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Our new cryo-EM structure explains how the MRN complex can act both as DNA double-strand break sensor & DNA tethering device, read the paper here: Huge thanks to all collaboration partners W.Roos, B.Steigenberger and C. Junge! #cryoEM, #DNArepair, #MRN

38,216 просмотров • 3 лет назад •via X (Twitter)

Комментарии: 4

Фото профиля Jae Lab
Jae Lab3 лет назад

Congratulations, Matthias et al.! 🥳🥳 That animation between the structure and the cryo image is crazy! 🤯😎

Фото профиля Michael Trakselis
Michael Trakselis3 лет назад

Wow this is impressive! Nice work all!

Фото профиля Rajiv Ranjan Singh
Rajiv Ranjan Singh3 лет назад

This is Incredible!! Congratulations to the Team!!

Фото профиля Vinod K Subramani
Vinod K Subramani3 лет назад

Wow 🤩 that’s a pretty lanky structure. Kudos to solving it 👍

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We've been told since childhood that evolution can explain everything in Life. But here is something that evolution cannot explain - something which only makes sense if it was designed: DNA folding. One strand of DNA is ~2m or 6.5ft long. That 2 meter strand is folded tightly into a precise package smaller than the tiniest speck of dust. And it's not folded randomly. It is folded with purpose. Because how DNA is folded determines which instructions are read. And the instructions that are read determine which program runs. And which program runs determines which type of cell will develop. Because not every cell needs all the instructions. Skin cells only need skin cell instructions. The rest is unnecessary. So the DNA for skin cells is folded so that only the skin cell instructions are accessible by the protein nanomachines that build the cells. The DNA fold is actually a precise 3D map that decides which genes turn on at precise moments of development. Without this precise map, a complex multicell organism could not develop properly. It would be utter chaos and death. Imagine trying to build a massive skyscraper where all the plans for every system - foundation, support structures, floor designs, room layouts, electrical, plumbing, air, windows, etc. - were all mixed together on one page. It would be impossible to read. But if you separate out each different system onto its own page, then it becomes possible to distinguish them and plan the construction. There is no evolutionary mechanism that can explain how the DNA code for new cells originated at the same time as the DNA folding capability to guide those different cell types during development. Without the folding, development is impossible. Without development, evolution is impossible. DNA programs and folding must exist together, from the start. This is an example of foresight and planning. Something only intelligence does. DNA folding is proof that Life was Divinely Designed.

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