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Our recent work in nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. next come>

31,881 views • 1 month ago •via X (Twitter)

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The bacterial flagellum looks like a simple tail, or whip. But it’s actually a rotating motor, and perhaps the most sophisticated protein complex nature has ever evolved. In e. coli, these motors are capable of astonishing speeds; about 15,000 rpm. (The world record, according to one study, is for a Vibrio cell that was “clocked at 100,000 rpm by laser microscopy.) The flagellum propels the cell forward at speeds of 20-30 microns per second, or roughly 15 body lengths per second. If scaled up to the size of a cheetah, E. coli would *nearly* be the fastest land organism. The darting movements of a microbe were first observed in 1676 by Antony van Leeuwenhoek, a Dutch cloth merchant. Antony was delighted by the motion of his “animalcules,” writing: “I must say, for my part, that no more pleasant sight has ever yet come before my eye than these many thousands of living creatures, seen all alive in a little drop of water, moving among one another, each several creature having its own proper motion.” But Leeuwenhoek did not see flagella. He assumed, rather, that these animalcules must be “furnished with paws” instead. Christian Ehrenberg would not properly describe flagella until 1836. But amazingly, all the way up until the 1970s, nobody actually knew how the flagellum spun! In 1973, there were two competing models people argued over: the helical-wave (bending) model and the rotating (corkscrew) model. The first model suggested that the flagellum whipped back and forth, side-to-side, to propel the cell like paddle. The corkscrew model suggested that the whole flagellum instead spins around like a screw. In 1974, the corkscrew model finally won out. For two separate studies, scientists affixed flagella to glass slides using antibodies, and watched as the cells spun around and around like corkscrews. And finally, in just the last year, high-resolution structures of the flagellum have revealed a LOT more about its intricate assembly. The tail is made from ~20,000 self-assembling copies of a single protein, called flagellin. A “driveshaft,” or rod, spins the tail and is itself made of 26 protein subunits. Each “motor” in E. coli consists of 11 stators, each of which is made from 7 proteins.(Other types of cells have even more stators, and swim with much higher torques.) The flagellum spins when protons flow into the cell through tiny channels in these stators; akin to water running through a turbine. Each proton makes a small part of the stator change shape and push against the rotor, nudging it forward one step. With dozens of stators working at once, these nudges quickly spin the propeller. I'm writing an essay for Asimov Press about this now, and am really enjoying learning about the flagellum and its history. It's an extraordinarily complicated structure, though, and has been a challenge to understand!

Niko McCarty.

51,893 views • 10 months ago

I'm proud to share that Glean has surpassed $300M ARR, just five months after crossing $200M and growing ~3x over the past 15 months. This is an exciting milestone for Glean, and it's a signal about where the enterprise AI market is heading. We’ve long believed the real challenge in enterprise AI is not access to models. It is grounding AI in how a company actually works: its people, knowledge, workflows, permissions, and systems. That’s even clearer now. The companies creating real value with AI are not just adopting better models. They are building systems that understand their business well enough to deliver reliable outcomes at scale. That is the real moat, and it is what we’ve been building at Glean: an unrivaled context layer for enterprise AI. That context has to work across the business, not just inside a single team or use case. We see that in how customers adopt Glean: more than 85% use it across five or more job functions. It also has to meet the security and governance demands of complex enterprises. We see that in who is choosing Glean: our Fortune 500 customer count nearly doubled year over year. And it has to make economic sense as usage grows. In our recent benchmark with Claude Cowork, Glean was preferred roughly 2.5x as often as off-the-shelf MCP tools and used 30% fewer tokens on average. Better context improves both quality and efficiency. I enjoyed talking with CNBC's Deirdre Bosa about this broader shift. In enterprise AI, the winners will not be defined by better models alone. They will be defined by who builds the strongest foundation for enterprise context. Thank you to our customers, partners, and team for helping us build the future of enterprise AI.

Arvind Jain

279,535 views • 1 month ago

Long Announcement (but there's a discount code at the end, it's worth it🤣) Back in 2016, when my son Aaron (then just 11 years old) invented the numeric damage counters and we decided to put it in production, our mission was clear: make tracking damage in the Pokémon TCG fast, easy, and accurate. By displaying exact values, players could simply add the numbers without second-guessing. This approach proved so effective that Pokémon themselves adopted this system for their Worlds dice at the 2018 Nashville Championships (read: they totally copied us 😆). And the rest is history💪 Now with this new menace Grimmsnarl ex — where damage constantly shifts turn by turn — clear and quick damage tracking has never been more essential. - In the first photo, Munki is at 10 damage and Grimmsnarl ex at 70 — all displayed using just one numeric counter each. And that's the beauty of numeric damage counter, just 1 damage counter 95% of the time takes care of what you need to display - In the video, you’ll see how easy it is to update damage. No need to pick it up and fumbling for the next number — Just identify the next number you need and rotate to it. -Still prefer D6 dice? That’s cool — some players do out of habit. But once damage hits 60+, you'll need two dice to show the total, whereas numeric counters still get it done with one. (If you're sticking with D6, check out our Drilled D6s — hands down the most stunning dice you'll find. Totally unbiased opinion, of course 😆) - Compare our design with the Pokémon ETB counters in the last photo — by design our counters increase in size with the number for quick visual clarity. Plus, since each one is precisely machined from billet aluminum, they stand firm and resist rolling, even when the cards are being moved. Still on the fence? No worries — we’ve got two great reasons to try them: 🔸 Use code marnie18 for 18% off your entire order when you include any damage counter set. 🔸 And enjoy a 30-day, no-questions-asked, money-back guarantee. If you don’t love them, just send them back. Clearer play. Cleaner board. Smarter counters. 👉 What are you waiting for?

TC Evolutions

21,945 views • 1 year ago

Exactly 2 months and 1 day ago I arrived as a SAFugee in Utah. “The best and most beautiful things in the world cannot be seen or even touched - they must be felt with the heart.“ — Helen Keller I have spent endless hours trying to find the words to describe what we experienced being here on the 4th of July 2026, and still the words simply cannot describe the emotions, pride, heartbreak and heart’s joy of that day. Tooele wow! You stirred up every emotion. We spent the entire day. The parade being our first ever will never be forgotten. The energy, the passion and commitment to family, loyalty, bravery and this great nation was felt in our hearts as we watched endless pride for this nation by young and old. Thank you for saying in action what we feel - thank you for our freedom America. We recognise and honor that it is earned by those who gave their lives so you and I can live this free! And to describe that feeling ‘free’ in words is impossible. My heart and mind is full. My soul confirms that there is only one better feeling than this and that is in the presence of the Almighty Himself. I am still singing. Today exactly 2 months and 1 day ago I landed in this great country. And I am more proud and grateful everyday. Wow this week has been full of awesome stuff. We are officially official. Our Utah real ID’s arrived. Thank you US Postal Services, thank you Utah and thank you America! I have applied for about 60 posts in Utah before I became official. Maybe this next week will see some success. That what has been set aside for me will come. I believe it will.

MjustM

16,511 views • 8 days ago

STEVE-1: A Generative Model for Text-to-Behavior in Minecraft paper page: Constructing AI models that respond to text instructions is challenging, especially for sequential decision-making tasks. This work introduces an instruction-tuned Video Pretraining (VPT) model for Minecraft called STEVE-1, demonstrating that the unCLIP approach, utilized in DALL-E 2, is also effective for creating instruction-following sequential decision-making agents. STEVE-1 is trained in two steps: adapting the pretrained VPT model to follow commands in MineCLIP's latent space, then training a prior to predict latent codes from text. This allows us to finetune VPT through self-supervised behavioral cloning and hindsight relabeling, bypassing the need for costly human text annotations. By leveraging pretrained models like VPT and MineCLIP and employing best practices from text-conditioned image generation, STEVE-1 costs just $60 to train and can follow a wide range of short-horizon open-ended text and visual instructions in Minecraft. STEVE-1 sets a new bar for open-ended instruction following in Minecraft with low-level controls (mouse and keyboard) and raw pixel inputs, far outperforming previous baselines. We provide experimental evidence highlighting key factors for downstream performance, including pretraining, classifier-free guidance, and data scaling. All resources, including our model weights, training scripts, and evaluation tools are made available for further research.

AK

144,704 views • 3 years ago

Today, we're announcing a $60M Series B led by Battery Ventures, bringing our total funding to $85M in just under a year. Also joining the round are founders and operators who’ve built generational companies of the last two decades – tobi lutke (CEO, Shopify), arash ferdowsi (Dropbox), Claire Hughes Johnson (Stripe), and more. The round came together in 6 days. Here's why. Every major category in enterprise software is seeing multiple AI-native challengers. CRM, ERP, ITSM – all being rebuilt from scratch by a new generation of companies applying AI to solve persistent problems we couldn’t before. Employee Management (also known as HCM) is the exception. It’s the last frontier, and we believe the most important one. The operating layer to manage people, run payroll, benefits, compliance, and IT, for every company in the world, is still built on architecture that predates AI by decades. This fundraise is the story of how Warp is changing that. The average Warp customer is growing 5x faster than their peers, with 1/10th of the HR and admin overhead. We’re seeing a massive shift happening in how the best companies run their people operations. From the fastest-growing AI-startups to massive public companies, the winning teams are running lean: HR, finance, and ops generalists who automate as much as possible, and use their time instead for strategic work that AI can’t automate. Warp is the platform of choice for ambitious companies operating at this new pace. Legacy HCMs help humans track the work. Warp uses AI to proactively complete the work. Workday was built for the last era. We're building for the next one. And it’s working. We've – - Doubled ARR in Q1 - On track to $2B+ payroll volume this year - Signed enterprise customers with thousands of employees - Launched entire product lines back-to-back: Warp benefits brokerage and Warp Fabric (our AI-native IT automation suite built in-house). A few thank-yous: 1. Our customers, the fastest-growing companies in the world, who trust us with their most critical systems. We wouldn't be here without you. 2. Our team - 50+ people in NYC who've built this platform, taken on the hardest problems in business-critical software. We're just getting started. 3. Our investors doubling down in this round, and some of our earliest believers – Sound Ventures (ashton kutcher, Effie Epstein), Derek Grant, (Arnav Sahu), Harj Taggar at Y Combinator, Balaji, Kevin Hartz, Kyle Vogt, Amjad Masad, HOF Capital (Fady Yacoub), colinevans (OpenAI) We're here to arm ambitious American companies with Workday-grade power, but with the usability and delight of an Apple product. With this new funding, we plan to fund deeper AI agents, tax and compliance infrastructure, expand our product suite, and support even closely our fast-growing customers. Come join us.

Ayush S

1,094,614 views • 20 days ago

Thank you Centre Pompidou Centre Pompidou, everyone who made Nature Manifesto happen, and all the people that took it in. We were happy to see the conversations that the use of AI in Nature Manifesto sparked !! Below is a message from Björk: ~~~ “ the flood of all things from AI is overwhelming !! i am super grateful for your concerns about it´s effects on the environment , it shows you care , are curious and have integrity . i am curious too , i would like to be more informed about the difference of "frugal" AI and the ones that do hugeenvironmental damage and want to be able to choose . i asked around and found out that both the visuals and the audio in our pompidou project were done with "frugal" AI . but i have a lot to learn . when we used some of the AI softwares to merge the animals voices to mine , some of the sounds were great but to be honest , the best blends of their voices and a human were done "manually" , me editing the sounds , choosing piece by piece , looking for personality , musicality and soul . with new technology , i try to use it as a tool to grow , not a crutch . for example when i used melodyne , i used it not for lazy voice progressions but spent even more time when using it . every note in every chord became intentionally more complex . ( for example choir in "thunderbolt" ) and hopefully stretched the potential more out , further than i would have in "normal analog" physical improvisations ... i felt with this new tool i could reach new places in my musical DNA , become MORE personal . more myself . in my opinion , this is how we will work in the future . humans can read emotions on an incredibly high scale . nature made us that way . if there is no soul in tomorrow's music made by AI it is because no-one put it there and we have to speak out and guard this as listeners . ( tbh there is a lot of soulless muzak on spotify already ... they don’t need any AI help for that ...) anything that is mass manufactured without the attention of creativity , is that way . AI or not so it is not about the tool it is what you do with it . " ~~~ The visuals for Nature Manifesto were crafted by the talented Sam Balfus, artificial intelligence being one of the multiple tools used in the process. The sound was produced in collaboration with artist Robin Meier and IRCAM IRCAM. IRCAM develops “frugal AI” capable of generating audio in real-time on local servers without a GPU, thus their models can f.ex. be embedded on tiny Raspberry Pi cards. We asked associate professor and researcher Philippe Esling to provide us with readings; Constance Douwe’s thesis “On the environmental impact of deep generative models for audio” and more, see links below. Nature Manifesto Immersive sound piece 3’40” (2024) 20 November to 9 December, 2024, Centre Pompidou, Paris. Presented as part of the forum “Biodiversity: Which culture for which future?” #ForumBiodiversité Concept and words by Björk & Aleph Music written and composed by Björk Curatorship: Chloé Siganos and Aleph Molinari Associate curator: Delphine Le Gatt Ircam Musical Computing: Robin Meier Wiratunga Sound engineer: Bergur Þórisson Animation: Sam Balfua Video editing: Santiago Molinari With activists: Camille Etienne, Claire Nouvian, Sigrun Perla Gísladóttir, Sæunn Júlía Sigurjónsdóttir, Titouan Pilliard, of BLOOM, Sustainable Ocean Alliance, and Ungir umhverfissinnar. In partnership with D&B Audio and Southby Productions. Reccommended resources :

björk

51,637 views • 1 year ago