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.Science Corporation’s retinal prosthesis helped patients who couldn’t recognize faces read full eye charts and do crossword puzzles. That progress will help fund a bio-hybrid neural interface that grows like an Avatar-style “new cranial nerve” for high-bandwidth communication.

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Ginkgo Bioworks CEO Jason Kelly explains how "cloud-style" automated science labs can create "millions of scientists" by democratizing access to experimentation: “Science is the formalization of human curiosity. The reason everyone doesn't do science today is that you're blocked by the cost and expense of all the physical infrastructure.” “If it was available cloud-style, for example, how many people would want to be doing science? Maybe they have a health condition they want to study themselves, maybe they have a new idea for a material, maybe they're a gardener and they want to make a new plant variety?” “I know that sounds crazy, but I'll tell you something else that sounded crazy. In 1960, if you said random, average people will program computers, that sounded insane.” "The model’s ability to access literature and be smart and tell you how to turn your question into an experiment—and then the autonomous labs that could do that experiment for you in the cloud—means we'll have millions of scientists, just like we have millions of programmers now as we made it easier."

Ginkgo Bioworks CEO Jason Kelly explains how "cloud-style" automated science labs can create "millions of scientists" by democratizing access to experimentation: “Science is the formalization of human curiosity. The reason everyone doesn't do science today is that you're blocked by the cost and expense of all the physical infrastructure.” “If it was available cloud-style, for example, how many people would want to be doing science? Maybe they have a health condition they want to study themselves, maybe they have a new idea for a material, maybe they're a gardener and they want to make a new plant variety?” “I know that sounds crazy, but I'll tell you something else that sounded crazy. In 1960, if you said random, average people will program computers, that sounded insane.” "The model’s ability to access literature and be smart and tell you how to turn your question into an experiment—and then the autonomous labs that could do that experiment for you in the cloud—means we'll have millions of scientists, just like we have millions of programmers now as we made it easier."

TBPN

13,054 Aufrufe • vor 6 Monaten

"We should do what the FDA has said they're doing: legalize several of the category 2 peptides that have the strongest safety and efficacy signals." — Max Marchione "Because that reduces net harm for patients and increases net benefit, even if pharma doesn't like it because they're not making money from their $100,000 biologic drug anymore." "When new data and new science come along, and there's a dangerous gray market, we need to accept that the times have changed and adapt the regulation."

"We should do what the FDA has said they're doing: legalize several of the category 2 peptides that have the strongest safety and efficacy signals." — Max Marchione "Because that reduces net harm for patients and increases net benefit, even if pharma doesn't like it because they're not making money from their $100,000 biologic drug anymore." "When new data and new science come along, and there's a dangerous gray market, we need to accept that the times have changed and adapt the regulation."

TBPN

14,300 Aufrufe • vor 5 Monaten

"In the future, you won't need any software at all. The neural network will completely replace it." - stephen balaban, co-founder of Lambda "Here's the idea: instead of generating a program, just go to ChatGPT and say, 'Hi, please behave like a calculator or a spreadsheet.'" "'Generate an ASCII user interface for me. And I want you to essentially just respond, implement the logic of that program in your mind.'" "This is what I call neural software. Normal software is really brittle. 'Neural software' can't have bugs, only misunderstandings." "Large language models will be the software you interact with." From Stephen's appearance on the show in May.

"In the future, you won't need any software at all. The neural network will completely replace it." - stephen balaban, co-founder of Lambda "Here's the idea: instead of generating a program, just go to ChatGPT and say, 'Hi, please behave like a calculator or a spreadsheet.'" "'Generate an ASCII user interface for me. And I want you to essentially just respond, implement the logic of that program in your mind.'" "This is what I call neural software. Normal software is really brittle. 'Neural software' can't have bugs, only misunderstandings." "Large language models will be the software you interact with." From Stephen's appearance on the show in May.

TBPN

28,665 Aufrufe • vor 10 Monaten

Max Hodak (Max Hodak) is the co-founder of Neuralink and founder of Science Corporation, a company building brain-computer interfaces that can restore sight. Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More than 40 patients have already received the treatment in clinical trials, including one who recently read a full novel for the first time in over a decade. In this episode of How to Build the Future, Max joined Garry Tan to discuss how BCIs work, what it takes to engineer the brain, and why brain-computer interfaces may become one of the most important technologies of the next decade. 00:26 — The retinal chip helping blind patients see 01:51 — What brain-computer interfaces really are 03:37 — Could BCIs enhance intelligence? 05:44 — The brain’s incredible plasticity 09:23 — What it feels like to see with an implant 13:01 — Can we restore full human vision? 17:55 — Is the brain basically a computer? 24:59 — Max Hodak’s path into brain tech 28:57 — How Neuralink actually started 33:10 — How the brain represents information 39:47 — Bio-hybrid brain interfaces 44:32 — Building the company Science 51:27 — The future of BCIs and human longevity

Max Hodak (Max Hodak) is the co-founder of Neuralink and founder of Science Corporation, a company building brain-computer interfaces that can restore sight. Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More than 40 patients have already received the treatment in clinical trials, including one who recently read a full novel for the first time in over a decade. In this episode of How to Build the Future, Max joined Garry Tan to discuss how BCIs work, what it takes to engineer the brain, and why brain-computer interfaces may become one of the most important technologies of the next decade. 00:26 — The retinal chip helping blind patients see 01:51 — What brain-computer interfaces really are 03:37 — Could BCIs enhance intelligence? 05:44 — The brain’s incredible plasticity 09:23 — What it feels like to see with an implant 13:01 — Can we restore full human vision? 17:55 — Is the brain basically a computer? 24:59 — Max Hodak’s path into brain tech 28:57 — How Neuralink actually started 33:10 — How the brain represents information 39:47 — Bio-hybrid brain interfaces 44:32 — Building the company Science 51:27 — The future of BCIs and human longevity

Y Combinator

155,054 Aufrufe • vor 5 Monaten

Excited to launch a new podcast dedicated to conversations on the future of neurotech, computing, intelligence, and more. First guest: Max Hodak founder & CEO of Science Corporation, which is building PRIMA, a retinal prosthetic that’s restoring meaningful vision for patients with blindness caused by age-related macular degeneration. Science is also developing a biohybrid brain implant that grows living neurons directly onto a silicon chip, then interfaces that system with the cortex. The possibility space here is vast and new. Imagine growing new areas of the brain. Sections 00:00 What counts as neurotech? 01:45 History of brain-computer interfaces and the smartphone dividend 07:25 PRIMA - How Science is restoring vision in blind patients 10:10 Why stimulating bipolar cells works when the optic nerve doesn't 30:30 Are we bottlenecked by biology or engineering? 32:40 Expanding the brain's bandwidth beyond 10 bits per second 37:00 Can we add new areas to the brain? 37:46 Biohybrid BCIs: neurons growing on a chip 39:20 What could neural augmentation look like? 01:13:20 How Science drives Fast R&D 01:44:00 How founders learn and level up This is the kind of discussion I’m excited to explore on this podcast. Enjoy! Full Episode 1 here and in links below.

Excited to launch a new podcast dedicated to conversations on the future of neurotech, computing, intelligence, and more. First guest: Max Hodak founder & CEO of Science Corporation, which is building PRIMA, a retinal prosthetic that’s restoring meaningful vision for patients with blindness caused by age-related macular degeneration. Science is also developing a biohybrid brain implant that grows living neurons directly onto a silicon chip, then interfaces that system with the cortex. The possibility space here is vast and new. Imagine growing new areas of the brain. Sections 00:00 What counts as neurotech? 01:45 History of brain-computer interfaces and the smartphone dividend 07:25 PRIMA - How Science is restoring vision in blind patients 10:10 Why stimulating bipolar cells works when the optic nerve doesn't 30:30 Are we bottlenecked by biology or engineering? 32:40 Expanding the brain's bandwidth beyond 10 bits per second 37:00 Can we add new areas to the brain? 37:46 Biohybrid BCIs: neurons growing on a chip 39:20 What could neural augmentation look like? 01:13:20 How Science drives Fast R&D 01:44:00 How founders learn and level up This is the kind of discussion I’m excited to explore on this podcast. Enjoy! Full Episode 1 here and in links below.

Juan Benet

405,127 Aufrufe • vor 4 Monaten

John: I was thinking about how 'AUM-weighted slop' isn't an excuse for slop. If you put 1% of your fund into startups that are like "We're the craziest and most degenerate companies," if that 1% gets 1000x more views than the other 99%, you'll be known as the slop fund.

John: I was thinking about how 'AUM-weighted slop' isn't an excuse for slop. If you put 1% of your fund into startups that are like "We're the craziest and most degenerate companies," if that 1% gets 1000x more views than the other 99%, you'll be known as the slop fund.

TBPN

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Bloomberg's Mark Gurman, who got the scoop on John Ternus's new gig as Apple CEO, explains why he thinks Ternus will do "a hell of a job" in his new role: "He has product sensibilities that Tim Cook simply doesn't have. He has product decision-making ability that Tim Cook certainly has, but wouldn't utilize because he himself knows that product-based decisions are not where he could have the most impact." "Just like Tim Cook really oversaw the operations part of Apple as CEO and left product development to other members of the executive team, my expectation is that John Ternus will be intimately involved with the product side of the organization as he was in his prior role to CEO. And will leave the operational side to people like Sabih Khan and Priya Balasubramaniam — the people who run the operations division at Apple." "He's going to pick his spots, and his spots are hardware and product development. There's a reason that when he chose his successor for the hardware engineering organization, he chose Tom Marieb. He's not an innovator, but he's an incredible execution guy when it comes to hardware engineering and product quality. Ternus did that because his belief is that he will still be intimately involved and still be that product visionary for Apple in this new chief executive position."

Bloomberg's Mark Gurman, who got the scoop on John Ternus's new gig as Apple CEO, explains why he thinks Ternus will do "a hell of a job" in his new role: "He has product sensibilities that Tim Cook simply doesn't have. He has product decision-making ability that Tim Cook certainly has, but wouldn't utilize because he himself knows that product-based decisions are not where he could have the most impact." "Just like Tim Cook really oversaw the operations part of Apple as CEO and left product development to other members of the executive team, my expectation is that John Ternus will be intimately involved with the product side of the organization as he was in his prior role to CEO. And will leave the operational side to people like Sabih Khan and Priya Balasubramaniam — the people who run the operations division at Apple." "He's going to pick his spots, and his spots are hardware and product development. There's a reason that when he chose his successor for the hardware engineering organization, he chose Tom Marieb. He's not an innovator, but he's an incredible execution guy when it comes to hardware engineering and product quality. Ternus did that because his belief is that he will still be intimately involved and still be that product visionary for Apple in this new chief executive position."

TBPN

22,760 Aufrufe • vor 4 Monaten

Anthropic's Sholto Douglas says Dario Amodei's internal communication style is producing a compendium of essays in the company's Slack that will have effectively charted the history of AGI once we get there. "He has a really, really cool communication style. He quite frequently puts out very well-reasoned essays. And throughout Slack, we'll have giant essay-length debates [about them]." "The essays are really nice because you can go back and read all the past ones, and it tells the history of Anthropic." "In many respects, it will be one of the better things, a decade from now, to chart the history of AGI. We'll be reading these compendium of essays."

Anthropic's Sholto Douglas says Dario Amodei's internal communication style is producing a compendium of essays in the company's Slack that will have effectively charted the history of AGI once we get there. "He has a really, really cool communication style. He quite frequently puts out very well-reasoned essays. And throughout Slack, we'll have giant essay-length debates [about them]." "The essays are really nice because you can go back and read all the past ones, and it tells the history of Anthropic." "In many respects, it will be one of the better things, a decade from now, to chart the history of AGI. We'll be reading these compendium of essays."

TBPN

468,802 Aufrufe • vor 9 Monaten

IN NEWS: Cubby raises a $2.75M seed round. We spoke with founder Truman Sacks about the product and why law students will pay for it. “Law school is a knockout, drag-out fight… firms see the rankings.” “The mindset is: I’ll invest in my future. Anything that helps me do better is an investment.” Cubby is the AI teaching assistant for law school students, trained on thousands of practice exams and case briefs, with a Duolingo-style experience calibrated to your course and professor. “We built an experience that mirrors how your specific professor teaches, because that’s who decides your grade.”

IN NEWS: Cubby raises a $2.75M seed round. We spoke with founder Truman Sacks about the product and why law students will pay for it. “Law school is a knockout, drag-out fight… firms see the rankings.” “The mindset is: I’ll invest in my future. Anything that helps me do better is an investment.” Cubby is the AI teaching assistant for law school students, trained on thousands of practice exams and case briefs, with a Duolingo-style experience calibrated to your course and professor. “We built an experience that mirrors how your specific professor teaches, because that’s who decides your grade.”

TBPN

27,975 Aufrufe • vor 1 Jahr

Haun Ventures CEO Katie Haun says we’re entering a new economy defined by three structural shifts: financial rails, new asset classes, and the agentic future. "We're taking this new fund of $1B and backing founders who are building what we're calling the new economy. When I say the new economy, I'm thinking about three structural shifts we're seeing right now." "The first is new financial rails and infrastructure. Think companies like Erebor. Gone are bankers hours and wire cut-offs. I mean, you're talking about global from day one, 24/7. This is a bank that opened on a Sunday." "Second are new assets and markets. It started as stablecoins, but we're now talking about tokenizing the stock market. You see companies like BlackRock, Coinbase, and Robinhood doing that. But it's also opened up new markets like prediction and perpetual markets." "The third structural shift is what we're calling the agentic future. It's not just AI broadly, it's where AI and crypto intersect. We're talking about building for a world where the end user is not necessarily a human of a financial product or service, but is a computer or an agent. How does that impact things like privacy? How does it impact things like provenance and trust? What form will they use? How will agents pay for things or subscribe to services?"

Haun Ventures CEO Katie Haun says we’re entering a new economy defined by three structural shifts: financial rails, new asset classes, and the agentic future. "We're taking this new fund of $1B and backing founders who are building what we're calling the new economy. When I say the new economy, I'm thinking about three structural shifts we're seeing right now." "The first is new financial rails and infrastructure. Think companies like Erebor. Gone are bankers hours and wire cut-offs. I mean, you're talking about global from day one, 24/7. This is a bank that opened on a Sunday." "Second are new assets and markets. It started as stablecoins, but we're now talking about tokenizing the stock market. You see companies like BlackRock, Coinbase, and Robinhood doing that. But it's also opened up new markets like prediction and perpetual markets." "The third structural shift is what we're calling the agentic future. It's not just AI broadly, it's where AI and crypto intersect. We're talking about building for a world where the end user is not necessarily a human of a financial product or service, but is a computer or an agent. How does that impact things like privacy? How does it impact things like provenance and trust? What form will they use? How will agents pay for things or subscribe to services?"

TBPN

68,444 Aufrufe • vor 3 Monaten

Jordi: The tech industry needs better narratives, and should consider how Steve Jobs might pitch AI. "He'd be saying, 'You now have a free doctor in your pocket that can diagnose a wide range of conditions.'" "He'd be talking about how this chatbot in your pocket seems simple but it will teach you languages, it will help you become an artist, help you become a musician. It will diagnose a condition for somebody who can't afford healthcare."

Jordi: The tech industry needs better narratives, and should consider how Steve Jobs might pitch AI. "He'd be saying, 'You now have a free doctor in your pocket that can diagnose a wide range of conditions.'" "He'd be talking about how this chatbot in your pocket seems simple but it will teach you languages, it will help you become an artist, help you become a musician. It will diagnose a condition for somebody who can't afford healthcare."

TBPN

26,046 Aufrufe • vor 7 Monaten

The event at which Tesla will unveil the new Roadster will include an "elaborate stunt" that involves showing the car, remotely operated, "racing onto a rollercoaster-like ramp and driving upside-down before righting itself and hovering in the air," The Information reported.

The event at which Tesla will unveil the new Roadster will include an "elaborate stunt" that involves showing the car, remotely operated, "racing onto a rollercoaster-like ramp and driving upside-down before righting itself and hovering in the air," The Information reported.

TBPN

56,060 Aufrufe • vor 16 Tagen

Udemy and Carbon Health founder Eren Bali explains Monogram, a new kind of AI interface that replaces the standard text-based chatbot with interactive visual experiences. Here's what he's building:

Udemy and Carbon Health founder Eren Bali explains Monogram, a new kind of AI interface that replaces the standard text-based chatbot with interactive visual experiences. Here's what he's building:

TBPN

17,677 Aufrufe • vor 2 Monaten

.Sam Altman says OpenAI will "obviously" have a version of Codex that "can do other knowledge-work tasks, and control your computer." "Of course we should have an ability to kick off new tasks from mobile, and we'll do that." "Really what you want is your single AI that's working for you on a unified backend. Access to all your data and ideas, and your stuff and your memory, and the ability to work across a lot of surfaces."

.Sam Altman says OpenAI will "obviously" have a version of Codex that "can do other knowledge-work tasks, and control your computer." "Of course we should have an ability to kick off new tasks from mobile, and we'll do that." "Really what you want is your single AI that's working for you on a unified backend. Access to all your data and ideas, and your stuff and your memory, and the ability to work across a lot of surfaces."

TBPN

109,046 Aufrufe • vor 5 Monaten

John: What's interesting about Ilya and SSI is that it's a venture-style bet: let the scientists experiment, maybe it will work out, and if it works it's huge. The expected value is high. What's crazy is that it's a venture-style bet at growth scale. And it's a massive amount of capital for something where the consensus is: "If he solves it, it's incredibly valuable, and he leap frogs everything. And if not, maybe he just gets lost in a sea of research and never really produces anything." Also: this type of capital deployment has been happening internally at Google for a long time, but it hasn't been that big of a deal because they have the engine for it.

John: What's interesting about Ilya and SSI is that it's a venture-style bet: let the scientists experiment, maybe it will work out, and if it works it's huge. The expected value is high. What's crazy is that it's a venture-style bet at growth scale. And it's a massive amount of capital for something where the consensus is: "If he solves it, it's incredibly valuable, and he leap frogs everything. And if not, maybe he just gets lost in a sea of research and never really produces anything." Also: this type of capital deployment has been happening internally at Google for a long time, but it hasn't been that big of a deal because they have the engine for it.

TBPN

71,508 Aufrufe • vor 9 Monaten

When travis kalanick was fundraising Uber's round that valued it at $70B, he ran four rooms simultaneously out of their New York office for an entire week, each booked in 90-minute slots across 12-hour days: "This is how we'd fundraise: we had four rooms in our New York office booked for a week with an hour-and-a-half slot on each. So for 12 hours in a day, four rooms going in parallel." "I'm in the $250M-and-over club, that's one room. Then there are these other rooms, down to the fourth room, which is like $25M checks. There's a guy who works for a guy, who works for a guy, who works for me who's doing that room." "But we're oversubscribed. So we started putting multiple investors in the same room. We were like, 'We're just out of slots dude. Let's go.'" "The storytelling we did, anybody on my team could tell that story and make it happen. And that was a big part. It was the story... then there is making it scalable so that there are 10 different people in a company that can pitch it at any given time. And that’s when you take it all the way."

When travis kalanick was fundraising Uber's round that valued it at $70B, he ran four rooms simultaneously out of their New York office for an entire week, each booked in 90-minute slots across 12-hour days: "This is how we'd fundraise: we had four rooms in our New York office booked for a week with an hour-and-a-half slot on each. So for 12 hours in a day, four rooms going in parallel." "I'm in the $250M-and-over club, that's one room. Then there are these other rooms, down to the fourth room, which is like $25M checks. There's a guy who works for a guy, who works for a guy, who works for me who's doing that room." "But we're oversubscribed. So we started putting multiple investors in the same room. We were like, 'We're just out of slots dude. Let's go.'" "The storytelling we did, anybody on my team could tell that story and make it happen. And that was a big part. It was the story... then there is making it scalable so that there are 10 different people in a company that can pitch it at any given time. And that’s when you take it all the way."

TBPN

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