2%, partially accurate, and 0.5%, inaccurate. It’s not perfect. I myself sometimes disagree with them. And of course, science is never standing still, so what appears accurate today might not be accurate in the future. However, X’s Community Notes uses more speech, not censorship, to provide context to controversial content. You can still agree or disagree with the content, even with a Community Note attached. What the EU wants is for its committees of experts, not Community Notes, to secretly decide what we can read and say online. This is unethical and unconstitutional. Another key part of the EU’s disinformation is that “researchers” should have access to X’s internal data, which Musk cut off when he bought Twitter. But those people who want the data aren’t researchers. They’re censorship activists, many of whom have deep relationships with governments in general and intelligence agencies in particular. If the EU succeeds in censoring X, Facebook, Google, and every other major Internet platform, then there is no free speech. There is only government-controlled speech. Many people rightly worry about the implications of a single man, Elon Musk, being all that stands between us and foreign governments’ totalitarian censorship plans. I worry about that, too. Our speech is inalienable. It is not something governments give to us. We need to fight back. While we should be grateful to Musk for standing up to the totalitarians in Europe, Brazil, and Australia, we must build a citizen’s movement to fight back. There’s three things you can do. First, share this video to raise the alarm. Second, add your email to our list here, so we can involve you in the future. And, third, consider making a donation to build the free speech movement and urge Congress and other social media companies to stand up for free speech against foreign interference.

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A monumental moment in medical history: the first gene therapy for genetic hearing loss is now FDA approved. As a former Regeneron scientist, I feel very proud. I had the opportunity to hear about this programme while it was still in development. It’s one of the few programmes that, every time you came across it, you felt the medical breakthrough in your bones and privileged just to be there while it was happening. At this moment, it’s important that we look 30 years back when researchers mapped a locus on chromosome 2 to congenital deafness in a Lebanese family ( They named it DFNB6 (later DFNB9) with no clue about the responsible gene. Three years later, the causal gene came to light: OTOF, encoding a protein called otoferlin ( Seven years after that, in 2006, pioneering work by Christine Petit revealed that otoferlin is a calcium sensor in the inner hair cell membrane, acting as a molecular trigger that converts sound into electric signals that the brain can read ( Twenty years fast forward, we now have a successful treatment. Thirty years from discovery to medicine. OTOF-related deafness is congenital, caused by complete deficiency of otoferlin. In these children, the cochlea is structurally intact, hair cells are there, the mechanics of sound transmission work. It’s just that final step, where hair cells hand off the signal to the auditory nerve through neurotransmitter release, that doesn’t happen. Sound arrives and dies at the synapse. It’s deafness due to a defect in the synapse caused by the absence of a single protein, which is what made this a beautiful, clean target for gene therapy. The treatment itself is a feat of molecular engineering. OTOF is too large to fit in a single AAV capsid. The team solved this elegantly by delivering the gene in two halves separately, which then get spliced to produce the full functional protein. A single surgical injection into the cochlea, a molecular miracle unfolds. Results from the CHORD trial were striking: of 20 evaluable patients, including children as young as 10 months, 80% showed meaningful hearing improvement, and by 48 weeks, 42% had achieved normal hearing including the ability to hear whispers. Otarmeni is not only the first gene therapy for deafness, it’s also the first dual-AAV therapy to be approved by the FDA. There are very few things in medicine that come close to giving back a sense like vision, hearing, or touch that a human never had from birth. It’s almost God’s work. A parent witnessing their child who was born deaf hearing their voice for the first time, it’s a joy that no words can describe. Multiply that by the fact that it came from a single injection, a repaired gene, and 30 years of science. We are truly in the golden era of medicine. Regeneron press release: Below video is from the NEJM publication of CHORD trial (Valayannopoulos et al. NEJM 2025)

Veera Rajagopal 

59,886 Aufrufe • vor 5 Monaten

Elad Gil’s 3 archetypes of hyper-successful founders Elad Gil has invested in and advised some of the largest companies in the world, including Stripe, Airbnb, Figma, Instacart, and Coinbase. When asked what made the founders of these companies so successful, Elad replies: “I think a lot of it is: Do you end up in the right market? Is the market big enough? Is it growing? Is it dynamic in the right way? I think half of it just is that you find the right market…. So you need the right market, but within that, there are tons of people who enter these markets and do horribly. So what’s different?” He notices that hyper-successful founders tend to fall into three buckets: “The first one is the polymathic, hyper-intellectual, yet very competitive person. And that’s probably Patrick and John [Collison] from Stripe. That was Larry and Sergey when I worked at Google — they were very polymathic, very deep on everything.” He continues: “I think the second one is the super hardcore, extremely focused, really really driven, overdrive founder. That may be Travis [Kalanick] from Uber… And I think there are almost signals of those because a lot of people in our ecosystem now, for example, are doing angel investing or they’re involved with lots of other companies while they’re running their own company. And this second class of founders doesn’t do any of that. They say no to everything, and they’re all-in on one thing.” Joe Lonsdale adds that this second type reminds him of Peter Thiel or Elon Musk in the early days: “I feel like Elon used to be more that way because he literally would say no to everything.” And then the third type of founder is one who is early to a network effects business: “If you have something that has network effects, you’re going to do well.” Video source: American Optimist Joe Lonsdale (2024)

Startup Archive

74,779 Aufrufe • vor 8 Monaten