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Played a quick game with Daniel Negreanu (Daniel Negreanu) before the podcast. Wild how fast someone at his level can read you. We spoke about how people behave when the stakes rise, what pressure does to decision-making, how influence works at a table, and physical cues. Also got into...

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Prakhar Gupta

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114,188 views • 8 months ago •via X (Twitter)

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Wide-ranging and somewhat controversial conversation with Tom Bilyeu — buckle up! 00:00:00 Welcoming dark horse, Tom Bilyeu to The Inside Rail 00:01:19 Tom Bilyeu’s Philosophical Approach to Life 00:03:26 Sponsor: Fresh Pressed Olive Oil Club 00:05:22 The Conscious Approach is Having a Moment 00:12:45 Sponsor: Caraway 00:14:15 How to Make Progress Today 00:30:22 All Problems Stem from Inflation 00:34:03 Tom’s Relationship with his Wife 00:53:00 A Message for Young Women 00:55:56 How Tom Committed to His Marriage 00:59:36 Hotness and Beauty 01:06:37 Porn and a Cultural Evolution 01:17:26 Creating Ritual in Life 01:23:12 Bret’s Relationship with Heather 01:27:12 Bret’s Advice for Young People 01:29:55 The Cassandra Complex 01:43:05 Bret on Teaching through DarkHorse 01:47:33 Tom on Reaching People 01:53:50 Tom on Current Events 02:17:50 Closing
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Wide-ranging and somewhat controversial conversation with Tom Bilyeu — buckle up! 00:00:00 Welcoming dark horse, Tom Bilyeu to The Inside Rail 00:01:19 Tom Bilyeu’s Philosophical Approach to Life 00:03:26 Sponsor: Fresh Pressed Olive Oil Club 00:05:22 The Conscious Approach is Having a Moment 00:12:45 Sponsor: Caraway 00:14:15 How to Make Progress Today 00:30:22 All Problems Stem from Inflation 00:34:03 Tom’s Relationship with his Wife 00:53:00 A Message for Young Women 00:55:56 How Tom Committed to His Marriage 00:59:36 Hotness and Beauty 01:06:37 Porn and a Cultural Evolution 01:17:26 Creating Ritual in Life 01:23:12 Bret’s Relationship with Heather 01:27:12 Bret’s Advice for Young People 01:29:55 The Cassandra Complex 01:43:05 Bret on Teaching through DarkHorse 01:47:33 Tom on Reaching People 01:53:50 Tom on Current Events 02:17:50 Closing

Bret Weinstein

50,030 views • 1 year ago

How does math research change when the cost of trying your first dumb idea goes to zero? Daniel Litt joins Greg Burnham and Anson Ho to discuss what today’s models can and can’t do in math, and how far they are from doing high-quality research. 0:00:00 What's the hardest math problem AI can solve today? 00:16:08 How helpful are today’s AI models for math research? 00:23:36 Junk papers, LLM-generated proofs, and the refereeing crisis 00:27:21 AI enables searching through problems at scale 00:33:49 When will AI be good enough to publish in top math journals? 00:42:15 What are the returns to intelligence? 00:59:50 Will AI solve Millennium problems? 01:11:54 Is math full of low-hanging fruit? 01:18:47 How Daniel has adapted his professional life to AI progress 01:25:28 What do AI math benchmarks actually measure? 01:33:05 Designing the Open Problems benchmark 01:56:35 Do mathematicians believe heuristic arguments about conjectures? 02:01:24 What if FrontierMath: Open Problems gets solved? 02:06:53 Is AI on the cusp of accelerating math progress?
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How does math research change when the cost of trying your first dumb idea goes to zero? Daniel Litt joins Greg Burnham and Anson Ho to discuss what today’s models can and can’t do in math, and how far they are from doing high-quality research. 0:00:00 What's the hardest math problem AI can solve today? 00:16:08 How helpful are today’s AI models for math research? 00:23:36 Junk papers, LLM-generated proofs, and the refereeing crisis 00:27:21 AI enables searching through problems at scale 00:33:49 When will AI be good enough to publish in top math journals? 00:42:15 What are the returns to intelligence? 00:59:50 Will AI solve Millennium problems? 01:11:54 Is math full of low-hanging fruit? 01:18:47 How Daniel has adapted his professional life to AI progress 01:25:28 What do AI math benchmarks actually measure? 01:33:05 Designing the Open Problems benchmark 01:56:35 Do mathematicians believe heuristic arguments about conjectures? 02:01:24 What if FrontierMath: Open Problems gets solved? 02:06:53 Is AI on the cusp of accelerating math progress?

Epoch AI

178,703 views • 6 months ago

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Infinite Loops 🎙

50,994 views • 4 months ago

Spoke with David Buss, a pioneer in human mating psychology. He’s one of the few people who’s actually studied why men and women choose each other the way they do — across cultures & time. We got into the basics of his work, how evolutionary psychology formed as a field, and why some of Freud’s ideas make sense in a modern context. We spoke about long-term vs short-term mating, why people pick bad partners, what makes someone “high value,” and the lies men and women tell each other without even realising it. Other Topics that we covered — emotional vs sexual cheating, why some patterns repeat across societies, what dating apps have done to us, and why men and women want such different things from each other. Episode attached in both English and Hindi Dubbed Timestamps ↓ 00:00 – What He Studies 04:36 – Freud’s Big Shift 05:55 – What Is Evolutionary Psychology 09:50 – Are Female Orgasms Necessary? 14:30 – Who Pays More for Bad Partners? 16:21 – Long-Term vs Short-Term Relationships 24:22 – Male vs Female Preferences 35:23 – Media Myths About Beauty 47:18 – Why Women Like Bad Boys 56:32 – Why Women Choose Status 01:00:52 – Lies Men & Women Tell 01:06:53 – Dating Patterns in India 01:11:33 – Emotional vs Sexual Cheating 01:14:47 – Are Humans Monogamous? 01:19:35 – Why Men Prefer Younger Women 01:22:06 – How Dating Apps Changed Mating 01:30:10 – Dating an AI 01:33:40 – Male vs Female Sexual Preferences 01:35:40 – Why Women Like Funny Men 01:37:31 – David on the Red Pill 01:39:32 – Does He Believe in Love?
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Prakhar Gupta

27,823 views • 8 months ago

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luba yudasina

151,807 views • 3 months ago

.Skip Bayless has built a career on delivering sharp takes, holding bold opinions, and never backing down from a debate, but this conversation revealed a side of him that most people never see. We discussed the work ethic that has fueled his decades in sports media, from his early days as a newspaper columnist to becoming one of the most recognizable personalities on television. Skip opened up about the sacrifices, the criticism, and the pressure that comes with living your life in front of an audience every single day. (00:02:05) – How Skip Stays in Shape at 73 (00:06:46) – Skip Bayless’ Origin Story (00:25:44) – Skip’s Ability to Debate (00:31:27) – Skip Bayless vs. Shannon Sharpe (00:34:50) – How Much Skip Bayless Loves Sports (00:42:57) – Is Skip Bayless Racist? (00:47:29) – An Insane Story You’ve Never Heard (00:58:15) – Skip Reflects on His Career (01:02:37) – Best Bayless Quotes (01:15:42) – Does Skip Have Any Regrets? (01:16:05) – LeBron James (01:36:30) – How Skip Changed the Lives of Shannon Sharpe, Stephen A. Smith, and More
1:56:20

.Skip Bayless has built a career on delivering sharp takes, holding bold opinions, and never backing down from a debate, but this conversation revealed a side of him that most people never see. We discussed the work ethic that has fueled his decades in sports media, from his early days as a newspaper columnist to becoming one of the most recognizable personalities on television. Skip opened up about the sacrifices, the criticism, and the pressure that comes with living your life in front of an audience every single day. (00:02:05) – How Skip Stays in Shape at 73 (00:06:46) – Skip Bayless’ Origin Story (00:25:44) – Skip’s Ability to Debate (00:31:27) – Skip Bayless vs. Shannon Sharpe (00:34:50) – How Much Skip Bayless Loves Sports (00:42:57) – Is Skip Bayless Racist? (00:47:29) – An Insane Story You’ve Never Heard (00:58:15) – Skip Reflects on His Career (01:02:37) – Best Bayless Quotes (01:15:42) – Does Skip Have Any Regrets? (01:16:05) – LeBron James (01:36:30) – How Skip Changed the Lives of Shannon Sharpe, Stephen A. Smith, and More

Sage Steele

42,173 views • 11 months ago

Months ago, Dustin Kittle reached out to me to tell me how our farmers are losing their farmland and the government is allowing it to happen. Dustin was one of the inspirations for starting my show in the first place because I thought to myself, "if people only knew." Last week I drove down to Tennessee to film this episode of him telling his story. I know I am a very small fish, but I hope this reaches the right people to make a difference to save our family farms. Dustin is not just a farmer, he is also a very successful lawyer. If he can't stop this, our small farms have no chance. We need President Trump and congress to step in immediately. --- 01:18 Dustin’s Background 03:30 Buying a Farm 07:35 What is Farm Credit? 09:27 Farm Credit Administration 12:34 Getting a Loan 22:37 Farm Credit Goes After His Mom 41:09 Extortion 47:22 File Complaint with FCA 58:51 What the FCA Did 01:05:47 Why is this Happening? 01:10:38 Foreclosure 01:19:21 After the Loan was Paid 01:25:08 FCA Releases Findings 01:31:21 Dustin Kittle Sues the President 02:02:25 What can we do? 02:06:56 Why Dustin was Targeted 02:21:05 Keeping People Quiet 02:22:51 What can Farmers Do? 02:25:38 Farm Credit Sues Dustin 02:29:35 Threats Against Dustin 02:34:20 Suing Biden and Not Trump 02:36:32 Foreign Governments Buying Farmland 02:37:46 What Farm Credit Does with the Land 02:43:14 What can we do - continued Quick Hitters 02:51:52 Thoughts on Brooke Rollins 02:56:35 Subsidies 03:01:54 Bird Flu 03:08:34 Country of Origin Labeling 03:10:32 Pesticide Immunity
3:28:52

Months ago, Dustin Kittle reached out to me to tell me how our farmers are losing their farmland and the government is allowing it to happen. Dustin was one of the inspirations for starting my show in the first place because I thought to myself, "if people only knew." Last week I drove down to Tennessee to film this episode of him telling his story. I know I am a very small fish, but I hope this reaches the right people to make a difference to save our family farms. Dustin is not just a farmer, he is also a very successful lawyer. If he can't stop this, our small farms have no chance. We need President Trump and congress to step in immediately. --- 01:18 Dustin’s Background 03:30 Buying a Farm 07:35 What is Farm Credit? 09:27 Farm Credit Administration 12:34 Getting a Loan 22:37 Farm Credit Goes After His Mom 41:09 Extortion 47:22 File Complaint with FCA 58:51 What the FCA Did 01:05:47 Why is this Happening? 01:10:38 Foreclosure 01:19:21 After the Loan was Paid 01:25:08 FCA Releases Findings 01:31:21 Dustin Kittle Sues the President 02:02:25 What can we do? 02:06:56 Why Dustin was Targeted 02:21:05 Keeping People Quiet 02:22:51 What can Farmers Do? 02:25:38 Farm Credit Sues Dustin 02:29:35 Threats Against Dustin 02:34:20 Suing Biden and Not Trump 02:36:32 Foreign Governments Buying Farmland 02:37:46 What Farm Credit Does with the Land 02:43:14 What can we do - continued Quick Hitters 02:51:52 Thoughts on Brooke Rollins 02:56:35 Subsidies 03:01:54 Bird Flu 03:08:34 Country of Origin Labeling 03:10:32 Pesticide Immunity

Anna Matson

88,930 views • 1 year ago

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI
1:30:01

He just quit. He was a primary editor for Diary of a CEO. So I asked him to tell all of his secrets for how he helps the Diary of a CEO be the number 1 podcast on YouTube. 00:00:00 Why Trailers Are Essential for Podcast Growth 00:03:30 Why Most People Are Doing Trailers Wrong 00:06:36 From Film and TV to Diary of a CEO 00:11:48 Retention Rates and What They Actually Mean 00:14:52 What Actually Makes a Podcast Good 00:17:00 Why the Guest Is 50% of Everything 00:22:59 What Makes a Great Podcast Host 00:26:31 Red Flags in Podcast Trailers 00:30:33 The Jefferson Fisher Hook Breakdown 00:34:16 The Louis Tomlinson Hook Breakdown 00:42:35 The 15 Point Checklist for the Perfect Trailer 00:45:28 The Oz Pearlman Hook (41 Second Rule) 00:48:06 The Laughter Track Hack 00:54:11 Sound Design and Visual Details 00:57:04 How to Choose Music Like a Film Director 01:00:02 Disney Imagineering Lesson 01:02:46 The Vanessa Van Edwards Hook Breakdown 01:07:02 The Kevin Hart Narrative Arc Breakdown 01:16:40 The A-B-C Storytelling Framework 01:20:13 The Easiest Win You Can Implement Right Now 01:22:36 How Diary of a CEO Uses AI

Grant

201,787 views • 5 days ago

How GPT-5 thinks, with OpenAI VP of Research Jerry Tworek 00:00 - Intro 01:01 - What Reasoning Actually Means in AI 02:32 - Chain of Thought: Models Thinking in Words 05:25 - How Models Decide How Long to Think 07:24 - Evolution from o1 to o3 to GPT-5 11:00 - The Road to OpenAI: Growing up in Poland, Dropping out of School, Trading 20:32 - Working on Robotics and Rubik's Cube Solving 23:02 - A Day in the Life: Talking to Researchers 24:06 - How Research Priorities Are Determined 26:53 - OpenAI's Culture of Transparency 29:32 - Balancing Research with Shipping Fast 31:52 - Using OpenAI's Own Tools Daily 32:43 - Pre-Training Plus RL: The Modern AI Stack 35:10 - Reinforcement Learning 101: Training Dogs 40:17 - The Evolution of Deep Reinforcement Learning 42:09 - When GPT-4 Seemed Underwhelming at First 45:39 - How RLHF Made GPT-4 Actually Useful 48:02 - Unsupervised vs Supervised Learning 49:59 - GRPO and How DeepSeek Accelerated US Research 53:05 - What It Takes to Scale Reinforcement Learning 55:36 - Agentic AI and Long-Horizon Thinking 59:19 - Alignment as an RL Problem 1:01:11 - Winning ICPC World Finals Without Specific Training 1:05:53 - Applying RL Beyond Math and Coding 1:09:15 - The Path from Here to AGI 1:12:23 - Pure RL vs Language Models
1:16:04

How GPT-5 thinks, with OpenAI VP of Research Jerry Tworek 00:00 - Intro 01:01 - What Reasoning Actually Means in AI 02:32 - Chain of Thought: Models Thinking in Words 05:25 - How Models Decide How Long to Think 07:24 - Evolution from o1 to o3 to GPT-5 11:00 - The Road to OpenAI: Growing up in Poland, Dropping out of School, Trading 20:32 - Working on Robotics and Rubik's Cube Solving 23:02 - A Day in the Life: Talking to Researchers 24:06 - How Research Priorities Are Determined 26:53 - OpenAI's Culture of Transparency 29:32 - Balancing Research with Shipping Fast 31:52 - Using OpenAI's Own Tools Daily 32:43 - Pre-Training Plus RL: The Modern AI Stack 35:10 - Reinforcement Learning 101: Training Dogs 40:17 - The Evolution of Deep Reinforcement Learning 42:09 - When GPT-4 Seemed Underwhelming at First 45:39 - How RLHF Made GPT-4 Actually Useful 48:02 - Unsupervised vs Supervised Learning 49:59 - GRPO and How DeepSeek Accelerated US Research 53:05 - What It Takes to Scale Reinforcement Learning 55:36 - Agentic AI and Long-Horizon Thinking 59:19 - Alignment as an RL Problem 1:01:11 - Winning ICPC World Finals Without Specific Training 1:05:53 - Applying RL Beyond Math and Coding 1:09:15 - The Path from Here to AGI 1:12:23 - Pure RL vs Language Models

Matt Turck

451,229 views • 9 months ago

Top Performance Coach Jim Murphy (Jim Murphy) reveals how to quiet the mind and execute when it matters most. Jim spent 5 years writing Inner Excellence, the mental toughness manual that shot from obscurity to #1 New York Times bestseller overnight when star athlete A.J. Brown was caught reading it on the sidelines of an NFL playoff game. 00:00 Introduction 01:01 The 3 Pillars of Inner Excellence 04:14 A Manual on Mental Toughness 07:55 Goals are Secondary 11:53 Clean Fuel vs. Dirty Fuel 14:23 What You Want Most 16:26 Ad Break 18:41 The Achievement Treadmill 21:47 The Busy Trap 22:34 The Best Vacation 25:39 What's Your Purpose? 27:41 The Spiral of Isolation 31:09 The Key to Performance 34:00 The Courage to Be Disliked 35:55 What the Most Successful People Do 39:49 Redefine Success and Failure 41:43 Comparison & Envy 42:53 Individual Cost and Collective Gain 46:31 Talking to Your Kids About Mental Toughness 47:34 Discovering Your Inner Excellence (Where to Start) 51:25 Tension Between Achievement and Happiness 55:09 Dealing With Guilt 58:10 Knowledge vs. Wisdom 01:01:21 Changing Focus to Accomplish Goals 01:05:40 Using Automatic Rules 01:10:40 Daily Mantras for Success 01:12:15 Ambition or Love? 01:14:52 Train Your Mind 01:15:38 What Is Success? Out now wherever you listen to the knowledge project. Includes paid partnerships.
1:16:32

Top Performance Coach Jim Murphy (Jim Murphy) reveals how to quiet the mind and execute when it matters most. Jim spent 5 years writing Inner Excellence, the mental toughness manual that shot from obscurity to #1 New York Times bestseller overnight when star athlete A.J. Brown was caught reading it on the sidelines of an NFL playoff game. 00:00 Introduction 01:01 The 3 Pillars of Inner Excellence 04:14 A Manual on Mental Toughness 07:55 Goals are Secondary 11:53 Clean Fuel vs. Dirty Fuel 14:23 What You Want Most 16:26 Ad Break 18:41 The Achievement Treadmill 21:47 The Busy Trap 22:34 The Best Vacation 25:39 What's Your Purpose? 27:41 The Spiral of Isolation 31:09 The Key to Performance 34:00 The Courage to Be Disliked 35:55 What the Most Successful People Do 39:49 Redefine Success and Failure 41:43 Comparison & Envy 42:53 Individual Cost and Collective Gain 46:31 Talking to Your Kids About Mental Toughness 47:34 Discovering Your Inner Excellence (Where to Start) 51:25 Tension Between Achievement and Happiness 55:09 Dealing With Guilt 58:10 Knowledge vs. Wisdom 01:01:21 Changing Focus to Accomplish Goals 01:05:40 Using Automatic Rules 01:10:40 Daily Mantras for Success 01:12:15 Ambition or Love? 01:14:52 Train Your Mind 01:15:38 What Is Success? Out now wherever you listen to the knowledge project. Includes paid partnerships.

Shane Parrish

575,883 views • 8 months ago

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:
1:46:38

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:

Sage Steele

46,033 views • 9 months ago

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors . Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging
1:29:44

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors . Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

Ashlee Vance

63,027 views • 9 months ago

Pierre Poilievre (Pierre Poilievre) shares his vision for making Canada the world's best place to build a life—with practical solutions for a more prosperous future. TKP is not a political podcast—and won't become one. I've invited both major party leaders to share their visions because I'm deeply concerned about how public discourse has degraded into angry soundbites. We've lost the ability to explore complex issues with patience and good faith. This conversation is my small effort to model what better dialogue might look like. (01:41) Headline vs Reality (03:55) From Opposition Party to Unifier (07:05) Parenthood Shapes Priorities (10:05) Differentiating from the Liberals (13:44) Economic Value Creation in Canada (16:48) WEF Opposition Stance (22:37) Opportunity Has Eroded (24:07) Balanced Budget Plan (26:55) Attracting Investments (34:05) Productivity Gap Explained (37:30) Tariffs Response Tactics (39:50) Reducing US Dependency (42:55) Interprovincial Trade Impacts (44:20) China (46:22) Media Accountability Challenges (50:22) Digital Free Speech Protections (53:50) Crime (01:00:40) Access to Health Care (01:04:55) A modern and effective Canadian military (01:09:50) AI: balance innovation with protection (01:12:50) Trust in government post-COVID (01:14:36) Climate change (01:17:30) Biggest misconceptions about him (01:18:30) What success for Canada looks like
1:19:26

Pierre Poilievre (Pierre Poilievre) shares his vision for making Canada the world's best place to build a life—with practical solutions for a more prosperous future. TKP is not a political podcast—and won't become one. I've invited both major party leaders to share their visions because I'm deeply concerned about how public discourse has degraded into angry soundbites. We've lost the ability to explore complex issues with patience and good faith. This conversation is my small effort to model what better dialogue might look like. (01:41) Headline vs Reality (03:55) From Opposition Party to Unifier (07:05) Parenthood Shapes Priorities (10:05) Differentiating from the Liberals (13:44) Economic Value Creation in Canada (16:48) WEF Opposition Stance (22:37) Opportunity Has Eroded (24:07) Balanced Budget Plan (26:55) Attracting Investments (34:05) Productivity Gap Explained (37:30) Tariffs Response Tactics (39:50) Reducing US Dependency (42:55) Interprovincial Trade Impacts (44:20) China (46:22) Media Accountability Challenges (50:22) Digital Free Speech Protections (53:50) Crime (01:00:40) Access to Health Care (01:04:55) A modern and effective Canadian military (01:09:50) AI: balance innovation with protection (01:12:50) Trust in government post-COVID (01:14:36) Climate change (01:17:30) Biggest misconceptions about him (01:18:30) What success for Canada looks like

Shane Parrish

847,030 views • 1 year ago

tylercowen is bullish on AI education — here's why. 00:00 -- Preview 00:24 -- President Carlos Carvalho's AI-generated intro 03:21 -- Cowen reacts to UATX's campus 04:38 -- The AI revolution is here. Who will lose the most? 06:05 -- AI lawyers 07:17 -- Don't underestimate this 10:41 -- Changes to the "upper upper middle class" 12:38 -- How to be successful 13:43 -- The rise of managerial empires 14:02 -- When will we have the first billion dollar company with one employee? 16:05 -- 10-20 year forecast 16:19 -- Why education is so behind 17:01 -- Should you be bullish on UATX? 18:36 -- Should you still read Homer? 21:50 -- Write to think 25:01 -- Meet more people 25:42 -- How to get hired 26:54 -- Is AI your best mentor? 38:17 -- How to curb cheating 39:02 -- The new life of the mind 42:34 -- Q&A: Will there be more status associated with real education or AI education? 45:50 -- Q&A: Why do tech-savvy students need to practice using AI? 47:56 -- Q&A: Do LLMs atrophy your mind? 49:29 -- Q&A: How do you avoid AI-dependency? 51:05 -- Q&A: Isn't this vision lonely and isolating? 53:06 -- Q&A: Do students need teachers? 55:36 -- Q&A: What are the four most important courses for undergrads? 57:49 -- Q&A: Which AI company will win the AI race in the next five years and why? 59:22 -- Q&A: Can AI teach religion? 01:01:32 -- Q&A: Will AI narrow or widen our world? 01:04:37 -- Q&A: What makes us human? 01:05:42 -- Q&A: What is art? 01:08:33 -- Q&A: It's easy to catch cheaters
1:10:31

tylercowen is bullish on AI education — here's why. 00:00 -- Preview 00:24 -- President Carlos Carvalho's AI-generated intro 03:21 -- Cowen reacts to UATX's campus 04:38 -- The AI revolution is here. Who will lose the most? 06:05 -- AI lawyers 07:17 -- Don't underestimate this 10:41 -- Changes to the "upper upper middle class" 12:38 -- How to be successful 13:43 -- The rise of managerial empires 14:02 -- When will we have the first billion dollar company with one employee? 16:05 -- 10-20 year forecast 16:19 -- Why education is so behind 17:01 -- Should you be bullish on UATX? 18:36 -- Should you still read Homer? 21:50 -- Write to think 25:01 -- Meet more people 25:42 -- How to get hired 26:54 -- Is AI your best mentor? 38:17 -- How to curb cheating 39:02 -- The new life of the mind 42:34 -- Q&A: Will there be more status associated with real education or AI education? 45:50 -- Q&A: Why do tech-savvy students need to practice using AI? 47:56 -- Q&A: Do LLMs atrophy your mind? 49:29 -- Q&A: How do you avoid AI-dependency? 51:05 -- Q&A: Isn't this vision lonely and isolating? 53:06 -- Q&A: Do students need teachers? 55:36 -- Q&A: What are the four most important courses for undergrads? 57:49 -- Q&A: Which AI company will win the AI race in the next five years and why? 59:22 -- Q&A: Can AI teach religion? 01:01:32 -- Q&A: Will AI narrow or widen our world? 01:04:37 -- Q&A: What makes us human? 01:05:42 -- Q&A: What is art? 01:08:33 -- Q&A: It's easy to catch cheaters

University of Austin (UATX)

27,770 views • 6 months ago

Michael Bolin (Michael Bolin) is the tech lead of the Codex open source repository at OpenAI and formerly a distinguished eng (E9) at Meta. I asked him for all the details on his career story and how he uses Codex for max benefit. Timestamps: 00:00:00 - Intro 00:00:56 - Chickenfoot 00:02:45 - Working at Google 00:06:34 - Overhauling Facebook's build system 00:16:36 - Rewriting Facebook's IDE 00:26:01 - Struggles after Principal Eng (E8) promo 00:28:39 - Building a virtual filesystem for Facebook 00:35:47 - Delayed Distinguished promo (E9) and learnings 00:39:56 - Joining OpenAI 00:43:05 - Research-led vs engineering-led cultures 00:44:53 - The story behind Codex 00:51:00 - How he uses Codex 00:57:00 - Why Codex's harness is open source 00:59:50 - Top technical book recommendations 01:05:02 - Why deep technical skills are still valuable (for now) 01:11:07 - How to start projects well 01:14:27 - Advice on writing better and career planning 01:17:06 - Advice for his younger self 01:19:10 - Outro He was a dream guest of mine and I'm excited to share his story with you all! Other places to watch: • YouTube: • Spotify: • Apple Podcasts: • Transcript:
1:20:03

Michael Bolin (Michael Bolin) is the tech lead of the Codex open source repository at OpenAI and formerly a distinguished eng (E9) at Meta. I asked him for all the details on his career story and how he uses Codex for max benefit. Timestamps: 00:00:00 - Intro 00:00:56 - Chickenfoot 00:02:45 - Working at Google 00:06:34 - Overhauling Facebook's build system 00:16:36 - Rewriting Facebook's IDE 00:26:01 - Struggles after Principal Eng (E8) promo 00:28:39 - Building a virtual filesystem for Facebook 00:35:47 - Delayed Distinguished promo (E9) and learnings 00:39:56 - Joining OpenAI 00:43:05 - Research-led vs engineering-led cultures 00:44:53 - The story behind Codex 00:51:00 - How he uses Codex 00:57:00 - Why Codex's harness is open source 00:59:50 - Top technical book recommendations 01:05:02 - Why deep technical skills are still valuable (for now) 01:11:07 - How to start projects well 01:14:27 - Advice on writing better and career planning 01:17:06 - Advice for his younger self 01:19:10 - Outro He was a dream guest of mine and I'm excited to share his story with you all! Other places to watch: • YouTube: • Spotify: • Apple Podcasts: • Transcript:

Ryan Peterman

119,601 views • 5 months ago

Here's exactly how a 22 year old returned 283% in last year's US Investing Championship: ∙Listening to the stocks you're trading ∙Managing risk, and fighting for huge R:R multiples ∙Martin's journey and key influences ∙Equity curve mindset Great work Martin Luk — Timestamps: 00:00 – How a 100% trade shifted Martin’s entire mindset 01:31 – Lessons from studying prior big movers 04:54 – Starting with $1,300 in 2020 and early influences 08:56 – From tripling his account to a brutal 50% drawdown 13:23 – Foundational growth through books, podcasts, and mentors 17:02 – Adopting a tighter stop strategy from Christian Kalayjian 24:27 – Martin’s swing trading style, low win rate, high R setups 30:50 – Why tight stops lead to parabolic R multiple gains 33:51 – Backtesting winners: Big movers rarely revisit breakout lows 36:00 – Ideal entry tactics: Inside days, ORH, and prior day highs 40:45 – Sell strategies: Into strength vs. trailing stops 47:50 – Case study: SMCI trade and painful exit mistake 55:10 – COIN trade driven by crypto correlation and pattern break 01:01:10 – GME & AMC: Fast gains using tight intraday structure 01:10:18 – Traditional breakout example: SOFI 01:16:33 – Parabolic trade and sell signals using volume and distance 01:21:19 – QUBT re-entry and lessons on precise breakout timing 01:24:52 – Best loss of the year: SMTC and honoring stops 01:26:50 – Mistakes from CSK and recognizing emotional entries 01:30:38 – Martin’s scanning system: Pre-market, daily, and leaders 01:35:22 – How watchlists reveal market health and trend 01:42:03 – Short setup breakdowns: Declining EMA + intraday resistance 01:50:12 – SMCI short and trailing rules for shorts vs. longs 01:55:03 – Using your equity curve as market feedback 02:01:09 – Martin’s top trading weaknesses and progress 02:03:07 – Reducing drawdowns: Lessons from SURF loss 02:08:01 – Final advice: Trading is a marathon, not a sprint Have a great weekend! 🦁
2:18:43

Here's exactly how a 22 year old returned 283% in last year's US Investing Championship: ∙Listening to the stocks you're trading ∙Managing risk, and fighting for huge R:R multiples ∙Martin's journey and key influences ∙Equity curve mindset Great work Martin Luk — Timestamps: 00:00 – How a 100% trade shifted Martin’s entire mindset 01:31 – Lessons from studying prior big movers 04:54 – Starting with $1,300 in 2020 and early influences 08:56 – From tripling his account to a brutal 50% drawdown 13:23 – Foundational growth through books, podcasts, and mentors 17:02 – Adopting a tighter stop strategy from Christian Kalayjian 24:27 – Martin’s swing trading style, low win rate, high R setups 30:50 – Why tight stops lead to parabolic R multiple gains 33:51 – Backtesting winners: Big movers rarely revisit breakout lows 36:00 – Ideal entry tactics: Inside days, ORH, and prior day highs 40:45 – Sell strategies: Into strength vs. trailing stops 47:50 – Case study: SMCI trade and painful exit mistake 55:10 – COIN trade driven by crypto correlation and pattern break 01:01:10 – GME & AMC: Fast gains using tight intraday structure 01:10:18 – Traditional breakout example: SOFI 01:16:33 – Parabolic trade and sell signals using volume and distance 01:21:19 – QUBT re-entry and lessons on precise breakout timing 01:24:52 – Best loss of the year: SMTC and honoring stops 01:26:50 – Mistakes from CSK and recognizing emotional entries 01:30:38 – Martin’s scanning system: Pre-market, daily, and leaders 01:35:22 – How watchlists reveal market health and trend 01:42:03 – Short setup breakdowns: Declining EMA + intraday resistance 01:50:12 – SMCI short and trailing rules for shorts vs. longs 01:55:03 – Using your equity curve as market feedback 02:01:09 – Martin’s top trading weaknesses and progress 02:03:07 – Reducing drawdowns: Lessons from SURF loss 02:08:01 – Final advice: Trading is a marathon, not a sprint Have a great weekend! 🦁

TraderLion

13,458 views • 1 year ago

E180: KAST Founder: Most crypto neobanks will be gone in 12 months raagulanpathy is the founder and CEO of KAST , a global stablecoin neobank, and a former Circle exec. He raised $80 million at a $600 million valuation on the thesis that the real prize isn't the stablecoin - it's the bank you build on top of it. We get into the money, the grind, and the token decision that pissed a chunk of his community off. Timestamps 00:00 Introduction 01:58 How Raagulan Decides What Gets Done At KAST 04:35 The Chaos KAST Employees Deal With Daily 05:38 Raagulan's Hiring Philosophy At KAST 07:02 Why Firing Is Harder Than Hiring 08:35 The One Error That Could Kill KAST 09:52 How Raagulan Convinces Stablecoin Skeptics 10:46 What Outsiders Miss About The Payment Industry 12:06 Why KAST Needs So Many Different Departments 18:32 Partnerships: Variational & Bitwise 19:24 Raagulan's Real Take On Fees 21:55 KAST's Best Type Of Customer 23:53 The Thing Raagulan Can't Say Publicly 26:54 Founders Can't Chase All These Three Things At Once 29:04 Raagulan's Experience With GLP-1s 31:39 How KAST Kept Growing When Bitcoin Crashed 50% 34:05 KAST Is On Track For $100 Million In Revenue 36:55 Why KAST Hasn't Blown Up From Overspending 41:04 Why Everyone's Racing To Build Neobanks 42:52 What Makes Neobanks So Hard To Build 44:54 Why Neobanks Keep Shutting Down 45:57 What KAST Offers That Exchanges Can't 49:14 KAST Isn't A Card Business 50:43 How KAST Is Building Momentum 54:57 Raagulan On His Competitors 56:29 Partnerships: KAST & Trezor 57:33 Kevin's Honest Take On KAST 58:59 What KAST Is Doing With the $80 Million they raised 01:01:55 Would Raagulan Ever Sell Equity? 01:06:57 Who Buys In At A $3B Valuation Next? 01:08:39 Is Your Money Actually Yours Inside KAST 01:10:49 What Happens To Your Money If KAST Collapses 01:17:38 Custodial Vs Self-Custodial: Pros And Cons 01:19:52 Why KAST Obsesses Over Design And Brand 01:22:42 Partnerships: Jupiter & Ethena 01:23:26 KAST Points & Token: Should The KAST Community Feel Cheated? 01:34:13 What's Actually Behind This Tokenized Stock? 01:35:25 The Hill Raagulan Will Die On 01:36:41 One Prediction That Comes True In 5 Years 01:37:59 Is The Worst Behind Us In Crypto? 01:42:57 The One Thing To Remember From This Conversation 01:45:16 Closing Thoughts
1:46:06

E180: KAST Founder: Most crypto neobanks will be gone in 12 months raagulanpathy is the founder and CEO of KAST , a global stablecoin neobank, and a former Circle exec. He raised $80 million at a $600 million valuation on the thesis that the real prize isn't the stablecoin - it's the bank you build on top of it. We get into the money, the grind, and the token decision that pissed a chunk of his community off. Timestamps 00:00 Introduction 01:58 How Raagulan Decides What Gets Done At KAST 04:35 The Chaos KAST Employees Deal With Daily 05:38 Raagulan's Hiring Philosophy At KAST 07:02 Why Firing Is Harder Than Hiring 08:35 The One Error That Could Kill KAST 09:52 How Raagulan Convinces Stablecoin Skeptics 10:46 What Outsiders Miss About The Payment Industry 12:06 Why KAST Needs So Many Different Departments 18:32 Partnerships: Variational & Bitwise 19:24 Raagulan's Real Take On Fees 21:55 KAST's Best Type Of Customer 23:53 The Thing Raagulan Can't Say Publicly 26:54 Founders Can't Chase All These Three Things At Once 29:04 Raagulan's Experience With GLP-1s 31:39 How KAST Kept Growing When Bitcoin Crashed 50% 34:05 KAST Is On Track For $100 Million In Revenue 36:55 Why KAST Hasn't Blown Up From Overspending 41:04 Why Everyone's Racing To Build Neobanks 42:52 What Makes Neobanks So Hard To Build 44:54 Why Neobanks Keep Shutting Down 45:57 What KAST Offers That Exchanges Can't 49:14 KAST Isn't A Card Business 50:43 How KAST Is Building Momentum 54:57 Raagulan On His Competitors 56:29 Partnerships: KAST & Trezor 57:33 Kevin's Honest Take On KAST 58:59 What KAST Is Doing With the $80 Million they raised 01:01:55 Would Raagulan Ever Sell Equity? 01:06:57 Who Buys In At A $3B Valuation Next? 01:08:39 Is Your Money Actually Yours Inside KAST 01:10:49 What Happens To Your Money If KAST Collapses 01:17:38 Custodial Vs Self-Custodial: Pros And Cons 01:19:52 Why KAST Obsesses Over Design And Brand 01:22:42 Partnerships: Jupiter & Ethena 01:23:26 KAST Points & Token: Should The KAST Community Feel Cheated? 01:34:13 What's Actually Behind This Tokenized Stock? 01:35:25 The Hill Raagulan Will Die On 01:36:41 One Prediction That Comes True In 5 Years 01:37:59 Is The Worst Behind Us In Crypto? 01:42:57 The One Thing To Remember From This Conversation 01:45:16 Closing Thoughts

MR SHIFT 🦁

170,665 views • 14 days ago

My Divot interview with The Church of Jesus Christ of Latter-day Saints Apostle Neil L. Andersen. We talk about how to build a life of faith, what happens after death, dangers of ego, strength of humility, good vs evil, how he was called as an Apostle, feeling forgiveness, and being my dad. Timestamps: 01:14 — The Burden Everyone Carries in Life 02:23 — The Real Game of Life: Good vs Evil 08:23 — Growing Up on a Farm 09:31 — The Experience That Expanded His World 11:21 — From Self to Service 12:40 — Why Helping Others Creates Meaning 16:48 — Faith Is a Muscle 23:41 — How to Rebuild Faith When You’ve Lost It 27:19 — Why Humility Is the Source of Real Strength 30:22 — Speaking About Faith in a Modern World 32:54 — What Happens After Death 40:01 — The Danger of Ego and Recognition 45:08 — The Call That Changed His Life 53:04 — Becoming an Apostle 57:13 — His Core Responsibility 01:03:20 — The Hardest Part: Helping People in Pain 01:14:00 — Forgiveness: Why You’re Never Too Far Gone 01:18:13 — The One Idea He Would Teach the World 01:19:08 — How He Measures a Good Life Hashtags: #faith #faithjourney #forgiveness #purpose #meaningoflife #lifelessons #personalgrowth #selfimprovement #mindset #humility #service #familyvalues #fatherandson #spiritualgrowth #resilience #leadership #divotpodcast
1:19:50

My Divot interview with The Church of Jesus Christ of Latter-day Saints Apostle Neil L. Andersen. We talk about how to build a life of faith, what happens after death, dangers of ego, strength of humility, good vs evil, how he was called as an Apostle, feeling forgiveness, and being my dad. Timestamps: 01:14 — The Burden Everyone Carries in Life 02:23 — The Real Game of Life: Good vs Evil 08:23 — Growing Up on a Farm 09:31 — The Experience That Expanded His World 11:21 — From Self to Service 12:40 — Why Helping Others Creates Meaning 16:48 — Faith Is a Muscle 23:41 — How to Rebuild Faith When You’ve Lost It 27:19 — Why Humility Is the Source of Real Strength 30:22 — Speaking About Faith in a Modern World 32:54 — What Happens After Death 40:01 — The Danger of Ego and Recognition 45:08 — The Call That Changed His Life 53:04 — Becoming an Apostle 57:13 — His Core Responsibility 01:03:20 — The Hardest Part: Helping People in Pain 01:14:00 — Forgiveness: Why You’re Never Too Far Gone 01:18:13 — The One Idea He Would Teach the World 01:19:08 — How He Measures a Good Life Hashtags: #faith #faithjourney #forgiveness #purpose #meaningoflife #lifelessons #personalgrowth #selfimprovement #mindset #humility #service #familyvalues #fatherandson #spiritualgrowth #resilience #leadership #divotpodcast

Derek Andersen

125,634 views • 3 months ago

Xavier Leroy (creator of OCaml) is an expert in compilers, formal verification of software and functional programming. This interview should be an approachable resource if you're curious about formal verification of software since I was learning that on the fly during it. In this episode: • OCaml compared with Rust and JavaScript • What is formal verification and how does it work • How languages call each other across boundaries • How to address "almost-correct" LLM code • How type inference works in programming languages Where to watch: • YouTube - • Spotify - • Apple Podcasts - • Transcript - Thank you to the sponsor of this episode for supporting my work: • WorkOS: makes your app Enterprise Ready with easy to use APIs to add SSO, SCIM, RBAC, and more in just a few lines of code, check them out at Chapters: 00:00 - Intro 00:43 - What sets OCaml apart 04:39 - OCaml vs Rust 07:57 - Why is manual memory management more performant 11:21 - Javascript vs OCaml 14:00 - Famous Rob Pike quote 16:05 - Type inference and how it works 22:12 - What is formal verification and how does it work 40:07 - What made multicore support difficult for OCaml 50:17 - How programming languages interface and call each other 57:41 - The danger of almost-correct LLM code 01:05:39 - How LLMs will change programming languages 01:10:26 - Industry vs academia 01:15:05 - Most interesting unsolved problems 01:18:30 - Top book recommendations for engineers 01:21:17 - Advice for his younger self 01:23:31 - Outro
1:24:27

Xavier Leroy (creator of OCaml) is an expert in compilers, formal verification of software and functional programming. This interview should be an approachable resource if you're curious about formal verification of software since I was learning that on the fly during it. In this episode: • OCaml compared with Rust and JavaScript • What is formal verification and how does it work • How languages call each other across boundaries • How to address "almost-correct" LLM code • How type inference works in programming languages Where to watch: • YouTube - • Spotify - • Apple Podcasts - • Transcript - Thank you to the sponsor of this episode for supporting my work: • WorkOS: makes your app Enterprise Ready with easy to use APIs to add SSO, SCIM, RBAC, and more in just a few lines of code, check them out at Chapters: 00:00 - Intro 00:43 - What sets OCaml apart 04:39 - OCaml vs Rust 07:57 - Why is manual memory management more performant 11:21 - Javascript vs OCaml 14:00 - Famous Rob Pike quote 16:05 - Type inference and how it works 22:12 - What is formal verification and how does it work 40:07 - What made multicore support difficult for OCaml 50:17 - How programming languages interface and call each other 57:41 - The danger of almost-correct LLM code 01:05:39 - How LLMs will change programming languages 01:10:26 - Industry vs academia 01:15:05 - Most interesting unsolved problems 01:18:30 - Top book recommendations for engineers 01:21:17 - Advice for his younger self 01:23:31 - Outro

Ryan Peterman

23,500 views • 17 days ago