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Our recent work in nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. next come>

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Ali Max Erturk

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31,853 views • 1 month ago •via X (Twitter)

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We have developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. MouseMapper uncovered obesity-induced whole-neuronal changes, most notably, a loss of trigeminal nerve endings linked to impaired whisker sensitivity, as well as tissue-specific macrophage clustering across the body. Kaltenecker, Horvath, Al-Maskari, Kolabas, Chen… Ertürk, bioRxiv (2024)
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