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Omega-3s may be one of the most powerful dietary tools for resolving inflammation and slowing biological aging In a 3-year randomized trial of healthy older adults, omega-3 alone slowed epigenetic aging, while vitamin D and resistance training alone did not But the biggest effect came when all three were...

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Omega-3 supplementation alone slowed epigenetic aging. Combined with vitamin D and resistance training, it reduced invasive cancer risk by 66%. — Andrew D. Huberman, Ph.D. & Dr. Rhonda Patrick
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Dr. Rhonda Patrick takes 2g/day of omega-3. Alone it slows biological aging on epigenetic clocks. Combined with Vitamin D and resistance training together, a Switzerland study showed it also leads to a 66% reduction in invasive cancer risk.
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Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.
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Supplementing with omega-3 fatty acids slows biological aging. Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging. These were the results of the 3-year-long DO-HEALTH study, which Prof Steve Horvath believes is one of the strongest pieces of evidence that simple interventions (that also likely correct a deficiency) are powerful ways to slow or reverse the aging process. We discuss this study and more in the latest episode of the FoundMyFitness podcast.

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5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits
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5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits

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A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.
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A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.

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4 supplements that give you the biggest bang for your buck: • Multivitamin — 3 large RCTs show it reduces brain aging by ~2 years and reverses episodic memory aging by ~5 years in older adults • Omega-3s — a high omega-3 index (8%+) is linked to 5 years of increased life expectancy and 90% lower risk of sudden cardiac death • Magnesium — a cofactor for 300+ biological processes including DNA repair and energy production; 60%+ of the US population is deficient • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years
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4 supplements that give you the biggest bang for your buck: • Multivitamin — 3 large RCTs show it reduces brain aging by ~2 years and reverses episodic memory aging by ~5 years in older adults • Omega-3s — a high omega-3 index (8%+) is linked to 5 years of increased life expectancy and 90% lower risk of sudden cardiac death • Magnesium — a cofactor for 300+ biological processes including DNA repair and energy production; 60%+ of the US population is deficient • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years

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Most people are deficient in omega-3s, and fixing that may be one of the easiest ways to improve how you age Taking about 2 grams per day of EPA and DHA can raise omega-3 status from roughly 4% to 8%, a shift associated with major gains in lifespan and cardiovascular protection At higher omega-3 index levels, studies have found about a 5-year increase in life expectancy, about a 90% lower risk of sudden cardiac death, and substantially lower Alzheimer’s risk Even more compelling, omega-3 supplementation slowed biological aging in a recent study of mostly active adults, showing benefits beyond just correcting an obvious deficiency
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Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

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Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation Human studies show it can significantly reduce TNF-alpha, a major inflammatory cytokine that helps drive epigenetic and biological aging Because elevated TNF-alpha is linked to faster biological aging, lowering it may be one way curcumin supports healthier aging The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable

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Consistent endurance exercise may be one of the most powerful ways to slow down biological aging. Six months of cycling (about 4.5 hours/week) reduced GrimAge by 7 months relative to the expected trajectory of normal aging. GrimAge is an epigenetic clock tied to mortality risk. Participants also increased VO₂ max by ~20%, and the reduction in GrimAge tracked with those gains in cardiorespiratory fitness, but not with changes in body composition. The anti-aging signal seemed to come more from becoming fitter, not just leaner. To Prof Steve Horvath, this suggests biological aging is, at least to some extent, modifiable. We discuss how exercise may slow biological aging in the latest episode of the podcast. Out now.

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For older adults, a daily multivitamin is a high-priority basic, not an optional supplement Across three COSMOS cognitive studies of adults 65+, a standard multivitamin (Centrum Silver) slowed global brain aging by about 2 years The biggest effect showed up in episodic memory (remembering experiences, names, faces, and events), which aged almost 5 years slower A related COSMOS analysis also found modest slowing in biological aging clocks, making this one of the lowest-effort ways to cover micronutrient gaps as the brain ages
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For older adults, a daily multivitamin is a high-priority basic, not an optional supplement Across three COSMOS cognitive studies of adults 65+, a standard multivitamin (Centrum Silver) slowed global brain aging by about 2 years The biggest effect showed up in episodic memory (remembering experiences, names, faces, and events), which aged almost 5 years slower A related COSMOS analysis also found modest slowing in biological aging clocks, making this one of the lowest-effort ways to cover micronutrient gaps as the brain ages

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If you want to meaningfully impact aging in America, start with obesity—few things erode longevity and quality of life as profoundly, accelerating the biological aging process and fueling nearly every major chronic disease. Obesity alone is linked to 13 types of cancer and cuts life expectancy by 3–10 years, depending on severity. It promotes DNA damage and accelerates our fundamental aging process—often measured by epigenetic age. It’s one of the principal differences between the U.S. and many of the world’s longest-lived nations. We’re overfed but undernourished. 60% of all calories Americans consume come from ultra-processed foods that: • Fail to induce proper satiety, pushing us to overeat. • Remain cheaper than whole foods, economically incentivizing the least healthy choices. • Hijack our dopamine reward pathways, reinforcing addictive eating behaviors. This trifecta—no satiety, low cost, and built-in addictiveness—keeps us in a cycle of poor health outcomes and runaway healthcare costs. But caloric excess is only part of the problem—we are also nutrient-deficient. Low omega-3 levels—affecting 80 to 90% of Americans—carry the same mortality risk as smoking. Vitamin D deficiency—easily corrected—compromises immune function, cognition, and longevity. Nearly half of Americans don't get enough magnesium—impairing DNA repair and increasing the risk of cancer. We are not solving these problems—we are medicating them. The average American over 65 takes five or more prescription drugs daily—stacking interactions that compound in unpredictable ways. We must start treating physical inactivity as a disease. It carries the same mortality risk as smoking, heart disease, and diabetes. Going from a low cardiorespiratory fitness to a low normal adds 2.1 years to life expectancy. By age 50, many Americans have already lost 10% of their peak muscle mass. By 70, many have lost up to 40%. This isn’t just about looking strong. It’s about survival. • Higher muscle mass means improved insulin sensitivity - it means a 30% lower mortality risk. • Grip strength is a stronger predictor of cardiovascular mortality - the number one cause of death in the United States - than high blood pressure. • The strongest middle-aged adults have a 42% lower dementia risk. And yet, we treat resistance training as optional. It is not. It is the most powerful intervention we have against aging including increasing muscle mass, strength and bone density. Hip fractures alone kill 20–60% of older adults within a year. This is a death sentence we can prevent with resistance training - which has been shown to lower fracture risk by 30-40%. The current RDA for protein is too low for older adults. Studies have shown when it's increased by half this reduces frailty by 32%, while doubling it, combined with resistance training, increases muscle mass by 27% and strength by 10% more than training alone. If we want to prevent muscle loss and frailty, we must update our protein recommendations and prioritize strength training. We must foster a culture of American exceptionalism built on daily, effortful exercise. Not as an afterthought. Not as a luxury. But as a non-negotiable foundation for aging, but also clear thinking, resilience, and even leadership. The body and brain are not separate. The consequences of poorly regulated blood sugar, sedentary living, and muscle loss are not just physical—they affect cognition, judgment, and resilience. We cannot medicate our way out of what we have behaved our way into. Grateful for the chance to share my voice at the Senate Aging Committee (Senate Aging Committee). A special thank you to Senator Rick Scott (Rick Scott) for making this opportunity possible.
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If you want to meaningfully impact aging in America, start with obesity—few things erode longevity and quality of life as profoundly, accelerating the biological aging process and fueling nearly every major chronic disease. Obesity alone is linked to 13 types of cancer and cuts life expectancy by 3–10 years, depending on severity. It promotes DNA damage and accelerates our fundamental aging process—often measured by epigenetic age. It’s one of the principal differences between the U.S. and many of the world’s longest-lived nations. We’re overfed but undernourished. 60% of all calories Americans consume come from ultra-processed foods that: • Fail to induce proper satiety, pushing us to overeat. • Remain cheaper than whole foods, economically incentivizing the least healthy choices. • Hijack our dopamine reward pathways, reinforcing addictive eating behaviors. This trifecta—no satiety, low cost, and built-in addictiveness—keeps us in a cycle of poor health outcomes and runaway healthcare costs. But caloric excess is only part of the problem—we are also nutrient-deficient. Low omega-3 levels—affecting 80 to 90% of Americans—carry the same mortality risk as smoking. Vitamin D deficiency—easily corrected—compromises immune function, cognition, and longevity. Nearly half of Americans don't get enough magnesium—impairing DNA repair and increasing the risk of cancer. We are not solving these problems—we are medicating them. The average American over 65 takes five or more prescription drugs daily—stacking interactions that compound in unpredictable ways. We must start treating physical inactivity as a disease. It carries the same mortality risk as smoking, heart disease, and diabetes. Going from a low cardiorespiratory fitness to a low normal adds 2.1 years to life expectancy. By age 50, many Americans have already lost 10% of their peak muscle mass. By 70, many have lost up to 40%. This isn’t just about looking strong. It’s about survival. • Higher muscle mass means improved insulin sensitivity - it means a 30% lower mortality risk. • Grip strength is a stronger predictor of cardiovascular mortality - the number one cause of death in the United States - than high blood pressure. • The strongest middle-aged adults have a 42% lower dementia risk. And yet, we treat resistance training as optional. It is not. It is the most powerful intervention we have against aging including increasing muscle mass, strength and bone density. Hip fractures alone kill 20–60% of older adults within a year. This is a death sentence we can prevent with resistance training - which has been shown to lower fracture risk by 30-40%. The current RDA for protein is too low for older adults. Studies have shown when it's increased by half this reduces frailty by 32%, while doubling it, combined with resistance training, increases muscle mass by 27% and strength by 10% more than training alone. If we want to prevent muscle loss and frailty, we must update our protein recommendations and prioritize strength training. We must foster a culture of American exceptionalism built on daily, effortful exercise. Not as an afterthought. Not as a luxury. But as a non-negotiable foundation for aging, but also clear thinking, resilience, and even leadership. The body and brain are not separate. The consequences of poorly regulated blood sugar, sedentary living, and muscle loss are not just physical—they affect cognition, judgment, and resilience. We cannot medicate our way out of what we have behaved our way into. Grateful for the chance to share my voice at the Senate Aging Committee (Senate Aging Committee). A special thank you to Senator Rick Scott (Rick Scott) for making this opportunity possible.

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407,428 просмотров • 1 год назад

These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.
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These are the supplements I give my aging parents: • A daily multivitamin • Vitamin D • High-DHA omega-3s • Ubiquinol (the reduced form of CoQ10) • Sulforaphane Why these? Large RCTs show improved cognition in older adults taking a standard multivitamin, with benefits equivalent to a brain that's 2-5 years younger. For vitamin D, more than 70% of older U.S. adults are insufficient, and aging skin produces far less vitamin D from sunlight (a 70-year-old makes roughly 4x less than their 20-year-old self). DHA is a key structural fat in the brain and supports cognitive function, especially important with aging and neurodegenerative risk, while CoQ10 supports mitochondrial energy production as levels drop with age. Finally, sulforaphane is a powerful activator of Nrf2, the body's master stress-response pathway, up-regulating glutathione and phase II detox enzymes.

Dr. Rhonda Patrick

217,153 просмотров • 8 месяцев назад

What micronutrients improve aging? There's no excuse for some of the widespread micronutrient deficiencies, especially in light of the fact that many may play a role in aging. Devoted to the ‘low hanging fruit’ of aging, I think many of you may enjoy this episode. TIMESTAMPS: (00:00) Introduction (01:10) Vitamin D deficiency (08:26) Magnesium's critical role in DNA repair (11:55) Dietary magnesium sources (13:11) Magnesium supplements (14:20) Exercise staves off age-related disease (14:58) Genetic SNPs & vitamin D deficiency (20:15) Low omega-3 intake from seafood (22:28) ALA's conversion into EPA & DHA (25:21) Omega-3 index (28:33) How omega-3s reduce inflammation (30:45) Omega-3s & muscle disuse atrophy (31:44) Don't avoid fish during pregnancy (34:08) Omega-3s are a low-hanging fruit (35:52) How to choose an omega-3 supplement (40:03) Why stressors benefit your genes (46:20) How to choose an exercise regimen (47:15) “Exercise snacks” (49:30) Brain benefits of lactate from vigorous exercise (52:29) Exercise & circulating tumor cells (54:36) Rhonda's workout regimen (55:44) Exercise for combating sleep deprivation (58:38) Exercise may be the best longevity "drug" Interview by Dr. Kalea Wattles (Dr. Kalea Wattles) originally for the ‘Pathways to Wellbeing’ podcast from The Institute for Functional Medicine (The Institute for Functional Medicine (IFM)).
1:00:02

What micronutrients improve aging? There's no excuse for some of the widespread micronutrient deficiencies, especially in light of the fact that many may play a role in aging. Devoted to the ‘low hanging fruit’ of aging, I think many of you may enjoy this episode. TIMESTAMPS: (00:00) Introduction (01:10) Vitamin D deficiency (08:26) Magnesium's critical role in DNA repair (11:55) Dietary magnesium sources (13:11) Magnesium supplements (14:20) Exercise staves off age-related disease (14:58) Genetic SNPs & vitamin D deficiency (20:15) Low omega-3 intake from seafood (22:28) ALA's conversion into EPA & DHA (25:21) Omega-3 index (28:33) How omega-3s reduce inflammation (30:45) Omega-3s & muscle disuse atrophy (31:44) Don't avoid fish during pregnancy (34:08) Omega-3s are a low-hanging fruit (35:52) How to choose an omega-3 supplement (40:03) Why stressors benefit your genes (46:20) How to choose an exercise regimen (47:15) “Exercise snacks” (49:30) Brain benefits of lactate from vigorous exercise (52:29) Exercise & circulating tumor cells (54:36) Rhonda's workout regimen (55:44) Exercise for combating sleep deprivation (58:38) Exercise may be the best longevity "drug" Interview by Dr. Kalea Wattles (Dr. Kalea Wattles) originally for the ‘Pathways to Wellbeing’ podcast from The Institute for Functional Medicine (The Institute for Functional Medicine (IFM)).

Dr. Rhonda Patrick

523,815 просмотров • 2 лет назад

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time
52:20

New presentation! At the recent A4M LongevityFest conference (American Academy of Anti-Aging Medicine (A4M)) I discussed how omega-3, vitamin D, and magnesium deficiencies accelerate aging, the life expectancy benefits from improving VO2 max, and the anti-cancer effects of vigorous exercise. Available on YouTube, Spotify, X, and everywhere else. Links in comment. Timestamps: 0:00 - Vitamin D, the gene regulator 5:58 - Vitamin D deficiency & mortality risk 9:24 - Optimal vitamin D levels & supplementation 11:10 - Magnesium deficiency & DNA damage 14:50 - Dangers of inadequate omega-3 intake 17:07 - Why you want your omega-3 index in the 8% range 23:17 - Vigorous exercise is the best longevity drug 24:50 - VO2 max & life expectancy 29:36 - VO2 max protocols 32:27 - Measuring VO2 max 33:34 - Reversing 20 years of heart aging 36:31 - Blood pressure benefits of vigorous exercise 37:48 - BDNF benefits of vigorous exercise 40:58 - Vigorous exercise improves focus & attention 42:11 - Exercise protocols for maximizing BDNF 43:13 - Anti-cancer effects of vigorous exercise 45:30 - How to use exercise snacks to break up sedentary time

Dr. Rhonda Patrick

106,103 просмотров • 2 лет назад

Rhonda Patrick dropped this on Mayim Bialik’s podcast:“As simple as a cheap daily multivitamin… it reversed brain aging by five years.” Three large randomized controlled trials showed that older adults taking a basic affordable multivitamin for a couple of years slowed cognitive aging by about 3 years and reversed episodic memory aging by roughly 5 years. The COSMOS trial and related studies found daily multivitamin use improved memory, executive function, and slowed brain aging in older adults, likely by filling common micronutrient gaps. It’s a reminder that sometimes the simplest things still pack a real punch. In our rush for fancy biohacks and expensive protocols, we often overlook basic, affordable interventions that actually have strong evidence behind them. What about you — do you take a daily multivitamin, or do you rely purely on food?
0:51

Rhonda Patrick dropped this on Mayim Bialik’s podcast:“As simple as a cheap daily multivitamin… it reversed brain aging by five years.” Three large randomized controlled trials showed that older adults taking a basic affordable multivitamin for a couple of years slowed cognitive aging by about 3 years and reversed episodic memory aging by roughly 5 years. The COSMOS trial and related studies found daily multivitamin use improved memory, executive function, and slowed brain aging in older adults, likely by filling common micronutrient gaps. It’s a reminder that sometimes the simplest things still pack a real punch. In our rush for fancy biohacks and expensive protocols, we often overlook basic, affordable interventions that actually have strong evidence behind them. What about you — do you take a daily multivitamin, or do you rely purely on food?

Camus

18,211 просмотров • 3 месяцев назад

Coffee may be the most overlooked anti-aging tool hiding in plain sight Emerging research reveals that coffee can actively slow biological aging—each daily cup consumed correlates with a 0.7–1 year reduction in epigenetic age Drinking 3+ cups daily reduces the risk of accelerated aging by 34–41% and lowers death risk from all causes (compared to non-coffee drinkers) by 27%, translating to nearly two extra years of life Even decaf delivers similar powerful benefits The takeaway is clear: Regular coffee drinkers consistently live longer
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Coffee may be the most overlooked anti-aging tool hiding in plain sight Emerging research reveals that coffee can actively slow biological aging—each daily cup consumed correlates with a 0.7–1 year reduction in epigenetic age Drinking 3+ cups daily reduces the risk of accelerated aging by 34–41% and lowers death risk from all causes (compared to non-coffee drinkers) by 27%, translating to nearly two extra years of life Even decaf delivers similar powerful benefits The takeaway is clear: Regular coffee drinkers consistently live longer

FoundMyFitness Clips

766,886 просмотров • 1 год назад