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Neurons don’t physically touch—they communicate across tiny gaps called synapses. Signals travel as electrical impulses within a neuron and chemical neurotransmitters between neurons, enabling thought, memory, and movement

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Science girl

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Your every thought, memory, and movement begins here: an electric spark turned chemical message, as one neuron whispers to the next. What you’re seeing This animation captures neurotransmission, the process that allows nerve cells to communicate across microscopic gaps called synapses. When an electrical impulse reaches the end of Cell A (the presynaptic neuron), it triggers the release of neurotransmitters—tiny signaling molecules that cross the synaptic cleft and bind to receptors on Cell B (the postsynaptic neuron). 🟡 Opens ion channels that generate a new electrical signal in the next neuron 🟡 Coordinates how the brain encodes movement, emotion, and thought 🟡 Operates on millisecond precision using hundreds of molecular components 💡 The bigger picture Neurotransmission is the foundation of consciousness, a seamless conversation of electricity and chemistry happening trillions of times each second. Every sensation, decision, and memory depends on this invisible dialogue between your brain’s 86 billion neurons.
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Your every thought, memory, and movement begins here: an electric spark turned chemical message, as one neuron whispers to the next. What you’re seeing This animation captures neurotransmission, the process that allows nerve cells to communicate across microscopic gaps called synapses. When an electrical impulse reaches the end of Cell A (the presynaptic neuron), it triggers the release of neurotransmitters—tiny signaling molecules that cross the synaptic cleft and bind to receptors on Cell B (the postsynaptic neuron). 🟡 Opens ion channels that generate a new electrical signal in the next neuron 🟡 Coordinates how the brain encodes movement, emotion, and thought 🟡 Operates on millisecond precision using hundreds of molecular components 💡 The bigger picture Neurotransmission is the foundation of consciousness, a seamless conversation of electricity and chemistry happening trillions of times each second. Every sensation, decision, and memory depends on this invisible dialogue between your brain’s 86 billion neurons.

William A. Wallace, Ph.D.

125,496 görüntüleme • 7 ay önce

neuron trying in vain to find and connect with other neurons
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neuron trying in vain to find and connect with other neurons

microscopic images.

79,466 görüntüleme • 1 yıl önce

How neurons release neurotransmitters. Credit: Rex Twedt #neuroscience #MedTwitter
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How neurons release neurotransmitters. Credit: Rex Twedt #neuroscience #MedTwitter

Hugo Chrost

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For most of neuroscience history (until the late 1980s/early 1990s), neurons were treated as the brain’s only decision-makers. That idea is changing. Astrocytes, once considered passive support cells, are now recognized as global regulators of brain state. They don’t encode individual thoughts or actions. Instead, they integrate activity across huge numbers of synapses and adjust how neural networks behave over time. By releasing modulatory signals and tracking slow changes in activity, astrocytes influence: -Alertness vs. fatigue -Stress vs. calm -Motivation vs. disengagement Importantly, they can shift brain function without rewiring neurons, by tuning the environment neurons operate in. The brain isn’t just wired. It’s regulated, and astrocytes play a central role in that regulation.
0:10

For most of neuroscience history (until the late 1980s/early 1990s), neurons were treated as the brain’s only decision-makers. That idea is changing. Astrocytes, once considered passive support cells, are now recognized as global regulators of brain state. They don’t encode individual thoughts or actions. Instead, they integrate activity across huge numbers of synapses and adjust how neural networks behave over time. By releasing modulatory signals and tracking slow changes in activity, astrocytes influence: -Alertness vs. fatigue -Stress vs. calm -Motivation vs. disengagement Importantly, they can shift brain function without rewiring neurons, by tuning the environment neurons operate in. The brain isn’t just wired. It’s regulated, and astrocytes play a central role in that regulation.

William A. Wallace, Ph.D.

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This pov of Neuron stage, ARMYs look like literal neurons lighting up
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This pov of Neuron stage, ARMYs look like literal neurons lighting up

𝓪⁷

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The interweaving and movement of lines as a metaphor for the neurons that form connections and shape our thoughts and memories. #light #design #artdirection #sidefx #houdini
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The interweaving and movement of lines as a metaphor for the neurons that form connections and shape our thoughts and memories. #light #design #artdirection #sidefx #houdini

Sergey Shurupov

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A time-lapse showing neurons growing and forming new connections as the brain learns
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A time-lapse showing neurons growing and forming new connections as the brain learns

Science girl

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Researchers grew rat neurons on a force sensor, which allowed them to discover that neurons develop tension after forming connections with other neurons, resulting in a contractile neural network. Without this contractility, neurons fail to fire. In PNAS:
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Researchers grew rat neurons on a force sensor, which allowed them to discover that neurons develop tension after forming connections with other neurons, resulting in a contractile neural network. Without this contractility, neurons fail to fire. In PNAS:

PNASNews

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Did you know about 21 million people worldwide are diagnosed with #epilepsy in 2021? Epilepsy’s pathophysiology involves the aberrant electrical activity of neurons in the brain. This typically stems from an imbalance between excitatory and inhibitory neurotransmitters, with increased excitation or reduced inhibition leading to hyperactive neural networks. These abnormal electrical discharges manifest as seizures, which can vary in intensity and impact depending on the specific regions of the brain affected by this pathophysiological imbalance.🧠 . Video credit silvan_haber_ #scientissimum #neurology #neurologia #MedTwitter #Worlds2023
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Did you know about 21 million people worldwide are diagnosed with #epilepsy in 2021? Epilepsy’s pathophysiology involves the aberrant electrical activity of neurons in the brain. This typically stems from an imbalance between excitatory and inhibitory neurotransmitters, with increased excitation or reduced inhibition leading to hyperactive neural networks. These abnormal electrical discharges manifest as seizures, which can vary in intensity and impact depending on the specific regions of the brain affected by this pathophysiological imbalance.🧠 . Video credit silvan_haber_ #scientissimum #neurology #neurologia #MedTwitter #Worlds2023

Scientissimum

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You’re looking at neurons growing and connecting in real time 🧠. A 65-hour recording of hippocampal activity in a rat brain. The hippocampus plays a crucial role in memory and learning. In this footage, neurons extend their dendrites and axons, building and reshaping connections across days. Capturing this process live offers a rare view into how neural circuits form and reorganize. Why this matters ⬇️ 1️⃣It’s a continuous, multi-day recording of living hippocampal neurons under the microscope 2️⃣You can clearly see dendritic branching and network formation 3️⃣It reveals the dynamic processes that drive brain development and plasticity Observing growth at this resolution helps researchers understand how neurons connect—and how disruptions in these processes might contribute to neurological or psychiatric conditions. Credit to Louis Romet and Dr. Christophe Leterrier for the video
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You’re looking at neurons growing and connecting in real time 🧠. A 65-hour recording of hippocampal activity in a rat brain. The hippocampus plays a crucial role in memory and learning. In this footage, neurons extend their dendrites and axons, building and reshaping connections across days. Capturing this process live offers a rare view into how neural circuits form and reorganize. Why this matters ⬇️ 1️⃣It’s a continuous, multi-day recording of living hippocampal neurons under the microscope 2️⃣You can clearly see dendritic branching and network formation 3️⃣It reveals the dynamic processes that drive brain development and plasticity Observing growth at this resolution helps researchers understand how neurons connect—and how disruptions in these processes might contribute to neurological or psychiatric conditions. Credit to Louis Romet and Dr. Christophe Leterrier for the video

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Neurons sense each other and try to connect.
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Neurons sense each other and try to connect.

Fascinating

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ASCII/Dither with Particle UI, representing Brain waves. Card on the right are Gamma wave (30–100 Hz) state, with high-end Beta waves (12–30 Hz) mixed in. Combined its rhythmic, synchronized electrical impulses generated by millions of neurons communicating simultaneously.
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ASCII/Dither with Particle UI, representing Brain waves. Card on the right are Gamma wave (30–100 Hz) state, with high-end Beta waves (12–30 Hz) mixed in. Combined its rhythmic, synchronized electrical impulses generated by millions of neurons communicating simultaneously.

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Neurons activated
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Neurons activated

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Scaling laws describe how loss changes with scale. Do neurons inside models change predictably too? We study vision and language models up to 30B params and find systematic scaling in neuron universality, specialization, and selectivity. Paper+code: 1/n
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Scaling laws describe how loss changes with scale. Do neurons inside models change predictably too? We study vision and language models up to 30B params and find systematic scaling in neuron universality, specialization, and selectivity. Paper+code: 1/n

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just neurons growing axons making connections and stuff that is all...
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just neurons growing axons making connections and stuff that is all...

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E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵
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E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵

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The PlantWave device allows us to “hear” what mushrooms communicate with each other. Using electrical signals that are then mapped to synthesizer and bass’s
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The PlantWave device allows us to “hear” what mushrooms communicate with each other. Using electrical signals that are then mapped to synthesizer and bass’s

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A microscopic view of neurons forming new connections
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A microscopic view of neurons forming new connections

Science girl

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Plants don’t have nerves. But when they’re injured, they send an electrical “SOS” that looks very familiar. When a leaf is cut or bitten, glutamate (the same amino acid that acts as a neurotransmitter in humans) spills out of the damaged cells. In plants, that glutamate flips on a series of glutamate-gated receptors, triggering a rapid calcium wave that races through the stem and leaves. It’s not pain. It’s not consciousness. But it is a long-distance danger signal. And what happens next is biology at its best: • Distant leaves ramp up their defenses • Genes for protection and repair switch on • Chemical pathways shift to heal tissue and deter future damage Humans use glutamate to communicate between neurons. Plants use it to communicate between cells and tissues. Two completely different systems, one molecule playing messenger in both. A reminder that living things often solve survival problems using the same biochemical tools… even when evolution sends them down very different paths. From: Gatsby Plant Science Education Program
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Plants don’t have nerves. But when they’re injured, they send an electrical “SOS” that looks very familiar. When a leaf is cut or bitten, glutamate (the same amino acid that acts as a neurotransmitter in humans) spills out of the damaged cells. In plants, that glutamate flips on a series of glutamate-gated receptors, triggering a rapid calcium wave that races through the stem and leaves. It’s not pain. It’s not consciousness. But it is a long-distance danger signal. And what happens next is biology at its best: • Distant leaves ramp up their defenses • Genes for protection and repair switch on • Chemical pathways shift to heal tissue and deter future damage Humans use glutamate to communicate between neurons. Plants use it to communicate between cells and tissues. Two completely different systems, one molecule playing messenger in both. A reminder that living things often solve survival problems using the same biochemical tools… even when evolution sends them down very different paths. From: Gatsby Plant Science Education Program

William A. Wallace, Ph.D.

49,966 görüntüleme • 6 ay önce