Loading video...

Video Failed to Load

There was a problem loading this video. This could be due to a temporary network issue or the video might be unavailable.

Resolving inflammation and preserving membrane fluidity are two powerful ways omega-3s support cardiovascular health. Chronic inflammation is one of the main drivers of atherosclerosis, which is likely why a higher omega-3 index has been associated with up to a 40% lower risk of cardiovascular events in observational studies. This... show more

Dr. Rhonda Patrick

1,845,587 subscribers

60,212 views • 6 days ago •via X (Twitter)

Health & Wellness Science & Technology

Anya Rossi• Live Now

Private livecam show

26 Comments

WorldPeptideAssociation6 days ago

i believe that inflammation is the foundation for all issues - this can be acute or chronic. or acute that turns into chronic issues including cancers.

Bryan6 days ago

Love it. Thanks again, Rhonda

beetjusthanginaround6 days ago

inflamation is gay

sciqst6 days ago

The 40% figure makes me wonder how much is residual confounding versus a causal effect—especially given mixed supplementation trials. Curious whether the association holds after accounting for statins and diet. Sci-Quest reviews the literature:

Dr. METAL6 days ago

Completely agree — resolving chronic inflammation and keeping cell membranes fluid are two of the biggest levers omega-3s pull for cardiovascular protection. What often gets missed is how much oral inflammation feeds that fire. Deep periodontal pockets pour cytokines and bacteria like P. gingivalis straight into circulation, driving the same systemic inflammatory load that damages arteries. Omega-3s help dampen that downstream signal while supporting membrane integrity everywhere, including the endothelium. I focus on high-quality sources (wild-caught salmon or a rigorously tested triglyceride-form fish oil) and keep my omega-3 index in the optimal range. It’s one of the few interventions that actually moves both oral and cardiovascular risk in the same direction. Solid clip, Rhonda. 🤘😎

RafaelLugo md6 days ago

Totally agree and believe so and also the antithrombin effects regulating arachidonic acid pathways and thromboxane a3 omega thread generate. Not to mention prostacyclin generation. So it is as expected multiple additive effects. Summary. Take the damn omega 3

Ptross_the_general 🇺🇸⭐️⭐️6 days ago

The pattern-tracking angle is useful here too—diet, sleep, movement, and how you feel over time can add context without chasing a single “superfood.” Small observations make for a better wellness conversation.

Sunny Day5 days ago

Seed oils are ver inflammatory

Owen Fitness6 days ago

Interesting connection between omega-3s, inflammation and cardiovascular health. How often do you recommend people actually test their omega-3 index?

PerformanceProtocol6 days ago

mega-3 index is a biomarker that correlates with overall dietary quality High fish eaters tend to eat better across the board The mechanism is solid but the magnitude needs an RCT to confirm

Dr. Biglee Murali | Strength, Hormones, Lifestyle6 days ago

Omega-3 is one of those nutrients where food-first makes a lot of sense.Fatty fish regularly can be a simple way to support triglycerides and cardiovascular health—without turning your diet into a supplement checklist.

EyeCoin6 days ago

Omega-3s support heart health by helping regulate inflammation and maintain healthy cell membranes.

Eric K Atwood6 days ago

CBD for inflamation, also doing sauna -> cold -> sauna type of activities

doug6 days ago

What is best quality brands

Dr. Olivia Dack, ND5 days ago

Mechanism is compelling, but keep the endpoint label visible: an observational omega-3 index association isn’t randomized event reduction, and “up to 40%” shouldn’t become a supplement promise. The membrane/resolution biology is still worth discussing.

Capsuline5 days ago

Fish oil oxidizes fast once opened. TOTOX score under 26 and peroxide value under 10 are markers worth checking on a COA. Softgels or sealed hard caps protect each dose from air contact. The membrane fluidity benefit holds much better when the oil is intact going in.

Brett Hudson | Zyndio5 days ago

The omega 3 index might be the most underrated biomarker in preventive health. When your index is below 4%, cardiovascular risk climbs dramatically. Above 8% and you are in a completely different risk category. Resolving chronic inflammation is not optional. God designed our cardiovascular system to last. We have to fuel it correctly. Are you tracking your omega 3 index?

Kit5 days ago

Change what you eat. The big inflammation food is sugar. I make sure I eat foods with <6gr of sugar in it. If I bake I substitute something else. I make sure I do not eat over >6gr a day. Sugar causes arthritis. More veggies, salmon, less sweets!

John Book6 days ago

Wild-caught salmon and sardines ----> Legit superfoods

John Loschiavo6 days ago

Bigger picture for me is keeping chronic inflammation down as we get older without turning it into another optimisation project. Omega-3s are a pretty easy place to start. Eat some oily fish, supplement if needed, then get on with the rest of the boring stuff that matters.

Andy Lemieux6 days ago

Best sources of omega 3?

Tuấn Rủi Ro6 days ago

40% quan sát, không phải

Pure City6 days ago

Worth noting that the 40% figure comes from association studies. In trials, EPA+DHA (VITAL, ASCEND, STRENGTH) missed its main heart endpoint; only prescription EPA at 4 g/day (REDUCE-IT) cut events, and high doses raise AF risk. Our review:

Whip_a_Tesla0075 days ago

Practical floor that tracks with the index work: fatty fish twice a week, or a tested omega-3 if diet is thin. Quieting chronic inflammation is the quiet cardiovascular win.

TJ Hubbard6 days ago

The membrane fluidity angle is underrated. Stiff cell membranes, stiff arteries, stiff thinking. Fluidity shows up everywhere. Most people chase exotic supplements while missing the foundational fats.

Activehood5 days ago

Excellent, thank you, my question is supplementation as effective as fatty fish for EPA and DHA intake. Do we need to supplement if we don't eat fish much?

Related Videos

Taking ~2 grams/day of omega-3s may be one of the simplest high-ROI habits for lifespan and cardiovascular health At that dose, most people can move their omega-3 index from ~4% to ~8%, a range linked in observational studies to a ~5-year increase in life expectancy and ~90% lower risk of sudden cardiac death To put that in perspective, a low omega-3 index has been associated with a life expectancy gap similar to smoking Yet the vast majority of Americans fall short on EPA and DHA Few interventions this impactful are this easy All you have to do is take a fish oil supplement

Taking ~2 grams/day of omega-3s may be one of the simplest high-ROI habits for lifespan and cardiovascular health At that dose, most people can move their omega-3 index from ~4% to ~8%, a range linked in observational studies to a ~5-year increase in life expectancy and ~90% lower risk of sudden cardiac death To put that in perspective, a low omega-3 index has been associated with a life expectancy gap similar to smoking Yet the vast majority of Americans fall short on EPA and DHA Few interventions this impactful are this easy All you have to do is take a fish oil supplement

FoundMyFitness Clips

65,937 views • 3 months ago

Taking around 2 grams of omega-3s per day might be one of the highest-ROI habits for lifespan and cardiovascular protection At that dose, most people can move their omega-3 index from ~4% to ~8%, a range associated in observational studies with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death Omega-3s also support brain function and mood, with clear benefits for depression and cognition Yet nearly 90% of Americans fall short of recommended EPA and DHA intake Few interventions this impactful are this easy

Taking around 2 grams of omega-3s per day might be one of the highest-ROI habits for lifespan and cardiovascular protection At that dose, most people can move their omega-3 index from ~4% to ~8%, a range associated in observational studies with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death Omega-3s also support brain function and mood, with clear benefits for depression and cognition Yet nearly 90% of Americans fall short of recommended EPA and DHA intake Few interventions this impactful are this easy

FoundMyFitness Clips

422,340 views • 6 months ago

Most people are deficient in omega-3s, and fixing that may be one of the easiest ways to improve how you age Taking about 2 grams per day of EPA and DHA can raise omega-3 status from roughly 4% to 8%, a shift associated with major gains in lifespan and cardiovascular protection At higher omega-3 index levels, studies have found about a 5-year increase in life expectancy, about a 90% lower risk of sudden cardiac death, and substantially lower Alzheimer’s risk Even more compelling, omega-3 supplementation slowed biological aging in a recent study of mostly active adults, showing benefits beyond just correcting an obvious deficiency

Most people are deficient in omega-3s, and fixing that may be one of the easiest ways to improve how you age Taking about 2 grams per day of EPA and DHA can raise omega-3 status from roughly 4% to 8%, a shift associated with major gains in lifespan and cardiovascular protection At higher omega-3 index levels, studies have found about a 5-year increase in life expectancy, about a 90% lower risk of sudden cardiac death, and substantially lower Alzheimer’s risk Even more compelling, omega-3 supplementation slowed biological aging in a recent study of mostly active adults, showing benefits beyond just correcting an obvious deficiency

FoundMyFitness Clips

20,682 views • 5 months ago

Taking ~1.5-2 grams/day of EPA and DHA is enough to move most people from a low omega-3 index (~4%) to the high range (~8%), with major benefits: • ~5-year increases in life expectancy compared to a low omega-3 index • 50-90% lower risk of sudden cardiac death • 25% fewer adverse cardiac events (REDUCE-IT trial) • ~30% reduced heart attack risk (VITAL study) For longevity and cardiovascular health, this is one of the simplest low-hanging fruits

Taking ~1.5-2 grams/day of EPA and DHA is enough to move most people from a low omega-3 index (~4%) to the high range (~8%), with major benefits: • ~5-year increases in life expectancy compared to a low omega-3 index • 50-90% lower risk of sudden cardiac death • 25% fewer adverse cardiac events (REDUCE-IT trial) • ~30% reduced heart attack risk (VITAL study) For longevity and cardiovascular health, this is one of the simplest low-hanging fruits

FoundMyFitness Clips

43,790 views • 3 months ago

Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.

Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.

Dr. Rhonda Patrick

494,966 views • 3 months ago

Higher omega-3 status is associated with dramatically lower Alzheimer’s risk. People with a high omega-3 index (~10%) have about a 50% lower risk of Alzheimer’s disease compared with those at the low end (~4%). Other studies have reported a dose-dependent relationship - for every 100 mg/day increase in omega-3 intake, Alzheimer’s disease and cognitive decline risk falls by about 10%. This is still largely correlative data. But when you combine a large risk reduction with a dose-dependent trend, it becomes hard to ignore. Practically, it may take roughly 2 g/day of omega-3s to move from a low omega-3 index toward that higher, more protective range.

Higher omega-3 status is associated with dramatically lower Alzheimer’s risk. People with a high omega-3 index (~10%) have about a 50% lower risk of Alzheimer’s disease compared with those at the low end (~4%). Other studies have reported a dose-dependent relationship - for every 100 mg/day increase in omega-3 intake, Alzheimer’s disease and cognitive decline risk falls by about 10%. This is still largely correlative data. But when you combine a large risk reduction with a dose-dependent trend, it becomes hard to ignore. Practically, it may take roughly 2 g/day of omega-3s to move from a low omega-3 index toward that higher, more protective range.

Dr. Rhonda Patrick

125,668 views • 5 months ago

Optimizing your omega-3 index might be one of the simplest ways to add years to your life Framingham data show that raising your omega-3 index from ~4% to ~8% is associated with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death In the same cohort, having low omega-3 levels (around 4%) carried a mortality risk comparable to smoking Meanwhile, nearly 90% (!) of Americans are not getting adequate EPA & DHA The fix? For most people, supplementing with roughly 2 g/day of EPA + DHA is enough to raise the omega-3 index from ~4% to ~8%

Optimizing your omega-3 index might be one of the simplest ways to add years to your life Framingham data show that raising your omega-3 index from ~4% to ~8% is associated with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death In the same cohort, having low omega-3 levels (around 4%) carried a mortality risk comparable to smoking Meanwhile, nearly 90% (!) of Americans are not getting adequate EPA & DHA The fix? For most people, supplementing with roughly 2 g/day of EPA + DHA is enough to raise the omega-3 index from ~4% to ~8%

FoundMyFitness Clips

76,174 views • 9 months ago

Optimizing your omega-3 intake might be one of the easiest ways to extend your lifespan Research shows having low omega-3 levels (omega-3 index below 4%) poses a mortality risk comparable to smoking Yet nearly 90% of Americans fall short of daily EPA & DHA requirements For most people, taking about 2g per day (EPA + DHA) increases omega-3 index from 4% to 8%—which is associated with a 5-year increase in life expectancy

Optimizing your omega-3 intake might be one of the easiest ways to extend your lifespan Research shows having low omega-3 levels (omega-3 index below 4%) poses a mortality risk comparable to smoking Yet nearly 90% of Americans fall short of daily EPA & DHA requirements For most people, taking about 2g per day (EPA + DHA) increases omega-3 index from 4% to 8%—which is associated with a 5-year increase in life expectancy

FoundMyFitness Clips

24,356 views • 1 year ago

Taking ~2 grams/day of fish oil is enough to move most people from a low omega-3 index (~4%) to the optimal range (~8%), with major benefits: • ~90% lower risk of sudden cardiac death • ~5-year increase in life expectancy (at higher omega-3 index levels) • Lower risk of dementia and other neurodegenerative disease • ~30% reduced heart attack risk (VITAL study) • ~25% fewer adverse cardiac events (REDUCE-IT trial) Concerns about “oxidized fish oil” are often overstated Quality definitely matters, but the bigger risk is not getting enough omega-3s at all

Taking ~2 grams/day of fish oil is enough to move most people from a low omega-3 index (~4%) to the optimal range (~8%), with major benefits: • ~90% lower risk of sudden cardiac death • ~5-year increase in life expectancy (at higher omega-3 index levels) • Lower risk of dementia and other neurodegenerative disease • ~30% reduced heart attack risk (VITAL study) • ~25% fewer adverse cardiac events (REDUCE-IT trial) Concerns about “oxidized fish oil” are often overstated Quality definitely matters, but the bigger risk is not getting enough omega-3s at all

FoundMyFitness Clips

171,314 views • 8 months ago

Dr. Rhonda Patrick says omega-3 is the single most powerful compound for reducing inflammation in the human body. She broke down why on the Huberman Lab podcast. In a clinical trial out of Switzerland, omega-3 was the only intervention that slowed epigenetic aging clocks. And when combined with Vitamin D and resistance training, the results compounded: • 66% reduction in invasive cancer risk • 90% reduction in sudden cardiac death • 5-year increase in life expectancy at high omega-3 index Patrick says omega-3s work by forming molecules called resolvins and protectins that actively resolve inflammation rather than just suppressing it. They also improve cell membrane fluidity, which directly affects how dopamine and serotonin receptors function in the brain. She recommends 2 grams per day to move from a low omega-3 index to a high one. Patrick says if she could only recommend one supplement to everyone she cares about, it would be omega-3. — Dr. Rhonda Patrick (Dr. Rhonda Patrick) on Andrew Huberman's (Andrew D. Huberman, Ph.D.) podcast PS: If you found this insightful, follow me as I continue sharing unconventional health content just like this.

Dr. Rhonda Patrick says omega-3 is the single most powerful compound for reducing inflammation in the human body. She broke down why on the Huberman Lab podcast. In a clinical trial out of Switzerland, omega-3 was the only intervention that slowed epigenetic aging clocks. And when combined with Vitamin D and resistance training, the results compounded: • 66% reduction in invasive cancer risk • 90% reduction in sudden cardiac death • 5-year increase in life expectancy at high omega-3 index Patrick says omega-3s work by forming molecules called resolvins and protectins that actively resolve inflammation rather than just suppressing it. They also improve cell membrane fluidity, which directly affects how dopamine and serotonin receptors function in the brain. She recommends 2 grams per day to move from a low omega-3 index to a high one. Patrick says if she could only recommend one supplement to everyone she cares about, it would be omega-3. — Dr. Rhonda Patrick (Dr. Rhonda Patrick) on Andrew Huberman's (Andrew D. Huberman, Ph.D.) podcast PS: If you found this insightful, follow me as I continue sharing unconventional health content just like this.

Goku

59,076 views • 5 months ago

3 low-effort supplements that have an outsized impact on long-term health: • Omega-3s — 2 g/day is a strong starting point; a high omega-3 index (8%+) is associated with longer life expectancy, lower cardiovascular risk, and slower epigenetic aging • Vitamin D — regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity; correcting deficiency may also slow epigenetic aging • Magnesium — roughly half of Americans don’t get enough; it’s a cofactor for 300+ biological processes, including DNA repair and energy production

3 low-effort supplements that have an outsized impact on long-term health: • Omega-3s — 2 g/day is a strong starting point; a high omega-3 index (8%+) is associated with longer life expectancy, lower cardiovascular risk, and slower epigenetic aging • Vitamin D — regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity; correcting deficiency may also slow epigenetic aging • Magnesium — roughly half of Americans don’t get enough; it’s a cofactor for 300+ biological processes, including DNA repair and energy production

FoundMyFitness Clips

30,928 views • 2 months ago

Three "superfoods" that I think everyone should eat weekly, if not daily: Dark leafy greens—they're a great source of magnesium, which most people are deficient in, plus folate and vitamin K. Blueberries—they're rich in polyphenols, which benefit brain health and improve cardiovascular disease risk factors. Just 1 cup per day can improve cognition. Salmon—it's one of the best sources of omega-3 fatty acids. Just make sure to opt for wild Atlantic salmon due to its high omega-3 and low mercury content. Eating salmon 2–3 times per week should get you the recommended amount of dietary omega-3.

Three "superfoods" that I think everyone should eat weekly, if not daily: Dark leafy greens—they're a great source of magnesium, which most people are deficient in, plus folate and vitamin K. Blueberries—they're rich in polyphenols, which benefit brain health and improve cardiovascular disease risk factors. Just 1 cup per day can improve cognition. Salmon—it's one of the best sources of omega-3 fatty acids. Just make sure to opt for wild Atlantic salmon due to its high omega-3 and low mercury content. Eating salmon 2–3 times per week should get you the recommended amount of dietary omega-3.

Dr. Rhonda Patrick

86,820 views • 1 year ago

Nattokinase isn’t high on my list for cardiovascular prevention. I don’t see convincing evidence that it should be a primary strategy for cardiovascular disease or stroke risk reduction. If the goal is cardiovascular prevention, there are options with much stronger support. Omega-3 fatty acids (EPA + DHA) have far better evidence. And if we’re talking specifically about atherosclerosis, berberine has a much more compelling evidence base—it’s been shown to reduce plaque formation, while also improving LDL, HbA1c, and glucose regulation. Nattokinase may be interesting mechanistically, but right now the clinical evidence just isn’t strong enough for me to view it as a serious front-line strategy.

Nattokinase isn’t high on my list for cardiovascular prevention. I don’t see convincing evidence that it should be a primary strategy for cardiovascular disease or stroke risk reduction. If the goal is cardiovascular prevention, there are options with much stronger support. Omega-3 fatty acids (EPA + DHA) have far better evidence. And if we’re talking specifically about atherosclerosis, berberine has a much more compelling evidence base—it’s been shown to reduce plaque formation, while also improving LDL, HbA1c, and glucose regulation. Nattokinase may be interesting mechanistically, but right now the clinical evidence just isn’t strong enough for me to view it as a serious front-line strategy.

Dr. Rhonda Patrick

246,470 views • 4 months ago

Most people think depression, anxiety, and brain fog start in the brain. But what if they actually start in the rest of your body? Chronic inflammation is one of the biggest drivers of modern disease—and it’s not just affecting your joints or your heart. Research shows it can also impact your mood, memory, focus, and overall mental health. In many cases, inflammation is something you can influence. Here’s what helps: ✔️ A whole-food, anti-inflammatory diet ✔️ Plenty of colorful plants and fiber ✔️ Omega-3-rich foods like wild fatty fish ✔️ Fermented foods to support the gut microbiome ✔️ Regular exercise ✔️ Prioritizing restorative sleep Your brain doesn’t exist in isolation. The health of your body shapes the health of your mind—and addressing inflammation may be one of the most powerful ways to support both. Here's the link to my new mental health program, The Brain-Shaping Academy, where you’ll learn the science behind the brain-body connection and how to use nutrition and lifestyle to build a healthier, more resilient brain:

Most people think depression, anxiety, and brain fog start in the brain. But what if they actually start in the rest of your body? Chronic inflammation is one of the biggest drivers of modern disease—and it’s not just affecting your joints or your heart. Research shows it can also impact your mood, memory, focus, and overall mental health. In many cases, inflammation is something you can influence. Here’s what helps: ✔️ A whole-food, anti-inflammatory diet ✔️ Plenty of colorful plants and fiber ✔️ Omega-3-rich foods like wild fatty fish ✔️ Fermented foods to support the gut microbiome ✔️ Regular exercise ✔️ Prioritizing restorative sleep Your brain doesn’t exist in isolation. The health of your body shapes the health of your mind—and addressing inflammation may be one of the most powerful ways to support both. Here's the link to my new mental health program, The Brain-Shaping Academy, where you’ll learn the science behind the brain-body connection and how to use nutrition and lifestyle to build a healthier, more resilient brain:

Mark Hyman, M.D.

35,228 views • 2 months ago

Omega-3s may be one of the most powerful dietary tools for resolving inflammation and slowing biological aging In a 3-year randomized trial of healthy older adults, omega-3 alone slowed epigenetic aging, while vitamin D and resistance training alone did not But the biggest effect came when all three were combined: omega-3, vitamin D, and resistance training slowed biological aging by about 3.8 months That may sound small, but it reflects a slower pace of aging that could compound over time The combo was also linked to ~40% lower pre-frailty and 61% lower invasive cancer incidence

Omega-3s may be one of the most powerful dietary tools for resolving inflammation and slowing biological aging In a 3-year randomized trial of healthy older adults, omega-3 alone slowed epigenetic aging, while vitamin D and resistance training alone did not But the biggest effect came when all three were combined: omega-3, vitamin D, and resistance training slowed biological aging by about 3.8 months That may sound small, but it reflects a slower pace of aging that could compound over time The combo was also linked to ~40% lower pre-frailty and 61% lower invasive cancer incidence

FoundMyFitness Clips

301,812 views • 4 months ago

🌿 Plant-based foods like flaxseeds, chia seeds, and walnuts are naturally rich in omega-3 fatty acids that help support the brain, heart, joints, and overall well-being. Adding a variety of whole foods to your daily meals is one of the simplest ways to nourish the body naturally. ✨

🌿 Plant-based foods like flaxseeds, chia seeds, and walnuts are naturally rich in omega-3 fatty acids that help support the brain, heart, joints, and overall well-being. Adding a variety of whole foods to your daily meals is one of the simplest ways to nourish the body naturally. ✨

Barbara Oneill

20,288 views • 4 months ago

Optimizing your omega-3 intake might be one of the simplest ways to extend your lifespan Robust cohort studies demonstrate a clear ~5-year lifespan increase in individuals with a high omega-3 index (around 8%) compared to those with low levels (~4%) Astonishingly, research shows low omega-3 levels (an omega-3 index below 4%) may carry the same mortality risk as regular smoking Yet nearly 90% of Americans fall short of daily EPA & DHA requirements, easily correctable by eating fish or taking a high-quality supplement

Optimizing your omega-3 intake might be one of the simplest ways to extend your lifespan Robust cohort studies demonstrate a clear ~5-year lifespan increase in individuals with a high omega-3 index (around 8%) compared to those with low levels (~4%) Astonishingly, research shows low omega-3 levels (an omega-3 index below 4%) may carry the same mortality risk as regular smoking Yet nearly 90% of Americans fall short of daily EPA & DHA requirements, easily correctable by eating fish or taking a high-quality supplement

FoundMyFitness Clips

63,394 views • 9 months ago

Omega-3 fatty acids can dramatically blunt the inflammatory spike caused by meals high in saturated fat and sugar These inflammatory meals cause lipopolysaccharide (LPS), a toxin from gut bacteria, to leak into your bloodstream, triggering inflammation This effect is especially pronounced when the meal is high in saturated fat and sugar and low in fiber or protein, amplifying the surge of this bacterial toxin entering circulation Human studies show omega-3s reduce this harmful post-meal response by dampening LPS leakage from the gut

Omega-3 fatty acids can dramatically blunt the inflammatory spike caused by meals high in saturated fat and sugar These inflammatory meals cause lipopolysaccharide (LPS), a toxin from gut bacteria, to leak into your bloodstream, triggering inflammation This effect is especially pronounced when the meal is high in saturated fat and sugar and low in fiber or protein, amplifying the surge of this bacterial toxin entering circulation Human studies show omega-3s reduce this harmful post-meal response by dampening LPS leakage from the gut

FoundMyFitness Clips

48,779 views • 6 months ago

American beef is basically metabolic syndrome on a plate. Dr. Robert Lustig compared Italian beef, Argentinian beef, and USA corn-fed beef. The American version is loaded with fat. Argentinians eat twice as much beef but have lower heart disease rates, because their cows graze on grass. American cows are force-fed corn and go from birth to slaughter in just 6 weeks (used to take 18 months). Lustig says those cows develop metabolic syndrome before slaughter… and so do people who eat them. Grass-fed beef has a significantly better omega-3 to omega-6 fatty acid ratio and higher levels of anti-inflammatory compounds like CLA compared to grain-fed beef. Studies link the high omega-6 content in grain-fed meat to increased systemic inflammation and higher cardiovascular risk.

American beef is basically metabolic syndrome on a plate. Dr. Robert Lustig compared Italian beef, Argentinian beef, and USA corn-fed beef. The American version is loaded with fat. Argentinians eat twice as much beef but have lower heart disease rates, because their cows graze on grass. American cows are force-fed corn and go from birth to slaughter in just 6 weeks (used to take 18 months). Lustig says those cows develop metabolic syndrome before slaughter… and so do people who eat them. Grass-fed beef has a significantly better omega-3 to omega-6 fatty acid ratio and higher levels of anti-inflammatory compounds like CLA compared to grain-fed beef. Studies link the high omega-6 content in grain-fed meat to increased systemic inflammation and higher cardiovascular risk.

Camus

54,091 views • 3 months ago

There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. Animal studies show omega-3 fatty acids augment muscle development: Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. But more importantly, we have human evidence: • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? (It often is for many of us.) Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. Show notes and transcript for this episode here:

There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. Animal studies show omega-3 fatty acids augment muscle development: Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. But more importantly, we have human evidence: • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? (It often is for many of us.) Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. Show notes and transcript for this episode here:

Dr. Rhonda Patrick

190,965 views • 3 years ago