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Replies blowing up in this tweet because Caedrel crashed out over it on stream Since I’m basically being called an idiot in this here’s the issues: 1) the problem right now is not people calling out costreamers it’s the opposite and Sjokz just addressed this on TikTok - costreamer...

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$ABCL CEO Carl Hansen explains the net negative overall value creation in biotech and how AbCellera plans to beat it: “I really think it can be beat because there’s a lot of mistakes that get made in where you allocate capital.” “If you’re a biotech and you start a company on a drug, and you go public and have a drug, and now the data is looking not that great, you just keep running that drug. … Because if you quit that drug, the company is done.” “So, because you’re so concentrated on one thing, you end up having blinders. It’s like a cult of a molecule. And even a real, practical, capital access problem that makes you continue to move things forward” ______________________________________ “Another problem is that many of the drugs that get started, get started by people who don’t understand the competitive or commercial landscape and have no intent of ever actually manufacturing it. … Because they know someone else is going to buy it. So then their framework is not ‘Am I making a drug that’s going to make a difference for people?’ The framework is ‘Can I make something that I think someone will take off my hands?’ And that happens a lot.” “There are many acquisitions where a big pharma company spends $10B, $20B, and it’s a complete bust. So really no value is generated for patients but someone was able to get a good exit on that because they anticipated what someone would want. And a lot of decision making gets done like that”. _______________________________________ “I’m not saying that we have this all solved. But what we’re trying to do is create a framework where we are able to take many bets so that we don’t fall in love with anything, or we don’t have to fall in love with anything. … And then always hold up very explicitly what we know and what we don’t know along the dimensions that matter. The dimensions that matter are - Will it work? That’s a science. - When it gets where will people care? - Is it differentiated? - Does it solve a big problem? In order to get it there, is there a path with our resources and expertise that would allow us to see it through?” “When you start to hold things up like that, you start to see where the mistakes are, where the uncertainties are, and you can be more rational in deciding ‘We’re going to run it to here because we get to flip the card and if the card goes the wrong way we’re going to kill it because we’ve got something else behind it.’” “I do think that if done right, and if you can pick the right opportunities, the success rate can be well higher than an order of magnitude better. … And there are examples of this… companies I’ve mentioned, you know, Regeneron, their success rate is at least 10x the industry in bringing programs forward and getting them approved. … So it’s… you can do it better that way”

Jack Prescott

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.David Deutsch: "What's currently called AI and AGI are not only different from each other, they are very close to being the exact opposites of each other. The reason is that an AI, current AI is like an AI that diagnoses diseases or an AI that plays chess or an AI that controls a huge factory. Those things have objective functions, that is they have a function that they are designed to maximize and that is why they are used in those particular applications. Or in military terms, you could say the objective is to hit the target. You might say the objective is to hit the target unless some thing specified, but it's a specified thing comes up in which case don't hit the target and so on. This is, as I said, almost the opposite of what humans do when humans think. For a start, the AI has to be obedient, that is it has to actually do the things it is programmed to do, whereas a human is fundamentally disobedient, especially when being creative. When a human plays chess, they are performing a completely different kind of computation. They don't do the same things, they don't investigate the same possibilities that the artificial chess playing machine does, because the artificial one is capable of looking at billions and billions of possibilities, whereas the human can only look at hundreds or something. They are doing something completely different. Another difference is that the human can explain, can write a book later, having become world champion, can write a book saying how I did it, as the computer program that beats the world champion can write no such book, because it has no idea how it did it. It was just following a program. I was doing this and that and that and none of that is illuminating. Also, third thing, the chess player can decide I don't want to play chess anymore, from now on I will play Go or from now on I will play tennis. If commanded to play chess, the functionality will deteriorate completely. Those things are different. What we want in an AGI is that it behaves in a way that cannot be specified in advance, because if you specified it, you would already have the answer. The AGI program has to give unexpected answers, answers to questions we didn't even know how to ask."

Deutsch Explains

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I shared a video from Nick Freitas yesterday about how to encourage and reach young men. You should check it out if you didn’t see it. Now, here is a clip that shows how to repel and discourage young men. This is so frustrating, Sean DeMars and Neil Shenvi. Leaving aside the whole “woke right” thing, whatever. You acknowledge that the Left has total cultural control. Then you mock the idea that white men are systemically discriminated against in our culture, or that we live in an effeminate gynocracy. What do you think the Left does with its total cultural control? You mock young men by claiming that their discrimination has no basis in reality, but has to be understood via some “gnostic” higher knowledge. This is not fair. We are starting to get more and more hard data on this issue. I will admit that there is an element of “look around, this should be obvious.” It should be, and you’re really sticking your head in the sand to deny these things. But being on the Right is to believe in God’s created reality. It’s not about “lived experience,” it’s about what is actually true. White men are being discriminated against in this culture, and the West has been feminized radically in the last 60 years. The biggest problem with the woke was always that they were wrong, beyond even their philosophical system. It wasn’t merely that they were claiming to be oppressed, but it was that this claim was wrong. "This argument sounds like that argument" is just so lazy when one was factually wrong, and one is factually right. The claims of the Right are correct in general. But at the end of the day, good luck crapping on young men like this. We'll see how that works out for you. I won’t be joining you.

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The Rapid Growth of SpaceX, Starlink, Starshield & Armada: “I am very grateful that SpaceX is an American company.” "Data centers in space is coming, & it makes sense" “5 years ago they hadn’t even launched Starlink—now it’s in 150 countries & it’s continuing to grow every week.” “It’s an unfair advantage that we have with Starshield.” “If the world can get access to SpaceX, I think that’s a good thing.” Dan Wright (Dan Wright), CEO of Armada Elon (Elon Musk) builds long-term advantage, then unleashes it at massive scale: SpaceX, Starlink, Tesla, Neuralink, xAI.. . . . "We started the company working with SpaceX & they’ve continued to be a great partner for us. What that means is that as SpaceX rolls out throughout the world—& most people don’t know 5 years ago they hadn’t even launched Starlink —it’s in 150 countries & it’s continuing to grow every week. We are the first mover when it comes to the infrastructure, & that partnership works really well because we complement the connectivity with the infrastructure & the AI. We always are at the edge. It’s funny, I get messages from our team all the time & it’s like the most crazy places you can imagine. And the edge is gonna continue to get redefined. I get calls literally—I was on the call with somebody and they’re like, “Hey, can we get one of these in Antarctica?” I’m like, “Well yeah, Starlink’s live in Antarctica. No reason why we can’t do that.” Obviously data center in space is the new hotness. Everybody’s talking about it." "Yeah, what’s the deal with that—so are you gonna get these in space?" :They are modular. I mean the edge is continuing—this is actually a debate that we have in terms of how soon it’s going to happen—but it’s definitely going to happen. Data centers in space is coming, and it makes sense, right? If you think about what SpaceX is talking about with Starship going to the moon—you’re going to need compute, especially as you start to think about Optimus robots building bases on the moon, later Mars. You’re going to need large amounts of compute. Not to mention a lot of the things that we do here on Earth, you’re gonna want to do there in space. And it’s a lot more efficient to do it, especially in hostile environments, if you can automate more of that—things like mining, for example. And so you’re gonna see data centers in space, and I’m sure we’re definitely gonna be a part of it. "What do you think about SpaceX’s rumored IPO for 2026?" "I mean, I think SpaceX is an incredible company and they have a ton of value. So I don’t have any insider information here—but I would say, hey, if the world can get access to SpaceX, I think that’s a good thing. Starlink is really amazing in the sense that it just continues to get better so fast. They’re rolling out in new countries every week in major markets. Just as a real recent example, just this last week they launched in South Korea—big market and an important ally for the US, so that’s a big deal. They’re also expanding the types of services that are available. It started as a consumer product, then they brought it to enterprise. Initially that was used more as a backup, and now it’s being used more as a primary—and that is because the service keeps getting better and better as more satellites go up into the sky. Each generation of satellite is also better, not to mention the terminals on the ground. There’s now multiple types of terminals, including the more recent minis that people really like—“Hey, I can put it in a backpack if I go on a hike or if I’m traveling. I can put it on the ski rack of my car.” Perfect internet all the time. All that does for us is it gives us more use cases that we can unlock. Now that you have connectivity on the oil rig, or on a farm, or a ranch—wherever you are—we can apply the AI to those situations on the ground without latency, and then send the metadata back to some other location that they want it. Part of the full-stack approach. And also with Starshield—that’s a huge advantage when you think about some of the conflicts that are going on. People talk to me a lot about this race with China and the geopolitical conflicts around the world. I am very grateful that SpaceX is an American company. I feel like it’s an unfair advantage that we have with Starshield available to the DoD. We want to be the first mover with the infrastructure and the AI to help solve problems at the edge, and the work we’re doing with the Navy is a good example of that."

Molly O’Shea

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