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New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). IBEC

31,351 Aufrufe • vor 1 Jahr •via X (Twitter)

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🧪 Back in the 1980s and early '90s, researchers started uncovering something suprising inside the aloe vera plant: a sugar molecule called acemannan. It wasn't just soothing burns or helping skin heal faster, it was communicating with the immune system. In lab tests and hospital settings, doctors noticed that aloe's compounds could help white blood cells "wake up" and respond more efficiently without overstimulation. 🦠One doctor working with HIV patients even saw immune markers improve after giving them the pure aloe extract. But as soon as the research gained traction, the story fizzled out. Funding dried up, pharmaceutical interests shifted focus, and the patents for acemannan extraction quietly got tucked away under corporate control. What had started as a promising immune discovery suddenly and conveniently disappeared. 🔒 Today, aloe is marketed mostly for skin care or digestion, but that's only a fraction of what it can do. Beneath its green skin lies a compound so unique that it was once granted "orphan drug status" by the FDA in 1995 for its role in supporting immune recovery in HIV patients. That should've been front page news but instead it was buried under the noise of pharmaceutical progress. 🌱 Interesting how this humble desert plant was quietly doing what billions of research dollars were still trying to replicate (helping the body remember how to heal itself but safely with no side effects, no contraindications and no toxicity levels.... ⭐️ Today only about 130 patents for proper extraction and stabilization exist, the most recent patent having the highest immune modulating 1,100 fractions in the world. This essentially means ideal compatibility for the body to recognize and use acemannan immediately upon taking. ❔ Think about how disruptive this could be if people actually started understanding how incredibly powerful their immune system was when it's function properly... -laurae_ramos

𝚃𝙷𝙴 𝚆𝙷𝙸𝚃𝙴 𝚁𝙰𝙱𝙱𝙸𝚃

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Neuralink Integration with ANKTIVA for Revolutionary Immunotherapy Elon Musk, a visionary collaboration opportunity by Dr. Sarabi and Grok. Dear Mr Musk: Good morning sir! I would like to bring to your attention the remarkable work of Dr. Patrick Soon-Shiong, who has developed a groundbreaking therapy, Anktiva, capable of supercharging key immune molecules to combat cancer and COVID-19. In a recent discussion with Tucker Carlson, Dr. Soon-Shiong described this advance as akin to the “E=mc²” of medicine—the discovery of “God’s equation,” a biological key that has eluded us for half a century until now. Just as Tesla has revolutionized the automotive and environmental industries, and SpaceX has advanced the expansion of humanity into a multi-planetary species to ensure our long-term survival, Anktiva represents a comparable paradigm shift in medicine, safeguarding human health and endurance. Given your shared commitment to advancing humanity, I respectfully inquire whether you might consider extending your support to Dr. Soon-Shiong in this critical pursuit. Moreover, I propose exploring the integration of Neuralink, employing the stepwise protocol outlined below, in collaboration with Dr. Soon-Shiong. Such a partnership could propel an unprecedented advancement in medicine and the future of humankind. Grok has developed a preliminary conceptual integration of Neuralink to enhance and supercharge IL-15 production 1/7: Identify Target Neural Circuits • Map the hypothalamic paraventricular nucleus (PVN) and dorsal motor nucleus of the vagus • Trace efferent projections from the PVN to the intermediolateral cell column (IML) in the spinal cord. • Identify sympathetic nerve fibers innervating the spleen and lymph nodes. • Map vagus nerve branches terminating in gut-associated lymphoid tissue and the hepatic portal system. 2/7: Implant Neuralink and Integrate with Neural Pathways • Place Neuralink electrodes in the PVN and dorsal motor nucleus of the vagus, using extended threads for subcortical/brainstem access. • Configure for recording/stimulation to modulate autonomic outflow to the IML at thoracic spinal levels. • Establish central control over peripheral pathways (e.g., splenic/vagus nerves) via targeted brain stimulation. 3/7: Develop Stimulation Protocols • Program Neuralink for high-frequency stimulation to the PVN for sympathetic activation. • Apply low-frequency patterned stimulation to the dorsal motor nucleus to engage feedback loops. • Modulate splenic/vagal pathways with phase-locked cycles through central interfaces. 4/7: Initiate Immune Cell Activation • Stimulate pathways to induce IFN-γ and TNF-α release in spleen/lymph nodes. • Trigger IL-15 transcription/translation in dendritic cells, monocytes, and epithelial cells. • Monitor for increased membrane-bound IL-15/IL-15Rα complex formation. 5/7: Enhance Local IL-15 Presentation • Concentrate stimulation at tumor/inflammation sites. • Promote immune cell clustering via chemokine/adhesion molecule induction. • Sustain localized IL-15/IL-15Rα trans-presentation to NK and CD8+ T cells. 6/7: Implement Real-Time Monitoring and Feedback • Record neural/immune biomarkers continuously via Neuralink telemetry. • Adjust stimulation based on IL-15 levels and NK/T cell activity. • Set safety thresholds to avoid excessive immune activation. 7/7: Synchronize with Immunotherapy • Time stimulation with IL-15 superagonists or adoptive therapies. • Evaluate synergies using immune monitoring/imaging. • Optimize based on patient responses. Thank you! #Neuralink #ANKTIVA #Grok #trendingvideo #cancer #medicalnews #health #trendingnow

Dr. Kash Sarabi

16,057 Aufrufe • vor 1 Jahr